Papillary Thyroid Cancer: Pathological Parameters As Prognostic Factors In Different Classes Of Age
Paolo Miccoli, M N Minuto, Clara Ugolini, Erica Panicucci, Marco Massi, Piero Berti, Fulvio Basolo
Published 2008 · Medicine
Download PDFAnalyze on Scholarcy
OBJECTIVE: To analyze aspects of a series of papillary thyroid carcinomas and evaluate the prognostic features specific to different age classes. STUDY DESIGN: Retrospective study. SUBJECTS AND METHODS: From 2000 to 2005, 2709 patients underwent a total thyroidectomy for papillary thyroid carcinoma in our department. Patients were divided into three groups: <18 years (G1), 19 to 45 years (G2), and >46 years (G3). Histologic and clinical features were statistically evaluated. RESULTS: Tumor size was larger in G1 when compared with both G2 and G3 (P < 0.0001). Infiltration of the thyroid capsule and node metastases were higher in G1 than both G2 and G3 (P < 0.0001). The Tall-cell variant was more represented in G2 and G3. CONCLUSION: In the pediatric population, papillary carcinoma is a more aggressive disease. Because pediatric cancers have a better prognosis than their adult counterparts, this does not influence patient outcome. Age can then be considered the most important factor in determining prognosis.
This paper references
Papillary thyroid carcinoma.
Ian D. Hay (1990)
Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989.
Ian D. Hay (1993)
Lymph node metastases in differentiated thyroid cancer under 2 cm.
Rishindra M. Reddy (2006)
Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan.
Paola Collini (2006)
Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system.
Ian D. Hay (1987)
Surgical therapy of the thyroid papillary carcinoma in children: experience with 56 patients groups ality Bilaterality Capsulated Thyroid capsule infiltration Node metastases
C Spinelli (2004)
Impact of nodal metastases on prognosis in patients with well-differentiated thyroid cancer.
Nigel J. P. Beasley (2002)
Special Variants of Differentiated Thyroid Cancer: Does It Alter the Extent of Surgery Versus Well-Differentiated Thyroid Cancer?
Tobias Carling (2006)
Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules
P Collini (2006)
Changing Clinical, Pathologic, Therapeutic, and Survival Patterns in Differentiated Thyroid Carcinoma
Blake Cady (1976)
Prognostic factors in papillary thyroid carcinoma and implications of large nodal metastasis.
Ashok R Shaha (2004)
Completion total thyroidectomy in children with thyroid cancer secondary to the Chernobyl accident.
Paolo Miccoli (1998)
Differentiated thyroid cancer in children and adolescents
Jamshid Farahati (1998)
Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children's Cancer Group.
Kurt D. Newman (1998)
Prognostic variables of papillary and follicular thyroid carcinoma patients with lymph node metastases and without distant metastases.
Jiunn Diann Lin (1999)
Childhood and adolescent thyroid carcinoma.
Perry Grigsby (2002)
Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients.
Martin Jean Schlumberger (1987)
An expanded view of risk-group definition in differentiated thyroid carcinoma.
Blake Cady (1988)
Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients.
Robert A. Frankenthaler (1990)
ES02 SIGNIFICANCE OF LYMPH NODE MICROMETASTASES IN PAPILLARY THYROID CARCINOMA
Isaac M. Cranshaw (2007)
This paper is referenced by
Thyroid Carcinoma Pattern Presentation According to Age
Fábio Muradás Girardi (2017)
Association of patient age with high-risk pathologic features in papillary thyroid cancer.
Adam C. Niemann (2017)
Incidence and malignancy rates of indeterminate pediatric thyroid nodules
Huiying Wang (2019)
Surgical management of well-differentiated thyroid cancer: state of the art.
James W Suliburk (2009)
Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients.
Ioannis Vasileiadis (2014)
, of Chernobyl Thyroid Cancer Radiation Exposure Does Not Significantly Contribute to the Risk of Recurrence
Pavel O. Rumyantsev (2017)
Pediatric thyroid cancer.
Diana Diesen (2012)
S-phase fraction and ploidy as predictive markers in primary disease and recurrence of papillary thyroid carcinoma.
António E. Pinto (2012)
Clinicopathologic and molecular disease prognostication for papillary thyroid cancer
Paolo Miccoli (2009)
Differentiated thyroid carcinoma: Prognostic stratification and molecular classification
M N Minuto (2013)
Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features in Children: An Institutional Experience and Literature Review
Huiying Wang (2019)
Clinicopathologic characteristics and surgical outcomes of elderly patients with thyroid cancer.
Hyung Seok Park (2014)
Age-based disparities in the use of total thyroidectomy for papillary thyroid carcinoma
I. V. Shevchyk (2017)
Expression of FoxP3 Protein Plays a Key Role in Thyroid Tumors in Children
Łukasz Szylberg (2014)
Expression of MMP-1 in invasive well-differentiated thyroid carcinoma
Aviram Mizrachi (2010)
SKYDLIAUKĖS VĖŽYS LIETUVOJE: IŠGYVENAMUMO POKYČIAI IR JIEMS ĮTAKOS TURINTYS VEIKSNIAI
Karolis Ulinskas (2016)
Prognosis and growth activity depend on patient age in clinical and subclinical papillary thyroid carcinoma.
Yasuhiro Ito (2014)
Sensitivity of fine-needle biopsy in detecting pediatric differentiated thyroid carcinoma.
Antje Redlich (2012)
Caracterização clinicopatológica de carcinoma papilífero de tireoide em crianças e adolescentes: uma série de casos
Danielle Pessôa Pereira (2013)
Mutation in BRAF and Other Members of the MAPK Pathway in Papillary Thyroid Carcinoma in the Pediatric Population.
Ryan J Gertz (2016)
Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study.
Yasuhiro Ito (2012)
Clinical Management of Thyroid Cancer
Kennichi Kakudo (2013)
Cancer of the thyroid gland in geriatric age: a single center retrospective study with a 10-year post-operative follow-up.
Giuseppe Santangelo (2014)
Thyroid papillary microcarcinoma: a descriptive and meta-analysis study.
Elio Roti (2008)
Surgical Strategy for Papillary Thyroid Microcarcinoma
Young don Lee (2014)
Thyroid surgical practices shaping thyroid cancer incidence in North-Eastern Italy.
Maria Rosa Pelizzo (2014)
Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years.
Yasuhiro Ito (2012)
Tall Cell Variant of Papillary Thyroid Carcinoma in Children
Paola Collini (2014)
Age and prognosis of papillary thyroid carcinoma: retrospective stratification into three groups
Jin Seong Cho (2012)
Features of papillary thyroid carcinoma in patients older than 75 years
Antonio Toniato (2011)
Higher serum TSH in thyroid cancer patients occurs independent of age and correlates with extrathyroidal extension.
Megan R Haymart (2009)
Clinical and molecular features of papillary thyroid cancer in adolescents and young adults.
Menno R. Vriens (2011)See more