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Ischemic Stroke And Excellent Recovery After Administration Of Intravenous Tissue Plasminogen Activator.

S. V. Jain, L. Morton
Published 2008 · Medicine

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Intravenous tissue plasminogen activator has become a mainstream treatment for ischemic hyperacute stroke in the adult population. Its safety and efficacy remain undetermined in the pediatric population. We present a teenager who was hospitalized with left-sided paralysis, and with decreased sensations on the left side. Head computed tomography indicated hyperdensity in the middle cerebral artery region, which confirmed the diagnosis of acute ischemic stroke. Her score on the National Institutes of Health stroke scale was 11. She received intravenous tissue plasminogen activator without any complications. At a follow-up visit 5 months after the stroke, the patient manifested mild apraxia in her left hand and mild expressive amusia. This case underscores the need for emergency head imaging in the pediatric population to establish a diagnosis. The excellent recovery in our patient indicates the need to establish thrombolytic treatment as an option for acute stroke in pediatric populations. It also suggests that tissue plasminogen activator can be used safely and effectively, even in pediatric populations. However, further studies are needed to establish the adequate dosage and adverse-effect profile in pediatric populations.
This paper references
10.1161/01.STR.31.2.398
Significant association of atrial vulnerability with atrial septal abnormalities in young patients with ischemic stroke of unknown cause.
K. Berthet (2000)
10.1212/WNL.47.3.835
Practice Advisory
Lippincott Williams Wilkins (1996)
10.1007/S11940-005-0047-6
Treatment and prevention of cerebrovascular disorders in children
J. Lynch (2005)
10.1097/01.nrl.0000195826.72179.0b
Stroke in Childhood
L. Jordan (2006)
10.1053/SPEN.2000.20226
New radiographic techniques to evaluate cerebrovascular disorders in children.
J. Hunter (2000)
10.1542/PEDS.109.1.116
Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke.
J. Lynch (2002)
10.1097/00008506-199604000-00018
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke t-PA Stroke Study Group:
Joakim Bjorkdahl (1996)
10.1542/peds.2005-2676
Mimics of Childhood Stroke: Characteristics of a Prospective Cohort
R. Shellhaas (2006)
10.1161/STROKEAHA.106.473983
Thrombolysis for Ischemic Stroke in Children: Data From the Nationwide Inpatient Sample
N. Janjua (2007)
Thrombolysis for schemic stroke in children . Data from the nationwide inpatient sample
J Carpenter (2007)
10.1016/S1474-4422(05)70120-4
In pursuit of evidence-based treatments for paediatric stroke: the UK and Chest guidelines
G. DeVeber (2005)
10.1056/NEJM199512143332401
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
J. Grotta (1995)
10.1007/BF03207044
Therapeutic approaches and advances in pediatric stroke
A. Kirton (2006)
10.4065/79.1.79
Patent foramen ovale and stroke.
S. Horton (2004)
10.1097/01.pec.0000092577.40174.61
Emergency Department Presentation of Pediatric Stroke
Kirsten K. Calder (2003)
10.1586/14737175.7.4.383
Treatment of arterial ischemic stroke in children
Jessica L. Carpenter (2007)
10.1590/S0004-282X2006000200002
Cerebrovascular disorders in childhood: etiology, clinical presentation, and neuroimaging findings in a case series study.
A. Matta (2006)



This paper is referenced by
10.1586/14737175.2014.884927
The prospects and predicaments of intravenous rt-PA in childhood ischemic stroke
R. Behrouz (2014)
10.1097/NRL.0000000000000050
Successful Systemic Thrombolysis in an Adolescent With Acute Ischemic Stroke
F. Viaro (2015)
10.1017/S1481803500010824
Successful treatment of pediatric stroke with recombinant tissue plasminogen activator (rt-PA): a case report and review of the literature.
S. Cremer (2008)
10.1016/j.jpeds.2015.03.051
The Pediatric Stroke Code: Early Management of the Child with Stroke.
J. Elbers (2015)
10.1177/0883073811408091
Potential Eligibility for Recombinant Tissue Plasminogen Activator Therapy in Children: A Population-Based Study
Laura L. Lehman (2011)
10.1016/S1474-4422(09)70106-1
Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study
Catherine M. Amlie-Lefond (2009)
10.3995/JSTROKE.33.408
Successful treatment of cerebral embolism in a juvenilewoman using intravenous rt-PA
Shinichi Shirai (2011)
10.1055/S-0039-1692670
Traumatic Vertebral Artery Dissection and Basilar Artery Occlusion/Stroke in a 7-Year-Old Child: A Case Report.
B. Phung (2019)
10.1016/j.jstrokecerebrovasdis.2009.03.019
Does mild deficit for patients with stroke justify the use of intravenous tissue plasminogen activator?
A. Hassan (2010)
10.1177/1747493018799958
Australian Clinical Consensus Guideline: The diagnosis and acute management of childhood stroke
T. Medley (2019)
10.1155/2011/734506
Pediatric Stroke: A Review
D. Tsze (2011)
10.1159/000203076
Thrombolysis in Acute Childhood Stroke: Design and Challenges of the Thrombolysis in Pediatric Stroke Clinical Trial
C. Amlie-Lefond (2009)
10.1136/archdischild-2016-312539
Question 2: Should thrombolytic agents be used in children presenting with acute ischaemic stroke?
Dhinesh Baskaran (2017)
10.1007/978-3-319-55994-0_76
Pediatric Neurovascular Disease
B. Curry (2018)
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