Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Antimicrobial Peptides, Nanotechnology, And Natural Metabolites As Novel Approaches For Cancer Treatment

M. Leite, N. B. da Cunha, F. Costa
Published 2018 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
ABSTRACT Despite the advances in tumor identification and treatment, cancer remains the primary driver of death around the world. Also, regular treatments for the disease are incapable of targeting particular cancer types at different stages since they are not specifically focused on harmful cells since they influence both solid and tumor cells, causing side effects and undesirable symptoms. Therefore, novel strategies should be developed to treat this disease. Several efforts have been made in this direction to find more effective alternatives to cancer treatment, such as the use of antimicrobial peptides (AMPs) with antitumoral activity, nanocarriers and natural compounds from a variety of sources. AMPs are more specific to their targets because of electrostatic interaction between AMPs and the cancer cells' plasma membrane. Nanocarriers may be used for the delivery of non‐soluble drugs, which are poorly stable or require a controlled release. In addition, natural compounds have been a rich source of anti‐cancer agents for decades. In this review, these three approaches will be discussed, showing recent advances and advantages of using these strategies to treat cancer as well as the combination of these approaches increasing anticancer activity.
This paper references
10.1016/j.jnutbio.2015.11.006
The role of natural polyphenols in cell signaling and cytoprotection against cancer development.
H. Lewandowska (2016)
10.1021/bm8009973
Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting.
M. L. Patil (2009)
10.2217/NNM-2016-0197
Treg cells as potential cellular targets for functionalized nanoparticles in cancer therapy.
H. Jonuleit (2016)
: Clinical relevance and therapeutic implications
M. E. Silva-Stenico (2013)
10.3390/md14010001
Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug
Javier A. García-Vilas (2015)
10.1002/jps.22121
New drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy.
K. Gardikis (2010)
10.1038/sj.bjc.6602479
NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
T. Hamaguchi (2005)
10.7554/eLife.01808
Phosphoinositide-mediated oligomerization of a defensin induces cell lysis
I. K. Poon (2014)
10.3892/ijo.2014.2604
Non-pegylated liposome-encapsulated doxorubicin citrate plus cyclophosphamide or vinorelbine in metastatic breast cancer not previously treated with chemotherapy:a multicenter phase III study.
V. Lorusso (2014)
10.1016/j.addr.2013.08.001
Carbon nanotubes in hyperthermia therapy.
R. Singh (2013)
10.1016/j.addr.2012.10.002
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.
H. Maeda (2013)
10.1155/2015/167642
Space Flight Effects on Antioxidant Molecules in Dry Tardigrades: The TARDIKISS Experiment
A. Rizzo (2015)
10.1016/j.colsurfb.2016.05.041
iRGD peptide as effective transporter of CuInZnxS2+x quantum dots into human cancer cells.
Łucja Przysiecka (2016)
10.2217/nnm.09.44
Stimulus-responsive targeted nanomicelles for effective cancer therapy.
M. Muthu (2009)
10.2217/nnm.10.113
The rise and rise of stealth nanocarriers for cancer therapy: passive versus active targeting.
N. Huynh (2010)
10.1007/s00280-016-2986-x
A phase I dose escalation study of NK012, an SN-38 incorporating macromolecular polymeric micelle
H. Burris (2016)
10.1115/1.3156800
Nanoparticles for thermal cancer therapy.
E. Day (2009)
10.1517/13543784.15.8.933
Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment
Jamie S. Mader (2006)
10.1186/s11671-016-1319-7
Facile Fabrication of Bi2WO6/Ag2S Heterostructure with Enhanced Visible-Light-Driven Photocatalytic Performances
R. Tang (2016)
From antimicrobial to anticancer peptides
D. Gaspar (2013)
10.1016/j.ijbiomac.2015.10.025
Nano-encapsulation of olive leaf phenolic compounds through WPC-pectin complexes and evaluating their release rate.
Adeleh Mohammadi (2016)
10.1016/j.drudis.2010.08.006
Cancer nanotechnology: application of nanotechnology in cancer therapy.
R. Misra (2010)
10.1002/bip.20917
Membrane interactions of designed cationic antimicrobial peptides: the two thresholds.
E. Glukhov (2008)
10.1016/j.phrs.2016.07.023
Novel targets for paclitaxel nano formulations: Hopes and hypes in triple negative breast cancer.
Anita K. Bakrania (2016)
10.1016/j.bbamcr.2014.11.006
Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics.
D. Gaspar (2015)
10.1016/j.jchromb.2016.01.003
Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line.
D. Gao (2016)
10.1016/j.nano.2015.11.012
Targeted nanosystems: Advances in targeted dendrimers for cancer therapy.
H. Yang (2016)
10.2174/1381612043383971
Membrane disrupting lytic peptides for cancer treatments.
C. Leuschner (2004)
10.1016/j.cmet.2017.08.017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Maria V. Liberti (2017)
10.1007/s00280-014-2523-8
Phase I clinical trial of pegylated liposomal mitoxantrone plm60-s: pharmacokinetics, toxicity and preliminary efficacy
J. Yang (2014)
10.1021/jm401907z
Combination of dendrimer-nanovector-mediated small interfering RNA delivery to target Akt with the clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer.
Shashwati Kala (2014)
10.1016/j.drudis.2013.05.011
Future directions for peptide therapeutics development.
Allan A. Kaspar (2013)
10.1016/j.biopha.2015.01.004
Toluhydroquinone, the secondary metabolite of marine algae symbiotic microorganism, inhibits angiogenesis in HUVECs.
Nan-Hee Kim (2015)
The rise and rise of stealth nanocarriers for cancer therapy: Passive versus active
N. T. Huynh (2010)
10.3109/1061186X.2015.1113539
Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa
Che Wang (2016)
10.3993/JFBI03201503
Mechanism of Anticancer Effects of Antimicrobial Peptides
X. Liu (2015)
10.4137/PMC.S13215
Antimicrobial Peptides and Their Analogs: Searching for New Potential Therapeutics
K. Midura-nowaczek (2014)
10.1016/j.thorsurg.2015.12.009
From Diagnosis to Treatment: Clinical Applications of Nanotechnology in Thoracic Surgery.
Christopher S Digesu (2016)
10.1038/srep34843
Electrochemical noise and impedance of Au electrode/electrolyte interfaces enabling extracellular detection of glioma cell populations
P. R. F. Rocha (2016)
10.1016/j.ijpharm.2016.12.060
Graphene quantum dots for cancer targeted drug delivery.
D. Iannazzo (2017)
10.1615/CritRevTherDrugCarrierSyst.2016015273
PLGA Nanoparticles and Their Versatile Role in Anticancer Drug Delivery.
Iliyas Khan (2016)
10.1016/j.bpj.2015.07.033
PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties
N. B. Leite (2015)
Anticancer peptides from bacteria. Bangladesh
T. M. Karpiński (2013)
10.3736/JCIM20100909
Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375.
A. Khuda-Bukhsh (2010)
10.2217/nnm.11.64
Quantum dots and carbon nanotubes in oncology: a review on emerging theranostic applications in nanomedicine.
A. Tan (2011)
10.1126/science.aad1329
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
M. Vétizou (2015)
10.1038/354056a0
Helical microtubules of graphitic carbon
S. Iijima (1991)
10.3389/fmicb.2013.00294
From antimicrobial to anticancer peptides. A review
D. Gaspar (2013)
ff ects of surface modi fi cation of quantum dots on viability and migration of triple - negative breast cancer cells
H. Chen
10.1128/MCB.22.6.1926-1935.2002
BMAP-28, an Antibiotic Peptide of Innate Immunity, Induces Cell Death through Opening of the Mitochondrial Permeability Transition Pore
A. Risso (2002)
10.3390/ijms13066849
Role of Helicity on the Anticancer Mechanism of Action of Cationic-Helical Peptides
Y. Huang (2012)
10.1002/ANIE.200460800
cRGD-functionalized polymer micelles for targeted doxorubicin delivery.
N. Nasongkla (2004)
10.1371/journal.pone.0186146
Detecting conservation benefits of marine reserves on remote reefs of the northern GBR
Carolina Castro-Sanguino (2017)
10.1186/1477-3155-11-S1-S4
Structure, assembly and dynamics of macromolecular complexes by single particle cryo-electron microscopy
A. Durand (2013)
10.1002/mas.21510
Phospholipids as cancer biomarkers: Mass spectrometry-based analysis.
R. Bandu (2018)
10.1007/s00280-014-2671-x
Phase I study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients
T. Chang (2014)
Nanocarriers as an emerging platform for cancer therapy
S. Wise (2007)
10.1016/j.drudis.2011.04.007
The impact of epigenomics on future drug design and new therapies.
Christopher A. Hamm (2011)
10.2147/IJN.S90198
Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy
I. Bwatanglang (2016)
10.1016/j.cllc.2012.11.005
Paclitaxel-loaded polymeric micelle (230 mg/m(2)) and cisplatin (60 mg/m(2)) vs. paclitaxel (175 mg/m(2)) and cisplatin (60 mg/m(2)) in advanced non-small-cell lung cancer: a multicenter randomized phase IIB trial.
S. Lee (2013)
10.1021/bc200367f
Mode of action of cationic antimicrobial peptides defines the tethering position and the efficacy of biocidal surfaces.
M. Bagheri (2012)
10.1038/nature18850
Microbiome-wide association studies link dynamic microbial consortia to disease
J. Gilbert (2016)
10.1111/j.0105-2896.2004.0124.x
Anti‐microbial peptides: from invertebrates to vertebrates
Philippe Bulet (2004)
10.1038/nnano.2012.237
Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.
A. Salvati (2013)
10.1038/nrmicro3496
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
P. Rutledge (2015)
10.1074/jbc.M114.554444
Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin*
Tianhua Zhang (2014)
Polymeric drugs for e ffi cient tumor - targeted drug delivery based on EPR
H. Maeda (2013)
10.1155/2016/5738694
Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites
X. Chen (2016)
10.1208/s12249-014-0251-3
Polymeric Micelles for Multi-Drug Delivery in Cancer
H. Cho (2014)
10.1016/j.colsurfb.2016.07.060
Multi-functional vesicles for cancer therapy: The ultimate magic bullet.
L. Tavano (2016)
10.1016/S0092-8674(00)81683-9
The Hallmarks of Cancer
D. Hanahan (2000)
10.1016/J.ORALONCOLOGY.2005.11.005
The cytotoxic effects of human neutrophil peptide-1 (HNP1) and lactoferrin on oral squamous cell carcinoma (OSCC) in vitro.
S. McKeown (2006)
10.1126/science.1240527
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
Noriho Iida (2013)
10.1016/j.phymed.2016.07.004
Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells.
D. Arora (2016)
10.1016/j.tibtech.2013.10.004
The potential legacy of cancer nanotechnology: cellular selection.
H. Patra (2014)
10.1126/science.aac4255
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Ayelet Sivan (2015)
10.1016/j.bbamem.2015.02.017
Understanding bacterial resistance to antimicrobial peptides: From the surface to deep inside.
Simone Maria-Neto (2015)
10.1371/journal.pone.0043958
Daptomycin Resistance in Enterococci Is Associated with Distinct Alterations of Cell Membrane Phospholipid Content
N. Mishra (2012)
10.1182/asheducation-2009.1.708
Dendrimer-based nanoparticles for cancer therapy.
J. Baker (2009)
10.1038/srep17608
Crossover from a heavy fermion to intermediate valence state in noncentrosymmetric Yb2Ni12(P,As)7
W. Jiang (2015)
10.2174/0929867322666150716114758
A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi.
S. Genovese (2015)
10.1038/s41598-017-04643-3
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride
R. Li (2017)
10.1016/j.ejpb.2008.11.010
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.
H. Maeda (2009)
Carbon nanotubes for cancer therapy and neurodegenerative diseases.
Elena Daniela Meliţă (2015)
Epigenetic targeting
J. Li (2017)
10.1515/ntrev-2013-0013
Nanotechnology for cancer treatment
W. Gmeiner (2015)
10.1002/hed.23397
Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer
S. Strieth (2014)
10.1007/s10989-014-9417-9
Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells
T. Arpornsuwan (2014)
10.3389/fchem.2017.00005
Peptides with Dual Antimicrobial and Anticancer Activities
Mário R Felício (2017)
10.1016/j.addr.2011.04.002
Role of tumor vascular architecture in drug delivery.
A. Narang (2011)
10.1093/annonc/mdt480
Final results of phase II trial of doxorubicin HCl liposome injection followed by bexarotene in advanced cutaneous T-cell lymphoma.
D. Straus (2014)
10.1016/j.jconrel.2010.08.027
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.
F. Danhier (2010)
10.1016/j.biomaterials.2014.10.057
Nanodiamonds coupled with plant bioactive metabolites: a nanotech approach for cancer therapy.
A. Gismondi (2015)
10.1007/s00270-010-9967-y
Nanotechnology and its Relationship to Interventional Radiology. Part II: Drug Delivery, Thermotherapy, and Vascular Intervention
S. Power (2010)
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.
G. Adams (2001)
10.3390/md13052909
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents
N. Janakiram (2015)
10.1016/j.ctrv.2016.10.008
Cell membrane modulation as adjuvant in cancer therapy.
S. Zalba (2017)
10.1016/j.ijpharm.2017.02.006
Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.
Yusuf A Haggag (2017)
10.1016/j.biomaterials.2014.05.091
Quantitative control of active targeting of nanocarriers to tumor cells through optimization of folate ligand density.
Zhaomin Tang (2014)
10.1128/AAC.00666-06
In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci
A. Giacometti (2007)
10.1371/journal.pone.0111575
Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials
T. Nguyen (2014)
10.1186/1477-3155-11-30
Carbon nanotubes as a novel tool for vaccination against infectious diseases and cancer
R. Gottardi (2013)
10.1038/nature12327
Structural basis for molecular recognition of folic acid by folate receptors
C. Chen (2013)
Hostdefence peptides from the glandular secretions of amphibians: Structure and activity
T. L. Pukala (2006)
10.1080/10611860701794353
Polymeric nanoparticles for cancer therapy
S. Parveen (2008)
10.1007/s00280-012-2048-y
A phase I study of liposomal-encapsulated docetaxel (LE-DT) in patients with advanced solid tumor malignancies
J. Deeken (2012)
10.2174/1568026615666150703115919
Model Membrane and Cell Studies of Antimicrobial Activity of Melittin Analogues.
Elaheh Jamasbi (2016)
10.3389/fmicb.2013.00001
Nucleic acid-based approaches to investigate microbial-related cheese quality defects
D. O'sullivan (2013)
10.1007/s10495-015-1169-2
Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
H. Gali-Muhtasib (2015)
10.1039/c7nr00888k
pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis.
Zetan Fan (2017)
10.1016/j.msec.2016.11.073
Liposome-based drug co-delivery systems in cancer cells.
Sepideh Zununi Vahed (2017)
10.1515/hsz-2012-0136
Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids
S. Gross (2012)
10.1002/psc.1167
Quality specifications for peptide drugs: a regulatory‐pharmaceutical approach
Valentijn Vergote (2009)
10.1016/j.ejca.2011.08.004
Myotax: a phase II trial of docetaxel plus non-pegylated liposomal doxorubicin as first-line therapy of metastatic breast cancer previously treated with adjuvant anthracyclines.
E. Curtit (2011)
10.1080/10611860701539584
Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines
K. Greish (2007)
10.1038/sj.onc.1207263
Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors
F. Costa (2004)
10.1016/j.addr.2010.11.005
Extravasation of polymeric nanomedicines across tumor vasculature.
M. Danquah (2011)
10.1016/S1359-6446(04)03276-3
Dendrimers and dendritic polymers in drug delivery.
E. Gillies (2005)
10.1038/srep09294
Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death
Fu-qian Wang (2015)
10.1186/s13148-015-0095-z
Epigenetic activities of flavonoids in the prevention and treatment of cancer
C. Busch (2015)
10.1158/1940-6207.CAPR-15-0350
Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses
C. Piyathilake (2016)
10.3390/md14050098
Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”
N. G. M. Gomes (2016)
10.1155/2016/6341870
Unravelling the Complexity of Inherited Retinal Dystrophies Molecular Testing: Added Value of Targeted Next-Generation Sequencing
I. Bernardis (2016)
10.2174/138920012802850010
Dendrimers in cancer therapeutics and diagnosis.
R. Guo (2012)
10.2174/138920306779025611
Anticancer alpha-helical peptides and structure/function relationships underpinning their interactions with tumour cell membranes.
S. Dennison (2006)
10.1038/s41598-017-04406-0
Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy
J. Li (2017)
10.2174/092986613805290435
Anticancer peptides and proteins: a panoramic view.
M. S. Libério (2013)
10.1371/journal.pone.0172850
The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells
Kateřina Voráčová (2017)
Paclitaxel-loaded polymeric micelles radiosensitize tumors via an oxygen effect
F. Danhier (2012)
10.1038/nbt1267
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
R. Hancock (2006)
10.1126/science.1240537
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
S. Viaud (2013)
10.1016/j.ejpb.2014.03.015
Dendronized nanoconjugates of lysine and folate for treatment of cancer.
K. Jain (2014)
10.18632/oncotarget.9710
16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment
R. Guerrero-Preston (2016)
10.1016/j.lfs.2013.03.016
Anticancer mechanisms of temporin-1CEa, an amphipathic α-helical antimicrobial peptide, in Bcap-37 human breast cancer cells.
Che Wang (2013)
10.1186/1471-2407-11-430
INSPIRE: A phase III study of the BLP25 liposome vaccine (L-BLP25) in Asian patients with unresectable stage III non-small cell lung cancer
Y. Wu (2011)
10.1128/AAC.02182-12
Correlation of Cell Membrane Lipid Profiles with Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus
N. Mishra (2012)
10.1016/j.peptides.2012.05.014
Antimicrobial peptides: Clinical relevance and therapeutic implications
Fabiano Pinheiro da Silva (2012)
10.1155/2015/735087
Plant Antimicrobial Peptides as Potential Anticancer Agents
J. Guzmán-Rodríguez (2015)
10.1371/journal.pone.0089504
Micronutrient Intakes among Women of Reproductive Age in Vietnam
P. Nguyen (2014)
10.1016/j.tibtech.2011.05.001
The expanding scope of antimicrobial peptide structures and their modes of action.
L. T. Nguyen (2011)
10.1128/AAC.03422-14
Heterogeneity of mprF Sequences in Methicillin-Resistant Staphylococcus aureus Clinical Isolates: Role in Cross-Resistance between Daptomycin and Host Defense Antimicrobial Peptides
A. Bayer (2014)
10.1016/j.phymed.2012.01.007
Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest.
N. A. M. N. Hazalin (2012)
10.3389/fphar.2017.00182
Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells
Guimiao Lin (2017)
10.1002/wnan.1268
Therapeutic applications of carbon nanotubes: opportunities and challenges.
G. Rogers-Nieman (2014)
10.1515/ntrev-2013-0042
Microfluidic systems and microreactors for the synthesis of new types of nanomaterials and nanomaterials of particularly high quality
J. Köhler (2014)
10.3390/md14070130
Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus
Sameh S Elhady (2016)
10.5483/BMBRep.2015.48.6.073
Anticancer activity of CopA3 dimer peptide in human gastric cancer cells
J. Lee (2015)
10.2174/092986709789712916
Liposome-encapsulated anticancer drugs: still waiting for the magic bullet?
R. Fanciullino (2009)
10.3389/fchem.2017.00001
The Effect of Selective D- or Nα-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20
W. Li (2017)
10.1016/j.bcp.2013.08.008
Role of glycosylation in the anticancer activity of antibacterial peptides against breast cancer cells.
Y. Han (2013)
10.1371/journal.pone.0137889
Lichen Secondary Metabolite, Physciosporin, Inhibits Lung Cancer Cell Motility
Yi Yang (2015)
10.1016/j.addr.2010.04.009
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect.
J. Fang (2011)
10.3390/ph6121543
Antimicrobial Peptides
A. Bahar (2013)
10.1016/S0924-8579(03)00180-8
Antimicrobial peptides in animals and their role in host defences.
K. Brogden (2003)
10.3390/md13106259
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells
J. Chen (2015)
10.1002/CHIN.201334239
AApeptides as a New Class of Antimicrobial Agents
Youhong Niu (2013)
10.1039/B512118N
Host-defence peptides from the glandular secretions of amphibians: structure and activity.
T. Pukala (2006)
10.3390/md12073818
Lamellarin O, a Pyrrole Alkaloid from an Australian Marine Sponge, Ianthella sp., Reverses BCRP Mediated Drug Resistance in Cancer Cells
Xiao-cong Huang (2014)
10.1186/s12860-016-0124-6
Erratum to: Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis
Callinice D. Capo-chichi (2016)
10.18632/oncotarget.17411
Peiminine inhibits colorectal cancer cell proliferation by inducing apoptosis and autophagy and modulating key metabolic pathways
Zhi Zheng (2017)
10.2147/IJN.S103994
Efficient intravesical therapy of bladder cancer with cationic doxorubicin nanoassemblies
X. Jin (2016)
10.2174/1389201014666131227114846
Natural products from cyanobacteria with antimicrobial and antitumor activity.
M. E. Silva-Stenico (2013)
10.1007/S10544-005-6174-8
Release of Biologically Functional Interferon-Alpha from a Nanochannel Delivery System
Gregory B. Lesinski (2005)
10.1248/BPB.29.1790
Nanocarriers: promising vehicle for bioactive drugs.
M. Rawat (2006)
10.3892/MCO.2014.356
Passive targeting of nanoparticles to cancer: A comprehensive review of the literature.
R. Bazak (2014)
10.1080/13543776.2016.1176149
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
Paulina Kosikowska (2016)
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Y. Matsumura (1986)
10.1016/j.plipres.2011.12.005
Role of lipids in the interaction of antimicrobial peptides with membranes.
Vitor Teixeira (2012)
10.1186/1475-2867-5-33
Cell biology as the basis of a better understanding of cancer
D. Wheatley (2005)
10.3389/fmicb.2013.00321
Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides
K. C. Mulder (2013)
10.1016/j.phrs.2016.09.018
Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on anti-tumour properties of ciliate bioactive molecules.
E. Catalani (2016)
10.1186/bcr3043
Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts
A. Hilchie (2011)
10.1080/21691401.2016.1228658
An update on applications of nanostructured drug delivery systems in cancer therapy: a review
Seyed Mohsen Aberoumandi (2017)
10.3390/ijms18030493
Short-Term Local Adaptation of Historical Common Bean (Phaseolus vulgaris L.) Varieties and Implications for In Situ Management of Bean Diversity
Stephanie M. Klaedtke (2017)
10.1016/J.YANE.2012.02.046
Hallmarks of Cancer: The Next Generation
M. Roizen (2012)
10.1166/JNN.2015.10614
Carbon Nanomaterials for Drug Delivery and Cancer Therapy.
Mrinmay Chakrabarti (2015)
10.3389/fphar.2017.00504
The Crux of the Medicine Prices' Controversy in Pakistan
K. Lee (2017)
10.3390/ph7050545
Human Antimicrobial Peptides and Proteins
G. Wang (2014)
10.1021/bm201098j
Designed antimicrobial and antitumor peptides with high selectivity.
J. Hu (2011)
10.1016/J.EUPROT.2014.05.003
The emergence of peptides in the pharmaceutical business: From exploration to exploitation
T. Uhlig (2014)
10.1016/j.addr.2008.08.005
Active targeting schemes for nanoparticle systems in cancer therapeutics.
J. D. Byrne (2008)
10.1016/j.jconrel.2012.03.020
Doxil®--the first FDA-approved nano-drug: lessons learned.
Y. Barenholz (2012)
10.7554/eLife.00590
Extinction risk and conservation of the world’s sharks and rays
N. Dulvy (2014)
10.1186/s12906-016-1247-1
Clausenidin induces caspase-dependent apoptosis in colon cancer
P. Waziri (2016)
10.1007/s10637-011-9709-2
Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
K. Kato (2011)
10.3322/caac.21332
Cancer statistics, 2016
R. Siegel (2016)
10.1088/0957-4484/22/3/035101
Surface functionalization of PLGA nanoparticles by non-covalent insertion of a homo-bifunctional spacer for active targeting in cancer therapy.
S. Thamake (2011)
10.1038/srep44414
Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer
G. C. Mânica (2017)
Phase II , multicenter , randomized trial of CPX - 351 ( cytarabine : daunor - ubicin ) liposome injection versus intensive salvage therapy in adults with fi rst relapse AML
J. E. Cortes (2014)
Quantum dots and carbon nanotubes in oncology : A review on emerging theranostic applications in
T. Tanaka
10.1038/ncomms10391
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis
Krista Dubin (2016)
10.1016/j.peptides.2008.12.019
Selective cancer cell cytotoxicity of enantiomeric 9-mer peptides derived from beetle defensins depends on negatively charged phosphatidylserine on the cell surface
T. Iwasaki (2009)
10.1016/j.drudis.2012.05.003
Carbon nanotube exploration in cancer cell lines.
P. Kesharwani (2012)
10.1016/J.DRUP.2003.11.002
Selective targeting of cancer cells using synthetic peptides.
M. Shadidi (2003)
10.1007/s10856-013-4969-3
Encapsulation of curcumin within poly(amidoamine) dendrimers for delivery to cancer cells
L. Wang (2013)
10.1007/s00726-010-0815-9
Antitumor and angiostatic peptides from frog skin secretions
H. Zoggel (2010)
10.1007/s00280-014-2452-6
Phase I and pharmacokinetic study of polymeric micelle-formulated paclitaxel in adult Chinese patients with advanced solid tumors
F. Lv (2014)
10.1186/S12906-016-1136-7
Decatropis bicolor (Zucc.) Radlk essential oil induces apoptosis of the MDA-MB-231 breast cancer cell line
C. Gómez (2016)
10.1016/j.pharmthera.2015.03.003
Epigenomes as therapeutic targets.
C. Hamm (2015)
10.1016/j.ejpb.2015.03.018
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.
Edgar Pérez-Herrero (2015)
10.1038/nbt.2572
Antimicrobial peptides stage a comeback
J. Fox (2013)
10.1016/j.drudis.2014.10.003
Peptide therapeutics: current status and future directions.
K. Fosgerau (2015)
10.1016/j.urolonc.2007.03.017
New frontiers in nanotechnology for cancer treatment.
F. Alexis (2008)
10.1016/j.nano.2015.10.018
Advances in silica based nanoparticles for targeted cancer therapy.
Yannan Yang (2016)
Graphene quantum dots for cancer targeted drug
D. Iannazzo (2017)
10.2217/nnm.14.130
Applications of dendrimers for brain delivery and cancer therapy.
Sukrut Somani (2014)
メソ多孔性のデラフォサイト型CuCrO 2 とスピネル型CuCr 2 O 4 合成と触媒反応 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Zhang Peng (2013)
10.2174/1389557514666141107120954
Alpha-helical cationic anticancer peptides: a promising candidate for novel anticancer drugs.
Y. Huang (2015)
10.1016/j.csbj.2015.11.005
Prediction of anticancer peptides against MCF-7 breast cancer cells from the peptidomes of Achatina fulica mucus fractions
Teerasak E-kobon (2016)
10.1155/2016/7242478
Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis
H. Wang (2016)
10.1002/med.20233
Perspectives and potential applications of nanomedicine in breast and prostate cancer
Y. Liu (2013)
10.1038/ncomms11852
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities
C. Bain (2016)
10.1080/10286020.2014.970535
Anticancer agents from marine sponges
Jianjun Ye (2015)
10.1002/chem.201302097
Polymeric micelles for multidrug delivery and combination therapy.
M. Aw (2013)
10.1074/jbc.M111.303602
Roles of Hydrophobicity and Charge Distribution of Cationic Antimicrobial Peptides in Peptide-Membrane Interactions*
Lois M. Yin (2012)
10.1016/J.BBAMEM.2007.11.008
Studies on anticancer activities of antimicrobial peptides.
D. Hoskin (2008)
10.1088/0957-4484/24/4/045102
Carbon nanotubes enhance the internalization of drugs by cancer cells and decrease their chemoresistance to cytostatics.
M. Mahmood (2013)
The research and applications of quantum dots as nanocarriers for targeted drug delivery and cancer therapy
Zhao (2016)
10.1186/1475-2867-5-21
Functional and structural characteristics of anticancer peptide Pep27 analogues
D. Lee (2004)
10.4143/crt.2009.41.1.1
Advances of cancer therapy by nanotechnology.
X. Wang (2009)
10.1186/s11671-016-1394-9
The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy
M. Zhao (2016)
10.1016/j.ijpharm.2012.08.042
Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs.
Y. Lu (2013)
10.1016/j.phrs.2016.07.006
Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment.
S. A. Kooijmans (2016)
10.1016/J.BIOMATERIALS.2005.02.038
Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes.
N. Dinauer (2005)
10.1074/jbc.M112.359067
Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides*
Louic Vermeer (2012)
10.1007/s00270-010-9961-4
Nanotechnology and its Relationship to Interventional Radiology. Part I: Imaging
S. Power (2010)
10.1016/S0169-409X(02)00015-7
Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery.
A. Lavasanifar (2002)
10.2147/IJN.S4241
Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers
D. Bharali (2009)
10.1186/1471-2407-11-1
Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
S. Watanabe (2010)
10.1038/bjc.2013.408
A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer
A. Ko (2013)
10.7150/jca.15758
Aberrant methylation of CDH13 can be a diagnostic biomarker for lung adenocarcinoma
W. Pu (2016)
10.1124/pr.55.1.2
Mechanisms of Antimicrobial Peptide Action and Resistance
M. Yeaman (2003)
10.1186/s12860-017-0141-0
Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells
Mytre Koul (2017)
Antimicrobial
F. P. Silva (2012)
10.1016/j.bmcl.2013.07.063
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide.
Yu-Cheng Hsiao (2013)
10.1016/j.ejpb.2015.10.007
Nanoparticle therapeutics: Technologies and methods for overcoming cancer.
B. B. S. Cerqueira (2015)
10.1186/s13148-014-0036-2
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients
Jian-Liang Chou (2014)
10.1155/2016/3681094
Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment
N. Martínez-Montiel (2016)
10.1007/s00280-015-2945-y
Technetium Tc 99m sulfur colloid phenotypic probe for the pharmacokinetics and pharmacodynamics of PEGylated liposomal doxorubicin in women with ovarian cancer
H. Giovinazzo (2015)
10.1016/j.immuni.2016.09.009
Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.
R. Daillère (2016)
10.1016/j.ygyno.2010.11.029
Novel nanotechnology approaches to diagnosis and therapy of ovarian cancer.
Paul B. S. Kim (2011)
Phase I clinical trial
J. Yang (2014)
10.1016/j.ejphar.2009.08.043
Cationic amphiphilic peptides with cancer-selective toxicity.
F. Schweizer (2009)
10.1038/nrc903
Ligand-targeted therapeutics in anticancer therapy
T. Allen (2002)
10.3390/md13063950
Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?
N. Gomes (2015)
10.1038/nri1936
Cancer despite immunosurveillance: immunoselection and immunosubversion
L. Zitvogel (2006)
10.1016/j.bmc.2011.04.046
Surface modified dendrimers: synthesis and characterization for cancer targeted drug delivery.
Anupama Sharma (2011)
10.1166/JBN.2013.1479
Pegylated dendrimer and its effect in fluorouracil loading and release for enhancing antitumor activity.
T. Ly (2013)
10.1038/srep27281
Climacostol reduces tumour progression in a mouse model of melanoma via the p53-dependent intrinsic apoptotic programme
C. Perrotta (2016)
10.1007/s00253-016-7718-y
Insect antimicrobial peptides: potential tools for the prevention of skin cancer
Miray Tonk (2016)
10.1007/s10637-011-9757-7
Phase II study of a cremophor-free, polymeric micelle formulation of paclitaxel for patients with advanced urothelial cancer previously treated with gemcitabine and platinum
J. Lee (2011)
10.1007/s12272-013-0112-8
Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa
Qing-Zhu Yang (2013)
10.1371/journal.pone.0128106
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
G. Chornokur (2015)
10.3390/ijms18030628
PAMAM Dendrimers Cross the Blood–Brain Barrier When Administered through the Carotid Artery in C57BL/6J Mice
Bhairavi Srinageshwar (2017)
10.1371/journal.pone.0104209
Oxygen-Carbon Nanotubes as a Chemotherapy Sensitizer for Paclitaxel in Breast Cancer Treatment
Yongkun Wang (2014)
10.1111/cas.12960
Development of polymeric micelles for targeting intractable cancers
N. Nishiyama (2016)
10.1016/j.addr.2012.03.008
Triazine dendrimers as drug delivery systems: from synthesis to therapy.
Jongdoo Lim (2012)
10.1007/s11095-010-0178-7
Clinical Developments in Nanotechnology for Cancer Therapy
J. Heidel (2010)
10.3892/ol.2012.1049
Analgesic-antitumor peptide induces apoptosis and inhibits the proliferation of SW480 human colon cancer cells
Yu Gu (2013)
10.1002/cncr.28974
Phase II, multicenter, randomized trial of CPX‐351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML
J. Cortes (2015)
10.2147/CMR.S7280
Epigenomics in cancer management
F. Costa (2010)
10.2147/IJN.S112660
Carbon nanotubes as cancer therapeutic carriers and mediators
K. H. Son (2016)
10.1016/j.tibtech.2008.01.002
Targeting tumors with peptides from natural sources.
S. K. Bhutia (2008)
10.1007/s00262-013-1444-4
Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP)
S. König (2013)
10.1016/j.jcis.2016.09.024
Effects of surface modification of quantum dots on viability and migration of triple-negative breast cancer cells.
H. Chen (2017)
10.1016/j.clml.2013.09.009
Phase II study of vincristine sulfate liposome injection (Marqibo) and rituximab for patients with relapsed and refractory diffuse large B-Cell lymphoma or mantle cell lymphoma in need of palliative therapy.
L. Kaplan (2014)
10.1016/j.jconrel.2016.11.015
To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
F. Danhier (2016)
Polymeric micelles for multidrug delivery
M. S. Aw (2013)
10.1007/s40142-016-0104-3
Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will
David Cano-Rodríguez (2016)
10.1021/acs.jmedchem.5b02016
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells.
X. Liu (2016)
10.1371/journal.pone.0049611
Liver Regeneration Signature in Hepatitis B Virus (HBV)-Associated Acute Liver Failure Identified by Gene Expression Profiling
Oriel Nissim (2012)
10.1016/J.IJANTIMICAG.2004.09.005
Antimicrobial peptides: premises and promises.
K. Reddy (2004)
10.1007/s10544-008-9209-0
Nanotechnology for breast cancer therapy
T. Tanaka (2009)



This paper is referenced by
10.1016/j.fsi.2020.06.029
Characterization and functional analysis of liver-expressed antimicrobial peptide-2 (LEAP-2) from golden pompano Trachinotus ovatus (Linnaeus 1758).
B. Liu (2020)
10.1080/15384047.2020.1763147
Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells
S. Min (2020)
10.1039/C8NJ00578H
Delivery of coumarin-containing all-trans retinoic acid derivatives via targeted nanoparticles encapsulating indocyanine green for chemo/photothermal/photodynamic therapy of breast cancer
Jia Jiao (2018)
10.31202/ECJSE.361663
General Evaluations of Nanoparticles
A. Kocak (2018)
10.1002/psc.3254
Cationic amphipathic peptide analogs of cathelicidin LL‐37 as a probe in the development of antimicrobial/anticancer agents
Athanasios Tzitzilis (2020)
10.1007/s10787-019-00589-2
Are peptides a solution for the treatment of hyperactivated JAK3 pathways?
Anja Dullius (2019)
10.3390/polym12092069
Hyaluronan-Arginine Interactions—An Ultrasound and ITC Study
Adam Jugl (2020)
10.1016/j.genrep.2020.100751
Cloning and the expression of the protein fusion enterocin-nisin-epidermicin as a candidate for the treatment of gastric cancer
Zeinab Yousefy (2020)
10.3389/fmicb.2019.01690
Bacterial Proteinaceous Compounds With Multiple Activities Toward Cancers and Microbial Infection
G. Rodrigues (2019)
10.1039/c9ra06172j
The antitumor activity of 4,4′-bipyridinium amphiphiles
Senlin Wang (2019)
10.3892/ijo.2020.5099
Anticancer peptide: Physicochemical property, functional aspect and trend in clinical application (Review)
W. Chiangjong (2020)
10.13345/j.cjb.190033
[Progress in the mechanisms of anticancer peptides].
X. Qiao (2019)
10.1016/bs.seda.2019.08.008
Misc. medical devices and technologies
Paramita Basu (2019)
10.1093/jxb/ery294
The role of antimicrobial peptides in plant immunity
M. L. Campos (2018)
10.1080/17512433.2020.1764347
Strategies for recombinant production of antimicrobial peptides with pharmacological potential
Kamila Botelho Sampaio de Oliveira (2020)
10.1016/j.chemphyslip.2020.105026
Pore-forming proteins: from defense factors to endogenous executors of cell death.
Haydee Mesa-Galloso (2020)
10.1080/10408398.2018.1561418
Seeds, fermented foods, and agricultural by-products as sources of plant-derived antibacterial peptides
Tsun-Thai Chai (2019)
10.1039/c9bm02080b
Melittin-encapsulating peptide hydrogels for enhanced delivery of impermeable anticancer peptides.
Jue-Ping Feng (2020)
10.3389/fmicb.2018.00855
Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges
L. S. Biswaro (2018)
10.3389/fneur.2020.00108
Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action
B. Meloni (2020)
10.15212/bioi-2020-0013
A Review for Antimicrobial Peptides with Anticancer Properties: Re-purposing of Potential Anticancer Agents
Cuiyu Zhong (2020)
jmbReview The Antimicrobial Peptide CopA 3 Inhibits Clostridium difficile Toxin A-Induced Viability Loss and Apoptosis in Neural Cells
Ie Na Yoon (2019)
10.1016/j.semcancer.2019.08.023
Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems.
Sobiya Zafar (2019)
10.1016/J.AQUACULTURE.2019.734263
Characterization and functional analysis of liver-expressed antimicrobial peptide-2 (LEAP-2) in Pelodiscus sinensis
Jianping Fu (2019)
Semantic Scholar Logo Some data provided by SemanticScholar