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Generation Of The Masticatory Central Pattern And Its Modulation By Sensory Feedback
Philippe Morquette, R. Lavoie, Mitch-David Fhima, X. Lamoureux, A. Kolta
Published 2012 · Biology, Medicine
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The basic pattern of rhythmic jaw movements produced during mastication is generated by a neuronal network located in the brainstem and referred to as the masticatory central pattern generator (CPG). This network composed of neurons mostly associated to the trigeminal system is found between the rostral borders of the trigeminal motor nucleus and facial nucleus. This review summarizes current knowledge on the anatomical organization, the development, the connectivity and the cellular properties of these trigeminal circuits in relation to mastication. Emphasis is put on a population of rhythmogenic neurons in the dorsal part of the trigeminal sensory nucleus. These neurons have intrinsic bursting capabilities, supported by a persistent Na(+) current (I(NaP)), which are enhanced when the extracellular concentration of Ca(2+) diminishes. Presented evidence suggest that the Ca(2+) dependency of this current combined with its voltage-dependency could provide a mechanism for cortical and sensory afferent inputs to the nucleus to interact with the rhythmogenic properties of its neurons to adjust and adapt the rhythmic output. Astrocytes are postulated to contribute to this process by modulating the extracellular Ca(2+) concentration and a model is proposed to explain how functional microdomains defined by the boundaries of astrocytic syncitia may form under the influence of incoming inputs.
This paper references
The Rat Brain in Stereotaxic Coordinates
G. Paxinos (1983)
Properties of rhythmically active reticular neurons around the trigeminal motor nucleus during fictive masticaton in the rat
Inoue Tomio (1992)
Effect of the stimulation of sensory inputs on the firing of neurons of the trigeminal main sensory nucleus in the rat.
A. Bernier (2010)
Microelectrode recordings from human oral mechanoreceptors
R. Johansson (1976)
Glia Contribute to the Purinergic Modulation of Inspiratory Rhythm-Generating Networks
A. G. Huxtable (2010)
Diversity of Functional Astroglial Properties in the Respiratory Network
D. Graß (2004)
The cellular basis of segmentation in the developing hindbrain
A. Lumsden (1990)
Dental microwear in adult and still-born guinea pigs (Cavia porcellus).
M. Teaford (1983)
Krox-20: a candidate gene for the regulation of pattern formation in the hindbrain.
P. Gilardi (1991)
Hoxa2- and Rhombomere-Dependent Development of the Mouse Facial Somatosensory Map
F. Oury (2006)
Ionic basis of spike after‐depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells.
R. Azouz (1996)
Functional organization of trigeminal subnucleus interpolaris: nociceptive and innocuous afferent inputs, projections to thalamus, cerebellum, and spinal cord, and descending modulation from periaqueductal gray.
H. Hayashi (1984)
Organization of projections from the spinal trigeminal subnucleus oralis to the spinal cord in the rat: A neuroanatomical substrate for reciprocal orofacial–cervical interactions
L. Devoize (2010)
Brainstem projections to the normal and noradrenergically hyperinnervated trigeminal motor nucleus
J. Vornov (1983)
Neural Control of Rhythmic Movements in Vertebrates
A. Cohen (1988)
Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions
S. Fraser (1990)
Light and electron microscopic observations of a direct projection from mesencephalic trigeminal nucleus neurons to hypoglossal motoneurons in the rat
J. Zhang (2001)
Masticatory Function in the Mammals
Karen M. Hemae (1967)
Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after‐hyperpolarization and excitability control in CA1 hippocampal pyramidal cells
N. Gu (2005)
Control of Locomotion in Bipeds, Tetrapods, and Fish
S. Grillner (1981)
Central connections of trigeminal primary afferent neurons: topographical and functional considerations.
N. Capra (1992)
Corticofugal direct projections to primary afferent neurons in the trigeminal mesencephalic nucleus of rats
C. Iida (2010)
Oral and facial representation in the trigeminal principal and rostral spinal nuclei of the cat
Y. Shigenaga (1986)
Distribution of premotoneurons for jaw-closing and jaw-opening motor nucleus receiving contacts from axon terminals of primary somatosensory cortical neurons in rats
Z. Chang (2009)
Oral-motor patterns of rhythmic trigeminal activity generated in fetal rat brainstem in vitro.
K. Ishihama (2003)
Riluzole inhibits the persistent sodium current in mammalian CNS neurons
A. Urbani (2000)
Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression.
C. Irving (2000)
Properties and interconnections of trigeminal interneurons of the lateral pontine reticular formation in the rat.
M. Bourque (2001)
Anatomical and physiological studies of knee joint innervation in the cat.
S. Skoglund (1956)
Brainstem Control of Swallowing: Localization and Organization of the Central Pattern Generator for Swallowing
A. Jean (1990)
Phase-linked modulation of excitability of presynaptic terminals of low-threshold afferent fibers in the inferior alveolar nerve during cortically induced fictive mastication in the guinea pig
I. Kurasawa (1988)
The development of mastication in rodents: from neurons to behaviors.
J. Turman (2007)
Rhythmical oral-motor activity recorded in an in vitro brainstem preparation.
M. Kogo (1996)
Prenatal development of spontaneous and evoked activity in the rat (Rattus norvegicus albinus).
C. Narayanan (1971)
Development of the mesencephalic trigeminal nucleus requires a paired homeodomain transcription factor, Drg11
Cheng-zhong Wang (2007)
Discharge patterns of trigeminal commissural last-order interneurons during fictive mastication in the rabbit.
R. Donga (1991)
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse
Dany Arsenault (2006)
Neuronal mechanisms of respiratory rhythm generation: an approach using in vitro preparation.
H. Onimaru (1997)
Distribution and central projections of primary afferent neurons that innervate the masseter muscle and mandibular periodontium: A double‐label study
N. Capra (1989)
Projections from dorsomedial part of the subnucleus oralis to the mesencephalic trigeminal neurons innervating the masseter muscle--a PHA-L and HRP double labeling study in the rat.
Zhang Jd (1998)
Bergmann glial cells form distinct morphological structures to interact with cerebellar neurons
J. Grosche (2002)
A transitional period of Ca2+‐dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells
S. Chen (2005)
Modifications of masticatory behavior after trigeminal deafferentation in the rabbit
T. Inoue (2004)
Modulation of rhythmogenic properties of trigeminal neurons contributing to the masticatory CPG.
A. Kolta (2010)
Intersubnuclear connections within the rat trigeminal brainstem complex.
M. Jacquin (1990)
Reorganization of Pontine Rhythmogenic Neuronal Networks in Krox-20 Knockout Mice
T. Jacquin (1996)
Corticofugal projections to trigeminal motoneurons innervating antagonistic jaw muscles in rats as demonstrated by anterograde and retrograde tract tracing
A. Yoshida (2009)
Excitatory actions of gaba during development: the nature of the nurture
Y. Ben-Ari (2002)
Effects of reversible bilateral inactivation of face primary motor cortex on mastication and swallowing
K. Yamamura (2002)
Electrical properties of interneurons found within the trigeminal motor nucleus
Sarah McDavid (2008)
Tensor tympani muscle: strange chewing muscle.
L. M. Ramírez (2007)
Pharmacological block of the electrogenic sodium pump disrupts rhythmic bursting induced by strychnine and bicuculline in the neonatal rat spinal cord.
L. Ballerini (1997)
Oral Feeding in the Preterm Infant
C. Lau (2006)
Persistent Na+ and K+-Dominated Leak Currents Contribute to Respiratory Rhythm Generation in the Pre-Bötzinger Complex In Vitro
H. Koizumi (2008)
Projection of jaw‐muscle spindle afferents to the caudal brainstem in rats demonstrated using intracellular biotinamide
P. Luo (1995)
Modulation of jaw muscle spindle discharge during mastication in the rabbit.
Y. Masuda (1997)
Excitatory GABAergic synaptic potentials in the mesencephalic trigeminal nucleus of adult rat in vitro
Y. Yokomizo (2005)
Neuroplasticity induced by tooth pulp stimulation in trigeminal subnucleus oralis involves NMDA receptor mechanisms.
S. J. Park (2001)
Role of the electrogenic Na/K pump in disinhibition-induced bursting in cultured spinal networks.
P. Darbon (2003)
Spatial Buffering during Slow and Paroxysmal Sleep Oscillations in Cortical Networks of Glial Cells In Vivo
F. Amzica (2002)
Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development.
M. Maconochie (2001)
Physiological and morphological characteristics of periodontal mesencephalic trigeminal neurons in the cat — intra-axonal staining with HRP
Y. Shigenaga (1989)
The differential expression patterns of messenger RNAs encoding K-Cl cotransporters (KCC1,2) and Na-K-2Cl cotransporter (NKCC1) in the rat nervous system
C. Kanaka (2001)
Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
J. E. Krettek (1978)
Peripheral Muscle Targets and Central Projections of the Mesencephalic Trigeminal Nucleus in Macaque Monkeys
N. Wang (2008)
Time of origin of neurons in the brain stem of the mouse.
E. T. Pierce (1973)
In DRG11 Knock-Out Mice, Trigeminal Cell Death Is Extensive and Does Not Account for Failed Brainstem Patterning
M. Jacquin (2008)
Cholinergic control of excitability of spinal motoneurones in the salamander
S. Chevallier (2006)
Arrangement and connections of mesencephalic trigeminal neurons in the rat.
J. Rokx (1986)
Bulbar neurones with axonal projections to the trigeminal motor nucleus in the cat
S. Landgren (2004)
Persistent sodium current, membrane properties and bursting behavior of pre-bötzinger complex inspiratory neurons in vitro.
C. D. Del Negro (2002)
A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements
C. Fornal (1996)
Insights into the bilateral cortical control of human masticatory muscles revealed by transcranial magnetic stimulation.
M. Nordstrom (2007)
Structure and histogenesis of the principal sensory nucleus of the trigeminal nerve: Effects of prenatal exposure to ethanol
M. Miller (1989)
Jaw, Facial, and Tongue Reflexes
R. Dubner (1978)
Mechanisms of oral somatosensory and motor functions and their clinical correlates.
B. Sessle (2006)
Intra-axonal recordings of cutaneous primary afferents during fictive locomotion in the cat.
J. Gossard (1989)
Persistent sodium currents in mesencephalic v neurons participate in burst generation and control of membrane excitability.
N. Wu (2005)
Handbook of Physiology. Section I. The Nervous System
L. G. Kempe (1982)
Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model.
J. Smith (2000)
Anatomical and electromyographic studies of the digastric muscle.
S. Widmalm (1988)
An anatomical demonstration of projections to the medullary dorsal horn (trigeminal nucleus caudalis) from rostral trigeminal nuclei and the contralateral caudal medulla
S. Hockfield (1982)
The locus coeruleus projects to the mesencephalic trigeminal nucleus in rats
Takeshi Takahashi (2010)
Amygdalotrigeminal projection in the rat: An anterograde tracing study.
N. Lazarov (2011)
Activity of neurons in the lower precentral cortex during voluntary and rhythmical jaw movements in the monkey
J. Lund (2004)
Differential discharge patterns of rhythmical activity in trigeminal motoneurons during fictive mastication and respiration in vitro
H. Koizumi (2002)
Amygdaloid projections to commissural interneurons for masticatory motoneurons
Y. Takeuchi (1988)
Response properties of trigeminal ganglion mechanosensitive neurons innervating the temporomandibular joint of the rabbit
A. Tsuboi (2009)
Sucking and Swallowing in Infants
J. Colley (1958)
The effects of cortical ablation on mastication in the rabbit
S. Enomoto (1987)
On the nature of the fundamental activity of the nervous centres; together with an analysis of the conditioning of rhythmic activity in progression, and a theory of the evolution of function in the nervous system
T. Brown (1914)
Encoding of amplitude and rate of forces applied to the teeth by human periodontal mechanoreceptive afferents.
M. Trulsson (1994)
Calcium and potassium changes in extracellular microenvironment of cat cerebellar cortex.
C. Nicholson (1978)
Monosynaptic circuitry of trigeminal proprioceptive afferents coordinating jaw movement with visceral and laryngeal activities in rats
J. Zhang (2005)
Membrane Resonance and Subthreshold Membrane Oscillations in Mesencephalic V Neurons: Participants in Burst Generation
N. Wu (2001)
NR3 protein expression in trigeminal neurons during postnatal development
K. Ishihama (2006)
Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.
Y. Qian (2002)
Oscillatory membrane potential activity in the soma of a primary afferent neuron.
C. Pedroarena (1999)
Calcium currents and calcium‐dependent potassium currents in mammalian medullary respiratory neurones.
D. Richter (1993)
Inspiratory bursts in the preBötzinger complex depend on a calcium‐activated non‐specific cation current linked to glutamate receptors in neonatal mice
R. W. Pace (2007)
The Persistent Sodium Current Generates Pacemaker Activities in the Central Pattern Generator for Locomotion and Regulates the Locomotor Rhythm
Sabrina Tazerart (2008)
Extracellular Ca2+ Depletion Contributes to Fast Activity-Dependent Modulation of Synaptic Transmission in the Brain
D. Rusakov (2003)
The action of calcium on the electrical properties of squid axons
B. Frankenhaeuser (1957)
Control of transmission in muscle group IA afferents during fictive locomotion in the cat.
J. Gossard (1996)
The intrinsic factors in the act of progression in the mammal
T. Brown (1911)
Projection from trigeminal nuclei to neurons of the mesencephalic trigeminal nucleus in rat
C. Buisseret-Delmas (1997)
Location of, and peripheral convergence on, the interneurone in the disynaptic path from the coronal gyrus of the cerebral cortex to the trigeminal motoneurones in the cat
K. Olsson (2004)
Control of M-current.
N. Marrion (1997)
FUNCTIONAL ORGANIZATION IN THE MAIN SENSORY TRIGEMINAL NUCLEUS AND IN THE ROSTRAL SUBDIVISION OF THE NUCLEUS OF THE SPINAL TRIGEMINAL TRACT IN THE CAT.
J. Eisenman (1963)
Analysis of rhythmical jaw movements produced by electrical stimulation of motor-sensory cortex of rabbits.
J. Lund (1984)
Mechanoreceptive afferent activity in the infraorbital nerve in man during speech and chewing movements
R. Johansson (2004)
GABAergic Control of Action Potential Propagation along Axonal Branches of Mammalian Sensory Neurons
D. Verdier (2003)
General principles of rhythmogenesis in central pattern generator networks.
R. Harris-Warrick (2010)
The central projection of masticatory afferent fibers to the trigeminal sensory nuclear complex and upper cervical spinal cord
Y. Shigenaga (1988)
Morphological characteristics and terminating patterns of masseteric neurons of the mesencephalic trigeminal nucleus in the rat: An intracellular horseradish peroxidase labeling study
P. Luo (1991)
A cineradiographic study of bottle feeding.
G. Ardran (1958)
Noradrenergic projections to brainstem nuclei: Evidence for differential projections from noradrenergic subgroups
R. Grzanna (1987)
Integration in trigeminal premotor interneurones in the cat
K. Westberg (2004)
Neurons of the trigeminal main sensory nucleus participate in the generation of rhythmic motor patterns
A. Tsuboi (2003)
Emergence of intrinsic bursting in trigeminal sensory neurons parallels the acquisition of mastication in weanling rats.
F. Brocard (2006)
Topographic representation of lower and upper teeth within the trigeminal sensory nuclei of adult cat as demonstrated by the transganglionic transport of horseradish peroxidase
Y. Shigenaga (1986)
Extracellular Calcium Modulates Persistent Sodium Current-Dependent Burst-Firing in Hippocampal Pyramidal Neurons
H. Su (2001)
Segmental patterns of neuronal development in the chick hindbrain
A. Lumsden (1989)
The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway
Chuan-Xi Xiang (2010)
Morphologic characteristics of physiologically defined neurons in the cat trigeminal nucleus principalis
A. Yoshida (1998)
Morphological evidence for recurrent jaw-muscle spindle afferent feedback within the mesencephalic trigeminal nucleus
P. Luo (1996)
Functional organization of the trigeminal motor system in man. A neurophysiological study.
G. Cruccu (1989)
Ion Channels of Excitable Membranes
B. Hille (2001)
Organization and morphology of masticatory neurons in the rat: A retrograde HRP study
M. Jacquin (1983)
Glial Cells and Neurotransmission An Inclusive View of Synaptic Function
D. Auld (2003)
Evidence that Trigeminal Brainstem Interneurons Form Subpopulations to Produce Different Forms of Mastication in the Rabbit
K. Westberg (1998)
Morphological and immunohistochemical characterization of interneurons within the rat trigeminal motor nucleus
S. McDavid (2006)
Discharge patterns of neurons in the medial pontobulbar reticular formation during fictive mastication in the rabbit
K. Westberg (2001)
The early development of cranial sensory ganglia and the potentialities of their component cells studied in quail-chick chimeras.
C. A. Lièvre (1982)
Feeding behavior in mammals: corticobulbar projection is reorganized during conversion from sucking to chewing.
A. Iriki (1988)
Force encoding by human periodontal mechanoreceptors during mastication.
M. Trulsson (2007)
Mastication and its control by the brain stem.
J. Lund (1991)
The dorsal trigeminal tract in the rhesus monkey.
M. Carpenter (1957)
Pioneer neurons in the mouse trigeminal sensory system.
D. Stainier (1990)
Formation of Whisker-Related Principal Sensory Nucleus-Based Lemniscal Pathway Requires a Paired Homeodomain Transcription Factor, Drg11
Y. Ding (2003)
Synaptic transmission from the supratrigeminal region to jaw-closing and jaw-opening motoneurons in developing rats.
S. Nakamura (2008)
Masticatory rhythm in intracellular potential of trigeminal motoneurons induced by stimulation of orbital cortex and amygdala in cats
Y. Nakamura (1978)
Impaired masticatory behavior in subjects with reduced periodontal tissue support.
Anders Johansson (2006)
Hindbrain patterning: Krox20 couples segmentation and specification of regional identity.
O. Voiculescu (2001)
Rhythmic antidromic discharges of single primary afferents recorded in cut dorsal root filaments during locomotion in the cat
R. Dubuc (1985)
Orderly migration of neurons to the principal sensory nucleus of the trigeminal nerve of the rat
W. M. Al-Ghoul (1993)
Somatotopic organization of tooth pulp primary afferent neurons in the cat
Y. Shigenaga (1989)
Calcium-dependent potassium channels play a critical role for burst termination in the locomotor network in lamprey.
A. El Manira (1994)
Input–output organization of jaw movement‐related areas in monkey frontal cortex
N. Hatanaka (2005)
Localization of premotoneurons for an NMDA-induced repetitive rhythmical activity to TMNs
A. Enomoto (2002)
The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation.
S. Nonchev (1996)
Direct projections from the magnocellular division of the basal nucleus of the amygdala to the principal part of the cortical masticatory area in the macaque monkey
N. Hatanaka (2000)
Physiological characterization, localization and synaptic inputs of bursting and nonbursting neurons in the trigeminal principal sensory nucleus of the rat
T. Athanassiadis (2005)
Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component.
J. Huguenard (1988)
Microdomains for neuron–glia interaction: parallel fiber signaling to Bergmann glial cells
Jens Grosche (1999)
Evidence for central timing of rhythmical mastication
P. G. Dellow (1971)
Organization of mammalian locomotor rhythm and pattern generation
D. McCrea (2008)
Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression
Shampa De (2005)
The histological structure of the receptors in the knee‐joint of the cat correlated with their physiological response
I. Boyd (1954)
Corticomotoneuronal contribution to the fractionation of muscle activity during precision grip in the monkey.
K. M. Bennett (1996)
A longitudinal electromyographic study of the postnatal maturation of mastication in the rabbit.
G. Langenbach (2001)
Examination of the relationships between jaw opener and closer rhythmical muscle activity in an in vitro brainstem jaw-attached preparation.
M. Kogo (1998)
Development of trigeminal mesencephalic and motor nuclei in relation to masseter muscle innervation in mice.
C. Widmer (1998)
Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system
J. Dai (2008)
Stimulus-evoked and seizure-related responses of extracellular calcium activity in spinal cord compared to those in cerebral cortex.
G. Somjen (1980)
Ultrastructure of jaw muscle spindle afferents within the rat trigeminal mesencephalic nucleus
S. Paik (2005)
NMDA-induced rhythmical activity in XII nerve of isolated CNS from newborn rats.
N. Katakura (1995)
Intrinsic response properties of bursting neurons in the nucleus principalis trigemini of the gerbil
V. M. Sandler (1998)
Ontogeny of feeding motor patterns in infant rats: an electromyographic analysis of suckling and chewing.
M. Westneat (1992)
KCNQ/M Channels Control Spike Afterdepolarization and Burst Generation in Hippocampal Neurons
C. Yue (2004)
From neuron to brain
J. Nicholls (1976)
Properties and plasticity of the primate somatosensory and motor cortex related to orofacial sensorimotor function
B. Sessle (2005)
Persistent sodium current in mammalian central neurons.
W. Crill (1996)
The Ontogeny of Mammalian Mastication
S. Herring (1985)
Sensory and motor responses of trigeminal and reticular neurons during ingestive behavior in rats
T. Yamamoto (2004)
Evidence that periodontal pressoreceptors provide positive feedback to jaw closing muscles during mastication.
G. Lavigne (1987)
Two major types of premotoneurons in the feline trigeminal nucleus oralis as demonstrated by intracellular staining with horseradish peroxidase
A. Yoshida (1994)
Trigeminocerebellar and trigemino-olivary projections in rats
N. Yatim (1996)
Differential distribution of cell bodies and central axons of mesencephalic trigeminal nucleus neurons supplying the jaw-closing muscles and periodontal tissue: A transganglionic tracer study in the cat
S. Nomura (1985)
Sensory components facilitating jaw-closing muscle activities in the rabbit
T. Morimoto (2004)
Functional properties of single neurons in the face primary motor cortex of the primate. II. Relations with trained orofacial motor behavior.
G. Murray (1992)
Astrocytes, from brain glue to communication elements: the revolution continues
A. Volterra (2005)
Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.
Sabrina Tazerart (2007)
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
C. Rivera (1999)
Nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat trigeminal motor nucleus: A double‐labeling study with cholera‐toxin as a retrograde tracer
P. Fort (1990)
Calcium-dependent plateau potentials in a crab stomatogastric ganglion motor neuron. II. Calcium-activated slow inward current.
B. Zhang (1995)
Inputs to nucleus pontis caudalis from adjacent trigeminal areas
G. Dal Bo (2005)
Ca2+‐Mediated Up‐Regulation of Ih in the Thalamus: How Cell‐Intrinsic Ionic Currents May Shape Network Activity
A. Lüthi (1999)
Astrocytes Control Breathing Through pH-Dependent Release of ATP
A. Gourine (2010)
Oscillatory bursting of phasically firing rat supraoptic neurones in low‐Ca2+ medium: Na+ influx, cytosolic Ca2+ and gap junctions.
Z. Li (1996)
Identification of brainstem interneurons projecting to the trigeminal motor nucleus and adjacent structures in the rabbit
A. Kolta (2000)
Preweaning feeding mechanisms in the rabbit.
G. Langenbach (1992)
Slow recovery from inactivation regulates the availability of voltage‐dependent Na+ channels in hippocampal granule cells, hilar neurons and basket cells
R. Ellerkmann (2001)
[The function of the brain].
T. Tokimitsu (1967)
Postnatal development of a persistent Na+ current in pyramidal neurons from rat sensorimotor cortex.
C. Alzheimer (1993)
Evidence for functional compartmentalization of trigeminal muscle spindle afferents during fictive mastication in the rabbit
K. Westberg (2000)
Neural control of feeding and swallowing.
S. Mistry (2008)
Orofacial mechanoreceptors in humans: encoding characteristics and responses during natural orofacial behaviors
M. Trulsson (2002)
Monosynaptic inhibition of neurons of the substantia nigra by caudato-nigral fibers.
M. Yoshida (1971)
Efferent and afferent connections of GABAergic neurons in the supratrigeminal and the intertrigeminal regions: An immunohistochemical tract-tracing study in the GAD67-GFP knock-in mouse
J. Li (2005)
The histaminergic innervation of the mesencephalic nucleus of the trigeminal nerve in rat brain: a light and electron microscopical study
N. Inagaki (1987)
Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations
J. Rubin (2009)
Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20.
S. Nonchev (1996)
Dopaminergic afferents to the mesencephalic trigeminal nucleus of the rat: a light and electron microscope immunocytochemistry study
J. Copray (1990)
Development of order in the rat trigeminal system
R. Erzurumlu (1983)
Synaptic inputs to trigeminal primary afferent neurons cause firing and modulate intrinsic oscillatory activity.
D. Verdier (2004)
Both oral and caudal parts of the spinal trigeminal nucleus project to the somatosensory thalamus in the rat
N. Guy (2005)
Compartments and their boundaries in vertebrate brain development
C. Kiecker (2005)
Cerebral cortical projections to the reticular regions around the trigeminal motor nucleus in the cat
Y. Yasui (1985)
Localization of oral–motor rhythmogenic circuits in the isolated rat brainstem preparation
S. Tanaka (1999)
Ultrastructural basis for synaptic transmission between jaw muscle spindle afferents and trigeminothalamic neurons in the rostral trigeminal sensory nuclei of the rat
P. Luo (1995)
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
S. Schneider-Maunoury (1993)
Primary afferent depolarization evoked by the activity of spinal scratching generator
K. V. Bayev (1981)
Vertebrate neuromuscular junctions: general morphology, molecular organization, and functional consequences
M. Salpeter (1987)
Rhythm generation for food-ingestive movements.
Y. Nakamura (2004)
Serotonergic innervation of mesencephalic trigeminal nucleus neurons: a light and electron microscopic study in the rat
J. Li (2000)
Mechanical entrainment of fictive locomotion in the decerebrate cat.
D. Kriellaars (1994)
Main characteristics of the hindlimb locomotor cycle in the decorticate cat with special reference to bifunctional muscles
C. Perret (1980)
Differential Foci and Synaptic Organization of the Principal and Spinal Trigeminal Projections to the Thalamus in the Rat
M. Williams (1994)
Physiologie nerveuse de la mastication chez le chat et le lapin. Reflexes de mastication. Reponses masticatrices corticales et centre cortical du gout
F. Bremer (1923)
Behavior of cutaneous mechanoreceptors recorded in mandibular division of Gasserian ganglion of the rabbit during movements of lower jaw.
K. Appenteng (1982)
Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals.
Christopher A. Del Negro (2010)
Persistent Sodium Currents Participate in Fictive Locomotion Generation in Neonatal Mouse Spinal Cord
Guisheng Zhong (2007)
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H. Ohmori (2012)
The Evolution of Neuroscience as a Research Field Relevant to Dentistry
K. Iwata (2019)
Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function
M. Piancino (2020)
Electrophysiological and morphological properties of rat supratrigeminal premotor neurons targeting the trigeminal motor nucleus.
S. Nakamura (2014)
Chewing Entrains Cyclical Actions but Interferes With Discrete Actions in Children.
Jessica Prebor (2020)
How addition of peach gel particles to yogurt affects oral behavior, sensory perception and liking of consumers differing in age.
M. Aguayo-Mendoza (2020)
Fisiología de la deglución normal
Franck Marmouset (2015)
Jaw-Neck Movement Integration in 6-year old Children Differs from that of Adults.
C. Österlund (2019)
Newly developed mastication activity reduction procedure rapidly induces abnormal atrophic change of the mandibular condyle in young and elder experimental animal models.
K. Matsumoto (2020)
Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differences
Inge Steuer (2019)
Prefrontal cortex activity induced by periodontal afferent inputs downregulates occlusal force
Takahiro Kishimoto (2019)
Modulation of spontaneous and volitional swallowing : methodological and behavioural analyses
K. Lamvik (2016)
Bite or brain: Implication of sensorimotor regulation and neuroplasticity in oral rehabilitation procedures
A. Kumar (2018)
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
D. Rémond (2015)
Mouse incising central pattern generator: Characteristics and modulation by pain
C. Widmer (2018)
Neurophysiological basis of feeding and swallowing and unresolved research questions
K. Yamamura (2013)
An fMRI Study of the Brain Network Involved in Teeth Tapping in Elderly Adults
T. Kobayashi (2020)
Adult Neurogenic Communication and Swallowing Disorders
Ming-Yen Hsiao (2018)
Paradoxical activity of the masseter muscles due to upper motoneuron involvement
P. Tacik (2013)
Estudo das variáveis cinemáticas da mastigação unilateral e habitual de indivíduos saudáveis
F. Pasinato (2017)
From periodontal mechanoreceptors to chewing motor control: A systematic review.
M. Piancino (2017)
Participation of a persistent sodium current and calcium-activated nonspecific cationic current to burst generation in trigeminal principal sensory neurons.
Kentaro Tsuruyama (2013)
Periodontal tactile input activates the prefrontal cortex
N. Higaki (2016)
Effect of mouth breathing on masticatory muscle activity during chewing food.
N. Ikenaga (2013)
Differentiation of cerebral representation of occlusion and swallowing with fMRI.
P. Mihai (2013)
Modeling of sodium currents from mesencephalic trigeminal neurons by system identification and sensitivity analysis
F. Davoine (2013)
Exquisitely heterogeneous : Combining different food textures to boost palatability
Marco Santagiuliana (2019)
Convergent Pre-motoneuronal Inputs to Single Trigeminal Motoneurons
M. Nonaka (2012)
Response to coincident inputs in electrically coupled primary afferents is heterogeneous and is enhanced by H-current (IH) modulation.
F. Davoine (2019)
Functional Imaging of Spinal Locomotor Networks
Chetan Nagaraja (2016)
Effect of natural mediotrusive contact on electromyographic activity of jaw and cervical muscles during chewing
A. Fuentes (2015)
Altered neural activation pattern during teeth clenching in temporomandibular disorders.
Shu-shu He (2016)See more