← Back to Search
Age At Menarche And Depressive Symptoms In Older Southern Chinese Women: A Mendelian Randomization Study In The Guangzhou Biobank Cohort Study
S. L. A. Yeung, C. Jiang, K. Cheng, Lin Xu, C. Schooling
Published 2018 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.
This paper references
Association of timing of menarche with depressive symptoms and depression in adolescence: Mendelian randomisation study
M. Sequeira (2017)
Age at menarche and cardiovascular risk factors using Mendelian randomization in the Guangzhou Biobank Cohort Study.
S. A. Au Yeung (2017)
Cohort profile: The Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong-Birmingham collaboration.
C. Jiang (2006)
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective Study
C. Gleason (2015)
Effect of estrogen replacement therapy on symptoms of depression and anxiety in non-depressive menopausal women
Frederico Navas Demétrio (2011)
Endometrial Cancer Association, C., Ovarian Cancer Association
F R Day (2017)
Early menarche and depressive symptoms from adolescence to young adulthood in a UK cohort.
C. Joinson (2013)
Age of Menarche and the Metabolic Syndrome in China
M. Heys (2007)
Nutritional Determinants of the Timing of Puberty.
E. Villamor (2016)
Boosted Regression (Boosting): An Introductory Tutorial and a Stata Plugin
Matthias Schonlau (2005)
Age at menarche and depression at the age of 31 years: findings from the Northern Finland
A Herva (1966)
Age at Onset of Puberty and Adolescent Depression: “Children of 1997” Birth Cohort
H. Wang (2016)
Writing Group for the Women's
J. E. Rossouw (2002)
Genetically predicted testosterone and cardiovascular risk factors in men: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study.
Jie Zhao (2014)
Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies
N. Hamajima (2012)
Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche
J. Perry (2014)
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology.
D. Lawlor (2008)
Negative Controls: A Tool for Detecting Confounding and Bias in Observational Studies
M. Lipsitch (2010)
Age at menarche and depression at the age of 31 years: findings from the Northern Finland 1966 Birth Cohort Study.
A. Herva (2004)
Genetics of age at menarche: a systematic review.
V. Dvornyk (2012)
Genetically predicted 17beta-estradiol, cognitive function and depressive symptoms in women: A Mendelian randomization in the Guangzhou Biobank Cohort Study.
S. A. Au Yeung (2016)
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
J. Rossouw (2002)
Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember?
A. Must (2002)
Sex and gender differences in mental disorders.
A. Riecher-Rössler (2017)
Age at menarche in Canada: results from the National Longitudinal Survey of Children & Youth
Ban Al-Sahab (2010)
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
F. Day (2017)
Why is depression more common among women than among men?
C. Kuehner (2017)
Past Occupational Dust Exposure, Depressive Symptoms and Anxiety in Retired Chinese Factory Workers: The Guangzhou Biobank Cohort Study
Q. Lin (2014)
Gender differences in depression. Critical review.
M. Piccinelli (2000)
Age at menarche in relation to adult height: the EPIC study.
N. C. Onland-Moret (2005)
This paper is referenced by
The association between pubertal status and depressive symptoms and diagnoses in adolescent females: A population-based cohort study
G. Lewis (2018)
Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study
M. Magnus (2020)
Shared genetic etiology of age of menarche and socioeconomic variables: No evidence for genetic overlap with psychiatric traits
Martin Steppan (2020)
The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype
I. Stanaway (2019)