Correlation Between Metabolic Tumor Volume And Pathologic Tumor Volume In Squamous Cell Carcinoma Of The Oral Cavity.
James D Murphy, Karen M Chisholm, Megan E. Daly, Ellen A. Wiegner, Daniel Truong, Andrei Iagaru, Peter G. Maxim, Billy W. Loo, Edward E Graves, Michael J. Kaplan, Christina S. Kong, Quynh-Thu Le
Published 2011 · Medicine
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PURPOSE To explore the relationship between pathologic tumor volume and volume estimated from different tumor segmentation techniques on (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in oral cavity cancer. MATERIALS AND METHODS Twenty-three patients with squamous cell carcinoma of the oral tongue had PET-CT scans before definitive surgery. Pathologic tumor volume was estimated from surgical specimens. Metabolic tumor volume (MTV) was defined from PET-CT scans as the volume of tumor above a given SUV threshold. Multiple SUV thresholds were explored including absolute SUV thresholds, relative SUV thresholds, and gradient-based techniques. RESULTS Multiple MTV's were associated with pathologic tumor volume; however the correlation was poor (R(2) range 0.29-0.58). The ideal SUV threshold, defined as the SUV that generates an MTV equal to pathologic tumor volume, was independently associated with maximum SUV (p=0.0005) and tumor grade (p=0.024). MTV defined as a function of maximum SUV and tumor grade improved the prediction of pathologic tumor volume (R(2)=0.63). CONCLUSIONS Common SUV thresholds fail to predict pathologic tumor volume in head and neck cancer. The optimal technique that allows for integration of PET-CT with radiation treatment planning remains to be defined. Future investigation should incorporate biomarkers such as tumor grade into definitions of MTV.
This paper references
Comparison between CT- and FDG-PET-defined target volumes for radiotherapy planning in head-and-neck cancers.
Bénédicte Henriques de Figueiredo (2009)
Screening for distant metastases in head and neck cancer patients by chest CT or whole body FDG-PET: a prospective multicenter trial.
Asaf Senft (2008)
Postradiation metabolic tumor volume predicts outcome in head-and-neck cancer.
James D Murphy (2011)
Standardized uptake value of 2-[(18)F] fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy.
Abdelkarim Said Allal (2002)
Normal uptake of F-18 FDG in the sublingual gland.
Trond Velde Bogsrud (2006)
Comparison of CT- and FDG-PET-defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer.
Arnold C Paulino (2005)
Can FDG-PET assist in radiotherapy target volume definition of metastatic lymph nodes in head-and-neck cancer?
Dominic A. X. Schinagl (2009)
Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study.
I. Frank Ciernik (2003)
Hybrid PET-CT simulation for radiation treatment planning in head-and-neck cancers: a brief technical report.
Dwight E Heron (2004)
Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer.
Trang H. La (2008)
Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma.
Faleh A Sawair (2003)
Tri-dimensional automatic segmentation of PET volumes based on measured source-to-background ratios: influence of reconstruction algorithms.
Jean-François Daisne (2003)
RT_Image: An Open-Source Tool for Investigating PET in Radiation Oncology
Edward E Graves (2007)
New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas.
Magne Bryne (1989)
Reliability of measuring volume by different methods for tumors of the musculoskeletal system.
Johan Somville (2001)
A gradient-based method for segmenting FDG-PET images: methodology and validation
Xavier Geets (2006)
Clinical evidence on PET-CT for radiation therapy planning in head and neck tumours.
Esther G. C. Troost (2010)
Image fusion between 18FDG-PET and MRI/CT for radiotherapy planning of oropharyngeal and nasopharyngeal carcinomas.
Takeshi Nishioka (2002)
Quantitative analysis of invasive front in tongue cancer using ultrasonography.
Ayano Kaneoya (2009)
Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen.
Jean-François Daisne (2004)
Positron emission tomography/computed tomography--imaging protocols, artifacts, and pitfalls.
Andreas Bockisch (2004)
The limitation of PET imaging for biological adaptive-IMRT assessed in animal models.
Nicolas Christian (2009)
Defining a radiotherapy target with positron emission tomography.
Quinten C Black (2002)
Standardized Uptake Value Atlas: Characterization of Physiological 2-Deoxy-2-[18F]fluoro-d-glucose Uptake in Normal Tissues
Yingbing Wang (2006)
Adaptive biological image-guided IMRT with anatomic and functional imaging in pharyngo-laryngeal tumors: impact on target volume delineation and dose distribution using helical tomotherapy.
Xavier Geets (2007)
Correlation of positron emission tomography standard uptake value and pathologic specimen size in cancer of the head and neck.
Ryan J. Burri (2008)
Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose.
Abdelkarim Said Allal (2004)
Positron emission tomography with [18F]fluorodeoxyglucose improves staging and patient management in patients with head and neck squamous cell carcinoma: a multicenter prospective study.
Max Lonneux (2010)
Invasive pattern grading score designed as an independent prognostic indicator in oral squamous cell carcinoma.
Yun-Ching Chang (2010)
This paper is referenced by
Utility of 18FDG-PET/CT for head and neck cancer staging, radiation therapy planning, and follow-up
Amar U. Kishan (2012)
A new method for segmentation of FDG PET metabolic tumour volume using the peritumoural halo layer and a 10-step colour scale. A study in patients with papillary thyroid carcinoma.
Sungmin Jun (2015)
PET-based radiation therapy planning.
Christina K. Speirs (2015)
18F-FDG PET/CT quantification in head and neck squamous cell cancer: principles, technical issues and clinical applications
Gianpiero Manca (2015)
Functional imaging in radiation therapy planning for head and neck cancer.
Luis Alberto Pérez Romasanta (2013)
Accurate FDG PET tumor segmentation using the peritumoral halo layer method: a study in patients with esophageal squamous cell carcinoma
Sungmin Jun (2018)
Pathological tumor volume predicts survival outcomes in oral squamous cell carcinoma
Nobuaki Mukoyama (2018)
Diffusion weighted MRI in head-and-neck cancer: geometrical accuracy.
Tim Schakel (2013)
Adaptive radiotherapy for head and neck cancer: Are we ready to put it into routine clinical practice?
Michael Francis Gensheimer (2018)
Tumor Volumes Measured From Static and Dynamic 18F-fluoro-2-deoxy-D-glucose Positron Emission Tomography-Computed Tomography Scan: Comparison of Different Methods Using Magnetic Resonance Imaging as the Criterion Standard
Hanwei Chen (2014)
Performance Evaluation of a Newly Developed MR-Compatible Mobile PET Scanner with Two Detector Layouts
Masao Watanabe (2019)
Defining PET standardized uptake value threshold for tumor delineation with metastatic lymph nodes in head and neck cancer.
Osamu Suzuki (2012)
Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer.
Hidenori Suzuki (2016)
Predictive and prognostic value of metabolic tumour volume and total lesion glycolysis in solid tumours
Christophe van de Wiele (2012)
Effect of different segmentation algorithms on metabolic tumor volume measured on 18F-FDG PET/CT of cervical primary squamous cell carcinoma
Weina Xu (2017)
Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer.
Ceri J Powell (2013)
Utility of PET for Radiotherapy Treatment Planning.
Beant Singh Gill (2015)
Volumetric comparison of positron emission tomography/computed tomography using 4′-[methyl-11C]-thiothymidine with 2-deoxy-2-18F-fluoro-D-glucose in patients with advanced head and neck squamous cell carcinoma
Kimiteru Ito (2015)
Advances in Radiotherapy for Head and Neck Cancer.
Vincent Grégoire (2015)
18F-FDG Metabolic Tumor Volume and Total Glycolytic Activity of Oral Cavity and Oropharyngeal Squamous Cell Cancer: Adding Value to Clinical Staging
Elizabeth H Dibble (2012)
Appropriate margin thresholds for isocontour metabolic volumetry of fluorine-18 fluorodeoxyglucose PET in sarcoma: a hybrid PET/MRI study
Hyunjong Lee (2016)
FDG PET metabolic tumor volume segmentation and pathologic volume of primary human solid tumors.
Praveen Sridhar (2014)
PET-based primary tumor volumetric parameters and survival of patients with non-small cell lung carcinoma.
Jessica M. Davison (2013)
The future of induction chemotherapy for head and neck squamous cell carcinoma.
Missak Haigentz (2012)
Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography
Abhinav K. Jha (2017)
Effects of Intratumoral Inflammatory Process on 18F-FDG Uptake: Pathologic and Comparative Study with 18F-Fluoro-α-Methyltyrosine PET/CT in Oral Squamous Cell Carcinoma
Mai Kim (2015)
Radiation Treatment Planning for Head and Neck Cancer with PET.
Charles B. Woods (2012)
Comparison of CT based and integrated f 18 FDG pet CT scan based gross tumour volume in head and neck cancers and evaluation of the different segmentation method for delineation of the target on pet scan.
Gayathri Gopu (2016)
Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging
John M Floberg (2018)
Tumor volume delineation in head and neck cancer with 18-fluor-fluorodeoxiglucose positron emission tomography: adaptive thresholding method applied to primary tumors and metastatic lymph nodes
Luis A. Pérez-Romasanta (2012)
18F-FDG PET/CT Mean SUV and Metabolic Tumor Volume for Mean Survival Time in Non–Small Cell Lung Cancer
Ercan Kurtipek (2015)
Functional imaging in radiation therapy planning for head and neck cancer
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