Online citations, reference lists, and bibliographies.

The Prognostic Role Of 18F-fluorodeoxyglucose PET In Head And Neck Cancer Depends On HPV Status.

Jon M Moan, Cecilie Delphin Amdal, Eirik Malinen, Jørund Graadal Svestad, Trond Velde Bogsrud, Einar Dale
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND AND PURPOSE Standardized uptake value (SUV) and related parameters derived from 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) PET/CT prior to radiochemotherapy of head and neck cancer (HNC) were significantly associated with survival in a number of studies. The aim of this study was to validate these findings and to evaluate the prognostic role of PET parameters also including clinical factors and HPV status. MATERIALS AND METHODS We reviewed 166 HNC cases with a radiotherapy planning FDG PET/CT scan. All patients received radiotherapy, 68-70 Gy with or without concomitant cisplatin. Primary endpoint was disease-free survival (DFS). Twelve clinical factors, including HPV, performance status, stage and treatment parameters and ten PET/CT image parameters including gross tumor volume (GTV), metastatic lymph node volume, SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were collected. Univariate and multivariate Cox regression analyses were employed. RESULTS Of the 166 patients included, 48 had locoregional and 23 had metastatic recurrence. None of the FDG PET parameters were significant in the univariate analysis using DFS as endpoint. HPV status, ECOG status and GTV-U (primary tumor and lymph node volume from CT) were statistically significant (p < 0.01). Only in the subgroup of HPV-unrelated HNC (HPV negative oropharyngeal cancer [OPC] and non-OPC; n = 73), the multivariate model could be improved by including MTV (p < 0.001). DFS events were 29 (31%) in HPV-related and 53 (73%) in HPV-unrelated HNC. CONCLUSION FDG PET parameters appear less important for overall prognostication of radiochemotherapy outcome for HNC. Still, the association between the FDG PET parameters and survival is strong for HNC not related to HPV. Tumor volume from CT is generally more closely related to outcome than parameters derived from FDG PET/CT.
This paper references
10.1016/j.oraloncology.2017.06.015
Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to Human Papillomavirus status.
Dan Ou (2017)
10.3322/caac.21389
Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.
William M Lydiatt (2017)
10.1002/cam4.295
Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy
Atsushi Hanamoto (2014)
10.1097/RLU.0000000000000255
FDG PET/CT Imaging of Oropharyngeal Squamous Cell Carcinoma: Characteristics of Human Papillomavirus–Positive and –Negative Tumors
Abdel Kader Tahari (2014)
10.1259/bjr.20170498
Development and validation of a radiomic signature to predict HPV (p16) status from standard CT imaging: a multicenter study
Ralph T H Leijenaar (2018)
10.1016/j.ijrobp.2003.08.004
Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume.
K S Clifford Chao (2004)
10.1259/BJR.20160217
Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist.
Jon Cacicedo (2016)
10.2967/jnumed.113.125542
PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm
Rathan Subramaniam (2014)
10.1097/RCT.0000000000000320
Difference Between HPV-Positive and HPV-Negative Non-Oropharyngeal Head and Neck Cancer: Texture Analysis Features on CT
Akifumi Fujita (2016)
10.1056/NEJMoa0912217
Human papillomavirus and survival of patients with oropharyngeal cancer.
K Kian Ang (2010)
10.21873/anticanres.13299
HPV Status and Survival in Non-Oropharyngeal Squamous Cell Carcinoma of the Head and Neck
Vanessa Wookey (2019)
10.1002/hed.24892
Long‐term outcome of 18F‐fluorodeoxyglucose‐positron emission tomography‐guided dose painting for head and neck cancer: Matched case‐control study
Dieter Berwouts (2017)
10.1002/hed.23920
Interaction of quantitative (18)F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.
Charlotte S. Schouten (2016)
10.1016/j.ctro.2017.10.005
Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand?
Haitham Mirghani (2018)
10.1002/hed.23394
Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer.
Malin Wendt (2014)
10.2967/jnumed.113.133801
Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis in Head and Neck Cancer: A Systematic Review and Meta-Analysis
Kyoungjune Pak (2014)
10.1016/0021-9681(87)90171-8
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.
Mary E. Charlson (1987)
10.1007/s11547-019-01028-6
CT assessment of tumor heterogeneity and the potential for the prediction of human papillomavirus status in oropharyngeal squamous cell carcinoma
Francesco Mungai (2019)
10.1007/s13566-012-0065-4
Prognostic value of 18F-FDG PET metabolic parameters in oropharyngeal squamous cell carcinoma
Adam A. Garsa (2012)
10.15761/OHNS.1000160
HPV impacts survival of stage IVC non-oropharyngeal HNSCC cancer patients
Adam Burr (2018)
10.1080/02841860600815407
Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT
Gabriela Studer (2007)
10.1016/j.ctro.2017.10.001
Radiomic analysis in prediction of Human Papilloma Virus status
Kaixian Yu (2017)
10.1097/RCT.0000000000000682
Computed Tomography-Based Texture Analysis to Determine Human Papillomavirus Status of Oropharyngeal Squamous Cell Carcinoma
Sara Ranjbar (2018)
10.1016/j.ijrobp.2017.06.002
Computed Tomography Radiomics Predicts HPV Status and Local Tumor Control After Definitive Radiochemotherapy in Head and Neck Squamous Cell Carcinoma.
Marta Bogowicz (2017)
10.3109/00016489.2014.905701
Association between the standardized uptake value and high-risk HPV in hypopharyngeal squamous cell carcinoma
Young-Hoon Joo (2014)
10.2214/AJR.14.12497
Prognostic value of FDG PET metabolic tumor volume in human papillomavirus-positive stage III and IV oropharyngeal squamous cell carcinoma.
Krishna C Alluri (2014)
10.1200/JCO.2008.19.3300
Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer.
Benjamin J. Moeller (2009)
10.1002/hed.25505
Volumetric 18F‐FDG‐PET parameters as predictors of locoregional failure in low‐risk HPV‐related oropharyngeal cancer after definitive chemoradiation therapy
Thong Chotchutipan (2019)
10.1002/hed.25337
Pretreatment metabolic tumor volume as a prognostic factor in HPV‐associated oropharyngeal cancer in the context of AJCC 8th edition staging
John M Floberg (2018)
10.2967/jnumed.112.119289
Textural Features of Pretreatment 18F-FDG PET/CT Images: Prognostic Significance in Patients with Advanced T-Stage Oropharyngeal Squamous Cell Carcinoma
Nai-Ming Cheng (2013)
10.1016/S0167-8140(98)00016-4
Nodal CT density and total tumor volume as prognostic factors after radiation therapy of stage III/IV head and neck cancer.
Gerhard G. Grabenbauer (1998)
10.3174/ajnr.A4285
Using Texture Analysis to Determine Human Papillomavirus Status of Oropharyngeal Squamous Cell Carcinomas on CT
K Buch (2015)
10.1016/j.radonc.2014.11.032
Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer.
Pernille Lassen (2014)
10.1016/j.ijrobp.2011.10.023
Validation that metabolic tumor volume predicts outcome in head-and-neck cancer.
Chad Tang (2012)
10.1007/s00259-012-2127-7
Use of pretreatment metabolic tumour volumes to predict the outcome of pharyngeal cancer treated by definitive radiotherapy
C. Z. Kao (2012)
10.1016/j.semradonc.2017.08.003
Molecular Imaging-Guided Radiotherapy for the Treatment of Head-and-Neck Squamous Cell Carcinoma: Does it Fulfill the Promises?
Vincent Grégoire (2018)
10.1007/s00259-012-2186-9
Prognostic value of pretreatment 18F-FDG PET/CT and human papillomavirus type 16 testing in locally advanced oropharyngeal squamous cell carcinoma
Nai-Ming Cheng (2012)
10.1002/hed.20796
Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon.
David Goldenberg (2008)
10.1007/s00259-014-2961-x
FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0
Ronald Boellaard (2014)
10.1016/j.ejca.2012.03.014
Population-based evidence of increased survival in human papillomavirus-related head and neck cancer.
Mari Nygård (2012)
10.1007/s00405-017-4748-8
Human papillomavirus in oropharyngeal squamous cell carcinoma in South-Eastern Norway: prevalence, genotype, and survival
Guro Haugen Fossum (2017)
10.1016/j.ijrobp.2009.08.063
Prospective imaging assessment of mortality risk after head-and-neck radiotherapy.
Benjamin J. Moeller (2010)
10.1056/NEJMoa1514493
PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.
Hisham Mehanna (2016)
10.1016/j.radonc.2006.07.006
Assessment of 18F PET signals for automatic target volume definition in radiotherapy treatment planning.
J Bernard Davis (2006)
10.1016/j.oraloncology.2014.06.018
The relative prognostic utility of standardized uptake value, gross tumor volume, and metabolic tumor volume in oropharyngeal cancer patients treated with platinum based concurrent chemoradiation with a pre-treatment [(18)F] fluorodeoxyglucose positron emission tomography scan.
Paul B Romesser (2014)
10.1002/hed.23296
Preoperative 18F-FDG PET/CT and high-risk HPV in patients with oropharyngeal squamous cell carcinoma.
Young-Hoon Joo (2014)
10.1038/srep11044
Radiomic feature clusters and Prognostic Signatures specific for Lung and Head & Neck cancer
Chintan Parmar (2015)
10.1093/jnci/djn011
Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.
Carole Fakhry (2008)
10.1097/RLU.0000000000001578
Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma
Esther Mena (2017)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar