Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Alterations In Oropharyngeal Sensory Evoked Potentials (PSEP) With Parkinson’s Disease

T. Pitts, K. Hegland, C. Sapienza, D. Bolser, P. Davenport
Published 2016 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Movement of a food bolus from the oral cavity into the oropharynx activates pharyngeal sensory mechanoreceptors. Using electroencephalography, somatosensory cortical-evoked potentials resulting from oropharyngeal mechanical stimulation (PSEP) have been studied in young healthy individuals. However, limited information is known about changes in processing of oropharyngeal afferent signals with Parkinson's disease (PD). To determine if sensory changes occurred with a mechanical stimulus (air-puff) to the oropharynx, two stimuli (S1-first; S2-s) were delivered 500ms apart. Seven healthy older adults (HOA; 3 male and 4 female; 72.2±6.9 years of age), and thirteen persons diagnosed with idiopathic Parkinson's disease (PD; 11 male and 2 female; 67.2±8.9 years of age) participated. Results demonstrated PSEP P1, N1, and P2 component peaks were identified in all participants, and the N2 peak was present in 17/20 participants. Additionally, the PD participants had a decreased N2 latency and gated the P1, P2, and N2 responses (S2/S1 under 0.6). Compared to the HOAs, the PD participants had greater evidence of gating the P1 and N2 component peaks. These results suggest that persons with PD experience changes in sensory processing of mechanical stimulation of the pharynx to a greater degree than age-matched controls. In conclusion, the altered processing of sensory feedback from the pharynx may contribute to disordered swallow in patients with PD.
This paper references
10.1152/JAPPL.1990.68.1.282
Effects of timing of inspiratory occlusion on cerebral evoked potentials in humans.
W. R. Revelette (1990)
10.1016/J.MEHY.2004.08.007
Psychotogenic drugs and delirium pathogenesis: the central role of the thalamus.
Jean-David Gaudreau (2005)
10.1002/MDS.870110110
Cricopharyngeal dysfunction in Parkinson's disease: Role in dysphagia and response to myotomy
L. J. Born (1996)
10.1177/000348949610500202
Supraglottic and Pharyngeal Sensory Abnormalities in Stroke Patients with Dysphagia
J. H. Martin (1996)
Evoked Potential Manual: A Practical Guide to Clinical Applications
E. Colon (1990)
10.1152/JAPPLPHYSIOL.01436.2005
Detection threshold for inspiratory resistive loads and respiratory-related evoked potentials.
P. Davenport (2007)
10.1016/j.clinph.2004.05.017
Characterising the central mechanisms of sensory modulation in human swallowing motor cortex
D. Gow (2004)
10.1016/j.parkreldis.2015.06.020
Incidence and mortality trends of aspiration pneumonia in Parkinson's disease in the United States, 1979-2010.
U. Akbar (2015)
10.1152/JAPPL.1986.60.6.1843
Respiratory-related cortical potentials evoked by inspiratory occlusion in humans.
P. Davenport (1986)
10.1152/JAPPL.1996.80.5.1785
Scalp topography of the short-latency components of the respiratory-related evoked potential in children
P. Davenport (1996)
10.1016/S1353-8020(03)00045-2
Swallowing disorders in Parkinson's disease.
A. Potulska (2003)
10.1016/0013-4694(83)90252-3
The cognitive P40, N60 and P100 components of somatosensory evoked potentials and the earliest electrical signs of sensory processing in man.
J. Desmedt (1983)
10.1016/j.biopsycho.2012.07.001
The effect of anxiety on respiratory sensory gating measured by respiratory-related evoked potentials
Pei-Ying S. Chan (2012)
10.1007/S00455-007-9090-7
Effects of Bolus Consistency on Timing and Safety of Swallow in Patients with Parkinson’s Disease
M. Troche (2008)
10.1002/hbm.20567
Cortical sources of visual evoked potentials during consciousness of executive processes
C. Babiloni (2009)
10.1093/BRAIN/122.9.1651
Sensory processing in Parkinson's and Huntington's disease: investigations with 3D H(2)(15)O-PET.
H. Boecker (1999)
10.1378/CHEST.124.3.1009
Impaired efficacy of cough in patients with Parkinson disease.
S. Ebihara (2003)
10.1378/chest.08-1389
Impact of expiratory muscle strength training on voluntary cough and swallow function in Parkinson disease.
T. Pitts (2009)
10.1002/ANA.410190310
Swallowing and speech production in Parkinson's disease
J. Robbins (1986)
10.1378/chest.129.1_suppl.154S
Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines.
C. S. Hammond (2006)
10.1007/s002210100813
Parallel cortical networks for volitional control of swallowing in humans
K. Mosier (2001)
10.1177/000348949910800802
Laryngopharyngeal Sensory Discrimination Testing and the Laryngeal Adductor Reflex
J. H. Martin (1999)
10.1097/NEN.0b013e3182801cde
Alpha-synuclein pathology and axonal degeneration of the peripheral motor nerves innervating pharyngeal muscles in Parkinson disease.
L. Mu (2013)
10.1111/1469-8986.3730310
The respiratory-related evoked potential: effects of attention and occlusion duration.
K. Webster (2000)
10.1136/jnnp.72.1.31
Swallowing and voice effects of Lee Silverman Voice Treatment (LSVT®): a pilot study
J. Logemann (2002)
10.1016/S0165-1781(01)00226-8
Gating of the vertex somatosensory and auditory evoked potential P50 and the correlation to skin conductance orienting response in healthy men
S. Arnfred (2001)
Brainstem auditory evoked potential (BAEP) in brucellosis.
A. Ashraf (2008)
10.1016/j.neuroimage.2006.12.011
Generators of the intracranial P50 response in auditory sensory gating
O. Korzyukov (2007)
10.1097/00005537-200107000-00010
Functional Magnetic Resonance Imaging of the Pediatric Swallow: Imaging the Cortex and the Brainstem
C. Hartnick (2001)
10.1212/WNL.38.1.64
State‐dependent changes in the N20 component of the median nerve somatosensory evoked potential
R. Emerson (1988)
10.1097/NEN.0b013e3182965886
Parkinson disease affects peripheral sensory nerves in the pharynx.
L. Mu (2013)
Urge to cough with voluntary suppression following mechanical pharyngeal stimulation.
K. Hegland (2011)
10.1016/S1388-2457(99)00060-7
The diagnostic value of motor evoked potentials
V. Lazzaro (1999)
10.1016/S1388-2457(01)00578-8
The effect of state on sensory gating: comparison of waking, REM and non-REM sleep
M. Kisley (2001)
10.1016/0168-5597(89)90058-0
Abnormalities of short-latency somatosensory evoked potentials in parkinsonian patients.
P. Rossini (1989)
10.1007/BF02406277
Physiological substrates of normal deglutition
J. Kennedy (2006)
10.1212/WNL.0b013e3181fef115
Aspiration and swallowing in Parkinson disease and rehabilitation with EMST
M. Troche (2010)
10.1016/S0006-8993(97)00756-7
Role of nucleus retroambigualis in respiratory reflexes evoked by superior laryngeal and vestibular nerve afferents and in emesis
T. Umezaki (1997)
10.1093/AGEING/AFL105
Hard to swallow: dysphagia in Parkinson's disease.
Nick Miller (2006)
10.1097/WNP.0b013e3181c2bcf7
Respiratory-Related-Evoked Potential Measures of Respiratory Sensory Gating in Attend and Ignore Conditions
Pei-Ying S. Chan (2009)
10.1097/00005537-200111000-00028
Bolus Transit and Airway Protection Coordination in Older Dysphagic Patients
K. Kendall (2001)
10.1378/chest.10-0342
Using voluntary cough to detect penetration and aspiration during oropharyngeal swallowing in patients with Parkinson disease.
T. Pitts (2010)
10.1097/PSY.0b013e31828251cf
Emotions and Neural Processing of Respiratory Sensations Investigated With Respiratory-Related Evoked Potentials
A. von Leupoldt (2013)
10.2170/JJPHYSIOL.6.162
Effects of deglutition upon the spike discharges of neurones in the respiratory center.
T. Hukuhara (1956)
10.1002/hed.21845
Swallow remodeling of respiratory neural networks
P. Davenport (2011)
10.1152/AJPGI.2001.280.4.G531
Swallow-related cerebral cortical activity maps are not specific to deglutition.
M. Kern (2001)
10.1152/japplphysiol.90722.2008
Respiratory-related evoked potential measures of respiratory sensory gating.
Pei-Ying S. Chan (2008)
10.1097/00005537-200202000-00025
Laryngeal Adductor Reflex and Pharyngeal Squeeze as Predictors of Laryngeal Penetration and Aspiration
J. Aviv (2002)
10.2307/2530855
Electric fields of the brain
P. Nunez (1981)
10.1016/0165-1838(84)90017-1
Control of the central swallowing program by inputs from the peripheral receptors. A review.
A. Jean (1984)
10.1016/S0006-8993(02)03549-7
Intracellular activity of superior laryngeal nerve motoneurons during fictive swallowing in decerebrate rats
Y. Saito (2002)
10.1007/s00455-007-9144-x
Voluntary Cough Production and Swallow Dysfunction in Parkinson’s Disease
T. Pitts (2007)
10.1164/AJRCCM.158.2.9705094
Defective motor control of coughing in Parkinson's disease.
G. Fontana (1998)
10.3389/fphys.2010.00167
Cortical Gating of Oropharyngeal Sensory Stimuli
K. Wheeler-Hegland (2011)
10.1016/0959-4388(94)90056-6
Sensory gating mechanisms of the thalamus
D. McCormick (1994)
10.1007/BF00918895
The acute effects of caffeine on evoked response, vigilance, and activity level in hyperkinetic children
C. Conners (1979)
10.1007/BF00228098
Activity of dorsal respiratory group inspiratory neurons during laryngeal-induced fictive coughing and swallowing in decerebrate cats
C. Gestreau (2004)
10.1007/BF01128868
Evolution of neuromagnetic topographic mapping
S. Williamson (2005)
10.1097/00005537-199709000-00018
Laryngopharyngeal Sensory Testing With Modified Barium Swallow As Predictors of Aspiration Pneumonia After Stroke
J. Aviv (1997)
10.1016/j.clinph.2003.11.021
A review of the evidence for P2 being an independent component process: age, sleep and modality
K. Crowley (2004)
10.2466/pms.1993.76.3.707
Effects of Caffeine and Diphenhydramine on Auditory Evoked Cortical Potentials
W. Tharion (1993)
10.1006/nimg.1999.0504
Human Movement-Related Potentials vs Desynchronization of EEG Alpha Rhythm: A High-Resolution EEG Study
C. Babiloni (1999)
10.1097/NEN.0b013e318258381b
Altered Pharyngeal Muscles in Parkinson Disease
L. Mu (2012)
10.2170/JJPHYSIOL.17.200
The nature and postnatal development of reflex deglutition in the kitten.
T. Sumi (1967)
10.1164/AJRCCM.161.6.9903077
Respiratory-related evoked potentials in children with life-threatening asthma.
P. Davenport (2000)
10.1016/0013-4694(78)90124-4
Effects of ethanol, caffeine, and placebo on the auditory evoked response.
J. Wolpaw (1978)
10.1136/jnnp.63.5.579
Response of parkinsonian swallowing dysfunction to dopaminergic stimulation
P. Hunter (1997)
10.1016/j.ijpsycho.2009.08.003
Single-trial event-related potentials to significant stimuli.
Jacqueline Rushby (2009)
10.1146/ANNUREV.NEURO.20.1.185
Sleep and arousal: thalamocortical mechanisms.
D. McCormick (1997)
10.1126/SCIENCE.424760
A brain event related to the making of a sensory discrimination.
W. Ritter (1979)
10.1186/s12883-015-0362-9
Rate of aspiration pneumonia in hospitalized Parkinson’s disease patients: a cross-sectional study
D. Martinez-Ramirez (2015)
10.1007/s00455-010-9308-y
Peak Morphology and Scalp Topography of the Pharyngeal Sensory-Evoked Potential
K. Wheeler-Hegland (2010)
10.1044/1092-4388(2008/013)
A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson's disease.
Jeri A. Logemann (2008)
10.1111/J.1469-8986.2007.00602.X
Influence of cognitive control and mismatch on the N2 component of the ERP: a review.
Jonathan R. Folstein (2008)
10.1016/j.parkreldis.2010.04.010
The cause of death in idiopathic Parkinson's disease.
S. Pennington (2010)
10.1016/j.resp.2009.12.006
Cortical sources of the respiratory-related evoked potential
A. Leupoldt (2010)
10.1007/BF00262751
The association of swallowing dysfunction and aspiration pneumonia
B. J. Martin (2004)
10.1152/JN.1956.19.1.44
An electromyographic analysis of reflex deglutition.
R. Doty (1956)
10.1007/BF02233643
Studies on the normal deglutition complex
G. Vantrappen (2005)
10.1152/japplphysiol.00798.2009
The role of nicotine on respiratory sensory gating measured by respiratory-related evoked potentials.
Pei-Ying S. Chan (2010)
10.1111/1469-8986.3760831
The relationship between respiratory-related evoked potentials and the perception of inspiratory resistive loads.
K. Webster (2000)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar