Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

In Vitro Polyphenol Effects On Apoptosis: An Update Of Literature Data.

V. Curti, A. Di Lorenzo, Marco Dacrema, J. Xiao, S. M. Nabavi, M. Daglia
Published 2017 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Polyphenols are secondary plant metabolites which have been studied extensively for their health-promoting properties, and which could also exert pharmacological activities ranging from anti-inflammatory effects, to cytotoxic activity against cancer cells. The main mechanism for programmed cell death is represented by apoptosis, and its dysregulation is involved in the etiopathology of cancer. As such, substances able to induce apoptosis in cancer cells could be used as new anticancer agents. The aim of this paper is to review literature data on the apoptotic effects of polyphenols and the molecular mechanisms through which they induce these effects in cancer cells. In addition, a brief summary of the new delivery forms used to increase the bioavailability, and clinical impact of polyphenols is provided. The studies reported show that many polyphenol rich plant extracts, originating from food and herbal medicine, as well as isolated polyphenols administered individually or in combination, can regulate cell apoptosis primarily through intrinsic and extrinsic mechanisms of action in in vitro conditions. Due to these promising results, the use of polyphenols in the treatment of cancer should therefore be deeply investigated. In particular, because of the low number of clinical trials, further studies are required to evaluate the anticancer activity of polyphenols in in vivo conditions.
This paper references
10.1002/jcp.24049
Biological effects of the plant‐derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells
Hee-jeong Im (2012)
10.1111/J.1365-2621.2007.01611.X
Phenolic content and profiles of selected wild fruits of Zimbabwe: Ximenia caffra, Artobotrys brachypetalus and Syzygium cordatum
A. R. Ndhlala (2008)
10.1016/j.foodchem.2012.10.112
Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca).
G. C. Tenore (2013)
10.1016/j.jchromb.2012.05.042
HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus.
M. Priya Rani (2012)
10.1016/j.foodchem.2014.05.060
Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells.
M. Vizzotto (2014)
10.1016/j.jconrel.2013.08.302
Tumor growth inhibition through targeting liposomally bound curcumin to tumor vasculature.
G. Mondal (2013)
10.1016/S1995-7645(14)60004-3
Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus.
Kilani-Jaziri Soumaya (2014)
10.1515/jbcpp-2014-0093
Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
D. Thomas (2015)
10.1021/acs.molpharmaceut.5b00820
Curcumin-Loading-Dependent Stability of PEGMEMA-Based Micelles Affects Endocytosis and Exocytosis in Colon Carcinoma Cells.
Teddy Chang (2016)
10.1021/JF030143F
Optimized and Validated HPLC Method for α- and γ-Tocopherol Measurement in Laurus nobilis Leaves. New Data on Tocopherol Content
D. Gómez-Coronado (2003)
10.1016/j.ejpb.2012.03.016
Design and evaluation of cyclodextrin-based delivery systems to incorporate poorly soluble curcumin analogs for the treatment of melanoma.
Deborah Michel (2012)
10.1016/j.msec.2016.11.107
Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: Curcumin.
Fatemeh Baghbani (2017)
10.1007/BF02913307
Apoptosis in health and disease and modulation of apoptosis for therapy: An overview
N. Singh (2008)
10.1038/nri2803
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules
G. Basile (2010)
10.1002/biof.1042
Curcumin uptake and metabolism
M. Metzler (2013)
10.3390/ijms16035762
Phenolic Composition and Antioxidant Properties of Different Peach [Prunus persica (L.) Batsch] Cultivars in China
Xiaoyong Zhao (2015)
10.1039/c5bm00479a
Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes.
Gopikrishna Moku (2016)
10.1155/2015/561589
Antioxidant and Proapoptotic Activities of Sclerocarya birrea [(A. Rich.) Hochst.] Methanolic Root Extract on the Hepatocellular Carcinoma Cell Line HepG2
M. F. Armentano (2015)
10.1248/bpb.b15-00186
Fulgidic Acid Isolated from the Rhizomes of Cyperus rotundus Suppresses LPS-Induced iNOS, COX-2, TNF-α, and IL-6 Expression by AP-1 Inactivation in RAW264.7 Macrophages.
J. Shin (2015)
10.1089/jmf.2012.0250
Rutabaga (Brassica napus L. var. napobrassica) seeds, roots, and sprouts: a novel kind of food with antioxidant properties and proapoptotic potential in Hep G2 hepatoma cell line.
P. Paśko (2013)
10.1016/j.foodchem.2013.09.018
Koelreuteria formosana extract impedes in vitro human LDL and prevents oxidised LDL-induced apoptosis in human umbilical vein endothelial cells.
Chin-Yin Lin (2014)
10.3390/nu6083084
Apoptosis Inducing Effects of Kuding Tea Polyphenols in Human Buccal Squamous Cell Carcinoma Cell Line BcaCD885
X. Zhao (2014)
10.1034/j.1600-065X.2003.00048.x
Caspase‐activation pathways in apoptosis and immunity
E. Creagh (2003)
10.1111/j.1469-8137.2008.02520.x
Distribution of glucosinolates and sulphur-rich cells in roots of field-grown canola (Brassica napus).
M. Mccully (2008)
10.3892/ijo.2017.3866
Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.
Chao-Hsiang Chang (2017)
10.1016/0031-9422(95)00260-E
Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide.
C. Thebtaranonth (1995)
10.1089/jmf.2011.0336
Tart cherry juice induces differential dose-dependent effects on apoptosis, but not cellular proliferation, in MCF-7 human breast cancer cells.
K. Martin (2012)
10.3390/ma9050316
Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials
Arianna Di Lorenzo (2016)
10.1039/c4fo00187g
Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation.
Lijuan Sun (2014)
10.1016/j.carbpol.2016.01.059
Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery.
P. Geetha (2016)
10.1007/s10616-015-9897-2
Phytoconstituents as apoptosis inducing agents: strategy to combat cancer
M. Kumar (2015)
10.1021/mp400366r
The combined effect of encapsulating curcumin and C6 ceramide in liposomal nanoparticles against osteosarcoma.
S. Dhule (2014)
10.1152/ajpendo.00218.2013
Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts.
B. Chen (2013)
10.1016/S1097-2765(02)00442-2
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.
Devrim Acehan (2002)
10.1016/j.kjms.2012.09.001
Mechanisms of apple polyphenols‐induced proliferation inhibiting and apoptosis in a metastatic oral adenoid cystic carcinoma cell line
Chao-qun Zheng (2013)
10.1186/1756-9966-30-87
Apoptosis in cancer: from pathogenesis to treatment
Rebecca S. Y. Wong (2011)
10.1016/j.fct.2012.06.035
In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR.
S. Borska (2012)
10.1016/j.semcdb.2015.01.006
Targeting extrinsic apoptosis in cancer: Challenges and opportunities.
S. Fulda (2015)
10.1016/j.foodchem.2014.03.060
Phytochemicals, nutritionals and antioxidant properties of two prickly pear cactus cultivars (Opuntia ficus indica Mill.) growing in Taif, KSA.
E. Abdel-Hameed (2014)
10.1038/sj.onc.1207101
The inhibitors of apoptosis: there is more to life than Bcl2
P. Liston (2003)
10.3945/an.111.000513
A comprehensive review of apples and apple components and their relationship to human health.
D. Hyson (2011)
10.3736/JCIM20030319
[Original studies on anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak in mice].
Zhen-xiao Sun (2003)
10.1038/cdd.2009.166
Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases
M. F. V. Delft (2010)
10.1021/acs.orglett.5b00596
Solanioic Acid, an Antibacterial Degraded Steroid Produced in Culture by the Fungus Rhizoctonia solani Isolated from Tubers of the Medicinal Plant Cyperus rotundus.
Pamoda B Ratnaweera (2015)
10.1016/J.APSB.2012.12.008
Research progress in the phytochemistry and biology of Ilex pharmaceutical resources
Da-Cheng Hao (2013)
10.18632/ONCOTARGET.2534
Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
L. Masuelli (2014)
10.1155/2013/956206
The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7)
N. F. Tanih (2013)
10.1055/s-0035-1555804
Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines.
K. Sharma (2016)
10.1021/jf400387c
Ultra-HPLC-MS(n) (Poly)phenolic profiling and chemometric analysis of juices from ancient Punica granatum L. Cultivars: a nontargeted approach.
L. Calani (2013)
10.1016/j.colsurfb.2017.01.051
Bypassing multidrug resistant ovarian cancer using ultrasound responsive doxorubicin/curcumin co-deliver alginate nanodroplets.
Fatemeh Baghbani (2017)
10.1055/S-2006-961423
(-)-Epicatechin-3-galloyl ester: a secretagogue compound from the bark of Sclerocarya birrea.
J. Galvez Peralta (1992)
People's Plants: A Guide to Useful Plants of Southern Africa
B. V. Wyk (2000)
10.1371/journal.pone.0068710
Growth Inhibition and Apoptosis Induction by (+)-Cyanidan-3-ol in Hepatocellular Carcinoma
J. Monga (2013)
10.1089/jmf.2012.0076
Effect of Annurca apple polyphenols on human HaCaT keratinocytes proliferation.
S. D'Angelo (2012)
10.1039/c5bm00433k
The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin.
S. Patra (2016)
10.1007/s10549-013-2667-y
Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells
A. Catania (2013)
10.1038/cdd.2009.212
Perforin deficiency and susceptibility to cancer
A. Brennan (2010)
10.1016/j.gene.2016.03.038
Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells.
M. Seçme (2016)
10.1038/bjc.1972.33
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
10.1083/JCB.144.2.281
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
E. Slee (1999)
10.1038/sj.leu.2402143
Suppression of apoptosis: role in cell growth and neoplasia
M. White (2001)
10.1177/1934578X1501001107
Analysis of Organic Acids, Deacetyl Asperulosidic Acid and Polyphenolic Compounds as a Potential Tool for Characterization of Noni (Morinda citrifolia) Products
Miroslava Bittová (2015)
10.1021/acs.molpharmaceut.5b00644
Systemic Codelivery of a Homoserine Derived Ceramide Analogue and Curcumin to Tumor Vasculature Inhibits Mouse Tumor Growth.
Sugata Barui (2016)
10.1016/j.ejpb.2010.12.006
Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model.
B. Wahlang (2011)
10.3390/pharmaceutics4040517
Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers
Y. B. Pawar (2012)
10.1039/c5fo00229j
Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.
A. F. Vinha (2015)
10.1080/01635581.2013.796999
Molecular Size Fractions of Bay Leaf (Laurus nobilis) Exhibit Differentiated Regulation of Colorectal Cancer Cell Growth In Vitro
L. Bennett (2013)
10.1016/j.ijpharm.2014.03.030
Preparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapy.
Gangjian Ji (2014)
10.1146/annurev-food-032814-014043
The Nutraceutical Bioavailability Classification Scheme: Classifying Nutraceuticals According to Factors Limiting their Oral Bioavailability.
D. J. Mcclements (2015)
10.2174/138161282006140220120640
Immunomodulating and anti-allergic effects of Negroamaro and Koshu Vitis vinifera fermented grape marc (FGM).
G. Marzulli (2014)
10.1016/0031-9422(82)85246-1
Flavonoids in leaves and inflorescences of australian Cyperus species
J. B. Harborne (1982)
10.1016/j.bbamem.2013.06.026
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.
Angelique Camilleri (2013)
10.1021/jf9022096
Anatomical, chemical, and biochemical characterization of cladodes from prickly pear [Opuntia ficus-indica (L.) Mill.].
G. Ginestra (2009)
10.1007/S00217-008-0946-3
Physicochemical and nutritional properties and volatile constituents of six Japanese plum (Prunus salicina Lindl.) cultivars
M. Lozano (2009)
10.1016/J.FOODCHEM.2006.06.066
Phenolic composition of Flacourtia indica, Opuntia megacantha and Sclerocarya birrea
A. R. Ndhlala (2007)
10.2147/IJN.S124276
The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
Y. Wang (2017)
10.3892/mmr.2014.2587
Inhibition of the invasion and migration of renal carcinoma 786‑o‑si3 cells in vitro and in vivo by Koelreuteria formosana extract.
Chin-Yin Lin (2014)
10.1021/jf3042648
An UPLC-MS/MS method for the simultaneous identification and quantitation of cell wall phenolics in Brassica napus seeds.
A. Frolov (2013)
10.1088/0957-4484/27/31/315105
Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery.
Lin Hou (2016)
10.1016/S0031-6865(99)00038-2
Apoptosis induced by death receptors.
P. Schneider (2000)
10.1002/mabi.201500142
Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells.
Serena Mancarella (2015)
10.1002/ijc.27409
Epicatechin‐rich cocoa polyphenol inhibits Kras‐activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
Hifzur R. Siddique (2012)
10.1016/J.FITOTE.2012.08.005
Occurrence of stilbene oligomers in Cyperus rhizomes.
T. Ito (2012)
10.1016/j.semcancer.2015.03.001
Broad targeting of resistance to apoptosis in cancer
R. Mohammad (2015)
10.47893/IJPPT.2017.1022
PHYSICO-CHEMICAL AND PHYTO-CHEMICAL STUDY OF RHIZOME of Cyperus rotundus LINN
Sri Ranjani Sivapalan (2017)
10.1016/j.ijpharm.2013.10.045
Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: optimization and pharmacokinetics.
Priyanka Arya (2014)
10.1016/j.fct.2012.08.015
In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity.
Yon-Suk Kim (2012)
10.1016/j.tiv.2013.05.015
Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin.
B. Sun (2013)
10.1038/sj.onc.1202591
Bcl-2 family proteins
John Calvin Reed (1998)
10.3109/10717544.2015.1066902
Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy
Mingzhen Lin (2016)
10.1007/s10549-012-2224-0
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation
N. Banerjee (2012)
10.1021/jf404826u
Analysis of flavonoids and hydroxycinnamic acid derivatives in rapeseeds (Brassica napus L. var. napus) by HPLC-PDA--ESI(--)-MS(n)/HRMS.
Yanlin Shao (2014)
10.1146/annurev-med-041610-134208
Familial and acquired hemophagocytic lymphohistiocytosis.
G. Janka (2012)
10.1016/j.jep.2010.08.063
Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.).
É. Dussossoy (2011)
10.1080/01635581.2014.951733
Flavonoid-Enriched Apple Fraction AF4 Induces Cell Cycle Arrest, DNA Topoisomerase II Inhibition, and Apoptosis in Human Liver Cancer HepG2 Cells
S. Sudan (2014)
10.1016/j.bmcl.2015.12.060
Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems.
Gautier M.A. Ndong Ntoutoume (2016)
10.1093/JN/137.12.2622
Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells.
L. Fini (2007)
10.1021/tx5000415
Neuroprotective potential of Laurus nobilis antioxidant polyphenol-enriched leaf extracts.
S. Pacifico (2014)
10.2174/0929867321666140815123852
Anthocyanins as a potential therapy for diabetic retinopathy.
S. F. Nabavi (2014)
10.1186/1472-6882-13-116
Attenuation of oxidative stress in U937 cells by polyphenolic-rich bark fractions of Burkea africana and Syzygium cordatum
W. Cordier (2013)
10.1016/S1875-5364(11)60013-7
Triterpenoid Saponins from the Leaves of Ilex kudingcha
Yan-Yun Che (2011)
10.1016/J.FOODRES.2014.03.070
Untargeted and targeted methodologies in the study of tea (Camellia sinensis L.)
M. Daglia (2014)
10.1080/14786419.2014.942303
In vitro evaluation of antiproliferative effect of ethyl gallate against human oral squamous carcinoma cell line KB
S. Mohan (2015)
10.1016/j.foodchem.2014.10.094
Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.
Jinping Cao (2015)
10.1152/ajpendo.00003.2012
Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts.
B. Chen (2012)
10.2217/nnm.12.126
Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum-based chemotherapeutic drugs.
Amal A. Alotaibi (2013)
10.1016/j.biopha.2016.12.042
Construction and comparison of different nanocarriers for co-delivery of cisplatin and curcumin: A synergistic combination nanotherapy for cervical cancer.
Changming Li (2017)
10.1002/jsfa.6968
Bioactives in cactus (Opuntia ficus-indica) stems possess potent antioxidant and pro-apoptotic activities through COX-2 involvement.
J. Kim (2015)
10.1002/PTR.2650070108
Pharmacological activity of a procyanidin isolated from Sclerocarya birrea bark: Antidiarrhoeal activity and effects on isolated guinea‐pig ileum
J. Gálvez (1993)
10.1002/jat.1725
Selective apoptotic effects of piceatannol and myricetin in human cancer cells
P. Morales (2012)
10.1080/01926230701320337
Apoptosis: A Review of Programmed Cell Death
S. Elmore (2007)



This paper is referenced by
10.1186/s12935-020-1100-y
Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
Khatereh Khorsandi (2020)
10.4149/gpb_2020024
Punicalagin induces apoptosis in A549 cell line through mitochondria-mediated pathway.
Mehmet Berköz (2020)
10.1016/j.phrs.2019.104265
Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies.
Z. Ma (2019)
10.1080/15287394.2020.1867275
Antigenotoxic effects of (-)-epigallocatechin-3-gallate (EGCG) and its relationship with the endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct repair (8-OHdG), and apoptosis in mice exposed to chromium(VI)
María Helena García-Rodríguez (2020)
10.1007/s10571-020-00930-2
Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling
W. Han (2020)
10.1080/87559129.2019.1630634
The Antiangiogenic Activity of Polyphenol-Rich Extracts and Its Implication on Cancer Chemoprevention
K. Chojnacka (2020)
10.1016/B978-0-444-64181-6.00003-6
Therapeutic Potentials of the Most Studied Flavonoids: Highlighting Antibacterial and Antidiabetic Functionalities
Hassan Rasouli (2019)
10.7324/japs.2018.8806
Dendrophthoe pentandra Leaves Extract Promotes Apoptotic Effects of Doxorubicin in Human Breast Cancer Cell via Modulation of Intracellular Calcium and Survivin
A. T. Endharti (2018)
2 CYTOCHROME P 450 CYP 1 METABOLISM OF HYDROXYLATED FLAVONES AND FLAVONOLS : SELECTIVE BIOACTIVATION OF LUTEOLIN IN BREAST CANCER CELLS
N. Wilsher (2017)
10.1016/j.fct.2017.10.051
Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.
N. Wilsher (2017)
10.1016/j.foodchem.2018.03.128
Molecular insight into the inclusion of the dietary plant flavonol fisetin and its chromophore within a chemically modified γ-cyclodextrin: Multi-spectroscopic, molecular docking and solubility studies.
B. Pahari (2018)
10.1016/J.COFS.2018.10.013
Polyphenols as potential antiproliferative agents: scientific trends
Mariana A V Carmo (2018)
10.1016/J.JFF.2018.05.001
Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity
K. Chojnacka (2018)
10.34172/jhp.2020.32
Phytochemical content, antioxidant activities and androgenic properties of four South African medicinal plants
Nelisiwe Prenate Masuku (2020)
10.1080/87559129.2020.1810700
Grape Polyphenols to Arrest in Vitro Proliferation of Human Leukemia Cells: A Systematic Review and Meta-analysis
Daniel J García-Martínez (2020)
10.1016/j.ejphar.2019.172533
Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.
Cláudia Silva (2019)
10.1016/j.foodchem.2018.07.111
Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.
H. Cao (2019)
10.3390/ijms19010027
Antiangiogenic Effect of Flavonoids and Chalcones: An Update
L. Mirossay (2017)
10.1016/j.fct.2018.04.001
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Xing Wei (2018)
10.3389/fcimb.2019.00455
Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets
H. Wang (2019)
10.4172/2167-7700.1000246
The Progress of Diallyl Disulfide in Anti-Cancer
Xia Lz (2017)
10.5772/INTECHOPEN.76651
The Role of Green Tea Polyphenols in the Protection from Hexavalent Chromium-Induced Genotoxic Damage
M. García-Rodríguez (2018)
10.15406/JLRDT.2018.04.00102
Citotoxyc and apoptotic activity of extracts from leaves and juice of passiflora edulis
J. Aguillón (2018)
10.1111/jfpe.13546
Effect of Ultraviolet irradiation on the stilbenoid content of blueberry leaves
Taeeun Kim (2020)
10.1016/j.fct.2018.02.056
Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities.
A. Nile (2018)
10.1039/c9fo00001a
Naringenin improves mitochondrial function and reduces cardiac damage following ischemia-reperfusion injury: the role of the AMPK-SIRT3 signaling pathway.
Li-Ming Yu (2019)
10.3390/plants9010026
Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin
C. Cappadone (2019)
Investigating the stimulatory mechanisms of phlorizin, phloretin and chlorogenic acid polyphenols on Akkermansia muciniphila in vitro
Ayano Hojo (2019)
10.1016/j.jphotobiol.2017.10.021
Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses.
Sourav Das (2018)
10.1016/j.biotechadv.2019.04.007
Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.
H. Khan (2019)
10.1177/0956462418797874
Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO2 ablative therapy: The PACT study (post-ablation immunomodulator treatment of condylomata with sinecatechins): a randomized, masked outcome assessment, multicenter trial
M. Puviani (2019)
10.1016/j.jep.2018.09.037
Are polyphenol antioxidants at the root of medicinal plant anti-cancer success?
A. B. Oyenihi (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar