Referencing for people who value simplicity, privacy, and speed.Get Citationsy
← Back to Search
In Vitro Polyphenol Effects On Apoptosis: An Update Of Literature Data.
V. Curti, A. Di Lorenzo, Marco Dacrema, J. Xiao, S. M. Nabavi, M. Daglia
Published 2017 · Biology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Polyphenols are secondary plant metabolites which have been studied extensively for their health-promoting properties, and which could also exert pharmacological activities ranging from anti-inflammatory effects, to cytotoxic activity against cancer cells. The main mechanism for programmed cell death is represented by apoptosis, and its dysregulation is involved in the etiopathology of cancer. As such, substances able to induce apoptosis in cancer cells could be used as new anticancer agents. The aim of this paper is to review literature data on the apoptotic effects of polyphenols and the molecular mechanisms through which they induce these effects in cancer cells. In addition, a brief summary of the new delivery forms used to increase the bioavailability, and clinical impact of polyphenols is provided. The studies reported show that many polyphenol rich plant extracts, originating from food and herbal medicine, as well as isolated polyphenols administered individually or in combination, can regulate cell apoptosis primarily through intrinsic and extrinsic mechanisms of action in in vitro conditions. Due to these promising results, the use of polyphenols in the treatment of cancer should therefore be deeply investigated. In particular, because of the low number of clinical trials, further studies are required to evaluate the anticancer activity of polyphenols in in vivo conditions.
This paper references
Biological effects of the plant‐derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells
Hee-jeong Im (2012)
Phenolic content and profiles of selected wild fruits of Zimbabwe: Ximenia caffra, Artobotrys brachypetalus and Syzygium cordatum
A. R. Ndhlala (2008)
Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca).
G. C. Tenore (2013)
HPTLC and reverse phase HPLC methods for the simultaneous quantification and in vitro screening of antioxidant potential of isolated sesquiterpenoids from the rhizomes of Cyperus rotundus.
M. Priya Rani (2012)
Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells.
M. Vizzotto (2014)
Tumor growth inhibition through targeting liposomally bound curcumin to tumor vasculature.
G. Mondal (2013)
Evaluation of in vitro antioxidant and apoptotic activities of Cyperus rotundus.
Kilani-Jaziri Soumaya (2014)
Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress
D. Thomas (2015)
Curcumin-Loading-Dependent Stability of PEGMEMA-Based Micelles Affects Endocytosis and Exocytosis in Colon Carcinoma Cells.
Teddy Chang (2016)
Optimized and Validated HPLC Method for α- and γ-Tocopherol Measurement in Laurus nobilis Leaves. New Data on Tocopherol Content
D. Gómez-Coronado (2003)
Design and evaluation of cyclodextrin-based delivery systems to incorporate poorly soluble curcumin analogs for the treatment of melanoma.
Deborah Michel (2012)
Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: Curcumin.
Fatemeh Baghbani (2017)
Apoptosis in health and disease and modulation of apoptosis for therapy: An overview
N. Singh (2008)
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules
G. Basile (2010)
Curcumin uptake and metabolism
M. Metzler (2013)
Phenolic Composition and Antioxidant Properties of Different Peach [Prunus persica (L.) Batsch] Cultivars in China
Xiaoyong Zhao (2015)
Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes.
Gopikrishna Moku (2016)
Antioxidant and Proapoptotic Activities of Sclerocarya birrea [(A. Rich.) Hochst.] Methanolic Root Extract on the Hepatocellular Carcinoma Cell Line HepG2
M. F. Armentano (2015)
Fulgidic Acid Isolated from the Rhizomes of Cyperus rotundus Suppresses LPS-Induced iNOS, COX-2, TNF-α, and IL-6 Expression by AP-1 Inactivation in RAW264.7 Macrophages.
J. Shin (2015)
Rutabaga (Brassica napus L. var. napobrassica) seeds, roots, and sprouts: a novel kind of food with antioxidant properties and proapoptotic potential in Hep G2 hepatoma cell line.
P. Paśko (2013)
Koelreuteria formosana extract impedes in vitro human LDL and prevents oxidised LDL-induced apoptosis in human umbilical vein endothelial cells.
Chin-Yin Lin (2014)
Apoptosis Inducing Effects of Kuding Tea Polyphenols in Human Buccal Squamous Cell Carcinoma Cell Line BcaCD885
X. Zhao (2014)
Caspase‐activation pathways in apoptosis and immunity
E. Creagh (2003)
Distribution of glucosinolates and sulphur-rich cells in roots of field-grown canola (Brassica napus).
M. Mccully (2008)
Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.
Chao-Hsiang Chang (2017)
Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide.
C. Thebtaranonth (1995)
Tart cherry juice induces differential dose-dependent effects on apoptosis, but not cellular proliferation, in MCF-7 human breast cancer cells.
K. Martin (2012)
Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials
Arianna Di Lorenzo (2016)
Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation.
Lijuan Sun (2014)
Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery.
P. Geetha (2016)
Phytoconstituents as apoptosis inducing agents: strategy to combat cancer
M. Kumar (2015)
The combined effect of encapsulating curcumin and C6 ceramide in liposomal nanoparticles against osteosarcoma.
S. Dhule (2014)
Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts.
B. Chen (2013)
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.
Devrim Acehan (2002)
Mechanisms of apple polyphenols‐induced proliferation inhibiting and apoptosis in a metastatic oral adenoid cystic carcinoma cell line
Chao-qun Zheng (2013)
Apoptosis in cancer: from pathogenesis to treatment
Rebecca S. Y. Wong (2011)
In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR.
S. Borska (2012)
Targeting extrinsic apoptosis in cancer: Challenges and opportunities.
S. Fulda (2015)
Phytochemicals, nutritionals and antioxidant properties of two prickly pear cactus cultivars (Opuntia ficus indica Mill.) growing in Taif, KSA.
E. Abdel-Hameed (2014)
The inhibitors of apoptosis: there is more to life than Bcl2
P. Liston (2003)
A comprehensive review of apples and apple components and their relationship to human health.
D. Hyson (2011)
[Original studies on anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak in mice].
Zhen-xiao Sun (2003)
Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases
M. F. V. Delft (2010)
Solanioic Acid, an Antibacterial Degraded Steroid Produced in Culture by the Fungus Rhizoctonia solani Isolated from Tubers of the Medicinal Plant Cyperus rotundus.
Pamoda B Ratnaweera (2015)
Research progress in the phytochemistry and biology of Ilex pharmaceutical resources
Da-Cheng Hao (2013)
Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas
L. Masuelli (2014)
The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7)
N. F. Tanih (2013)
Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines.
K. Sharma (2016)
Ultra-HPLC-MS(n) (Poly)phenolic profiling and chemometric analysis of juices from ancient Punica granatum L. Cultivars: a nontargeted approach.
L. Calani (2013)
Bypassing multidrug resistant ovarian cancer using ultrasound responsive doxorubicin/curcumin co-deliver alginate nanodroplets.
Fatemeh Baghbani (2017)
(-)-Epicatechin-3-galloyl ester: a secretagogue compound from the bark of Sclerocarya birrea.
J. Galvez Peralta (1992)
People's Plants: A Guide to Useful Plants of Southern Africa
B. V. Wyk (2000)
Growth Inhibition and Apoptosis Induction by (+)-Cyanidan-3-ol in Hepatocellular Carcinoma
J. Monga (2013)
Effect of Annurca apple polyphenols on human HaCaT keratinocytes proliferation.
S. D'Angelo (2012)
The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin.
S. Patra (2016)
Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells
A. Catania (2013)
Perforin deficiency and susceptibility to cancer
A. Brennan (2010)
Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells.
M. Seçme (2016)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
E. Slee (1999)
Suppression of apoptosis: role in cell growth and neoplasia
M. White (2001)
Analysis of Organic Acids, Deacetyl Asperulosidic Acid and Polyphenolic Compounds as a Potential Tool for Characterization of Noni (Morinda citrifolia) Products
Miroslava Bittová (2015)
Systemic Codelivery of a Homoserine Derived Ceramide Analogue and Curcumin to Tumor Vasculature Inhibits Mouse Tumor Growth.
Sugata Barui (2016)
Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model.
B. Wahlang (2011)
Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers
Y. B. Pawar (2012)
Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.
A. F. Vinha (2015)
Molecular Size Fractions of Bay Leaf (Laurus nobilis) Exhibit Differentiated Regulation of Colorectal Cancer Cell Growth In Vitro
L. Bennett (2013)
Preparation of novel curcumin-loaded multifunctional nanodroplets for combining ultrasonic development and targeted chemotherapy.
Gangjian Ji (2014)
The Nutraceutical Bioavailability Classification Scheme: Classifying Nutraceuticals According to Factors Limiting their Oral Bioavailability.
D. J. Mcclements (2015)
Immunomodulating and anti-allergic effects of Negroamaro and Koshu Vitis vinifera fermented grape marc (FGM).
G. Marzulli (2014)
Flavonoids in leaves and inflorescences of australian Cyperus species
J. B. Harborne (1982)
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols.
Angelique Camilleri (2013)
Anatomical, chemical, and biochemical characterization of cladodes from prickly pear [Opuntia ficus-indica (L.) Mill.].
G. Ginestra (2009)
Physicochemical and nutritional properties and volatile constituents of six Japanese plum (Prunus salicina Lindl.) cultivars
M. Lozano (2009)
Phenolic composition of Flacourtia indica, Opuntia megacantha and Sclerocarya birrea
A. R. Ndhlala (2007)
The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals
Y. Wang (2017)
Inhibition of the invasion and migration of renal carcinoma 786‑o‑si3 cells in vitro and in vivo by Koelreuteria formosana extract.
Chin-Yin Lin (2014)
An UPLC-MS/MS method for the simultaneous identification and quantitation of cell wall phenolics in Brassica napus seeds.
A. Frolov (2013)
Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery.
Lin Hou (2016)
Apoptosis induced by death receptors.
P. Schneider (2000)
Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells.
Serena Mancarella (2015)
Epicatechin‐rich cocoa polyphenol inhibits Kras‐activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
Hifzur R. Siddique (2012)
Occurrence of stilbene oligomers in Cyperus rhizomes.
T. Ito (2012)
Broad targeting of resistance to apoptosis in cancer
R. Mohammad (2015)
PHYSICO-CHEMICAL AND PHYTO-CHEMICAL STUDY OF RHIZOME of Cyperus rotundus LINN
Sri Ranjani Sivapalan (2017)
Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: optimization and pharmacokinetics.
Priyanka Arya (2014)
In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity.
Yon-Suk Kim (2012)
Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin.
B. Sun (2013)
Bcl-2 family proteins
John Calvin Reed (1998)
Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy
Mingzhen Lin (2016)
Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation
N. Banerjee (2012)
Analysis of flavonoids and hydroxycinnamic acid derivatives in rapeseeds (Brassica napus L. var. napus) by HPLC-PDA--ESI(--)-MS(n)/HRMS.
Yanlin Shao (2014)
Familial and acquired hemophagocytic lymphohistiocytosis.
G. Janka (2012)
Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.).
É. Dussossoy (2011)
Flavonoid-Enriched Apple Fraction AF4 Induces Cell Cycle Arrest, DNA Topoisomerase II Inhibition, and Apoptosis in Human Liver Cancer HepG2 Cells
S. Sudan (2014)
Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems.
Gautier M.A. Ndong Ntoutoume (2016)
Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells.
L. Fini (2007)
Neuroprotective potential of Laurus nobilis antioxidant polyphenol-enriched leaf extracts.
S. Pacifico (2014)
Anthocyanins as a potential therapy for diabetic retinopathy.
S. F. Nabavi (2014)
Attenuation of oxidative stress in U937 cells by polyphenolic-rich bark fractions of Burkea africana and Syzygium cordatum
W. Cordier (2013)
Triterpenoid Saponins from the Leaves of Ilex kudingcha
Yan-Yun Che (2011)
Untargeted and targeted methodologies in the study of tea (Camellia sinensis L.)
M. Daglia (2014)
In vitro evaluation of antiproliferative effect of ethyl gallate against human oral squamous carcinoma cell line KB
S. Mohan (2015)
Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.
Jinping Cao (2015)
Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts.
B. Chen (2012)
Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum-based chemotherapeutic drugs.
Amal A. Alotaibi (2013)
Construction and comparison of different nanocarriers for co-delivery of cisplatin and curcumin: A synergistic combination nanotherapy for cervical cancer.
Changming Li (2017)
Bioactives in cactus (Opuntia ficus-indica) stems possess potent antioxidant and pro-apoptotic activities through COX-2 involvement.
J. Kim (2015)
Pharmacological activity of a procyanidin isolated from Sclerocarya birrea bark: Antidiarrhoeal activity and effects on isolated guinea‐pig ileum
J. Gálvez (1993)
Selective apoptotic effects of piceatannol and myricetin in human cancer cells
P. Morales (2012)
Apoptosis: A Review of Programmed Cell Death
S. Elmore (2007)
This paper is referenced by
Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis
Khatereh Khorsandi (2020)
Punicalagin induces apoptosis in A549 cell line through mitochondria-mediated pathway.
Mehmet Berköz (2020)
Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies.
Z. Ma (2019)
Antigenotoxic effects of (-)-epigallocatechin-3-gallate (EGCG) and its relationship with the endogenous antioxidant system, 8-hydroxydeoxyguanosine adduct repair (8-OHdG), and apoptosis in mice exposed to chromium(VI)
María Helena García-Rodríguez (2020)
Valproic Acid Sensitizes Glioma Cells to Luteolin Through Induction of Apoptosis and Autophagy via Akt Signaling
W. Han (2020)
The Antiangiogenic Activity of Polyphenol-Rich Extracts and Its Implication on Cancer Chemoprevention
K. Chojnacka (2020)
Therapeutic Potentials of the Most Studied Flavonoids: Highlighting Antibacterial and Antidiabetic Functionalities
Hassan Rasouli (2019)
Dendrophthoe pentandra Leaves Extract Promotes Apoptotic Effects of Doxorubicin in Human Breast Cancer Cell via Modulation of Intracellular Calcium and Survivin
A. T. Endharti (2018)
2 CYTOCHROME P 450 CYP 1 METABOLISM OF HYDROXYLATED FLAVONES AND FLAVONOLS : SELECTIVE BIOACTIVATION OF LUTEOLIN IN BREAST CANCER CELLS
N. Wilsher (2017)
Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.
N. Wilsher (2017)
Molecular insight into the inclusion of the dietary plant flavonol fisetin and its chromophore within a chemically modified γ-cyclodextrin: Multi-spectroscopic, molecular docking and solubility studies.
B. Pahari (2018)
Polyphenols as potential antiproliferative agents: scientific trends
Mariana A V Carmo (2018)
Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity
K. Chojnacka (2018)
Phytochemical content, antioxidant activities and androgenic properties of four South African medicinal plants
Nelisiwe Prenate Masuku (2020)
Grape Polyphenols to Arrest in Vitro Proliferation of Human Leukemia Cells: A Systematic Review and Meta-analysis
Daniel J García-Martínez (2020)
Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.
Cláudia Silva (2019)
Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.
H. Cao (2019)
Antiangiogenic Effect of Flavonoids and Chalcones: An Update
L. Mirossay (2017)
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.
Xing Wei (2018)
Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets
H. Wang (2019)
The Progress of Diallyl Disulfide in Anti-Cancer
Xia Lz (2017)
The Role of Green Tea Polyphenols in the Protection from Hexavalent Chromium-Induced Genotoxic Damage
M. García-Rodríguez (2018)
Citotoxyc and apoptotic activity of extracts from leaves and juice of passiflora edulis
J. Aguillón (2018)
Effect of Ultraviolet irradiation on the stilbenoid content of blueberry leaves
Taeeun Kim (2020)
Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities.
A. Nile (2018)
Naringenin improves mitochondrial function and reduces cardiac damage following ischemia-reperfusion injury: the role of the AMPK-SIRT3 signaling pathway.
Li-Ming Yu (2019)
Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin
C. Cappadone (2019)
Investigating the stimulatory mechanisms of phlorizin, phloretin and chlorogenic acid polyphenols on Akkermansia muciniphila in vitro
Ayano Hojo (2019)
Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses.
Sourav Das (2018)
Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.
H. Khan (2019)
Efficacy of sinecatechins 10% as proactive sequential therapy of external genital warts after laser CO2 ablative therapy: The PACT study (post-ablation immunomodulator treatment of condylomata with sinecatechins): a randomized, masked outcome assessment, multicenter trial
M. Puviani (2019)
Are polyphenol antioxidants at the root of medicinal plant anti-cancer success?
A. B. Oyenihi (2019)See more