Online citations, reference lists, and bibliographies.

Effect Of The Intervertebral Disc On Vertebral Bone Strength Prediction: A Finite-Element Study.

D. Anitha, Thomas Baum, Jan S. Kirschke, Karupppasamy Subburaj
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND CONTEXT Osteoporotic vertebral fractures (OVFs) are a prevalent skeletal condition in the elderly but the mechanism behind these fractures remain unclear due to the complex biomechanical interplay between spinal segments such as the vertebra and intervertebral discs (IVDs). PURPOSE To investigate the biomechanical influence of IVDs by (i) comparing finite element (FE)-predicted failure load with experimentally measured failure load of functional spinal units (FSUs) and (ii) comparing this correlation with those of FE-predicted failure load and bone mineral density (BMD) of the single central vertebra with experimentally measured failure load. STUDY DESIGN A computational biomechanical analysis. PATIENT SAMPLE Ten thoracic FSUs consisting of a central vertebra, the adjacent intervertebral discs (IVDs), and the upper and lower halves of the adjacent vertebrae were harvested from formalin-fixed human donors (4 males, 6 females; mean age of 82±9 years). OUTCOME MEASURES The outcome measures included the prediction of vertebral strength and determination of BMD in FSUs and the single central vertebra and the correlation of both measures with experimentally measured vertebral strength of the FSUs. METHODS The FSUs underwent clinical multi-detector computed tomography (MDCT) (spatial resolution: 250 × 250 × 600 μm3). BMD was determined for the FSUs from the MDCT images of the central vertebrae. FE-predicted failure load was calculated in the single central vertebra of the FSUs alone and the entire FSUs. Experimentally measured failure load of the FSUs was determined in a uniaxial biomechanical test. RESULTS BMD of the central vertebrae correlated significantly with experimentally measured failure load (R2 = 0.66, p<0.02), whereas FE-predicted failure load of the central vertebra showed no significant correlation with experimentally measured failure load (p=0.07). However, FE-predicted failure load of FSUs best predicted experimentally measured failure load of FSUs (R2 = 0.93, p<0.0001). CONCLUSIONS This study demonstrated that routine clinical MDCT images can be an accurate and feasible tool for prediction of OVFs using patient-specific FE analysis of FSU models. CLINICAL SIGNIFICANCE Improved management of OVFs is essential amidst current clinical challenges. Implementation of a vertebral strength assessment tool could result in more accurate prediction of osteoporotic fracture risk and aid clinicians with better targeted early treatment strategies.
This paper references
10.1016/j.joca.2010.10.005
Formalin fixation affects equilibrium partitioning of an ionic contrast agent-microcomputed tomography (EPIC-μCT) imaging of osteochondral samples.
K E M Benders (2010)
10.1016/S0021-9290(01)00010-0
Correlation of thoracic and lumbar vertebral failure loads with in situ vs. ex situ dual energy X-ray absorptiometry.
Dominik Bürklein (2001)
10.1016/j.jbiomech.2006.11.021
How does the geometry affect the internal biomechanics of a lumbar spine bi-segment finite element model? Consequences on the validation process.
Jérôme Noailly (2007)
10.1007/s00198-011-1568-3
QCT-based finite element models predict human vertebral strength in vitro significantly better than simulated DEXA
Enrico Dall’Ara (2011)
10.1097/01.brs.0000253961.40910.c1
Comparison of Animals Used in Disc Research to Human Lumbar Disc Geometry
Grace D. O'Connell (2007)
10.1097/MD.0000000000005825
Risk of vertebral compression fractures in multiple myeloma patients
Dr. R. Anitha (2017)
10.1016/0021-9290(94)90014-0
The relationship between the structural and orthogonal compressive properties of trabecular bone.
Rick Goulet (1994)
10.1016/j.bone.2007.05.017
Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body.
Senthil K. Eswaran (2007)
10.1016/S0021-9290(96)80016-9
Formalin fixation strongly influences biomechanical properties of the spine.
Hans Joachim Wilke (1996)
10.1016/S8756-3282(03)00210-2
Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography.
Ruairidh Crawford (2003)
10.1186/s12880-015-0066-z
Osteoporosis imaging: effects of bone preservation on MDCT-based trabecular bone microstructure parameters and finite element models
Thomas Baum (2015)
10.1016/j.bone.2006.10.025
Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength.
Jenni M. Buckley (2007)
10.1097/01.brs.0000146049.52152.da
Mechanical Conditions That Accelerate Intervertebral Disc Degeneration: Overload Versus Immobilization
Ian A. F. Stokes (2004)
10.1177/0954411917708806
Development and validation of a subject-specific finite element model of the functional spinal unit to predict vertebral strength
Chu-Hee Lee (2017)
10.1002/jbm.820281111
Correlations between orthogonal mechanical properties and density of trabecular bone: use of different densitometric measures.
Joyce H. Keyak (1994)
10.1016/S1350-4533(01)00045-5
Improved prediction of proximal femoral fracture load using nonlinear finite element models.
Joyce H. Keyak (2001)
10.1186/s40634-016-0072-2
Quantitative Computed Tomography (QCT) derived Bone Mineral Density (BMD) in finite element studies: a review of the literature
Nikolas K. Knowles (2016)
10.1115/1.2241637
Sensitivity of vertebral compressive strength to endplate loading distribution.
Jenni M. Buckley (2006)
10.1016/0268-0033(94)90018-3
Formalin fixation effects on vertebral bone density and failure mechanics: an in-vitro study of human and sheep vertebrae.
Stephen J. Edmondston (1994)
10.2106/JBJS.RVW.O.00048
Challenging the Conventional Standard for Thoracic Spine Range of Motion: A Systematic Review
Sean L. Borkowski (2016)
10.1016/S0045-7949(02)00400-5
Finite element model of a lumbar spinal motion segment to predict circadian variation in stature
Raghu N. Natarajan (2003)
10.1016/j.medengphy.2015.03.007
Finite element analysis predicts experimental failure patterns in vertebral bodies loaded via intervertebral discs up to large deformation.
Allison L. Clouthier (2015)
10.1016/j.jbiomech.2007.10.012
An accurate finite element model of the cervical spine under quasi-static loading.
Amaya Pérez del Palomar (2008)
10.1097/00007632-198403000-00003
Stress analysis of the lumbar disc-body unit in compression. A three-dimensional nonlinear finite element study.
S A Shirazi-Adl (1984)
10.1097/00007632-200010010-00003
Impact Response of the Intervertebral Disc in a Finite-Element Model
Choon-Ki Lee (2000)
10.1016/0021-9290(94)90005-1
Nonlinear stress analysis of the whole lumbar spine in torsion--mechanics of facet articulation.
Aboulfazl Shirazi-Adl (1994)
10.1016/S0140-6736(02)08761-5
Diagnosis of osteoporosis and assessment of fracture risk
John A. Kanis (2002)
10.1080/10255840802078022
A patient-specific finite element methodology to predict damage accumulation in vertebral bodies under axial compression, sagittal flexion and combined loads
Yan Chevalier (2008)
10.1016/j.jbiomech.2014.04.015
Finite element analyses of human vertebral bodies embedded in polymethylmethalcrylate or loaded via the hyperelastic intervertebral disc models provide equivalent predictions of experimental strength.
Yongtao Lu (2014)
10.1016/j.jbiomech.2003.11.018
Simulated influence of osteoporosis and disc degeneration on the load transfer in a lumbar functional spinal unit.
Anne Polikeit (2004)
10.1038/srep38441
Effects of dose reduction on bone strength prediction using finite element analysis
D. Anitha (2016)
10.1016/S1350-4533(03)00081-X
Comparison of in situ and in vitro CT scan-based finite element model predictions of proximal femoral fracture load.
Joyce H. Keyak (2003)
10.1016/1350-4533(95)97314-F
Relations of mechanical properties to density and CT numbers in human bone.
Jae Young Rho (1995)
10.4158/EP151019.RA
BEYOND DXA: ADVANCES IN CLINICAL APPLICATIONS OF NEW BONE IMAGING TECHNOLOGY.
Monika Pawłowska (2016)
10.1016/j.ejmp.2009.08.002
Noninvasive prediction of vertebral body compressive strength using nonlinear finite element method and an image based technique.
Ahad Zeinali (2010)
10.1016/0021-9290(94)90056-6
Predicting the compressive mechanical behavior of bone.
Tony S. Keller (1994)
VERTEBRAL STABILITY IN MULTIPLE MYELOMA PATIENTS: A FINITE-ELEMENT STUDY
D. Anitha (2017)
10.1002/jor.24117
Case‐specific non‐linear finite element models to predict failure behavior in two functional spinal units
Karlijn H J Groenen (2018)
10.1016/j.jbiomech.2009.07.042
An accurate validation of a computational model of a human lumbosacral segment.
Veronica Moramarco (2010)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar