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Quantifying Modes Of 3D Cell Migration.

M. Driscoll, G. Danuser
Published 2015 · Biology, Medicine

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Although it is widely appreciated that cells migrate in a variety of diverse environments in vivo, we are only now beginning to use experimental workflows that yield images with sufficient spatiotemporal resolution to study the molecular processes governing cell migration in 3D environments. Since cell migration is a dynamic process, it is usually studied via microscopy, but 3D movies of 3D processes are difficult to interpret by visual inspection. In this review, we discuss the technologies required to study the diversity of 3D cell migration modes with a focus on the visualization and computational analysis tools needed to study cell migration quantitatively at a level comparable to the analyses performed today on cells crawling on flat substrates.
This paper references
10.1016/j.cell.2011.11.001
Computer Vision in Cell Biology
G. Danuser (2011)
10.1016/j.cell.2008.09.043
Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
V. Sanz-Moreno (2008)
10.1073/PNAS.94.25.13661
Cell locomotion and focal adhesions are regulated by substrate flexibility.
R. Pelham (1997)
10.1109/ICIP.2013.6738722
Automatic detection of 3D cell protrusions using spherical wavelets
Christel Ducroz (2013)
10.1038/nbt.1612
V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets
H. Peng (2010)
10.1117/12.2086370
OMERO and Bio-Formats 5: flexible access to large bioimaging datasets at scale
J. Moore (2015)
10.1002/JCB.240370205
“Dynamic morphology system”: A method for quantitating changes in shape, pseudopod formation, and motion in normal and mutant amoebae of Dictyostelium discoideum
D. Soll (1988)
10.1038/nmeth.3222
Guide to light-sheet microscopy for adventurous biologists
E. Reynaud (2014)
10.1038/nrm3897
Physical influences of the extracellular environment on cell migration
G. Charras (2014)
10.1016/j.cell.2014.02.052
Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
K. Stroka (2014)
10.1016/j.ceb.2013.04.004
Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.
Elizabeth R Zhang (2013)
10.1002/(SICI)1097-0169(1998)41:3<225::AID-CM4>3.0.CO;2-I
A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells.
D. Wessels (1998)
10.1038/nmeth.2047
BioImageXD: an open, general-purpose and high-throughput image-processing platform
P. Kankaanpää (2012)
10.1093/bioinformatics/btp699
Bisque: a platform for bioimage analysis and management
K. Kvilekval (2010)
10.1038/ncomms8516
Superstatistical analysis and modelling of heterogeneous random walks
C. Metzner (2015)
10.1038/nmeth.2761
Quantifying cell-generated mechanical forces within living embryonic tissues
O. Campàs (2014)
10.1109/ISBI.2014.6867884
3D shape analysis using overcomplete spherical wavelets: Application to BLEB detection in cell biology
R. Tournemenne (2014)
10.1126/science.1257998
Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Bi-Chang Chen (2014)
10.7554/eLife.05864
MorphoGraphX: A platform for quantifying morphogenesis in 4D
Pierre Barbier de Reuille (2015)
10.1016/j.bpj.2013.01.016
Fast two-dimensional bubble analysis of biopolymer filamentous networks pore size from confocal microscopy thin data stacks.
M. Molteni (2013)
10.1038/nmeth.3204
cellPACK: A Virtual Mesoscope to Model and Visualize Structural Systems Biology
G. Johnson (2015)
10.1371/journal.pcbi.1002780
ACME: Automated Cell Morphology Extractor for Comprehensive Reconstruction of Cell Membranes
K. Mosaliganti (2012)
10.1038/nrm3786
Advances in whole-embryo imaging: a quantitative transition is underway
Periklis Pantazis (2014)
10.1109/MCG.2007.323435
Rainbow Color Map (Still) Considered Harmful
David Borland (2007)
10.1038/nmeth.3036
Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data
F. Amat (2014)
10.1038/nmeth.1531
Measurement of mechanical tractions exerted by cells in three-dimensional matrices
Wesley R. Legant (2010)
10.1145/2516971.2516977
Geodesics in heat: A new approach to computing distance based on heat flow
Keenan Crane (2013)
10.1371/journal.pbio.1002106
The Extent and Consequences of P-Hacking in Science
M. Head (2015)
10.1038/nrm3861
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
M. Krause (2014)
10.1007/s00441-015-2144-5
Light sheet-based fluorescence microscopy (LSFM) for the quantitative imaging of cells and tissues
F. Pampaloni (2015)
10.1371/journal.pbio.1001059
An Adhesion-Dependent Switch between Mechanisms That Determine Motile Cell Shape
Erin L. Barnhart (2011)
10.1038/ncb2003
A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo
E. Kardash (2010)
10.1093/bioinformatics/btq212
Automatic reconstruction of 3D neuron structures using a graph-augmented deformable model
H. Peng (2010)
10.1146/annurev-cellbio-101512-122308
Mathematical modeling of eukaryotic cell migration: insights beyond experiments.
G. Danuser (2013)
Les éléments aléatoires de nature quelconque dans un espace distancié
M. Fréchet (1948)
10.1038/srep09081
SOAX: A software for quantification of 3D biopolymer networks
Ting Xu (2015)
10.1073/pnas.1006327107
Dictyostelium amoebae and neutrophils can swim
Nicholas P. Barry (2010)
10.1083/jcb.201210152
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
K. Wolf (2013)
10.1016/j.bpj.2013.05.016
A simplified implementation of the bubble analysis of biopolymer network pores.
S. Muenster (2013)
10.1109/CVPR.2010.5540010
Delineating trees in noisy 2D images and 3D image-stacks
G. González (2010)
10.1529/biophysj.108.135939
Robust pore size analysis of filamentous networks from three-dimensional confocal microscopy.
W. Mickel (2008)
10.1111/j.1365-2818.2008.02141.x
An algorithm for extracting the network geometry of three‐dimensional collagen gels
A. Stein (2008)
10.1126/science.1162493
Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy
P. J. Keller (2008)
10.1038/ncb2775
Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions
Melda Tozluoglu (2013)
Cell guidance by ultrafine topography in vitro.
P. Clark (1991)
10.1242/dev.107730
Quantitative 4D analyses of epithelial folding during Drosophila gastrulation
Zia Khan (2014)
10.1098/rspb.1980.0017
The Croonian Lecture, 1978 - The crawling movement of metazoan cells
M. Abercrombie (1980)
10.1109/ISBI.2012.6235681
Characterization of cell shape and deformation in 3D using Spherical Harmonics
Christel Ducroz (2012)
10.1145/1073204.1073228
Fast exact and approximate geodesics on meshes
Vitaly Surazhsky (2005)
10.1103/PhysRevLett.102.058103
Pushing off the walls: a mechanism of cell motility in confinement.
R. Hawkins (2009)
10.1016/j.ceb.2013.05.005
The role and regulation of blebs in cell migration
E. Paluch (2013)
10.1242/dev.086256
Quantitative semi-automated analysis of morphogenesis with single-cell resolution in complex embryos
Claudiu A Giurumescu (2012)
10.1038/nmeth.2019
Fiji: an open-source platform for biological-image analysis
Johannes E. Schindelin (2012)
10.1038/nrm3873
Three-dimensional organotypic culture: experimental models of mammalian biology and disease
Eliah R. Shamir (2014)
10.1126/science.1256965
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix
R. Petrie (2014)
10.1371/journal.pcbi.1002392
Cell Shape Dynamics: From Waves to Migration
Meghan K. Driscoll (2012)
10.1201/B10679
Data visualization - principles and practice
A. Telea (2007)
10.1083/JCB.200811132
Announcing the JCB DataViewer, a browser-based application for viewing original image files
E. Hill (2008)
10.1038/nmeth.1896
OME Remote Objects (OMERO): a flexible, model-driven data management system for experimental biology
C. Allan (2012)
10.1083/jcb.201201124
Nonpolarized signaling reveals two distinct modes of 3D cell migration
R. Petrie (2012)
10.1083/jcb.200209006
Compensation mechanism in tumor cell migration
K. Wolf (2003)
10.1016/j.ceb.2009.05.003
Mechanical modes of 'amoeboid' cell migration.
Tim Lämmermann (2009)
10.1016/j.cell.2012.10.008
Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens
Liang Gao (2012)
10.1145/1165734.1165736
Zooming versus multiple window interfaces: Cognitive costs of visual comparisons
M. Plumlee (2006)
10.1016/j.molcel.2015.02.033
Imaging live-cell dynamics and structure at the single-molecule level.
Z. Liu (2015)
10.1186/1471-2105-14-296
3D time series analysis of cell shape using Laplacian approaches
Cheng-Jin Du (2013)
10.1126/SCIENCE.1100035
Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy
J. Huisken (2004)
10.1038/nprot.2014.011
Extensible visualization and analysis for multidimensional images using Vaa3D
H. Peng (2014)
10.1038/ncomms3896
Mechanisms of leading edge protrusion in interstitial migration
K. Wilson (2013)
10.1038/ncb3092
Myosin-II controls cellular branching morphogenesis and migration in 3D by minimizing cell surface curvature
Hunter Elliott (2015)
10.1016/j.bpj.2015.05.013
Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy
Kevin M. Dean (2015)
10.1179/000870403235002042
ColorBrewer.org: An Online Tool for Selecting Colour Schemes for Maps
Mark Harrower (2003)
10.1145/2504435.2504442
Digital geometry processing with discrete exterior calculus
Keenan Crane (2013)
10.1038/nmeth.3363
In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy
D. Chittajallu (2015)
10.1038/nrm3874
A guide to the visual analysis and communication of biomolecular structural data
G. Johnson (2014)
10.1002/CM.970270102
Three-dimensional dynamics of pseudopod formation and the regulation of turning during the motility cycle of Dictyostelium.
D. Wessels (1994)
10.1038/nmeth.2075
Icy: an open bioimage informatics platform for extended reproducible research
F. Chaumont (2012)
10.1016/j.cell.2011.11.016
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
P. Friedl (2011)
Information Visualization: Perception for Design
C. Ware (2000)
10.1073/pnas.1010396108
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
R. Poincloux (2011)
10.1016/j.cell.2015.01.008
Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility
V. Ruprecht (2015)
10.1016/j.cell.2015.01.007
Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
Y. Liu (2015)
10.1016/j.bpj.2013.05.015
Response to "a simplified implementation of the bubble analysis of biopolymer networks pores".
M. Molteni (2013)
10.1529/BIOPHYSJ.105.070383
Morphodynamic profiling of protrusion phenotypes.
M. Machacek (2006)
10.1093/bioinformatics/btv109
Population-scale three-dimensional reconstruction and quantitative profiling of microglia arbors
M. Megjhani (2015)
10.1038/ncb3138
Myosin II-mediated cell shape changes and cell intercalation contribute to primitive streak formation
E. Rozbicki (2015)
10.1016/J.DEVCEL.2006.09.023
Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow.
H. Blaser (2006)
10.1098/rsif.2014.1355
Cost–benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments
Melda Tozluoglu (2015)
10.1038/nature06887
Rapid leukocyte migration by integrin-independent flowing and squeezing
Tim Lämmermann (2008)
10.1038/ncb3134
Force transmission during adhesion-independent migration
M. Bergert (2015)
10.1073/pnas.1318967111
Three-dimensional cell migration does not follow a random walk
Pei-Hsun Wu (2014)
10.1002/bies.201200032
Toward the virtual cell: Automated approaches to building models of subcellular organization “learned” from microscopy images
T. E. Buck (2012)



This paper is referenced by
10.1016/j.ceb.2016.03.025
Multiple mechanisms of 3D migration: the origins of plasticity.
R. Petrie (2016)
10.1038/s41598-017-12636-5
Liquid Marble as Bioreactor for Engineering Three-Dimensional Toroid Tissues
R. Vadivelu (2017)
10.3389/fimmu.2019.02436
LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System
Silvia Dusi (2019)
10.1109/TMI.2018.2873842
3-D Quantification of Filopodia in Motile Cancer Cells
C. Castilla (2019)
10.1101/809871
Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered Tractions
Susan E Leggett (2019)
10.1002/cyto.a.23249
Untangling cell tracks: Quantifying cell migration by time lapse image data analysis
Carl-Magnus Svensson (2018)
10.1101/066761
Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina
J. Icha (2016)
10.3934/BIOPHY.2017.4.615
Physical role of nuclear and cytoskeletal confinements in cell migration mode selection and switching
C. Mierke (2017)
10.1016/j.devcel.2016.01.022
Quantitative Multiscale Cell Imaging in Controlled 3D Microenvironments.
E. Welf (2016)
10.1098/rsif.2019.0619
A minimal computational model for three-dimensional cell migration
Yuansheng Cao (2019)
10.1101/164921
TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics
Yue Hou (2017)
10.1016/j.devcel.2017.10.030
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.
Mohammad Goudarzi (2017)
10.1016/j.patter.2020.100170
Bioimage Analysis and Cell Motility
Aleix Boquet-Pujadas (2021)
10.1088/1674-1056/26/12/128707
Derivation of persistent time for anisotropic migration of cells
Y. Liu (2017)
10.1101/859397
Cell Tracking Profiler: a user-driven analysis framework for evaluating 4D live cell imaging data
C. Mitchell (2019)
10.1109/TMI.2018.2845884
FiloGen: A Model-Based Generator of Synthetic 3-D Time-Lapse Sequences of Single Motile Cells With Growing and Branching Filopodia
D. V. Sorokin (2018)
10.1038/s41598-018-30408-7
Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion
O. Tolde (2018)
10.1038/s41598-018-25337-4
TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics
Yue Hou (2018)
10.1101/376608
Cell morphological motif detector for high-resolution 3D microscopy images
M. Driscoll (2018)
10.1038/s41592-019-0539-z
Robust and automated detection of subcellular morphological motifs in 3D microscopy images
M. Driscoll (2019)
10.1242/jcs.241422
Cell Tracking Profiler – a user-driven analysis framework for evaluating 4D live-cell imaging data
C. Mitchell (2020)
Modeling Liver Diseases Using Hepatic Cell Microarrays
Alexander David Roth (2018)
10.1083/jcb.201604095
Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina
J. Icha (2016)
10.1039/c7bm00272f
Multicellular tumor invasion and plasticity in biomimetic materials.
Susan E Leggett (2017)
10.1073/pnas.1918296117
Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions
Susan E Leggett (2020)
The effects of mechanical properties and physical inputs on stem cells of the central nervous system
P. Clarkson (2018)
10.1101/080416
Single Cell Phenotyping Reveals Heterogeneity among Haematopoietic Stem Cells Following Infection
A. MacLean (2016)
10.1109/ICIP.2019.8803721
Toward Robust Fully 3D Filopodium Segmentation and Tracking in Time-Lapse Fluorescence Microscopy
Martin Maška (2019)
Automatic Segmentation of Cells of Different Types in Fluorescence Microscopy Images
Hamid Fehri (2018)
10.1016/j.bpj.2018.08.005
Effect of Cytoskeleton Elasticity on Amoeboid Swimming.
M. Ranganathan (2018)
10.1002/stem.2692
Single Cell Phenotyping Reveals Heterogeneity Among Hematopoietic Stem Cells Following Infection
A. MacLean (2017)
10.1038/s41467-017-02193-w
Revealing chiral cell motility by 3D Riesz transform-differential interference contrast microscopy and computational kinematic analysis
A. Tamada (2017)
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