Metabolomics: Applications To Food Science And Nutrition Research
D. S. Wishart
Published 2008 · Biology
Download PDFAnalyze on Scholarcy
Metabolomics is an emerging field of “omics” research that focuses on high-throughput characterization of small molecule metabolites in biological matrices. As such, metabolomics is ideally positioned to be used in many areas of food science and nutrition research. This review focuses on the recent trends and potential applications of metabolomics in four areas of food science and technology: (1) food component analysis; (2) food quality/authenticity assessment; (3) food consumption monitoring; and (4) physiological monitoring in food intervention or diet challenge studies.
This paper references
GMD@CSB.DB: the Golm Metabolome Database
J. Kopka (2005)
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile.
Kirty S. Solanky (2003)
Susceptibility of human metabolic phenotypes to dietary modulation.
C. Stella (2006)
Fruit juice authentication by 1H NMR spectroscopy in combination with different chemometrics tools
M. Cuny (2008)
Nondestructive quantification of organic compounds in whole milk without pretreatment by two-dimensional NMR spectroscopy.
Fangyu Hu (2007)
Metabolomics: building on a century of biochemistry to guide human health
J. German (2005)
Urinary 1-methylhistidine is a marker of meat consumption in Black and in White California Seventh-day Adventists.
T. Myint (2000)
Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours.
N. Seeram (2006)
Profiling of carotenoids in tomato juice by one- and two-dimensional NMR.
S. Tiziani (2006)
Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil.
P. Bogani (2007)
A rapid and automated low resolution NMR method to analyze oil quality in intact oilseeds.
Rosilene Aparecida Prestes (2007)
Metabolite profiling of grape: Flavonols and anthocyanins.
F. Mattivi (2006)
Nondestructive NMR determination of oil composition in transformed canola seeds
W. C. Hutton (1999)
High-resolution (13)C nuclear magnetic resonance spectroscopy pattern recognition of fish oil capsules.
M. Aursand (2007)
METLIN: A Metabolite Mass Spectral Database
C. A. Smith (2005)
Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa).
A. L. Brantsaeter (2007)
Magnetic Resonance Diagnostics: A New Technology for High-Throughput Clinical Diagnostics
D. Wishart (2001)
Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production.
Cláudia Almeida (2006)
Metabolomics and biochemical profiling in drug discovery and development.
Watkins Sm (2002)
Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry
M. Ye (2007)
Metabolite profiling of tomato (Lycopersicon esculentum) using 1H NMR spectroscopy as a tool to detect potential unintended effects following a genetic modification.
G. Le Gall (2003)
Metabolomics in human nutrition: opportunities and challenges.
M. Gibney (2005)
Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy.
Otvos Jd (2002)
Dose-dependent utilisation of casein-linked lysinoalanine, N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine in rats.
V. Somoza (2006)
Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.
H. Ito (2005)
Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline.
S. Zeisel (2007)
Chemometrics in metabonomics.
J. Trygg (2007)
Tanker milk variability according to farm feeding practices: vitamins A and E, carotenoids, color, and terpenoids.
C. Agabriel (2007)
Metabolic profiling of flavonol metabolites in human urine by liquid chromatography and tandem mass spectrometry.
Yun-Jeong Hong (2004)
Measuring the metabolome: current analytical technologies.
W. B. Dunn (2005)
A strategy for annotating the human milk glycome.
Milady Niñonuevo (2006)
Biomarker discovery using high-dimensional lipid analysis
Michelle M. Wiest (2007)
Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects.
P. Castilla (2006)
Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach.
I. A. Castro (2005)
Early detection of graft failure using the blood metabolic profile of a liver recipient.
N. Serkova (2007)
Whole-grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a 1H NMR-based metabonomic approach.
A. Fardet (2007)
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods.
L. Mennen (2006)
Consumption of high-pressurized vegetable soup increases plasma vitamin C and decreases oxidative stress and inflammatory biomarkers in healthy humans.
C. Sánchez-Moreno (2004)
Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians, and patients taking low dose aspirin
J. Lawrence (2003)
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
J. Nicholson (1999)
Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes.
B. Girennavar (2006)
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
J. Lindon (2004)
Effect of resveratrol, tyrosol and beta-sitosterol on oxidised low-density lipoprotein-stimulated oxidative stress, arachidonic acid release and prostaglandin E2 synthesis by RAW 264.7 macrophages.
M. Vivancos (2008)
Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection.
W. Mullen (2004)
The application of NMR and MS methods for detection of adulteration of wine, fruit juices, and olive oil. A review
N. Ogrinc (2003)
Water-soluble constituents of cumin: monoterpenoid glucosides.
T. Ishikawa (2002)
Microclimate influence on mineral and metabolic profiles of grape berries.
G. E. Pereira (2006)
Water-soluble constituents of coriander.
T. Ishikawa (2003)
Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake.
H. Thompson (2006)
Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans.
M. Walsh (2006)
Systems biology, metabolic modelling and metabolomics in drug discovery and development.
D. Kell (2006)
LMPD: LIPID MAPS proteome database
D. Cotter (2006)
Phytochemical Databases of Chinese Herbal Constituents and Bioactive Plant Compounds with Known Target Specificities
T. Ehrman (2007)
Polar constituents of celery seed.
J. Kitajima (2003)
Macadamia Nut Consumption Modulates Favourably Risk Factors for Coronary Artery Disease in Hypercholesterolemic Subjects
M. Garg (2007)
Metabonomics: Its Potential as a Tool in Toxicology for Safety Assessment and Data Integration
Griffin Jl (2004)
Validation of (1)H NMR spectroscopy as an analytical tool for methylamine metabolites in urine.
M. Lee (2006)
Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers
B. M. de Rooij (1996)
Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry.
Wolfgang Bicker (2006)
The association between betaine and choline intakes and the plasma concentrations of homocysteine in women.
S. Chiuve (2007)
HMDB: the Human Metabolome Database
D. Wishart (2007)
Water-soluble constituents of caraway: aromatic compound, aromatic compound glucoside and glucides.
T. Matsumura (2002)
A Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato1
S. Moco (2006)
Targeted profiling: quantitative analysis of 1H NMR metabolomics data.
A. Weljie (2006)
Discrimination between orange juice and pulp wash by (1)H Nuclear Magnetic Resonance spectroscopy: identification of marker compounds.
G. Le Gall (2001)
Evolving window zone selection method followed by independent component analysis as useful chemometric tools to discriminate between grapefruit juice, orange juice and blends.
M. Cuny (2007)
Monitoring the health to disease continuum with global metabolic profiling and systems biology.
L. Schnackenberg (2006)
Quantification of organic and amino acids in beer by 1H NMR spectroscopy.
L. Nord (2004)
Metabolic profiling with gas chromatography-mass spectrometry and its application to clinical medicine.
T. Niwa (1986)
Influence of feeding on metabolite excretion evidenced by urine 1H NMR spectral profiles: a comparison between subjects living in Rome and subjects living at arctic latitudes (Svaldbard).
C. Zuppi (1998)
Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism
S. H. Moolenaar (2003)
An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys.
H. C. Bertram (2007)
This paper is referenced by
Application of metabolomics to toxicology of drugs of abuse: A mini review of metabolomics approach to acute and chronic toxicity studies.
K. Zaitsu (2016)
Targeted metabolomics profiles are strongly correlated with nutritional patterns in women
Werner Romisch-MarglKarsten (2012)
Plants' Metabolites as Potential Antiobesity Agents
Najla Gooda Sahib (2012)
Chapter 11 – NMR-Based Metabolomics in Food Quality Control
Alberta Tomassini (2013)
Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives
Xiuxia Du (2013)
Advances in NMR-Based Metabolomics
G A Nagana Gowda (2014)
Review of methods for analysis of carotenoids
Kamila Amorim-Carrilho (2014)
Comparison of frozen and fresh apple pulp for NMR-based metabolomic analysis
Claudio Santucci (2015)
Advances in high-resolution mass spectrometry based on metabolomics studies for food – a review
Josep Rubert (2015)
Metabolomic approaches in the discovery of potential urinary biomarkers of drug-induced liver injury (DILI)
Ana Margarida Araújo (2017)
A Combination of Metabolites Predicts Adherence to the Mediterranean Diet Pattern and Its Associations with Insulin Sensitivity and Lipid Homeostasis in the General Population: The Fenland Study, United Kingdom
Tammy Y N Tong (2019)
Metabolomics Profile of Potato Tubers after Phosphite Treatment
Xingxi Gao (2018)
Metabolomics Approach Reveals the Effects of Breed and Feed on the Composition of Chicken Eggs
Tatsuhiko Goto (2019)
Advances in NMR-based biofluid analysis and metabolite profiling.
Shucha Zhang (2010)
Setting up qualitative strategies for screening the composition of marker fractions from various wild growing plants in Friuli
Lavinia Alexandru (2012)
Nutrimetabolomic strategies to develop new biomarkers of intake and health effects.
Rafael Llorach (2012)
Phytochemical composition changes in untreated stem juice of Tinospora cordifolia (W) Mier during refrigerated storage
Amey Shirolkar (2013)
Novel MS-based approaches and applications in food metabolomics
Clara Ibáñez (2013)
Using metabolomics to evaluate food intake
Claudine Manach (2015)
Enhancing metabolomics research through data mining.
Ibon Martínez‐Arranz (2015)
A urinary metabonomics analysis of long-term effect of acetochlor exposure on rats by ultra-performance liquid chromatography/mass spectrometry.
Longxue Li (2016)
Food Safety Challenges in China
Muyeong Seak Yang (2016)
Mass Spectrometry-Based Metabolomics of Agave Sap (Agave salmiana) after Its Inoculation with Microorganisms Isolated from Agave Sap Concentrate Selected to Enhance Anticancer Activity
Luis Millones Figueroa (2017)
Translational Metabolomics: Current Challenges and Future Opportunities
Farhana R Pinu (2019)
Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet
Qi Jin (2019)
Variation in secondary metabolites in a unique set of tomato accessions collected in Turkey.
Sena Bakir (2020)
Chapter 9 – Mass Spectrometry
George Kaklamanos (2012)
Breeding for coffee quality
Christophe Montagnon (2012)
Improved stability of TMS derivatives for the robust quantification of plant polar metabolites by gas chromatography-mass spectrometry.
A. Vilchez Quero (2014)
LC–MS/MS-based metabolome analysis detected changes in the metabolic profiles of small and large intestinal adenomatous polyps in ApcMin/+ mice
Makoto Suzuki (2016)
Dynamic changes of postprandial plasma metabolites after intake of corn-soybean meal or casein-starch diets in growing pigs
T. Li (2019)
Reproducibility of non-fasting plasma metabolomics measurements across processing delays
Ying Wang (2018)See more