Online citations, reference lists, and bibliographies.

Severe Lumbar Intervertebral Disc Degeneration Is Associated With Modic Changes And Fatty Infiltration In The Paraspinal Muscles At All Lumbar Levels, Except For L1-L2: A Cross-Sectional Analysis Of 50 Symptomatic Women And 50 Age-Matched Symptomatic Men.

Emel Ece Özcan-Ekşi, Murat Şakir Ekşi, Mehmet Akif Akçal
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND Low back pain is a common public health problem associated with lumbar intervertebral disc degeneration. It is still unclear, however, whether intervertebral disc degeneration is an isolated process or accompanied by other degenerative events. We analyzed whether disc degeneration was associated with vertebral end-plate changes and fatty infiltration in the paraspinal muscles. We also aimed to identify whether the severity of disc degeneration influenced this association. METHODS Intervertebral disc degeneration, vertebral end-plate changes, and fatty infiltration in the multifidus, erector spinae, and psoas muscles at all lumbar intervertebral disc levels were evaluated on lumbar spine magnetic resonance images of 50 symptomatic women and 50 age-matched symptomatic men. RESULTS The women had greater lumbar intervertebral disc degeneration scores at L4-L5 and L5-S1 and in total. The women had more fatty infiltration in the multifidus and erector spinae muscles at L4-L5 and L5-S1. The men had more fatty infiltration in the psoas muscle at L5-S1. Patients with severe intervertebral disc degeneration were more likely to have increased fatty infiltration in the multifidus and erector spinae muscles. The rate of vertebral end-plate changes was also greater in the patients with severe intervertebral disc degeneration. CONCLUSIONS Severe disc degeneration in the lumbar spine is closely associated with Modic changes and fatty infiltration in the multifidus and erector spinae muscles. We suggest that disc degeneration is not an isolated event but, rather, a continuum of events that could more clearly be shown in future prospective, large sample-size studies.
This paper references
10.1186/1741-7015-5-2
Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain?
Per Kjaer (2007)
10.7150/ijms.8770
A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration
Helen Elizabeth Gruber (2014)
10.1097/BRS.0b013e3181bc98f1
People With Recurrent Low Back Pain Respond Differently to Trunk Loading Despite Remission From Symptoms
David A. Macdonald (2010)
10.1016/j.rehab.2017.09.005
Pregnancy-related low back pain in women in Turkey: Prevalence and risk factors.
Savas Sencan (2018)
10.1016/j.ocl.2006.08.001
Sexual dimorphism in degenerative disorders of the spine.
Neil A. Manson (2006)
10.1016/j.spinee.2013.10.042
Patterns of lumbar disc degeneration are different in degenerative disc disease and disc prolapse magnetic resonance imaging analysis of 224 patients.
Rishi Mugesh Kanna (2014)
10.1097/01.brs.0000248453.51165.0b
Rapid Atrophy of the Lumbar Multifidus Follows Experimental Disc or Nerve Root Injury
Paul William Hodges (2006)
10.1053/crad.1999.0340
Correlation between the MRI changes in the lumbar multifidus muscles and leg pain.
Deiary F. Kader (2000)
10.1097/00007632-200002150-00016
Low back pain in relation to lumbar disc degeneration.
Katariina Luoma (2000)
10.1097/00007632-200009010-00009
Histochemistry and Morphology of the Multifidus Muscle in Lumbar Disc Herniation: Comparative Study Between Diseased and Normal Sides
Wei-guo Zhao (2000)
10.1007/s00586-013-3148-z
Image changes of paraspinal muscles and clinical correlations in patients with unilateral lumbar spinal stenosis
Yanyu Chen (2013)
10.1097/00007632-200212010-00002
Classification of Age-Related Changes in Lumbar Intervertebral Discs: 2002 Volvo Award in Basic Science
Norbert Boos (2002)
10.1097/BRS.0b013e3181a18263
Degenerative Lumbar Disc and Facet Disease in Older Adults: Prevalence and Clinical Correlates
Gregory Evan Hicks (2009)
10.1007/s00198-010-1200-y
Relationship between gender, bone mineral density, and disc degeneration in the lumbar spine: a study in elderly subjects using an eight-level MRI-based disc degeneration grading system
Yong-Jun Wang (2010)
10.1016/j.arth.2013.04.045
Assessment of fatty degeneration of the gluteal muscles in patients with THA using MRI: reliability and accuracy of the Goutallier and quartile classification systems.
Florian J. Engelken (2014)
10.1097/00007632-199005000-00012
Preliminary Evaluation of a Scheme for Grading the Gross Morphology of the Human Intervertebral Disc
James P. Thompson (1990)
10.1007/s00256-015-2252-z
Lumbar multifidus muscle changes in unilateral lumbar disc herniation using magnetic resonance imaging
Naime Altınkaya (2015)
10.2519/jospt.2011.3410
Behavior of the lumbar multifidus during lower extremity movements in people with recurrent low back pain during symptom remission.
David A. Macdonald (2011)
10.2307/2529310
The measurement of observer agreement for categorical data.
J. Richard Landis (1977)
10.1097/00007632-200103150-00012
Histochemical Changes in the Multifidus Muscle in Patients With Lumbar Intervertebral Disc Herniation
Kiyoshi Yoshihara (2001)
10.1186/1471-2474-9-51
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers
Mari Kuisma (2008)
10.1371/journal.pone.0048074
MRI Assessment of Lumbar Intervertebral Disc Degeneration with Lumbar Degenerative Disease Using the Pfirrmann Grading Systems
Li-peng Yu (2012)
10.1016/j.jmpt.2013.12.010
Reliability of the Goutallier classification in quantifying muscle fatty degeneration in the lumbar multifidus using magnetic resonance imaging.
Patrick J. Battaglia (2014)
10.1097/BRS.0b013e3181f2a177
The Effects of Age, Sex, Ethnicity, and Spinal Level on the Rate of Intervertebral Disc Degeneration: A Review of 1712 Intervertebral Discs
Krzysztof B. Siemionow (2011)
10.1148/radiol.2403050820
Fat content of lumbar paraspinal muscles in patients with chronic low back pain and in asymptomatic volunteers: quantification with MR spectroscopy.
Bernard Mengiardi (2006)
10.1148/radiology.168.1.3289089
Imaging of degenerative disk disease.
Michael Modic (1988)
Degenerative disc disease of the lumbar spine on MRI.
Wayne M West (2010)
10.1016/j.spinee.2012.08.020
Is level- and side-specific multifidus asymmetry a marker for lumbar disc pathology?
Michele Battie (2012)
10.1097/00003086-199407000-00014
Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan.
Daniel Goutallier (1994)
10.1148/radiology.166.1.3336678
Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging.
Michael Modic (1988)
10.1016/j.math.2012.06.007
Increased intramuscular fatty infiltration without differences in lumbar muscle cross-sectional area during remission of unilateral recurrent low back pain.
Roseline D'hooge (2012)
10.1016/j.pain.2008.12.002
Why do some patients keep hurting their back? Evidence of ongoing back muscle dysfunction during remission from recurrent back pain
David A. Macdonald (2009)
10.1007/s00586-016-4503-7
Paraspinal muscle asymmetry and fat infiltration in patients with symptomatic disc herniation
Maryse Fortin (2016)
10.1097/00007632-200109010-00011
Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration
Christian W A Pfirrmann (2001)
10.1097/00007632-198709000-00002
1987 Volvo Award in Clinical Sciences: A New Clinical Model for the Treatment of Low-Back Pain
Gordon Waddell (1987)
10.1186/s12891-016-1297-z
Lumbar disc degeneration is associated with modic change and high paraspinal fat content – a 3.0T magnetic resonance imaging study
Andrew J. Teichtahl (2016)
10.1111/sms.12301
Do variations in paraspinal muscle morphology and composition predict low back pain in men?
Maryse Fortin (2015)
10.1097/01.brs.0000148014.15210.64
ISSLS Prize Winner: A Study of Diffusion in Human Lumbar Discs: A Serial Magnetic Resonance Imaging Study Documenting the Influence of the Endplate on Diffusion in Normal and Degenerate Discs
Shanmughanathan Rajasekaran (2004)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar