Online citations, reference lists, and bibliographies.
← Back to Search

Prodrome In Epilepsy

F. Besag, M. Vasey
Published 2018 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
BACKGROUND Prodromal symptoms (PS) of epileptic seizures are clinically well-recognized but relatively little researched. The purpose of this review was to examine the evidence in the literature for the existence of prodrome and the reported frequency and nature of prodromal characteristics. METHODS We performed a PubMed review of the clinical characteristics, frequency, and duration of PS in papers published between 2007 and 2017. We also reviewed findings from prospective studies into the predictive performance of prodrome. In a second analysis, we reviewed studies reporting a single symptom/sign of prodrome. RESULTS In 8 studies reporting on the prevalence of prodrome, we found a mean frequency of 21.9%. The most frequent symptoms were "funny feeling" (10.4%), confusion (9.0%), anxiety (8.6%), and irritability (7.7%), but other features were also reported. The duration of prodrome was typically between 10min and 3days, with most prodromes lasting for between 30min and 24h. In studies that reported a single prodromal symptom/sign, headache was the most frequent: 8% with a range of between 1.2 and 30%. CONCLUSIONS Prodromes are characterized by a broad spectrum of preictal symptoms that may be experienced for a duration of between 10min and several days, which usually persist until seizure onset. Opinion is divided on their precise nature and value as predictors of seizures. A greater understanding of prodromes might offer insights into the preictal period and hold promise for new seizure management therapies.
This paper references
10.1111/epi.12355
Modeling seizure self‐prediction: An e‐diary study
S. Haut (2013)
10.1016/S1059-1311(96)80107-5
Perceived self-control of seizures in young people with epilepsy
C. Cull (1996)
10.1016/j.yebeh.2010.05.008
Views of patients with epilepsy on seizure prediction devices
A. Schulze-Bonhage (2010)
[Epileptic prodromal manifestations and episodic affective symptoms: nonspecific complaints or non-convulsive status epilepticus?].
U. Sailer (1991)
10.1212/01.WNL.0000052998.58526.A9
Premonitory symptoms in migraine
N. Giffin (2003)
10.1111/epi.12534
Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
C. Heck (2014)
10.1186/s10194-015-0556-y
Headache in epilepsy: prevalence and clinical features
G. Mainieri (2015)
10.1212/01.wnl.0000278112.48285.84
Seizure occurrence
S. Haut (2007)
10.1212/01.wnl.0000188820.17776.cd
Preictal headache in partial epilepsy
A. Yankovsky (2005)
10.1111/j.1528-1167.2009.02424.x
Interictal dysphoric disorder and periictal dysphoric symptoms in patients with epilepsy
M. Mula (2010)
10.1016/j.yebeh.2016.02.018
The interictal dysphoric disorder of epilepsy: Legend or reality?
M. Mula (2016)
10.1016/S1059-1311(05)80124-4
Coping with the uncertainty of uncontrolled epilepsy
J. Murray (1993)
10.1093/NQ/S6-X.256.415A
Translation of Hippocrates
Chas. Jas. Fèret (1884)
10.1007/s10194-010-0191-6
Comorbidity between headache and epilepsy in a pediatric headache center
I. Toldo (2010)
10.1001/jama.1901.02470390050021
Epilepsy and Other Chronic Convulsive Diseases: Their Causes, Symptoms, and Treatment
W. Gowers (2008)
10.1007/978-90-481-2646-0_25
A Neurophenomenological Study of Epileptic Seizure Anticipation
C. Petitmengin (2010)
10.1186/1129-2377-15-70
High prevalence of headaches in patients with epilepsy
Xiang-Qing Wang (2014)
10.1016/j.seizure.2013.03.013
Epileptic prodromes: Are they nonconvulsive status epilepticus?
J. Alving (2013)
10.1016/j.yebeh.2007.06.014
Whatever happened to the “epileptic prodrome”?
D. C. Taylor (2007)
10.1016/j.yebeh.2012.02.007
Clinical features of the pre-ictal state: Mood changes and premonitory symptoms
S. Haut (2012)
10.1016/j.pediatrneurol.2008.05.012
Peri-ictal headache in children: prevalence and character.
Shayne Cai (2008)
10.1016/S0896-6273(01)00262-8
Epileptic Seizures May Begin Hours in Advance of Clinical Onset A Report of Five Patients
B. Litt (2001)
10.1016/j.wneu.2013.01.078
A primer on brain-machine interfaces, concepts, and technology: a key element in the future of functional neurorestoration.
B. Lee (2013)
10.1016/j.yebeh.2006.05.013
Seizure anticipation: Are neurophenomenological approaches able to detect preictal symptoms?
C. Petitmengin (2006)
10.1016/S0920-1211(99)00093-5
Seizure precipitants and perceived self-control of seizures in adults with poorly-controlled epilepsy
S. Spector (2000)
10.1016/j.yebeh.2015.12.023
Self-control of epileptic seizures by nonpharmacological strategies
Iliana Kotwas (2016)
10.1111/j.1528-1167.2008.01574.x
Headache in patients with epilepsy: A prospective incidence study
P. Kwan (2008)
10.1111/ene.12049
Interictal and periictal headache in patients with epilepsy
B. Duchaczek (2013)
10.1016/j.eplepsyres.2013.12.013
Comorbidity between headache and epilepsy in a Chinese epileptic center
Xiang-Qing Wang (2014)
10.1212/01.wnl.0000252352.26421.13
Can patients with epilepsy predict their seizures?
S. Haut (2007)
10.1016/j.yebeh.2014.12.025
Periictal and interictal headache including migraine in Dutch patients with epilepsy: A cross-sectional study
W. Hofstra (2015)
10.1046/j.1528-1157.2001.09800.x
High and Low Perceived Self‐Control of Epileptic Seizures
S. Spector (2001)
10.1016/j.yebeh.2009.07.045
Initial symptoms, precipitant factors, and techniques to control epileptic seizures: The carer’s perspective
J. Pinikahana (2009)
10.3389/fnhum.2013.00617
Microcognitive science: bridging experiential and neuronal microdynamics
C. Petitmengin (2013)
10.1093/HRP/8.1.8
Dysphoric disorders and paroxysmal affects: recognition and treatment of epilepsy-related psychiatric disorders.
D. Blumer (2000)
10.1016/j.clinph.2004.08.025
On the predictability of epileptic seizures
F. Mormann (2005)
10.3349/ymj.2010.51.2.219
Multi-Center Study on Migraine and Seizure-Related Headache in Patients with Epilepsy
K. Heo (2010)
10.1016/j.seizure.2013.04.022
Characteristics of headache in children with epilepsy
H. Kanemura (2013)
10.1016/j.yebeh.2011.02.004
Are prodromes preictal events? A prospective PDA-based study
T. Maiwald (2011)
10.1176/ajp.19.2.198
Epilepsy: Its Symptoms, Treatment, and Relation to Other Chronic Convulsive Diseases
J. R. Reynolds (1862)
10.1016/j.concog.2007.05.006
Anticipating seizure: Pre-reflective experience at the center of neuro-phenomenology
C. Petitmengin (2007)
10.1016/S0920-1211(03)00002-0
Epileptic seizures are preceded by a decrease in synchronization
F. Mormann (2003)
Die Epilepsien : spezielle Pathologie und Therapie
D. Janz (1969)
10.1016/j.seizure.2004.11.002
Perceived self-control of seizures in patients with uncontrolled partial epilepsy
S. Lee (2005)
10.1007/s10194-007-0398-3
Headaches add to the burden of epilepsy
Marte Syvertsen (2007)
10.1016/j.yebeh.2005.05.014
Anxiety in patients with epilepsy: Systematic review and suggestions for clinical management
S. Beyenburg (2005)
10.3233/BEN-2011-0314
Ictal and Peri-Ictal Psychopathology
M. Mula (2011)
10.1016/j.yebeh.2009.06.004
The lived experience of initial symptoms of and factors triggering epileptic seizures
J. Pinikahana (2009)
10.1006/ebeh.2000.0107
Epilepsy from the Patient's Perspective: Review of Results of a Community-Based Survey
R. Fisher (2000)
10.1016/j.yebeh.2008.08.002
On the prevalence of bipolar disorder in epilepsy
M. Mula (2008)
10.1016/j.eplepsyres.2006.02.001
Seizure anticipation by patients with focal and generalized epilepsy: A multicentre assessment of premonitory symptoms
A. Schulze-Bonhage (2006)
10.1016/S1059-1311(97)80035-0
Hungarian multicentre epidemiologic study of the warning and initial symptoms (prodrome, aura) of epileptic seizures
P. Rajna (1997)
10.1016/j.seizure.2008.10.007
Prodromal symptoms in epileptic patients: Clinical characterization of the pre-ictal phase
A. Scaramelli (2009)
10.1046/j.1526-4610.2002.02154.x
Headache Associated with Epileptic Seizures: Epidemiology and Clinical Characteristics
S. Foerderreuther (2002)
10.1016/j.yebeh.2016.03.028
Correlation between headaches and affective symptoms in patients with epilepsy
J. Seo (2016)
10.1016/S1059-1311(05)80128-1
Premonitory symptoms in epilepsy
J. Hughes (1993)
10.1016/j.seizure.2013.04.016
Relations between epileptic seizures and headaches
F. Gameleira (2013)
10.3805/EANDS.2.17
Subjective and Objective Premonitory Symptoms as Epileptic Prodromes
H. Sue (2009)
CLINICAL EVALUATION OF HEADACHE IN PATIENTS WITH EPILEPSY IN A TERTIARY CARE HOSPITAL
T.C.R.Ramakrishnan K.Mugundhan (2017)
10.18869/ACADPUB.CJNS.1.3.41
THE PREVALENCE OF MIGRAINE AND TENSION TYPE HEADACHES AMONG EPILEPTIC PATIENTS
N. Ashjazadeh (2015)
10.1007/s00381-011-1428-7
Peri-ictal and inter-ictal headache in children and adolescents with idiopathic epilepsy: a multicenter cross-sectional study
A. Verrotti (2011)
10.3238/arztebl.2009.0407
Deep brain stimulation: a new approach to the treatment of epilepsy.
A. Schulze-Bonhage (2009)
10.1016/j.yebeh.2010.03.011
Seizure prediction and recall
J. Dubois (2010)
10.1016/j.yebeh.2012.04.063
Pre-ictal psychiatric symptoms
M. Mula (2013)
10.1097/00005053-198608000-00005
Mood Change Preceding Epileptic Seizures
P. Blanchet (1986)
10.1046/j.1528-1157.2001.22001.x
Glossary of Descriptive Terminology for Ictal Semiology: Report of the ILAE Task Force on Classification and Terminology
W. Blume (2001)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar