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The MiR-134 Attenuates The Expression Of Transcription Factor FOXM1 During Pluripotent NT2/D1 Embryonal Carcinoma Cell Differentiation.

Yan Chen, Lei Meng, Qiqi Yu, Difei Dong, Guixiang Tan, Xiaoqin Huang, Yongjun Tan
Published 2015 · Biology, Medicine
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Transcription factor FOXM1 plays a critical role in maintenance of stem cell pluripotency through stimulating the transcription of pluripotency-related genes in mouse pluripotent stem cells. In this study, we have found that the repression of FOXM1 expression is mediated by FOXM1 3'UTR during retinoic acid-induced differentiation of human pluripotent NT2/D1 embryonal carcinoma cells. FOXM1 3'UTR contains a microRNA response element (MRE) for miR-134, which has been shown to attenuate the expression of pluripotency-related genes post-transcriptionally during mouse embryonic stem cell differentiation. We have determined that miR-134 is induced during RA-induced differentiation of NT2/D1 cells and the overexpression of miR-134 represses the expression of FOXM1 protein but not FOXM1 mRNA. Furthermore, the expression of OCT4 is diminished by FOXM1 knockdown and the OCT4 promoter is regulated directly by FOXM1, suggesting that FOXM1 is required for maintaining the expression of OCT4 in NT2/D1 cells. Together, our results suggest that FOXM1 is essential for human pluripotent stem cells and miR-134 attenuates its expression during differentiation.
This paper references
Transcription factors in liver development, differentiation, and regeneration.
R. Costa (2003)
Serial [18F]Fluorodeoxyglucose Positron Emission Tomography after Human Neuronal Implantation for Stroke
C. C. Meltzer (2001)
Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells
Zhongqiu Xie (2010)
Embryonic stem cell-specific MicroRNAs.
H. Houbaviy (2003)
FoxM1c Counteracts Oxidative Stress-induced Senescence and Stimulates Bmi-1 Expression*
Samuel K M Li (2008)
Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult
H. Ye (1997)
Foxm1b transcription factor is essential for Please cite this article
V. V. Kalinichenko (2004)
Chk 2 mediates stabilization of the FoxM 1 transcription factor to stimulate expression of DNA repair genes
P. Raychaudhuri (2007)
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration
X. Wang (2002)
Foxm 1 transcription factor is required for maintenance of pluripotency of P 19 embryonal carcinoma cells
Zhongqiu Xie (2010)
Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate neural differentiation.
Yongjun Tan (2010)
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Katherine Krupczak-Hollis (2004)
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
Yvonne Tay (2009)
Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.
P. Nelson (2002)
In vitro differentiation potential of human embryonic versus adult stem cells.
Gemma E. Rooney (2010)
The biology of teratocarcinomas
Peter N. Goodfellow (1982)
In vitro and in vivo characterization of hNT neuron neurotransmitter phenotypes
S. Saporta (2000)
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.
Y. Tay (2008)
A brain-specific microRNA regulates dendritic spine development
G. Schratt (2006)
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
L. Lim (2005)
Control of developmental timing in Caenorhabditis elegans.
V. Ambros (2000)
Embryonic Stem Cell Specific MicroRNAs Regulate the G1/S Transition and Promote Rapid Proliferation
Yangming Wang (2008)
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
J. Brennecke (2003)
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor.
V. Kalinichenko (2004)
The functions of animal microRNAs
V. Ambros (2004)
Foxm1 Mediates LIF/Stat3-Dependent Self-Renewal in Mouse Embryonic Stem Cells and Is Essential for the Generation of Induced Pluripotent Stem Cells
Guixiang Tan (2014)
Association between mouse nude gene expression and the initiation of epithelial terminal differentiation.
D. Lee (1999)
Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver
X. Wang (2001)
Retinoic Acid Promotes Ubiquitination and Proteolysis of Cyclin D1 during Induced Tumor Cell Differentiation*
M. Spinella (1999)
FoxM1 is required for execution of the mitotic programme and chromosome stability
Jamila Laoukili (2005)
Teratocarcinomas and mammalian embryogenesis.
G. R. Martin (1980)
miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells.
Jipeng Li (2012)
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome - dependent proteolysis of the cyclin - dependent inhibitor p 27
A. Simeone Mavilio (2000)
Kosik, Specific microRNAs modulate embryonic stem cell-derived neurogenesis, Stem Cells
A. M. Krichevsky (2006)
Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase
I. Wang (2005)
Potential of Embryonic and Adult Stem Cells in vitro
J. Czyz (2003)
Forkhead box M 1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF ( Skp 2 – Cks 1 ) ubiquitin ligase
Y. J. Chen (2005)
Combinatorial microRNA target predictions
Azra Krek (2005)
Sequential DNA Methylation of the Nanog and Oct-4 Upstream Regions in Human NT2 Cells during Neuronal Differentiation*
P. Deb-Rinker (2005)
Differential connexin expression, gap junction intercellular coupling, and hemichannel formation in NT2/D1 human neural progenitors and terminally differentiated hNT neurons.
Sherri Boucher (2003)
Chk2 Mediates Stabilization of the FoxM1 Transcription Factor To Stimulate Expression of DNA Repair Genes
Y. Tan (2006)
Pluripotent stem cell lines.
J. Yu (2008)
Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe.
D. Wonsey (2005)
Assessment of pluripotency and multilineage differentiation potential of NTERA-2 cells as a model for studying human embryonic stem cells.
R. Pal (2006)
Control of developmental timing by micrornas and their targets.
A. Pasquinelli (2002)
Two-fold elevation of expression of FoxM1 transcription factor in mouse embryonic fibroblasts enhances cell cycle checkpoint activity by stimulating p21 and Chk1 transcription.
Y. Tan (2010)
Soprano, Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells
D. R. Soprano (2007)
Premature Expression of the Winged Helix Transcription Factor HFH-11B in Regenerating Mouse Liver Accelerates Hepatocyte Entry into S Phase
H. Ye (1999)
Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro.
P. Andrews (1984)
Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.
H. Ye (1997)
Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells.
D. Soprano (2007)
Keirstead, In vitro differentiation potential of human embryonic versus adult stem cells
G. E. Rooney (2010)
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.
C. Kanellopoulou (2005)
Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro.
P. Andrews (1984)
Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells.
M. B. Newman (2005)
Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27.
G. Baldassarre (2000)
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
A. Krichevsky (2006)
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
H. Wu (2007)
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
R. Pillai (2005)
Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.
N. Hattori (2007)
Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma
S. Freemantle (2002)
Temporal expression changes during differentiation of neural stem cells derived from mouse embryonic stem cell.
Joon-Ik Ahn (2004)
Human NT2/D1 cells differentiate into functional astrocytes.
M. Bani-Yaghoub (1999)
Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells.
J. Sandhu (2002)
Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks.
S. Karsten (2003)
Oncomirs — microRNAs with a role in cancer
A. Esquela-Kerscher (2006)
RNA interference : RNA
G. J. Hannon (2002)
Unified nomenclature for the winged helix/forkhead transcription factors.
K. Kaestner (2000)
Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid.
F. Mavilio (1988)
Human embryonal carcinoma stem cells: models of embryonic development in humans.
S. Przyborski (2004)

This paper is referenced by
Modulation of all-trans retinoic acid-induced MiRNA expression in neoplastic cell lines: a systematic review
Lara Lima (2019)
Retinoic acid and microRNA.
Lijun Wang (2020)
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis
Hao Liu (2019)
Role of leukemia inhibitory factor in the nervous system and its pathology
P. Ostasov (2015)
Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1
Cheng-Cao Sun (2016)
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
miR‐134 inhibits non‐small cell lung cancer growth by targeting the epidermal growth factor receptor
Qin Qin (2016)
Diallyl disulfide suppresses FOXM1-mediated proliferation and invasion in osteosarcoma by upregulating miR-134.
Yonggang Li (2018)
MicroRNA-134-5p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection
Ying Yu Wang (2019)
Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation
Maria Teresa Quaranta (2016)
The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells.
Chi-Leung Kwok (2016)
MicroRNA and Retinoic Acid.
Reza Gholikhani-Darbroud (2019)
FOXM1 in sarcoma: role in cell cycle, pluripotency genes and stem cell pathways
Fergal C. Kelleher (2016)
MicroRNA-1345 p Regulates Media Degeneration through Inhibiting VSMC Phenotypic Switch and Migration in Thoracic Aortic Dissection
Ying Wang (2019)
F-box protein FBXL2 inhibits gastric cancer proliferation by ubiquitin-mediated degradation of forkhead box M1.
Liang-qing Li (2016)
Inhibition of miR-134 Protects Against Hydrogen Peroxide-Induced Apoptosis in Retinal Ganglion Cells
Yi Shao (2015)
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