Referencing for people who value simplicity, privacy, and speed.Get Citationsy
← Back to Search
Long-term Growth Hormone Treatment Preserves GH-induced Memory And Mood Improvements: A 10-year Follow-up Study In GH-deficient Adult Men
L. Arwert, J. Deijen, Maartje Müller, M. Drent
Published 2005 · Psychology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Growth hormone (GH) replacement therapy with duration of several years is known to be safe and beneficial in GH-deficient adult patients. However, long-term follow-up data on GH substitution, cognition, and well-being are scarce. The purpose of this study was to investigate whether the benefits of GH replacement in psychological functioning found in previous studies lasting up to 2 years are preserved over a 10-year follow-up period. Twenty-three men (mean age at baseline 28.6 years) with childhood-onset GH deficiency were studied during a 10-year period of GH substitution. Memory tasks, mood questionnaires, and IGF-I values were obtained at baseline and after 0.5, 1, 2, 3, 5, and 10 years of GH substitution. Both mood and memory improved during GH therapy. After 6 months of treatment, anxiety and tension were reduced and vigor had improved. Memory improved after 1 year of substitution. These improvements were maintained during the 10-year follow-up period. Higher intra-subject IGF-I levels were associated with better mood (anxiety, tension, vigor). This study shows that 10 years of GH therapy is beneficial in terms of well-being and cognitive functioning in childhood-onset GH-deficient men. It may be concluded that once the decision to start GH treatment has been taken, this may imply that GH therapy has to be continued for a long period to maintain the psychological improvements and to prevent a relapse.
This paper references
Effects of Physiologic Growth Hormone Therapy on Bone Density and Body Composition in Patients with Adult-Onset Growth Hormone Deficiency
H. Baum (1996)
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
F. Nyberg (2000)
One‐year follow‐up of quality of life in adults with untreated growth hormone deficiency
X. Badía (1998)
OCCURRENCE AND DISTRIBUTION OF AROMATIC l‐AMINO ACID (l‐DOPA) DECARBOXYLASE IN THE HUMAN BRAIN
K. Lloyd (1972)
Clinical aspects of growth hormone deficiency in adults.
H. D. de Boer (1995)
Quality of life of growth hormone (GH) deficient young adults during discontinuation and restart of GH therapy
P. J. Stouthart (2003)
The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory.
L. Derogatis (1974)
Bidirectional modulation of basal forebrain N-methyl-d-aspartate receptor function differentially affects visual attention but not visual discrimination performance
J. Turchi (2001)
Neuroscience in Medicine
P. Conn (2003)
Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional Ability
M. Papadakis (1996)
Is the central nervous system a target for growth hormone and insulin‐like growth factors?
V. Han (1995)
Effect of growth hormone on brain neurotransmitters
P. Burman (1993)
Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency.
J. C. ter Maaten (1999)
A shortened version of the Profile of Mood States.
S. Shacham (1983)
Growth hormone treatment in adults with childhood onset growth hormone deficiency: effects on psychological capabilities.
A. Sartorio (1995)
Manual for the State-Trait Anxiety Inventory
C. Spielberger (1970)
Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
A. Adem (1989)
The growth hormone deficiency syndrome in adults
R. Cuneo (1992)
H. Mclennan (1963)
Monitoring of growth hormone replacement therapy in adults, based on measurement of serum markers.
H. D. de Boer (1996)
Quality of Life of Adults with Growth Hormone Deficiency: a Controlled Study
S. Bjork (1989)
Dissociating the effects of altered dopaminergic function on performance and learning
R. J. Beninger (1989)
Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study
O. Almqvist (1986)
Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency.
M. Degerblad (1990)
The effects of antidepressants on the cerebrospinal fluid homovanillic acid/5‐hydroxyindoleacetic acid ratio
E. Risby (1987)
The effect of long‐term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH‐deficient adults
F. Gilchrist (2002)
Quality of Life Assessment Before and After Growth Hormone Treatment in Adults with Growth Hormone Deficiency
G. Mcgauley (1989)
The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients.
J. Gibney (1999)
The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.
F. Salomon (1989)
Growth hormone deficiency and quality of life.
G. Mcgauley (1996)
Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency.
G. Johannsson (1996)
Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects
A. Rollero (1998)
Age-Sensitive Cognitive Function, Growth Hormone and Insulin-Like Growth Factor 1 Plasma Levels in Healthy Older Men
A. Aleman (2000)
Cognitive impairments and mood disturbances in growth hormone deficient men
J. B. Deijen (1996)
Cognitive changes during growth hormone replacement in adult men
J. B. Deijen (1998)
Treatment of growth hormone-deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters.
J. Johansson (1995)
Statistical Power Analysis for the Behavioral Sciences
J. Cohen (1969)
Growth hormone treatment affects brain neurotransmitters and thyroxine
P. Burman (1996)
This paper is referenced by
Growth hormone replacement therapy in adults with growth hormone deficiency: benefits and cost-effectiveness
F. Tanrıverdi (2006)
Troubles endocriniens à distance d’une agression cérébrale : quel retentissement ? Quel bilan ? ☆
S. Ciancia (2012)
Growth hormone rescues hippocampal synaptic function after sleep deprivation.
Eunyoung Kim (2010)
Global view of the mechanisms of improved learning and memory capability in mice with music-exposure by microarray
B. Meng (2009)
Neurobehavioral and quality of life changes associated with growth hormone insufficiency after complicated mild, moderate, or severe traumatic brain injury.
D. Kelly (2006)
Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players: a prospective study.
D. Kelly (2014)
Growth hormone biases amygdala network activation after fear learning
B. Gisabella (2016)
The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study
Carmilla M. M. Licht (2014)
Application of in vitro [35S]GTPγ-S autoradiography in studies of growth hormone effects on opioid receptors in the male rat brain
J. Johansson (2013)
More Than Growth? A Study of the Additional Functions of Growth Hormone in the Human Body
Damien Chance Hutchins (2019)
Improving effects of long-term growth hormone treatment on monoaminergic neurotransmission and related behavioral tests in aged rats.
S. Esteban (2010)
Transmembrane delivery and biological effect of human growth hormone via a phage displayed peptide in vivo and in vitro.
T. Zhang (2010)
Behavioural phenotyping of male growth hormone-releasing hormone (GHRH) knockout mice.
S. Leone (2014)
Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation
A. Quintana (2018)
EFFECTS OF TESTOSTERONE AND GROWTH HORMONE ON LONG-TERM RETENTION AND EXTINCTION OF A PASSIVE AVOIDANCE RESPONSE IN YOUNG AND AGED RATS
S. Schneider-Rivas (2007)
Growth hormone (GH) increases cognition and expression of ionotropic glutamate receptors (AMPA and NMDA) in transgenic zebrafish (Danio rerio)
A. L. Studzinski (2015)
The neurocognitive consequences of non-functioning pituitary adenoma and its treatment
Alana Tooze (2010)
Cognition in the adult with childhood-onset GH deficiency.
I. C. van Nieuwpoort (2008)
Growth hormone replacement therapy in patients with traumatic brain injury.
O. Moreau (2013)
Breakfast consumption and mental health: a systematic review and meta-analysis of observational studies.
Hoda Zahedi (2020)
Neurocognitive function in adults with growth hormone deficiency.
P. S. V. Dam (2005)
A Role for Central Nervous Growth Hormone-Releasing Hormone Signaling in the Consolidation of Declarative Memories
M. Hallschmid (2011)
Wirkung von Wachstumshormon auf die deklarative Gedächtniskonsolidierung im Tiefschlaf
Erlangung der Doktorwürde (2007)
Terapia sustitutiva a largo plazo del déficit de hormona de crecimiento en la edad adulta
D. Cabo (2011)
Effect of Growth Hormone on Hippocampal Synaptic Function during Sleep Deprivation
E. Kim (2009)
Growth hormone and insulin-like growth factor 1 secretions in eating disorders: Correlations with psychopathological aspects of the disorders
F. Brambilla (2018)
Healthcare utilization, quality of life and patient-reported outcomes during two years of GH replacement therapy in GH-deficient adults--comparison between Sweden, The Netherlands and Germany.
B. Saller (2006)
The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature
M. Falleti (2006)
Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study.
M. Sathiavageeswaran (2007)
Physical distress, emotional status, and quality of life in patients with nasopharyngeal cancer complicated by post-radiotherapy endocrinopathy.
B. Lue (2008)
Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications
M. Finken (2018)
The Effects of Growth Hormone Treatment on Health-Related Quality of Life in Children
L. Sheppard (2006)See more