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Role Of Uncoupled And Non-coupled Oxidations In Maintenance Of Safely Low Levels Of Oxygen And Its One-electron Reductants.

V. Skulachev
Published 1996 · Chemistry, Materials Science, Medicine

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To proceed at a high rate, phosphorylating respiration requires ADP to be available. In the resting state, when the energy consumption is low, the ADP concentration decreases so that phosphorylating respiration ceases. This may result in an increase in the intracellular concentrations of O 2 as well as of one-electron O 2 reductants such as These two events should dramatically enhance non-enzymatic formation of reactive oxygen species, i.e. of , and OH, and, hence, the probability of oxidative damage to cellular components. In this paper, a concept is put forward proposing that non-phosphorylating (uncoupled or non-coupled) respiration takes part in maintenance of low levels of both O 2 and the O 2 reductants when phosphorylating respiration fails to do this job due to lack of ADP. In particular, it is proposed that some increase in the H + leak of mitochondrial membrane in State 4 lowers , stimulates O 2 consumption and decreases the level of which otherwise accumulates and serves as one-electron O 2 reductant. In this connection, the role of natural uncouplers (thyroid hormones), recouplers (male sex hormones and progesterone), non-specific pore in the inner mitochondrial membrane, and apoptosis, as well as of non-coupled electron transfer chains in plants and bacteria will be considered.
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Yin and Yang of mitochondrial ROS in Drosophila.
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The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion
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Expansion of the "Sodium World" through Evolutionary Time and Taxonomic Space.
M. I. Kozlova (2020)
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Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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Electron Transport Mechanism of Mitochondrial Respiratory MegacomplexI2III2IV2
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10.3389/fphar.2019.01277
Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes
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Molecular evolution of thermogenic uncoupling protein 1 and implications for medical intervention of human disease.
Michael Gaudry (2019)
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Mitochondrial Reactive Oxygen Species Aging Theory
V. Skulachev (2019)
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