Online citations, reference lists, and bibliographies.
← Back to Search

The MRNA Of The Translationally Controlled Tumor Protein P23/TCTP Is A Highly Structured RNA, Which Activates The DsRNA-dependent Protein Kinase PKR.

Ulrich-Axel Bommer, A. Borovjagin, M. A. Greagg, I. Jeffrey, P. Russell, K. Laing, M. Lee, M. Clemens
Published 2002 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
The dsRNA-activated protein kinase PKR is involved in signal transduction pathways that mediate cellular processes as diverse as cell growth and differentiation, the stress response, and apoptosis. PKR was originally described as an interferon-inducible elF2alpha kinase involved in the antiviral defense mechanism of the cell. The interaction of the kinase with specific viral RNAs has been studied in much detail, but information about cellular mRNAs, which are able to bind and activate PKR, is scarce. In search for such cellular mRNAs, we developed a cloning strategy to identify individual mRNA species from the dsRNA-rich fraction of Daudi cell poly(A)+ RNA. Two out of five cDNA clones we obtained contained sequences derived from the mRNA of the translationally controlled tumor protein P23/TCTP, indicating that this mRNA is present in the dsRNA-rich fraction. Secondary structure predictions and gel electrophoretic mobility investigations on P23/TCTP transcripts confirmed the potential of this mRNA to form extensive secondary structure. A full-length P23 transcript, but not a truncated version thereof, was able to bind to PKR in vitro and in vivo. Transient transfection experiments in human 293 cells showed that coexpression of full-length P23 mRNA leads to partial inhibition of the expression of a beta-galactosidase reporter gene in trans. Additional coexpression of a dominant negative mutant of PKR or of adenovirus VA1 RNA suppressed this inhibition, indicating that it is mediated by PKR. Studies on P23/TCTP expression in cells from PKR-knockout mice suggest that P23/TCTP mRNA translation is regulated by PKR. Hence, our results demonstrate that the mRNA of P23/TCTP may both activate PKR and be subject to translational regulation by this kinase.
This paper references
10.1159/000015238
Chromosomal localization1 of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to13q12→q14
S. Macdonald (1999)
10.1016/S0300-9084(97)86712-0
The regulation of the protein kinase PKR by RNA.
H. Robertson (1996)
10.1016/0092-8674(93)90579-F
Genetic complementation reveals a novel regulatory role for 3′ untranslated regions in growth and differentiation
F. Rastinejad (1993)
10.1016/S1357-2725(98)00136-8
PKR, apoptosis and cancer.
R. Jagus (1999)
10.1006/BBRC.1997.6305
The secondary structure of a fourteen-nucleotide fragment of the hairpin ribozyme.
J. D. Brinegar (1997)
10.1016/0042-6822(89)90112-8
Mechanism of interferon action. Activation of the human P1/eIF-2 alpha protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA.
J. R. Bischoff (1989)
Oncogene
Br Williams
10.1016/S1357-2725(98)00131-9
eIF4E activity is regulated at multiple levels.
B. Raught (1999)
Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78.
C. R. Prostko (1992)
10.1101/087969618.39.547
15 PERK and Translational Control by Stress in the Endoplasmic Reticulum
D. Ron (2000)
10.1111/J.1432-1033.1991.TB15673.X
Activation of the double-stranded RNA-dependent eIF-2 alpha kinase by cellular RNA from 3T3-F442A cells.
J. Li (1991)
10.1046/J.1432-1327.1998.2570062.X
Structure of the promoter and complete sequence of the gene coding for the rabbit translationally controlled tumor protein (TCTP) P23.
H. Thiele (1998)
10.1146/ANNUREV.BIOCHEM.68.1.913
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
A. Gingras (1999)
10.1089/107999099313677
The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?
S. Tan (1999)
10.1074/JBC.270.11.6211
Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores (*)
C. R. Prostko (1995)
10.1101/087969458.30.139
5 Protein Kinases That Phosphorylate eIF2 and eIF2B, and Their Role in Eukaryotic Cell Translational Control
M. Clemens (1996)
10.1038/sj.cdd.4400327
Differentially expressed genes in C6.9 glioma cells during vitamin D-induced cell death program
C. Baudet (1998)
10.1021/BI953028+
A Eukaryotic Translation Initiation Factor 2-Associated 67 kDa Glycoprotein Partially Reverses Protein Synthesis Inhibition by Activated Double-Stranded RNA-Dependent Protein Kinase in Intact Cells
S. Wu (1996)
10.1093/nar/25.13.2672
Characterization and mapping of the double-stranded regions involved in activation of PKR within a cellular RNA from 3T3-F442A cells
R. Petryshyn (1997)
10.1007/s004270000088
A cnidarian homologue of translationally controlled tumor protein (P23/TCTP)
L. Yan (2000)
10.1016/S0167-4781(98)00077-3
Identification of heavy metal induced changes in the expression patterns of the translationally controlled tumour protein (TCTP) in the earthworm Lumbricus rubellus1.
S. Stürzenbaum (1998)
10.1006/EXCR.1999.4721
Expression of a PKR dominant-negative mutant in myogenic cells interferes with the myogenic process.
S. Salzberg (2000)
10.1016/S0171-9335(99)80052-1
The Plasmodium falciparum translationally controlled tumor protein: subcellular localization and calcium binding.
J. Bhisutthibhan (1999)
10.1002/1615-9861(200107)1:7<880::AID-PROT880>3.0.CO;2-2
Cellular distribution of translationally controlled tumor protein in rat and human testes
E. Guillaume (2001)
10.1093/NAR/18.18.5401
Removal of double-stranded contaminants from RNA transcripts: synthesis of adenovirus VA RNAI from a T7 vector.
K. H. Mellits (1990)
10.1016/S1357-2725(98)00127-7
Translational control: the cancer connection.
M. Clemens (1999)
1996+ A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated doublestranded RNA-dependent protein kinase in intact
S Wu (1996)
10.1016/0167-4781(90)90161-T
Epstein-Barr virus gene expression in interferon-treated cells. Implications for the regulation of protein synthesis and the antiviral state.
P. Clarke (1990)
10.1111/J.1432-1033.1993.TB17998.X
Reversal of the double-stranded-RNA-induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR.
Tyson V. Sharp (1993)
10.1002/j.1460-2075.1988.tb03141.x
Effects of mutations in stem and loop regions on the structure and function of adenovirus VA RNAI.
K. H. Mellits (1988)
The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure.
H. Boehm (1989)
Involvement of PKR in the regulation of myogenesis.
Y. Kronfeld-Kinar (1999)
vitamin D-induced cell death program+ Cell Death Differ
R Benndorf (1988)
10.1007/BF00986961
Regulation of protein synthesis by mRNA structure
N. K. Gray (2004)
10.1074/jbc.273.26.16192
The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin*
J. Bhisutthibhan (1998)
Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.
K. Scorsone (1987)
Translational regulation of the mammalian growth-related protein P23: involvement of eIF-4E.
U. Bommer (1994)
+ Double - stranded RNA - activated protein kinase ( PKR ) is negatively regulated by 60 S ribosomal subunit protein L 18 +
KU Kumar (1999)
10.1093/nar/22.13.2512
The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA
Q. Xiao (1994)
10.1128/MCB.18.1.58
Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR
W. Chu (1998)
10.1016/S1097-2765(00)80330-5
Perk is essential for translational regulation and cell survival during the unfolded protein response.
H. Harding (2000)
10.1074/jbc.272.2.1291
A Model for the Double-stranded RNA (dsRNA)-dependent Dimerization and Activation of the dsRNA-activated Protein Kinase PKR*
S. Wu (1997)
10.1006/BBRC.2000.4103
The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation.
S. Kimball (2001)
10.1016/S0304-3835(00)00460-2
Expression of translationally controlled tumor protein mRNA in human colon cancer.
S. Chung (2000)
+ A complex RNA sequence determines the internal initiation of en - cephalomyocarditis virus RNA translation + Nucleic Acids Res
AG Evstafieva (1991)
10.1128/AAC.45.8.2397-2399.2001
Immunoprecipitation of [3H]Dihydroartemisinin Translationally Controlled Tumor Protein (TCTP) Adducts from Plasmodium falciparum-Infected Erythrocytes by Using Anti-TCTP Antibodies
J. Bhisutthibhan (2001)
10.1016/0092-8674(93)90320-P
Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin
F. Rastinejad (1993)
10.1016/0042-6822(86)90468-X
Variable repeats and poly (A)-stretches in the leader sequence of alfalfa mosaic virus RNA 3.
K. Langereis (1986)
10.1073/PNAS.78.9.5712
Transcriptional and translational control of cytoplasmic proteins after serum stimulation of quiescent Swiss 3T3 cells.
G. Thomas (1981)
10.1128/JVI.74.12.5577-5586.2000
Parameters of Human Immunodeficiency Virus Infection of Human Cervical Tissue and Inhibition by Vaginal Virucides
P. Greenhead (2000)
10.1074/jbc.271.3.1756
Double-stranded (ds) RNA Binding and Not Dimerization Correlates with the Activation of the dsRNA-dependent Protein Kinase (PKR) (*)
S. Wu (1996)
Translational control of gene expression
N. Sonenberg (2000)
10.1101/GAD.13.24.3280
A cis-acting element in the 3'-untranslated region of human TNF-alpha mRNA renders splicing dependent on the activation of protein kinase PKR.
F. Osman (1999)
10.1093/NAR/19.3.665
A complex RNA sequence determines the internal initiation of encephalomyocarditis virus RNA translation.
A. Evstafieva (1991)
Genetic complementation reveals a novel regulatory role for 39 untranslated regions in growth and differentiation+ Cell 72:903–917+
F Rastinejad (1993)
10.4049/jimmunol.166.11.6545
Molecular Identification of IgE-Dependent Histamine-Releasing Factor as a B Cell Growth Factor1
H. Kang (2001)
10.1038/16729
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
H. Harding (1999)
10.1089/JIR.1997.17.503
The double-stranded RNA-dependent protein kinase PKR: structure and function.
M. Clemens (1997)
10.1101/087969458.30.295
10 Regulation of Protein Synthesis by Calcium
A. Nairn (1996)
The 5 9 - untranslated region of p 23 mRNA from the Ehrlich ascites tumor is involved in translation control of the growth related protein p 23 +
H Boehm (1991)
10.1016/0166-6851(92)90205-X
Purification of novel calcium binding proteins from Trypanosoma brucei: properties of 22-, 24- and 38-kilodalton proteins.
N. Haghighat (1992)
10.1093/NAR/19.18.4999
RNA--protein interactions within the internal translation initiation region of encephalomyocarditis virus RNA.
A. Borovjagin (1991)
10.1038/311079A0
Inhibition of mRNA binding to ribosomes by localized activation of dsRNA-dependent protein kinase
A. D. Benedetti (1984)
Tumor suppression by RNA from the 3' untranslated region of alpha-tropomyosin.
F. Rastinejad (1993)
2000+ PERK and translational control by stress in the endoplasmic reticulum+ In: Sonenberg N, Hershey JWB, Mathews MB, eds+ Translational control of gene expression+ Cold Spring Harbor
D Ron
10.1083/JCB.103.6.2137
Translational control of mRNA expression during the early mitogenic response in Swiss mouse 3T3 cells: identification of specific proteins
G. Thomas (1986)
10.1038/90415
Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones
P. Thaw (2001)
10.1101/087969618.39.671
22 Translational Control of TOP mRNAs
O. Meyuhas (2000)
2000+ A cnidarian homologue of translationally controlled tumor protein
L Yan (2000)
The 5'-untranslated region of p23 mRNA from the Ehrlich ascites tumor is involved in translation control of the growth related protein p23.
H. Boehm (1991)
10.1128/MCB.3.7.1197
Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide.
R. Yenofsky (1983)
10.1038/sj.onc.1203127
PKR; a sentinel kinase for cellular stress
B. Williams (1999)
10.1101/087969618.39.695
23 S6 Phosphorylation and Signal Transduction
S. Fumagalli (2000)
10.1101/087969618.39.933
34 Translational Reprogramming during Influenza Virus Infection
S. Tan (2000)
Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.
S. Shama (1995)
Characterization and mapping of the double - stranded regions involved in activation of PKR within a cellular RNA from 3 T 3F 442 A cells +
RA Petryshyn (1997)
10.1084/JEM.183.3.1265
An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils
J. Schroeder (1996)
10.1159/000237542
Human recombinant histamine-releasing factor.
S. Macdonald (1997)
10.1002/j.1460-2075.1989.tb08601.x
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.
D. Scherly (1989)
10.1016/0092-8674(93)90577-D
The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA
W. Boelens (1993)
Blau HM+ 1993+ Tumor suppression by RNA from the 39 untranslated region of alphatropomyosin+
F Rastinejad
Double-Stranded RNA-Activated Protein Kinase ( PKR ) Is Negatively Regulated by 60 S Ribosomal Subunit Protein L 18 KOTLO
K. Kumar (1999)
10.1073/PNAS.82.13.4341
Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.
A. Laurent (1985)
10.1074/JBC.270.28.16619
Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis (*)
S. Srivastava (1995)
10.1126/SCIENCE.7542803
Molecular identification of an IgE-dependent histamine-releasing factor.
S. Macdonald (1995)
10.1002/jlb.57.3.507
Identification of macrophage activation associated proteins by two‐dimensional gel electrophoresis and microsequencing
B. Walsh (1995)
10.1002/(SICI)1097-0061(20000115)16:1<23::AID-YEA503>3.0.CO;2-A
Identification and transcription control of fission yeast genes repressed by an ammonium starvation growth arrest
C. Bonnet (2000)
10.1016/S1097-2765(01)00264-7
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival.
H. Harding (2001)
Translational control of TOP mRNAs+ In: Sonenberg N, Hershey JWB, Mathews MB, eds+ Translational control of gene expression+ Cold Spring Harbor
O Meyuhas (2000)
Molecular identification of IgE-dependent histamine-releasing factor as a B cell growth factor+ Kaufman RJ+ 2000+ The double-stranded RNA-activated protein kinase PKR+ In
Hs Kang (2001)
10.1016/S1357-2725(98)00133-2
Translational control of growth factor and proto-oncogene expression.
A. Willis (1999)
10.1002/ELPS.1150180127
Translationally controlled tumor protein: A protein identified in several nontumoral cells including erythrocytes
J. Sanchez (1997)
10.1093/NAR/17.20.8367
cDNA sequence coding for a translationally controlled human tumor protein.
B. Gross (1989)
10.1017/S1355838200991544
Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR.
B. Tian (2000)
Regulation of protein synthesis by calcium+ In: Hershey JWB, Mathews MB, Sonenberg N, eds+ Translational control of gene expression+ Cold Spring Harbor
Ac Nairn (1996)
10.1016/S1097-2765(01)00265-9
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
D. Scheuner (2001)
10.1093/OXFORDJOURNALS.PCP.A029377
Dark-induced accumulation of mRNA for a homolog of translationally controlled tumor protein (TCTP) in Pharbitis.
K. Sage-Ono (1998)
10.1046/J.1432-1327.1998.2530531.X
Regulation of translation initiation factors by signal transduction.
M. Kleijn (1998)
10.1093/NAR/16.8.3497
Regulation of in vitro translation by double-stranded RNA in mammalian cell mRNA preparations.
G. Pratt (1988)
10.1016/S1357-2725(96)00169-0
PKR--a protein kinase regulated by double-stranded RNA.
M. Clemens (1997)
10.1042/0264-6021:3420683
Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level.
A. Xu (1999)
The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle.
Y. Gachet (1999)
10.1101/087969618.39.503
13 The Double-stranded RNA-activated Protein Kinase PKR
R. Kaufman (2000)
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
M. Adams (1995)
10.1042/BST023316S
Features of the translational regulation of the mammalian growth-related protein P23.
A. Borovjagin (1995)
10.1073/PNAS.93.1.508
In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.
S. Davis (1996)
10.1073/PNAS.79.19.5876
Messenger RNA species partially in a repressed state in mouse sarcoma ascites cells.
R. Yenofsky (1982)
10.1128/MCB.18.12.7499
Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control
Y. Shi (1998)
10.1093/HMG/10.15.1531
Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
A. Peel (2001)
10.1021/bi953028
A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells.
S. Wu (1996)
1996+ In vitro activation of the interferoninduced, double-stranded RNA-dependent protein kinase PKR by RNA from the 39 untranslated regions of human alphatropomyosin+
S Davis (1996)
10.1016/0014-4827(88)90148-6
Growth phase-dependent proteins of the Ehrlich ascites tumor analyzed by one- and two-dimensional electrophoresis.
R. Benndorf (1988)
10.1046/J.1432-1327.2000.01609.X
Expression of the gene and processed pseudogenes encoding the human and rabbit translationally controlled tumour protein (TCTP).
H. Thiele (2000)
10.1093/NAR/27.22.4369
The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors.
F. Terenzi (1999)
10.1006/JMBI.1996.0543
Secondary structure probing of potato spindle tuber viroid (PSTVd) and sequence comparison with other small pathogenic RNA replicons provides evidence for central non-canonical base-pairs, large A-rich loops, and a terminal branch.
F. Gast (1996)
10.1128/JVI.67.12.7695-7700.1993
Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.
D. Thomis (1993)
10.1016/S0079-6603(08)60034-3
Regulation of translational initiation during cellular responses to stress.
C. Brostrom (1998)



This paper is referenced by
10.1158/0008-5472.CAN-08-0074
Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.
S. Pervin (2008)
10.1038/onc.2009.380
Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responses
U-A Bommer (2010)
10.1172/JCI59072
Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.
J. Kashiwakura (2012)
10.1371/journal.pone.0005732
Proton Pump Inhibitors Exert Anti-Allergic Effects by Reducing TCTP Secretion
Sunghee Choi (2009)
10.1007/BF03033316
Identification of AGE-modified proteins in SH-SY5Y and OLN-93 Cells
AndrÉ K. Langer (2009)
10.1371/journal.pone.0127196
Telomerase Activity and Telomere Length in Daphnia
Charles A. Schumpert (2015)
10.1016/bs.acc.2017.06.006
Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases.
Decha Pinkaew (2017)
10.1007/s11033-008-9369-2
Molecular cloning and characterization of the translationally controlled tumor protein from Fenneropenaeus chinensis
S. Wang (2008)
Translationally Controlled Tumor Protein Participates in DNA Repair in Low Dose γ- Irradiated Cells
J. Zhang (2009)
10.2174/1874838401205010041
HRF-Interacting Molecules
Toshiaki Kawakami (2012)
10.1086/BBLv221n3p290
A Novel TCTP Gene From the Crustacean Eriocheir sinensis: Possible Role Involving Metallic Cu2+ Stress
Q. Wang (2011)
10.1080/15592324.2015.1071003
AtTCTP2 mRNA and protein movement correlates with formation of adventitious roots in tobacco
Roberto Toscano-Morales (2016)
Involvement of Translationally controlled tumor protein in Tomato yellow spot virus infection
P. O. Andrade (2017)
10.1016/J.JMB.2006.01.099
Specific recognition of HIV TAR RNA by the dsRNA binding domains (dsRBD1-dsRBD2) of PKR.
I. Kim (2006)
10.1016/J.FREERADBIOMED.2005.03.030
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
H. Poon (2005)
10.1016/J.JMB.2007.06.028
Viral dsRNA inhibitors prevent self-association and autophosphorylation of PKR.
S. McKenna (2007)
10.1155/2012/369384
Role of Translationally Controlled Tumor Protein in Cancer Progression
T. H. Chan (2012)
10.20381/RUOR-3044
Proteomic Analysis Identifies Translationally Controlled Tumor Protein as a Potential Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension
Jessie R Lavoie (2013)
10.1007/978-3-319-67591-6_7
Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development.
Léo Betsch (2017)
10.1016/j.ejcb.2016.12.002
Acetylation of translationally controlled tumor protein promotes its degradation through chaperone-mediated autophagy.
A. Bonhoure (2017)
10.3389/fnmol.2018.00399
Growth Cone Tctp Is Dynamically Regulated by Guidance Cues
Cláudio Gouveia Roque (2018)
10.1089/JIR.2006.0152
Nuclear transcription of long hairpin RNA triggers innate immune responses.
Michael P Gantier (2007)
10.1016/S1001-0742(11)61060-7
Influence and mechanism of N-(3-oxooxtanoyl)-L-homoserine lactone (C8-oxo-HSL) on biofilm behaviors at early stage.
S. Xia (2012)
10.1016/S0079-6603(03)01012-2
Phylogenetics and functions of the double-stranded RNA-binding motif: a genomic survey.
B. Tian (2003)
Investigation of two early events in amyotrophic lateral sclerosis -MRNA oxidation and up-regulation of a novel protective factor MSUR1-
Yueming Chang (2007)
10.1261/rna.1007408
Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner.
S. R. Nallagatla (2008)
10.1371/journal.pone.0069398
TCTP Is an Androgen-Regulated Gene Implicated in Prostate Cancer
M. Kaarbø (2013)
10.1007/s11033-013-2806-x
The role of CcTpt1 in scale and early embryo development in common carp (Cyprinus carpio, Cyprinidae)
Li Jiang (2013)
10.14348/molcells.2016.0039
Incredible RNA: Dual Functions of Coding and Noncoding
Jin-Wu Nam (2016)
10.1101/190314
The differentially expressed translationally controlled tumor proteins TCTP1 and TCTP2 in Trypanosoma brucei
Borka Jojic (2017)
10.1016/j.fsi.2013.04.021
The response profiles of HSPA12A and TCTP from Mytilus galloprovincialis to pathogen and cadmium challenge.
L. You (2013)
10.1016/j.jplph.2012.11.014
Molecular cloning, expression profiles and characterization of a novel translationally controlled tumor protein in rubber tree (Hevea brasiliensis).
D. Li (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar