Online citations, reference lists, and bibliographies.

Review: Enhancing Gastrointestinal Health In Dairy Cows.

J. C. Plaizier, M Danesh Mesgaran, H Derakhshani, Helen M. Golder, Ehsan Khafipour, Joachim L Kleen, I Lean, Juan J. Loor, G Penner, Qendrim Zebeli
Published 2018 · Medicine, Biology
Cite This
Download PDF
Analyze on Scholarcy
Share
Due to their high energy requirements, high-yielding dairy cows receive high-grain diets. This commonly jeopardises their gastrointestinal health by causing subacute ruminal acidosis (SARA) and hindgut acidosis. These disorders can disrupt nutrient utilisations, impair the functionalities of gastrointestinal microbiota, and reduce the absorptive and barrier capacities of gastrointestinal epithelia. They can also trigger inflammatory responses. The symptoms of SARA are not only due to a depressed rumen pH. Hence, the diagnosis of this disorder based solely on reticulo-rumen pH values is inaccurate. An accurate diagnosis requires a combination of clinical examinations of cows, including blood, milk, urine and faeces parameters, as well as analyses of herd management and feed quality, including the dietary contents of NDF, starch and physical effective NDF. Grain-induced SARA increases acidity and shifts availabilities of substrates for microorganisms in the reticulo-rumen and hindgut and can result in a dysbiotic microbiota that are characterised by low richness, diversity and functionality. Also, amylolytic microorganisms become more dominant at the expense of proteolytic and fibrolytic ones. Opportunistic microorganisms can take advantage of newly available niches, which, combined with reduced functionalities of epithelia, can contribute to an overall reduction in nutrient utilisation and increasing endotoxins and pathogens in digesta and faeces. The reduced barrier function of epithelia increases translocation of these endotoxins and other immunogenic compounds out of the digestive tract, which may be the cause of inflammations. This needs to be confirmed by determining the toxicity of these compounds. Cows differ in their susceptibility to poor gastrointestinal health, due to variations in genetics, feeding history, diet adaptation, gastrointestinal microbiota, metabolic adaptation, stress and infections. These differences may also offer opportunities for the management of gastrointestinal health. Strategies to prevent SARA include balancing the diet for physical effective fibre, non-fibre carbohydrates and starch, managing the different fractions of non-fibre carbohydrates, and consideration of the type and processing of grain and forage digestibility. Gastrointestinal health disorders due to high grain feeding may be attenuated by a variety of feed supplements and additives, including buffers, antibiotics, probiotics/direct fed microbials and yeast products. However, the efficacy of strategies to prevent these disorders must be improved. This requires a better understanding of the mechanisms through which these strategies affect the functionality of gastrointestinal microbiota and epithelia, and the immunity, inflammation and 'gastrointestinal-health robustness' of cows. More representative models to induce SARA are also needed.
This paper references
10.1186/s12917-016-0755-z
Rumen-derived lipopolysaccharide enhances the expression of lingual antimicrobial peptide in mammary glands of dairy cows fed a high-concentrate diet
Di Jin (2016)
Monensin, a new biologically active compound. I. Discovery and isolation.
Michael E. Haney (1967)
10.2527/1995.7351449x
Kinetics of hydration and functional specific gravity of fibrous feed by-products.
Shaukat Ali Bhatti (1995)
10.2527/AF.2016-0018
Effects of grain feeding on microbiota in the digestive tract of cattle
Ehsan Khafipour (2016)
10.1046/j.1439-0442.2003.00569.x
Subacute ruminal acidosis (SARA): a review.
Joachim Lübbo Kleen (2003)
10.1016/j.anifeedsci.2004.12.005
Statistical evaluation of early- and mid-lactation dairy cow responses to dietary sodium bicarbonate addition
Wenping Hu (2005)
CONTROLLING METHANE PRODUCTION WITH VIRGINIAMYCIN
Eh Clayton (1996)
Nutritional ecology of the ruminant, 2nd ed
PJ Van Soest (1994)
10.3168/jds.2011-4447
Effects of subacute ruminal acidosis challenges on fermentation and endotoxins in the rumen and hindgut of dairy cows.
Shucong Li (2012)
10.1016/S1471-4906(01)02169-X
Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?
Mihai G. Netea (2002)
10.1016/J.LIVSCI.2014.01.026
Efficacy and mode of action of selected non-ionophore antibiotics and direct-fed microbials in relation to Megasphaera elsdenii NCIMB 41125 during in vitro fermentation of an acidosis-causing substrate
Heinz H. Meissner (2014)
10.1007/s00018-011-0822-3
Composition and functional role of the mucus layers in the intestine
Malin E. V. Johansson (2011)
10.2527/jas1976.433657x
Effect of Monensin on Rumen Fermentation in Vitro and in Vivo
Leonard F. Richardson (1976)
10.3168/jds.2008-1656
Alfalfa pellet-induced subacute ruminal acidosis in dairy cows increases bacterial endotoxin in the rumen without causing inflammation.
Ehsan Khafipour (2009)
10.1055/s-0038-1651195
Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin.
J. O. Levin (1968)
10.2460/javma.2004.224.1446
Interactions between lipopolysaccharide and the intestinal epithelium.
Julia E. Tomlinson (2004)
10.3168/jds.2015-10417
Divergent utilization patterns of grass fructan, inulin, and other nonfiber carbohydrates by ruminal microbes.
Mary Hall (2016)
10.1007/springerreference_37341
The acute-phase response.
Benedikt H. J. Pannen (1995)
10.1080/17450390109386202
Effect of starch application into the proximal duodenum of ruminants on starch digestibility in the small and total intestine
Angelika Matthé (2001)
10.1186/s13028-015-0128-9
Indicators of induced subacute ruminal acidosis (SARA) in Danish Holstein cows
Anne Mette Danscher (2015)
10.2527/jas.2014-8570
Direct-fed microbials containing lactate-producing bacteria influence ruminal fermentation but not lactate utilization in steers fed a high-concentrate diet.
N. M. Kenney (2015)
10.2527/jas1984.5861465x
Ionophores: their effect on production efficiency and mode of action.
Werner G. Bergen (1984)
STARCH DIGESTION IN RUMINANTS- PROBLEMS, SOLUTIONS AND OPPORTUNITIES
Jennifer Rowel (2014)
10.3168/jds.2014-8226
Modification of the feeding behavior of dairy cows through live yeast supplementation.
Trevor J. Devries (2014)
10.1016/0921-4488(95)00647-4
Effect of virginiamycin on ruminal fermentation in faunated or ciliate-free sheep overfed with barley grain
T G Nagaraja (1995)
10.1016/j.tvjl.2007.12.017
Subacute ruminal acidosis (SARA) in grazing Irish dairy cows.
Luke O'Grady (2008)
10.1126/science.1058830
Factors That Alter Rumen Microbial Ecology
James B. Russell (2001)
10.1136/vr.164.22.681
Subacute ruminal acidosis in Dutch dairy herds
Joachim Lübbo Kleen (2009)
10.2527/jas.2012-5379
In vivo indices for predicting acidosis risk of grains in cattle: Comparison with in vitro methods.
I Lean (2013)
10.2527/jas.2008-1446
Effects of dietary changes and yeast culture (Saccharomyces cerevisiae) on rumen microbial fermentation of Holstein heifers.
David Moya (2009)
10.2527/jas.2015-9009
Using organic acids to control subacute ruminal acidosis and fermentation in feedlot cattle fed a high-grain diet.
Diwakar Vyas (2015)
10.3168/jds.2007-0572
Modeling the adequacy of dietary fiber in dairy cows based on the responses of ruminal pH and milk fat production to composition of the diet.
Q. Zebeli (2008)
10.4137/BBI.S15389
High-throughput Methods Redefine the Rumen Microbiome and Its Relationship with Nutrition and Metabolism
Joshua Clay McCann (2014)
10.3168/jds.S0022-0302(96)76508-6
Why do many ruminal bacteria die and lyse so quickly?
James E. Wells (1996)
10.1099/mic.0.27602-0
Influence of flavomycin on ruminal fermentation and microbial populations in sheep.
Joan E. Edwards (2005)
10.1038/nrmicro2746
How glycan metabolism shapes the human gut microbiota
Nicole M. Koropatkin (2012)
10.2527/jas.2015-9694
A meta-analysis of lasalocid effects on rumen measures, beef and dairy performance, and carcass traits in cattle.
Helen M. Golder (2016)
Prevalence of subacute ruminal acidosis (SARA) on UK dairy farms
O Atkinson (2014)
10.3168/JDS.2006-601
The definition of acidosis in dairy herds predominantly fed on pasture and concentrates.
E. Bramley (2008)
10.1186/1751-0147-55-48
Prevalence and consequences of subacute ruminal acidosis in German dairy herds
Joachim L Kleen (2013)
10.1073/pnas.0806191105
Gene-centric metagenomics of the fiber-adherent bovine rumen microbiome reveals forage specific glycoside hydrolases
Jennifer M. Brulc (2009)
10.2527/jas.2016-0638
Effects of subacute ruminal acidosis and low feed intake on short-chain fatty acid transporters and flux pathways in Holstein steers.
A. H. Laarman (2016)
10.3168/jds.2016-12162
Effect of increasing the proportion of dietary concentrate on gastrointestinal tract measurements and brush border enzyme activity in Holstein steers.
Paweł Górka (2017)
10.3168/jds.2011-5167
The relationship between rumen acidosis resistance and expression of genes involved in regulation of intracellular pH and butyrate metabolism of ruminal epithelial cells in steers.
Nicole A Schlau (2012)
10.1111/j.1939-165X.2006.tb00112.x
Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period.
M F Humblet (2006)
10.5713/AJAS.2010.R.08
Direct-fed microbials for ruminant animals.
Ja Kyeom Seo (2010)
10.1152/physiolgenomics.00117.2010
Rumen epithelial adaptation to high-grain diets involves the coordinated regulation of genes involved in cholesterol homeostasis.
Michael A Steele (2011)
10.3389/fmicb.2015.00296
Redundancy, resilience, and host specificity of the ruminal microbiota: implications for engineering improved ruminal fermentations
Paul J. Weimer (2015)
10.5713/ajas.1995.553
Influence of direct-fed microbials on ruminal microbial fermentation and performance of ruminants - A Review -
Ik Koo Yoon (1995)
10.1071/ar9951137
Responses in ciliated protozoa and rumen fermentation in sheep supplemented with barley plus virginiamycin
Tiruvoor G. Nagaraja (1995)
10.1146/annurev.ecolsys.35.021103.105711
Regime shifts, resilience, and biodiversity in ecosystem management
Carl Folke (2004)
10.1038/nature06541
Gene-specific control of inflammation by TLR-induced chromatin modifications
Simmie L. Foster (2008)
10.1016/j.tvjl.2007.12.016
Subacute ruminal acidosis in dairy cows: the physiological causes, incidence and consequences.
Jan C. Plaizier (2008)
10.3168/JDS.2007-0257
Acidosis and lipopolysaccharide from Escherichia coli B:055 cause hyperpermeability of rumen and colon tissues.
D. G. Emmanuel (2007)
10.1093/jas/skx049
Effect of ruminal acidosis and short-term low feed intake on indicators of gastrointestinal barrier function in Holstein steers.
Rae-Leigh Amanda Pederzolli (2018)
10.2527/1995.7319
Effects of dietary virginiamycin on performance and liver abscess incidence in feedlot cattle.
Joseph A. Rogers (1995)
Physiologic responses of ruminants to toxic factors extracted from rumen bacteria and rumen fluid.
Charles H. Mullenax (1966)
10.1016/j.tvjl.2007.12.018
Production diseases of the transition cow.
Finbar J. Mulligan (2008)
10.1016/j.tim.2015.03.002
Fate, activity, and impact of ingested bacteria within the human gut microbiota.
Muriel Derrien (2015)
10.4141/A03-115
Nutritional practices on Manitoba dairy farms
Jan C. Plaizier (2004)
10.1071/AN13381
Interactions between microbial consortia in biofilms: a paradigm shift in rumen microbial ecology and enteric methane mitigation
R. A. Leng (2014)
10.1038/srep14567
Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range
G. Henderson (2015)
10.1111/jpn.12592
Prevalence and consequence of subacute ruminal acidosis in Polish dairy herds
Barbara Stefańska (2017)
10.5860/choice.32-4505
Nutritional Ecology of the Ruminant
Peter J. Van Soest (1994)
10.3168/jds.2007-0474
Effects of propionibacteria and yeast culture fed to steers on nutrient intake and site and extent of digestion.
K V Lehloenya (2008)
10.3168/jds.2015-9393
The influence of age and weaning on permeability of the gastrointestinal tract in Holstein bull calves.
Katie M. Wood (2015)
10.4141/A04-033
Effect of monensin on meal frequency during sub-acute ruminal acidosis in dairy cows
David E. Lunn (2005)
10.3168/jds.2017-13321
Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows.
Tianle Xu (2017)
10.3168/jds.2016-11570
Characteristics of dairy cows with a greater or lower risk of subacute ruminal acidosis: Volatile fatty acid absorption, rumen digestion, and expression of genes in rumen epithelial cells.
Xuri Gao (2016)
10.3168/jds.S0022-0302(05)72674-6
Metabolic predictors of displaced abomasum in dairy cattle.
Stephen J LeBlanc (2005)
10.1371/journal.pone.0177675
Livestock metabolomics and the livestock metabolome: A systematic review
Seyed Ali Goldansaz (2017)
10.1371/journal.pone.0126910
Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis
Takhar Kasumov (2015)
10.1016/j.tvjl.2007.12.021
The monitoring, prevention and treatment of sub-acute ruminal acidosis (SARA): a review.
Jörg M D Enemark (2008)
10.3168/jds.S0022-0302(93)77407-X
Another theory for the action of ruminal buffer salts: decreased starch fermentation and propionate production.
James B. Russell (1993)
10.3168/jds.2014-8638
Effects of various starch feeding regimens on responses of dairy cows to intramammary lipopolysaccharide infusion.
Paige Nicole Gott (2015)
10.1080/00039420412331273259
Digesta characteristics of dorsal, middle and ventral rumen of cows fed with different hay qualities and concentrate levels
Myqerem Tafaj (2004)
10.3168/jds.S0022-0302(04)73469-4
Dose dependency and individual variability of the lipopolysaccharide-induced bovine acute phase protein response.
S Jacobsen (2004)
10.1152/ajpgi.90442.2008
Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep.
Jörg R Aschenbach (2009)
10.1128/AEM.00388-10
Rumen Microbial Population Dynamics during Adaptation to a High-Grain Diet
Samodha C. Fernando (2010)
10.4314/SAJAS.V39I4.51129
Effect of Megasphaera elsdenii NCIMB 41125 drenching on health and performance of steers fed high and low roughage diets in the feedlot
K-J. Leeuw (2010)
10.1371/journal.pone.0111596
High Concentrate Diet Induced Mucosal Injuries by Enhancing Epithelial Apoptosis and Inflammatory Response in the Hindgut of Goats
Shiyu Tao (2014)
10.1007/s004240000285
Transport, catabolism and release of histamine in the ruminal epithelium of sheep
Jörg R. Aschenbach (2000)
10.1038/4441022a
Microbial ecology: Human gut microbes associated with obesity
Ruth E. Ley (2006)
10.1111/j.1439-0396.2007.00696.x
Subacute rumen acidosis in lactating cows: an investigation in intensive Italian dairy herds.
M. Morgante (2007)
10.3168/jds.S0022-0302(97)76026-0
Bovine acidosis: implications on laminitis.
James E. Nocek (1997)
10.1128/aem.39.3.604-610.1980
Effect of pH on the efficiency of growth by pure cultures of rumen bacteria in continuous culture.
James B. Russell (1980)
10.2527/2003.8114_suppl_2E120x
Bacterial direct-fed microbials in ruminant diets: Performance response and mode of action
Clinton R. Krehbiel (2003)
10.3389/fmicb.2016.00426
The Features of Fecal and Ileal Mucosa-Associated Microbiota in Dairy Calves during Early Infection with Mycobacterium avium Subspecies paratuberculosis
H Derakhshani (2016)
10.3168/jds.2012-6109
Grain-based versus alfalfa-based subacute ruminal acidosis induction experiments: Similarities and differences between changes in milk fatty acids.
E. Colman (2013)
Recent advances in understanding the interactions between nutrition and immunity in farm animals
KC Klassing (2013)
Effects of tylosin on concentrations of Fusobacterium necrophorum and fermentation products in the rumen of cattle fed a high-concentrate diet.
T G Nagaraja (1999)
10.1046/j.1365-2672.2003.02024.x
Establishing populations of Megasphaera elsdenii YE 34 and Butyrivibrio fibrisolvens YE 44 in the rumen of cattle fed high grain diets.
A V Klieve (2003)
New Approaches to Control of Ruminal Acidosis in Dairy Cattle
I Lean (2000)
10.1111/j.1439-0396.2007.00765.x
Effects of induced subacute ruminal acidosis on milk fat content and milk fatty acid profile.
Francis Enjalbert (2008)
10.3945/jn.109.108506
Epithelial capacity for apical uptake of short chain fatty acids is a key determinant for intraruminal pH and the susceptibility to subacute ruminal acidosis in sheep.
Gregory B. Penner (2009)
10.1053/j.gastro.2014.07.020
Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota.
Lindsey G. Albenberg (2014)
A meta-analysis of the impact of monensin in lactating dairy cattle
TF Duffield (2008)
10.1111/apha.12155
Bicarbonate-dependent transport of acetate and butyrate across the basolateral membrane of sheep rumen epithelium.
Franziska Dengler (2014)
10.3168/jds.2014-8162
Effects of duration of moderate increases in grain feeding on endotoxins in the digestive tract and acute phase proteins in peripheral blood of yearling calves.
J. C. Plaizier (2014)
10.3168/jds.2013-7166
Effects of feed additives on rumen and blood profiles during a starch and fructose challenge.
Helen M. Golder (2014)
10.1080/00365520310003129
Luminal salmonella endotoxin affects epithelial and mast cell function in the proximal colon of pigs.
Jörg R Aschenbach (2003)
Feeding low-starch diets to lactating dairy cows
HM Dann (2010)
10.1016/j.anaerobe.2013.02.005
Grain-rich diets differently alter ruminal and colonic abundance of microbial populations and lipopolysaccharide in goats.
Barbara U Metzler-Zebeli (2013)
10.4141/cjas80-108
RUMEN METABOLISM AND FEEDLOT RESPONSES BY STEERS FED TYLOSIN AND MONENSIN
G. M. J. Horton (1980)
10.1016/J.ANIFEEDSCI.2011.12.004
Subacute ruminal acidosis (SARA), endotoxins and health consequences
Jan C. Plaizier (2012)
10.1007/s11306-010-0227-6
Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows
B. Ametaj (2010)
10.1186/s40104-016-0100-1
High-concentrate feeding upregulates the expression of inflammation-related genes in the ruminal epithelium of dairy cattle
Ruiyang Zhang (2016)
10.1071/AN14285
Characterising barrier function among regions of the gastrointestinal tract in Holstein steers
Gregory B. Penner (2014)
10.2527/jas.2012-5669
Short-term feed restriction impairs the absorptive function of the reticulo-rumen and total tract barrier function in beef cattle.
Shaofeng Zhang (2013)
10.2527/jas.2015-0261
Liver abscesses in cattle: A review of incidence in Holsteins and of bacteriology and vaccine approaches to control in feedlot cattle.
Raghavendra G Amachawadi (2016)
10.1051/rnd:19910609
Effects of a low dietary linoleic acid level on intestinal morphology and enterocyte brush border membrane lipid composition.
Raymond Christon (1991)
10.1186/1471-2334-10-240
Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcεR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases
Saulo Fernandes Saturnino (2010)
10.1186/1751-0147-51-39
Ruminal acidosis and the rapid onset of ruminal parakeratosis in a mature dairy cow: a case report
Michael A Steele (2009)
10.3168/jds.2014-8049
Effects of partial mixed rations and supplement amounts on milk production and composition, ruminal fermentation, bacterial communities, and ruminal acidosis.
H. Golder (2014)
10.1016/j.vetimm.2005.02.003
A 7872 cDNA microarray and its use in bovine functional genomics.
Robin E. Everts (2005)
10.2527/jas.2012-5774
Recovery of absorptive function of the reticulo-rumen and total tract barrier function in beef cattle after short-term feed restriction.
Shaofeng Zhang (2013)
10.1371/journal.pone.0033306
Composition and Similarity of Bovine Rumen Microbiota across Individual Animals
Elie Jami (2012)
10.2527/jas.2005-652
Efficacy of ionophores in cattle diets for mitigation of enteric methane.
Howard Guan (2006)
10.2527/jas.2013-6472
Duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: short-chain fatty acid and lactate absorption, saliva production, and blood metabolites.
Tyler Schwaiger (2013)
10.1371/journal.pone.0123942
Epigenetic Mechanisms Contribute to the Expression of Immune Related Genes in the Livers of Dairy Cows Fed a High Concentrate Diet
Guangjun Chang (2015)
10.3168/jds.2011-4465
Rumen epithelial adaptation to ruminal acidosis in lactating cattle involves the coordinated expression of insulin-like growth factor-binding proteins and a cholesterolgenic enzyme.
Michael A Steele (2012)
Controlling methane production with virginiamycin . Animal production in Australia
EH Clayton (1996)
10.1196/annals.1419.022
Plant cell wall breakdown by anaerobic microorganisms from the Mammalian digestive tract.
Harry J. Flint (2008)
10.1016/j.vetimm.2008.10.305
Impact of oxidative stress on the health and immune function of dairy cattle.
Lorraine M Sordillo (2009)
10.3168/jds.S0022-0302(92)78069-2
Effect of yeast culture supplement on production, rumen fermentation, and duodenal nitrogen flow in dairy cows.
Lourens Johannes Christoffel Erasmus (1992)
10.3168/jds.S0022-0302(07)71577-1
Effects of prepartum administration of a monensin controlled release capsule on rumen pH, feed intake, and milk production of transition dairy cows.
A M Fairfield (2007)
10.3920/978-90-8686-781-3_124
Recent advances in understanding the interactions between nutrients and immunity in farm animals
Kirk C. Klasing (2013)
10.1371/journal.pone.0081602
Downregulation of Cellular Protective Factors of Rumen Epithelium in Goats Fed High Energy Diet
Manfred Hollmann (2013)
10.1111/jpn.12230
Effects of essential oils, yeast culture and malate on rumen fermentation, blood metabolites, growth performance and nutrient digestibility of Baluchi lambs fed high-concentrate diets.
M. Malekkhahi (2015)
10.3168/jds.2013-6700
Increased papillae growth and enhanced short-chain fatty acid absorption in the rumen of goats are associated with transient increases in cyclin D1 expression after ruminal butyrate infusion.
Moolchand Malhi (2013)
10.1016/J.LIVSCI.2011.05.009
Effects of the inclusion of dried molassed sugar beet pulp in a low-forage diet on the digestive process and blood biochemical parameters of Holstein steers
Mohsen Mojtahedi (2011)
10.3844/AJAVSP.2013.8.27
BUTYRATE-MEDIATED GENOMIC CHANGES INVOLVED IN NON-SPECIFIC HOST DEFENSES, MATRIX REMODELING AND THE IMMUNE RESPONSE IN THE RUMEN EPITHELIUM OF COWS AFFLICTED WITH SUBACUTE RUMINAL ACIDOSIS
L. Dionissopoulos (2013)
10.1128/CMR.8.2.268
Endotoxemia: methods of detection and clinical correlates.
J. Hurley (1995)
10.1016/J.ANIFEEDSCI.2015.10.010
Impact of Saccharomyces cerevisiae fermentation product and subacute ruminal acidosis on production, inflammation, and fermentation in the rumen and hindgut of dairy cows
Shengli Li (2016)
10.1016/J.ANIFEEDSCI.2014.11.009
Thyme and cinnamon essential oils: Potential alternatives for monensin as a rumen modifier in beef production systems
behzad khorrami (2015)
10.2527/jas1981.531206x
Prevention of lactic acidosis in cattle by lasalocid or monensin.
T G Nagaraja (1981)
10.1111/j.1530-0277.2001.tb02418.x
Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin.
Nobuyuki Enomoto (2001)
10.2527/jas1981.522418x
Effects of lasalocid or monensin on lactate-producing or -using rumen bacteria.
Stanley M Dennis (1981)
10.2527/jas.2014-7594
Experimental acute rumen acidosis in sheep: consequences on clinical, rumen, and gastrointestinal permeability conditions and blood chemistry.
Andrea Minuti (2014)
10.1371/journal.pone.0083424
Characterization of the Core Rumen Microbiome in Cattle during Transition from Forage to Concentrate as Well as during and after an Acidotic Challenge
Renée M Petri (2013)
10.1186/s12917-015-0549-8
Evaluation of eating and rumination behaviour in 300 cows of three different breeds using a noseband pressure sensor
Ueli Braun (2015)
10.1079/AHRR200237
Transfer of energy substrates across the ruminal epithelium: implications and limitations.
Gotthold Gaebel (2002)
10.1128/AEM.00739-09
Rumen Microbiome Composition Determined Using Two Nutritional Models of Subacute Ruminal Acidosis
Ehsan Khafipour (2009)
10.1016/j.plipres.2013.12.001
Regulation of energy metabolism by long-chain fatty acids.
Manabu T. Nakamura (2014)
10.2527/jas.2013-6471
The duration of time that beef cattle are fed a high-grain diet affects the recovery from a bout of ruminal acidosis: dry matter intake and ruminal fermentation.
Tyler Schwaiger (2013)
10.1016/j.cvfa.2007.04.002
Acidosis in feedlot cattle.
T G Nagaraja (2007)
10.1016/0377-8401(89)90050-3
Efficacy of supplemental dietary neutralizing agents for lactating dairy cows. A review
Charles R. Staples (1989)
10.1007/s00248-017-0940-z
Changes in Microbiota in Rumen Digesta and Feces Due to a Grain-Based Subacute Ruminal Acidosis (SARA) Challenge
Jan C. Plaizier (2017)
10.3168/jds.S0022-0302(07)71569-2
Ruminal lipopolysaccharide concentration and inflammatory response during grain-induced subacute ruminal acidosis in dairy cows.
G. N. Gozho (2007)
10.22099/ijvr.2009.1085
Prevalence of subacute ruminal acidosis in some dairy herds of Khorasan Razavi province, northeast of Iran
Javad Tajik (2009)
10.1186/s12917-016-0907-1
Lipopolysaccharide derived from the digestive tract triggers an inflammatory response in the uterus of mid-lactating dairy cows during SARA
Muhammad Shahid Bilal (2016)
10.1128/AAC.7.3.349
Inhibitory Effects of Lipophilic Acids and Related Compounds on Bacteria and Mammalian Cells
C. W. Sheu (1975)
10.1016/j.anaerobe.2013.08.003
Impact of subacute ruminal acidosis (SARA) adaptation on rumen microbiota in dairy cattle using pyrosequencing.
Sheng-yong Mao (2013)
10.1016/J.ANIFEEDSCI.2015.02.006
In vitro ruminal fermentation of ground and dry-rolled barley grain differing in starch content
Uchenna Y. Anele (2015)
10.1128/aem.56.6.1588-1593.1990
Effect of ionophores and pH on growth of Streptococcus bovis in batch and continuous culture.
Jerry M. Chow (1990)
10.3168/jds.2014-8640
The periparturient period is associated with structural and transcriptomic adaptations of rumen papillae in dairy cattle.
Michael A Steele (2015)
10.3168/jds.2008-1389
A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation.
Ehsan Khafipour (2009)
10.3168/jds.S0022-0302(88)79930-0
Dietary Buffering Requirements of the Lactating Dairy Cow: A Review
Ruud A.M. Erdman (1988)
Ruminal acidosis in a 21-month-old Holstein heifer.
Helen M. Golder (2014)
10.1152/ajpregu.00035.2014
Short-term adaptation of the ruminal epithelium involves abrupt changes in sodium and short-chain fatty acid transport.
B. L. Schurmann (2014)
10.2527/jas1986.633888x
Response to monensin in cattle during subacute acidosis.
Douglas G Burrin (1986)
10.3168/jds.S0022-0302(97)76038-7
Effect of yeast culture (Saccharomyces cerevisiae) on adaptation of cows to diets postpartum.
Peter H. Robinson (1997)
10.1016/s0749-0720(20)30038-4
Veterinary Clinics of North America. Food Animal Practice
Claude Saegerman (2012)
10.3168/jds.2011-4421
Invited review: Role of physically effective fiber and estimation of dietary fiber adequacy in high-producing dairy cattle.
Q. Zebeli (2012)
10.1007/s11306-017-1204-0
Comparative metabolome analysis of ruminal changes in Holstein dairy cows fed low- or high-concentrate diets
Ruiyang Zhang (2017)
10.1093/jn/134.1.11
An energy-rich diet causes rumen papillae proliferation associated with more IGF type 1 receptors and increased plasma IGF-1 concentrations in young goats.
Zanming Shen (2004)
10.1111/j.1365-2672.2009.04376.x
Effects of sampling location and time, and host animal on assessment of bacterial diversity and fermentation parameters in the bovine rumen.
Michael Y. Li (2009)
10.2527/jas.2010-3460
Ruminant Nutrition Symposium: Productivity, digestion, and health responses to hindgut acidosis in ruminants.
Tanya F Gressley (2011)
10.3168/jds.S0022-0302(04)73142-2
Comparison of techniques for measurement of rumen pH in lactating dairy cows.
Todd F. Duffield (2004)
10.3168/jds.2014-8219
Efficacy of the direct-fed microbial Enterococcus faecium alone or in combination with Saccharomyces cerevisiae or Lactococcus lactis during induced subacute ruminal acidosis.
Jocelyne Chiquette (2015)
10.3168/jds.S0022-0302(97)76075-2
Creating a system for meeting the fiber requirements of dairy cows.
David R. Mertens (1997)
10.1016/J.LIVSCI.2017.07.015
Gastrointestinal endotoxin and metabolic responses in cows fed and recovered from two different grain-rich challenges
Muhammad Qumar (2017)
10.3168/jds.2007-0608
A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects.
Todd F. Duffield (2008)
10.3168/jds.2012-5403
A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows.
F. Saleem (2012)
10.1111/j.1749-6632.1998.tb09016.x
Effect of bile acids on endotoxin in vitro and in vivo (physico-chemical defense). Bile deficiency and endotoxin translocation.
Lóránd Bertók (1998)
Increased understandings of ruminal acidosis in dairy cattle
Helen M. Golder (2013)
10.1016/j.cvfa.2014.07.003
Feeding, evaluating, and controlling rumen function.
I Lean (2014)
Monensin, a new biologically active compound. II. Fermentation studies.
William Max Stark (1967)
10.3168/jds.2015-10351
Development and physiology of the rumen and the lower gut: Targets for improving gut health.
Michael A Steele (2016)
10.1016/J.ANIFEEDSCI.2007.04.019
Effects of active dry yeasts on the rumen microbial ecosystem : Past, present and future
Frédérique Chaucheyras-Durand (2008)
10.1177/1753425907087267
Clearance of bacterial lipopolysaccharides and lipid A by the liver and the role of arginino-succinate synthase
Motonobu Satoh (2008)
10.1016/j.cbpa.2008.01.015
Host-bacterial coevolution and the search for new drug targets.
J. Zaneveld (2008)
10.3168/jds.2011-5080
Meta-analysis reveals threshold level of rapidly fermentable dietary concentrate that triggers systemic inflammation in cattle.
Q. Zebeli (2012)
10.3168/jds.S0022-0302(05)73048-4
Inducing subacute ruminal acidosis in lactating dairy cows.
K M Krause (2005)
10.1128/aem.58.8.2583-2591.1992
Response surface analysis of the effects of pH and dilution rate on Ruminococcus flavefaciens FD-1 in cellulose-fed continuous culture.
Y Shi (1992)
10.3168/jds.S0022-0302(99)75340-3
Diagnostic methods for the detection of subacute ruminal acidosis in dairy cows.
Edgar F. Garrett (1999)
10.1152/ajpregu.00120.2010
Bovine rumen epithelium undergoes rapid structural adaptations during grain-induced subacute ruminal acidosis.
Michael A Steele (2011)
10.1016/S0168-6445(03)00019-6
Ionophore resistance of ruminal bacteria and its potential impact on human health.
James B. Russell (2003)
10.1071/ar9950393
Virginiamycin to protect sheep fed wheat, barley or oats from grain poisoning under simulated drought feeding conditions
Si Godfrey (1995)
10.2527/JAM2016-0484
0484 Phosphorus utilization on dairy farms in Manitoba.
Vajira Senaratne (2016)
10.1128/aem.53.7.1620-1625.1987
Susceptibility and resistance of ruminal bacteria to antimicrobial feed additives.
T G Nagaraja (1987)
10.1007/s00253-008-1528-9
Effect of monensin feeding and withdrawal on populations of individual bacterial species in the rumen of lactating dairy cows fed high-starch rations
Paul J. Weimer (2008)
10.2527/jas1987.6541064x
In vitro lactic acid inhibition and alterations in volatile fatty acid production by antimicrobial feed additives.
T G Nagaraja (1987)
10.18632/oncotarget.7371
Lipopolysaccharide derived from the digestive tract activates inflammatory gene expression and inhibits casein synthesis in the mammary glands of lactating dairy cows
Kai Zhang (2016)
10.2527/jas1982.543649x
Effect of lasalocid, monensin or thiopeptin on lactic acidosis in cattle.
T G Nagaraja (1982)
10.1146/annurev-micro-092412-155618
Biomass utilization by gut microbiomes.
Bryan A. White (2014)
10.1038/nrmicro3050
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Abdessamad El Kaoutari (2013)
10.1152/ajpregu.00425.2004
Functional organization of the bovine rumen epithelium.
C Graham (2005)
10.1186/1751-0147-44-S1-S141
Bovine Endotoxicosis – Some Aspects of Relevance to Production Diseases. A Review*
Pia Haubro Andersen (2003)
10.1146/annurev.nutr.23.011702.073408
Nutritional regulation of milk fat synthesis.
Dale Elton Bauman (2003)
Effect of grain- and alfalfa pellet-induced sub-acute rumen acidosis (SARA) challenges on oxidative stress in dairy cows
O Karmin (2011)
10.18632/oncotarget.18151
Rumen-derived lipopolysaccharide provoked inflammatory injury in the liver of dairy cows fed a high-concentrate diet
Junfei Guo (2017)
10.2527/jas.2010-3301
Ruminant Nutrition Symposium: Role of fermentation acid absorption in the regulation of ruminal pH.
Jörg R Aschenbach (2011)
10.3168/jds.S0022-0302(97)76207-6
A new method of measuring diet abrasion and its effect on the development of the forestomach.
R. H. Greenwood (1997)
10.2527/1998.761275x
Acidosis in cattle: a review.
F N Owens (1998)
10.4141/CJAS10047
Review: The use of direct fed microbials to mitigate pathogens and enhance production in cattle
Tim A McAllister (2011)
10.3844/AJAVSP.2012.84.91
Adaptation to High Grain Diets Proceeds Through Minimal Immune System Stimulation and Differences in Extracellular Matrix Protein Expression in A Model of Subacute Ruminal Acidosis in Non-lactating Dairy Cows
Louis Dionissopoulos (2012)



This paper is referenced by
10.1017/S002202992000031X
Contrasting effects of high-starch and high-sugar diets on ruminal function in cattle.
Andrea Francesio (2020)
10.1017/s0022029920000369
Ruminal epithelium: a checkpoint for cattle health.
Lisa Baaske (2020)
10.1007/s11250-020-02261-2
Effects of inclusion of corn gluten feed in dairy rations on dry matter intake, milk yield, milk components, and ruminal fermentation parameters: a meta-analysis
Babak Darabighane (2020)
10.1016/j.anifeedsci.2019.114299
Effects of dietary supplementation of inulin on rumen fermentation and bacterial microbiota, inflammatory response and growth performance in finishing beef steers fed high or low-concentrate diet
Ke Tian (2019)
10.1016/J.ANIFEEDSCI.2019.02.002
Effect of extruded linseed supplementation, grain source and pH on dietary and microbial fatty acid outflows in continuous cultures of rumen microorganisms
Valérie Berthelot (2019)
10.1017/S1751731118002690
Herbivore nutrition supporting sustainable intensification and agro-ecological approaches.
Isabelle Cassar-Malek (2018)
10.1093/jas/skz308
Effects of a blend of Saccharomyces cerevisiae-based direct-fed microbial and fermentation products in the diet of newly weaned beef steers: Growth performance, whole-blood immune gene expression, serum biochemistry and plasma metabolome.
James A. Adeyemi (2019)
10.3390/microorganisms8060877
An Overview of the Elusive Passenger in the Gastrointestinal Tract of Cattle: The Shiga Toxin Producing Escherichia coli
Panagiotis Sapountzis (2020)
10.3389/fmicb.2019.02861
Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock
Ferenc Peles (2019)
10.3168/jds.2019-16294
Potential for a localized immune response by the ruminal epithelium in nonpregnant heifers following a short-term subacute ruminal acidosis challenge.
Coral Kent-Dennis (2019)
10.1017/S1751731119001629
Combinations of non-invasive indicators to detect dairy cows submitted to high-starch-diet challenge
C Villot (2019)
10.1007/978-3-030-21309-1_7
Designer Probiotics: The Next-Gen High Efficiency Biotherapeutics
Birbal Singh (2019)
10.1017/s1751731119003112
Review: Rumen sensors: data and interpretation for key rumen metabolic processes.
Jan Dijkstra (2020)
10.3389/fmicb.2019.02761
Differently Pre-treated Alfalfa Silages Affect the in vitro Ruminal Microbiota Composition
Thomas Hartinger (2019)
Semantic Scholar Logo Some data provided by SemanticScholar