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Design Of Hybrid Hydrogels With Self-assembled Nanogels As Cross-linkers: Interaction With Proteins And Chaperone-like Activity.

N. Morimoto, T. Endo, Y. Iwasaki, K. Akiyoshi
Published 2005 · Medicine, Chemistry

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New hybrid hydrogels with nanogel domains were obtained by using polymerizable self-assembled nanogels as cross-linkers. Methacryloyl groups were introduced to cholesteryl group-bearing pullulan (CHP). The methacryloyl group-bearing CHPs (CHPMAs) formed nanogels by their self-association in water (R(g) = 14-17 nm). CHPMA nanogels were polymerized with 2-methacryloyloxyethyl phosphorylcholine (MPC) by radical polymerization in a semidilute aqueous solution. CHPMA nanogels acted as effective cross-linkers for gelation. TEM observation showed that the nanogel structure was retained after gelation and that the nanogels were well dispersed in the macrogel. The hybrid hydrogels showed two well-defined networks such as a nanogel intranetwork structure of less than 10 nm (physically cross-linking) and an internetwork structure of several hundred nanometers (chemically cross-linking). The immobilized nanogels retained their ability to trap and release protein (insulin was used as a model protein) by host-guest interaction of the cholesteryl group and cyclodextrin and also showed high chaperone-like activity for refolding of chemically denatured protein.



This paper is referenced by
10.1002/9780470152928.CH6
Nanogels: Chemistry to Drug Delivery
Murali M Yallapu (2007)
10.1016/j.jconrel.2009.11.023
Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function.
T. Hirakura (2010)
10.1098/rsif.2010.0223
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Kangwon Lee (2010)
10.1016/j.carbpol.2017.04.089
Pullulan: A novel molecule for biomedical applications.
R. Singh (2017)
10.2745/DDS.29.323
Development of nanogel engineering for new protein drug delivery system and medical applications
Kazunari Akiyoshi (2014)
The role of microbial pullulan, a biopolymer in pharmaceutical approaches: A review.
Bishwambhar Mishra (2011)
10.2147/IJN.S61566
Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model
Toshimi Sato (2015)
10.1002/art.30151
Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice.
Paksinee Kamolratanakul (2011)
10.1016/J.JCONREL.2007.01.004
Polysaccharide hydrogels for modified release formulations.
T. Coviello (2007)
10.21007/etd.cghs.2017.0429
Biodegradable Polymeric Biomaterials in Different Forms for Long-acting Contraception and Drug Delivery to the Eye and Brain
D. Janagam (2017)
10.1016/J.EURPOLYMJ.2019.02.020
The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels
Lorena Anna Ditta (2019)
10.1016/j.msec.2020.111390
Facile Synthesis of Nanogels modified Fe3O4@Ag NPs for the efficient adsorption of Bovine & Human Serum Albumin
M. T. Shah (2021)
10.1039/d0bm00986e
Functional zwitterionic biomaterials for administration of insulin.
Xingyu Chen (2020)
10.1039/B916942C
High mechanical strength and rapid response rate of poly(N-isopropyl acrylamide) hydrogel crosslinked by starch-based nanospheres
Y. Tan (2010)
10.3390/polym12061266
Conformation of Pullulan in Aqueous Solution Studied by Small-Angle X-ray Scattering
J. Yang (2020)
10.1007/s10924-020-01775-y
Synthesis of Nano-Polymer Supported on Nano-Hydrogel Chitosan Base and Its Application for DOX Delivery
Babak Ghaem (2020)
10.1007/978-1-4419-5919-5_18
Self-assembled Nanogel Engineering
Nobuyuki Morimoto (2010)
10.1246/CL.2012.202
Self-assembled Nanogel Engineering for Advanced Biomedical Technology
Yoshihiro Sasaki (2012)
10.1016/j.msec.2016.05.095
One pot synthesis and characterization of Fe3O4 Nanorod-PNIPA Nanogel Composite for protein adsorption.
Kausar Rajar (2016)
10.1002/POLA.22820
Controlled Release and Interaction of Protein Using Self-Assembling Peptide RATEA16 Nanofiber Hydrogels
Ying Zhao (2008)
10.5360/MEMBRANE.36.191
Nanogel Engineering for Development of New Drug Delivery System
Shin-ichi Sawada (2011)
10.1016/j.jcis.2017.01.002
Robust, tough and anti-fatigue cationic latex composite hydrogels based on dual physically cross-linked networks.
S. Gu (2017)
10.1016/j.jconrel.2009.06.025
Raspberry-like assembly of cross-linked nanogels for protein delivery.
Urara Hasegawa (2009)
10.1002/MABI.200600101
Amphiphilic poly(D,L-lactic acid)/poly(ethylene glycol)/poly(D,L-lactic acid) nanogels for controlled release of hydrophobic drugs.
W. Lee (2006)
10.1016/j.colsurfb.2011.09.025
Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery.
Asako Shimoda (2012)
10.1016/j.msec.2014.10.025
High-performance scaffolds on titanium surfaces: osteoblast differentiation and mineralization promoted by a globular fibrinogen layer through cell-autonomous BMP signaling.
N. Horasawa (2015)
Nouveaux hydrogels à base de polysaccharide obtenus par voie biomimétique ou par photoréticulation.
A. Hadrich (2019)
10.1016/J.CHROMA.2007.01.116
Characterizing property distributions of polymeric nanogels by size-exclusion chromatography.
T. Mourey (2007)
10.1002/POLA.21958
Formation of nanogel aggregates by an amphiphilic cholesteryl‐poly(amidoamine) dendrimer in aqueous media
D. Zhang (2007)
10.1007/s13233-012-0054-x
Biodegradable nanogel-integrated hydrogels for sustained protein delivery
Asako Shimoda (2012)
Host responses to microgel-based biomaterial interfaces
A. Bridges (2008)
10.4155/tde.15.71
Polymer-based vehicles for therapeutic peptide delivery.
J. Zhang (2015)
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