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Multiplexed Detection Of Protein Cancer Markers With Biobarcoded Nanoparticle Probes.
S. Stoeva, J. Lee, J. Smith, S. Rosen, C. Mirkin
Published 2006 · Chemistry, Medicine
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We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings.
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