Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Multiplexed Detection Of Protein Cancer Markers With Biobarcoded Nanoparticle Probes.

S. Stoeva, J. Lee, J. Smith, S. Rosen, C. Mirkin
Published 2006 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings.



This paper is referenced by
10.1002/elps.201400001
Highly sensitive detection of cancer cells based on the DNA barcode assay and microcapillary electrophoretic analysis
Soyi Chung (2014)
10.1016/j.bios.2017.01.051
A universal aptameric biosensor: Multiplexed detection of small analytes via aggregated perylene-based broad-spectrum quencher.
Rong Hu (2017)
10.1038/srep30577
Efficient double-quenching of electrochemiluminescence from CdS:Eu QDs by hemin-graphene-Au nanorods ternary composite for ultrasensitive immunoassay
J. Liu (2016)
10.1016/J.PMATSCI.2017.04.001
Nucleic acid based polymer and nanoparticle conjugates: Synthesis, properties and applications
A. Kundu (2017)
10.1016/j.aca.2009.04.017
A rapid and simple method for ultrasensitive electrochemical immunoassay of protein by an electric field-driven strategy.
F. Yan (2009)
10.1016/j.bmcl.2008.07.064
Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification.
Eric Schopf (2008)
10.1201/9781315371535-8
Tuning Optical Properties of Lanthanide Upconversion Nanoparticles
Y. Zhang (2016)
10.1039/B608442G
Protein detection using biobarcodes.
Uwe R. Müller (2006)
10.1016/j.biochi.2010.07.004
A gold nanoparticle-based strategy for label-free and colorimetric screening of DNA triplex binders.
Cuie Chen (2010)
10.1016/j.bios.2010.04.010
Nanotechniques in proteomics: current status, promises and challenges.
Sandipan Ray (2010)
10.1002/smll.201000262
Aptatag-based multiplexed assay for protein detection by surface-enhanced Raman spectroscopy.
L. Fabris (2010)
10.1016/j.addr.2010.03.004
DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications☆
Michael J. Campolongo (2010)
10.1021/ac200398x
Ultrasensitive immunoassay of protein biomarker based on electrochemiluminescent quenching of quantum dots by hemin bio-bar-coded nanoparticle tags.
Dajie Lin (2011)
10.1016/j.bios.2012.04.039
Highly-sensitive electrochemical immunosensing method based on dual amplification systems.
T. Yasukawa (2012)
10.1373/CLINCHEM.2006.082271
Ultrasensitive densitometry detection of cytokines with nanoparticle-modified aptamers.
Yuan-Yuan Li (2007)
10.1586/erm.09.47
Microelectrical sensors as emerging platforms for protein biomarker detection in point-of-care diagnostics
David L Arruda (2009)
Evanescent field enhanced fluorescence on a photonic crystal surface
A. Pokhriyal (2013)
10.1016/j.saa.2012.04.085
Indole-3-acetic acid biosensor based on G-rich DNA labeled AuNPs as chemiluminescence probe coupling the DNA signal amplification.
X. Hun (2012)
Progress With a Purpose: Eliminating Suffering and Death Due to Cancer
A. C. Eschenbach (2006)
10.1038/nprot.2007.201
Detection of proteins using a colorimetric bio-barcode assay
J. Nam (2007)
10.1016/j.bios.2013.12.066
Enzyme-free and label-free ultrasensitive electrochemical detection of DNA and adenosine triphosphate by dendritic DNA concatamer-based signal amplification.
S. Liu (2014)
10.1039/c1cc12659h
Antibody-functionalized SERS tags with improved sensitivity.
N. Guarrotxena (2011)
10.1007/978-981-13-0848-2
Quorum Sensing and its Biotechnological Applications
V. C. Kalia (2018)
10.1016/j.bios.2018.05.006
Dual-wavebands-resolved electrochemiluminescence multiplexing immunoassay with dichroic mirror assistant photomultiplier-tubes as detectors.
F. Zhang (2018)
10.1016/j.tibtech.2015.03.002
Digital detection of biomarkers assisted by nanoparticles: application to diagnostics.
M. Cretich (2015)
10.1021/acs.bioconjchem.6b00529
Universal Biotin-PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins.
A. Scott (2017)
10.1021/ac200713f
Amplification strategy using aggregates of ferrocene-containing cationic polythiophene for sensitive and specific electrochemical detection of DNA.
Patricia Harding Lepage (2011)
10.3762/bjnano.6.28
Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization
Lisa Landgraf (2015)
10.1007/S11051-010-0101-5
Surface modification of permalloy (Ni80Fe20) nanoparticles for biomedical applications
G. Qin (2011)
10.1016/B978-044453057-8.50013-1
CHAPTER 11 – Digestive Ripening, or “Nanomachining,” to Achieve Nanocrystal Size Control
K. Klabunde (2008)
10.1002/anie.200904359
Gold nanoparticles for biology and medicine.
D. Giljohann (2010)
10.1002/elps.201900007
Two‐step signal amplification for high‐sensitivity detection of biomarkers using gold nanoparticle–based conjugates
P. Zhang (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar