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Polymer-caged Lipsomes: A PH-responsive Delivery System With High Stability.
S. Lee, H. Chen, C. Dettmer, T. O’Halloran, S. Nguyen
Published 2007 · Chemistry, Medicine
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Polymer-incorporated liposomes were prepared from preformed liposomes and a cholesterol-functionalized poly(acrylic acid) additive via a simple drop-in procedure. These modified liposomes possess surface-active carboxylate groups that can be cross-linked with telechelic 2,2‘-(ethylenedioxy)bis(ethylamine) linkers, resulting in polymer-caged liposomes (PCLs) that are highly stable and have tunable pH-sensitive responses.
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