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Methodology For The Preparation Of N-guanidino-modified Arginines And Related Derivatives

F. Wagenaar, J. Kerwin
Published 1993 · Chemistry

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Methods for the preparation of N G -modified arginines and N δ -heterocyclic ornithines are described. The reactive cyanamide intermediate tert-butyl N α -Boc-N δ -cyano-L-ornithinate (2), prepared either by treatment of tert-butyl N α -Boc-L-ornithinate (5) with cyanogen bromide or by dehydration of tert-butyl N α -Boc-L-citrullinate (6), was utilized to prepare N G -hydroxy-L-arginine, N G -amino-L-arginine, and N G -methoxy-L-arginine



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