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Steroidal Alkaloids From The Leaves Of Sarcococca Coriacea Of Nepalese Origin.

S. Kalauni, M. Choudhary, F. Shaheen, M. D. Manandhar, Atta-ur-rahman, M. B. Gewali, A. Khalid
Published 2001 · Chemistry, Medicine

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Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.
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