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Highly Enantioselective Alpha-aminoxylation Of Aldehydes And Ketones With A Polymer-supported Organocatalyst.

D. Font, Amaia Bastero, S. Sayalero, C. Jimeno, M. A. Pericàs
Published 2007 · Chemistry, Medicine

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The first catalytic enantioselective alpha-aminoxylation of aldehydes and ketones using an insoluble, polymer-supported organocatalyst (1) derived from trans-4-hydroxyproline is reported (ee: 96-99%). Reaction rates in the aminoxylation of cyclic ketones with 1 are higher than those reported with l-proline. The insoluble nature of 1 simplifies workup conditions and allows catalyst recycling without an apparent decrease in enantioselectivity or yield.



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