← Back to Search
Survey Of GMP Bulk Reactions Run In A Research Facility Between 1985 And 2002
R. Dugger, and John A. Ragan, D. Ripin
Published 2005 · Chemistry
Download PDFAnalyze on Scholarcy
A review of reactions scaled in the GMP facilities at the Pfizer-Groton site was undertaken. Reactions were categorized into one of seven categories: carbon−carbon bond formation, carboxylic acid derivative interconversion, carbon−nitrogen bond formation, carbon−oxygen bond formation, red-ox, salt formation/resolution, and other. Reactions scaled from 1997 to 2002 were compared to chemistry scaled from 1985 to 1996 to look for changes in the nature of chemistry being scaled between the two time periods. Reactions were further subcategorized within those categories, and some interesting trends were noted.
This paper is referenced by
Recyclable palladium catalyst cloths for carbon-carbon coupling reactions
M. Wilson (2017)
ipase immobilization on hyroxypropyl methyl cellulose support and ts applications for chemo-selective synthesis of-amino ester ompounds irtikumar
C. Badgujar (2016)
De novo synthesis of polysubstituted naphthols and furans using photoredox neutral coupling of alkynes with 2-bromo-1,3-dicarbonyl compounds.
H. Jiang (2013)
Palladium Nanoparticles Supported in the Nanospaces of Imidazolium-Based Bifunctional PMOs: The Role of Plugs in Selectivity Changeover in Aerobic Oxidation of Alcohols
B. Karimi (2015)
The Continuous Catalytic Debenzylation of 1,4-Dibenzyloxybenzene with H2 in THF Expanded with High Pressure CO2
Geoffrey R Akien (2010)
Cu(II)-catalyzed oxidative esterification of 2-carbonyl substituted phenols from the alcohol oxidation level
Satyasheel Sharma (2013)
Sodium cyanide‐promoted copper‐catalysed aerobic oxidative synthesis of esters from aldehydes
N. Nowrouzi (2017)
NH3⋅H2O: The Simplest Nitrogen‐Containing Ligand for Selective Aerobic Alcohol Oxidation to Aldehydes or Nitriles in Neat Water
Guofu Zhang (2018)
A General and Practical Palladium-Catalyzed Direct α-Arylation of Amides with Aryl Halides.
B. Zheng (2014)
Ruthenium(II) carbonyl complexes containing pyridoxal thiosemicarbazone and trans-bis(triphenylphosphine/arsine): Synthesis, structure and their recyclable catalysis of nitriles to amides and synthesis of imidazolines
R. Manikandan (2015)
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
D. Constable (2007)
Recent advances in immobilized metal catalysts for environmentally benign oxidation of alcohols.
T. Matsumoto (2008)
Copper Catalyzed Selective Oxidation of Benzyl Alcohol to Benzaldehyde
Pradeep D. Lokhande (2012)
Lithium Enolates Derived from Pyroglutaminol: Mechanism and Stereoselectivity of an Azaaldol Addition.
Michael J. Houghton (2016)
Expanding the medicinal chemistry synthetic toolbox
J. Boström (2018)
Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1 : 1 ratio under solvent-free conditions
Zhi Tang (2017)
Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes.
N. Guimond (2009)
Highly efficient, organocatalytic aerobic alcohol oxidation.
M. Shibuya (2011)
A manganese Schiff base complex immobilized on copper–ferrite magnetic nanoparticles as an efficient and recyclable nanocatalyst for selective oxidation of alcohols
Mahmood Tavakoli Hafshejani (2018)
Lithiumdiisopropylamid: Reaktionskinetik in Lsung und Folgerungen fr die organische Synthese
David B. Collum (2007)
Novel 2,2,6,6‐Tetramethylpiperidine 1‐Oxyl–Iodobenzene Hybrid Catalyst for Oxidation of Primary Alcohols to Carboxylic Acids
T. Yakura (2011)
2-Iodoxybenzenesulfonic acid as an extremely active catalyst for the selective oxidation of alcohols to aldehydes, ketones, carboxylic acids, and enones with oxone.
M. Uyanik (2009)
Hypervalent iodine-mediated oxidation of alcohols.
M. Uyanik (2009)
Enantioselective Alkylation of 2-Alkyl Pyridines Controlled by Organolithium Aggregation.
Joshua J Gladfelder (2019)
Nitrene chemistry in organic synthesis: still in its infancy?
Geoffroy Dequirez (2012)
Phosphotungstic Acid Supported on MgAl2O4 Nanoparticles as an Efficient and Reusable Nanocatalyst for Benzylic Alcohols Oxidation with Hydrogen Peroxide
Reza Hajavazzade (2019)
LDA-mediated domino carbolithiation reactions of vinylidenecyclopropanes with but-3-yn-2-one and 1-phenylprop-2-yn-1-one
Bei-li Lu (2010)
Copper-catalyzed direct alkenylation of N-iminopyridinium ylides.
J. Mousseau (2010)
Minisci reactions: Versatile CH-functionalizations for medicinal chemists
M. Duncton (2011)
Lewis‐Acid‐Catalyzed Benzylic Reactions of 2‐Methylazaarenes with Aldehydes
D. Mao (2014)
Csp3–N bond formation in aminothiophenes by 1,1-dibromo isocyanide: the unexpected 1,5-binucleophilicity of substrates
Amir Hossein Vahabi (2017)
Industrial applications of the Diels-Alder reaction.
Jacques-Alexis Funel (2013)See more