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Synthesis Of Pyrazines From Rhodium-catalyzed Reaction Of 2H-Azirines With N-sulfonyl 1,2,3-triazoles.

T. Ryu, Y. Baek, P. Lee
Published 2015 · Chemistry, Medicine

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An efficient synthetic route to a wide range of trisubstituted pyrazines is developed from Rh-catalyzed reaction of 2H-azirines with N-sulfonyl-1,2,3-triazoles through the elimination of nitrogen molecule and arylsulfinic acid. The present reaction proceeds through formation of in situ generated dihydropyrazines.
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