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Total Synthesis Of (-)-Carinatine A And (+)-Lycopladine A.

Lingxing Meng
Published 2016 · Chemistry, Medicine

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An efficient synthesis of two Lycopodium alkaloids, (-)-carinatine A and (+)-lycopladine A, is achieved in eight steps. The synthesis features an intramolecular aldol reaction for assembling the 6,5-fused ring system, a subsequent Tsuji-Trost allylation for generating a quarternary carbon center, and a 6π-electrocyclization to form the pyridine ring.
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