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Visible-Light-Mediated Monoselective Ortho C-H Arylation Of 6-Arylpurine Nucleosides With Diazonium Salts.

L. Liang, Ming-Sheng Xie, Haixia Wang, Hong-Ying Niu, G. Qu, H. Guo
Published 2017 · Medicine, Chemistry

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A combined palladium- and photoredox-catalyzed monoselective arylation of 6-arylpurine nucleosides has been developed by employing purine as a directing group via the photoredox reaction, and many functional groups are well tolerated in this direct C-H arylation condition. Various of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry could be obtained under visible light irradiation at room temperature within 4 h.
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