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Catalyst-Dependent Selective Hydrogenation Of Nitriles: Selective Synthesis Of Tertiary And Secondary Amines.

Y. Monguchi, Masahiro Mizuno, T. Ichikawa, Y. Fujita, E. Murakami, T. Hattori, T. Maegawa, Y. Sawama, H. Sajiki
Published 2017 · Chemistry, Medicine

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In the presence of palladium on carbon (Pd/C) as a catalyst, hydrogenation of aliphatic nitriles in cyclohexane efficiently proceeded at 25-60 °C under ordinary hydrogen gas pressure to afford the corresponding tertiary amines. However, the use of rhodium on carbon (Rh/C) led to the highly selective generation of secondary amines. Hydrogenation of aromatic nitriles and cyclohexanecarbonitrile selectively produced secondary amines in the presence of either Pd/C or Rh/C.
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