Online citations, reference lists, and bibliographies.
← Back to Search

Controllable Nonspecific Protein Adsorption By Charged Hyperbranched Polyglycerol Thin Films.

Yaming Yu, H. Frey
Published 2015 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Antifouling thin films derived from charged hyperbranched polyglycerol (hbPG) layers were fabricated and evaluated. The anionic hbPG (a-hbPG) monolayers and cationic hbPG/anionic hbPG (c/a-hbPG) bilayers were adsorbed on the underlying self-assembled monolayers (SAMs) of cysteamine and 3-mercaptopropionic acid (3-MPA) by electrostatic interaction, respectively, and their procession was monitored by surface plasmon resonance spectroscopy (SPR). The adsorption of bovine serum albumin (BSA) and fibrinogen on the premade a-hbPG and c/a-hbPG thin films was measured and the capability of these thin films to resist nonspecific protein adsorption was evaluated by SPR as well. It is observed that the c/a-hbPG bilayer films possessed good antifouling properties. With c/a-hbPG bilayers consisting of higher molecular weight a-hbPG, the adsorption of BSA and fibrinogen were as low as 0.015 ng/mm(-2) and 0.0076 ng/mm(-2), respectively, comparable to the traditionally ultralow antifouling surfaces (<0.05 ng/mm(-2) of nonspecific protein adsorption). This work proved that the charged hbPG thin films can strongly reduce the nonspecific protein adsorption and have the promise for the antifouling coatings with improved performance.
This paper references
Characterization of protein-resistant dextran monolayers.
R. A. Frazie (2000)
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis
T. Moro (2004)
Surface plasmon resonance studies of protein binding on plasma polymerized di(ethylene glycol) monovinyl ether films
Z. Zhang (2003)
Autoxidation of pyridoxalated hemoglobin polyoxyethylene conjugate.
T. Talarico (1998)
Surface modification of poly(tetrafluoroethylene) films via grafting of poly(ethylene glycol) for reduction in protein adsorption
P. Wang (2000)
Biomaterials: where we have been and where we are going.
B. Ratner (2004)
Synthesis and characterization of glycerol dendrons, self-assembled monolayers on gold: a detailed study of their protein resistance.
M. Wyszogrodzka (2009)
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
E. Ostuni (2001)
Polyelectrolyte multilayers capped with polyelectrolytes bearing phosphorylcholine and triethylene glycol groups: parameters influencing antifouling properties.
Andreas Reisch (2009)
Interfaces and thin films as seen by bound electromagnetic waves.
W. Knoll (1998)
Ultralow fouling polyacrylamide on gold surfaces via surface-initiated atom transfer radical polymerization.
Q. Liu (2012)
Antifouling poly(β-peptoid)s.
S. Lin (2011)
Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties.
R. K. Kainthan (2008)
Protein adsorption on oligo(ethylene glycol)-terminated alkanethiolate self-assembled monolayers: The molecular basis for nonfouling behavior.
L. Li (2005)
Factors that determine the protein resistance of oligoether self-assembled monolayers --internal hydrophilicity, terminal hydrophilicity, and lateral packing density.
S. Herrwerth (2003)
The conformation of serum albumin in solution: a combined phosphorescence depolarization-hydrodynamic modeling study.
M. L. Ferrer (2001)
Poly-2-methyl-2-oxazoline: a peptide-like polymer for protein-repellent surfaces.
Rupert Konradi (2008)
Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol.
M. Oudshoorn (2007)
Electrospun zwitterionic poly(sulfobetaine methacrylate) for nonadherent, superabsorbent, and antimicrobial wound dressing applications.
Reza Lalani (2012)
Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma--material selection and protein immobilization optimization.
Hana Vaisocherová (2009)
Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA.
J. Dalsin (2005)
Polyelectrolyte multilayer coatings that resist protein adsorption at rest and under stretching
Andreas Reisch (2008)
Ellipsometry as a tool to study the adsorption behavior of synthetic and biopolymers at the air–water interface
J. De Feijter (1978)

This paper is referenced by
Hard and soft nanocomposites enabled by rationally designed nonlinear copolymers derived from high functionality polyols
James Iocozzia (2018)
Hyperbranched Polyglycerol Grafting on the Surface of Silica-Coated Nanoparticles for High Colloidal Stability and Low Nonspecific Interaction
Prasanta Panja (2017)
Behavior of lysozyme adsorbed onto biological liquid crystal lipid monolayer at the air/water interface*
Xiaolong Lu (2016)
Polyglycidol of Linear or Branched Architecture Immobilized on a Solid Support for Biomedical Applications
M. Bochenek (2020)
A Clean and Simple Route to Soft, Biocompatible Nanocapsules via UV-Cross-Linkable Azido-Hyperbranched Polyglycerol
James Iocozzia (2017)
Thermal transitions in hyperbranched polyester-polyol assemblies on carbon
E. Farias (2018)
Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications.
Srinivas Abbina (2017)
Thioether-Bearing Hyperbranched Polyether Polyols with Methionine-Like Side-Chains: A Versatile Platform for Orthogonal Functionalization.
Jan Seiwert (2017)
Introduction of an antifouling photoelectrode: an effective strategy for a high-performance photoelectrochemical cytosensor.
Linzheng Ma (2020)
The detection of brucellosis antibody in whole serum based on the low-fouling electrochemical immunosensor fabricated with magnetic Fe3O4@Au@PEG@HA nanoparticles.
Shuli Lv (2018)
From Homogeneous to Heterogeneous: A Simple Approach to Prepare Polymer Brush Modified Surfaces for Anti-Adhesion of Bacteria
X. Zhang (2018)
Poly-l-lysine/heparin multilayer coatings prevent blood protein adsorption.
A. Barrantes (2017)
Semantic Scholar Logo Some data provided by SemanticScholar