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Controllable Nonspecific Protein Adsorption By Charged Hyperbranched Polyglycerol Thin Films.

Yaming Yu, H. Frey
Published 2015 · Chemistry, Medicine

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Antifouling thin films derived from charged hyperbranched polyglycerol (hbPG) layers were fabricated and evaluated. The anionic hbPG (a-hbPG) monolayers and cationic hbPG/anionic hbPG (c/a-hbPG) bilayers were adsorbed on the underlying self-assembled monolayers (SAMs) of cysteamine and 3-mercaptopropionic acid (3-MPA) by electrostatic interaction, respectively, and their procession was monitored by surface plasmon resonance spectroscopy (SPR). The adsorption of bovine serum albumin (BSA) and fibrinogen on the premade a-hbPG and c/a-hbPG thin films was measured and the capability of these thin films to resist nonspecific protein adsorption was evaluated by SPR as well. It is observed that the c/a-hbPG bilayer films possessed good antifouling properties. With c/a-hbPG bilayers consisting of higher molecular weight a-hbPG, the adsorption of BSA and fibrinogen were as low as 0.015 ng/mm(-2) and 0.0076 ng/mm(-2), respectively, comparable to the traditionally ultralow antifouling surfaces (<0.05 ng/mm(-2) of nonspecific protein adsorption). This work proved that the charged hbPG thin films can strongly reduce the nonspecific protein adsorption and have the promise for the antifouling coatings with improved performance.
This paper references
10.1016/S0142-9612(99)00270-7
Characterization of protein-resistant dextran monolayers.
R. A. Frazie (2000)
10.1038/nnano.2007.387
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
10.1038/NMAT1233
Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis
T. Moro (2004)
10.1021/LA026980D
Surface plasmon resonance studies of protein binding on plasma polymerized di(ethylene glycol) monovinyl ether films
Z. Zhang (2003)
10.1006/BBRC.1998.9312
Autoxidation of pyridoxalated hemoglobin polyoxyethylene conjugate.
T. Talarico (1998)
10.1163/156856200743634
Surface modification of poly(tetrafluoroethylene) films via grafting of poly(ethylene glycol) for reduction in protein adsorption
P. Wang (2000)
10.1146/ANNUREV.BIOENG.6.040803.140027
Biomaterials: where we have been and where we are going.
B. Ratner (2004)
10.1021/bm801093t
Synthesis and characterization of glycerol dendrons, self-assembled monolayers on gold: a detailed study of their protein resistance.
M. Wyszogrodzka (2009)
10.1021/LA010384M
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
E. Ostuni (2001)
10.1021/la8037846
Polyelectrolyte multilayers capped with polyelectrolytes bearing phosphorylcholine and triethylene glycol groups: parameters influencing antifouling properties.
Andreas Reisch (2009)
10.1146/ANNUREV.PHYSCHEM.49.1.569
Interfaces and thin films as seen by bound electromagnetic waves.
W. Knoll (1998)
10.1021/bm201814p
Ultralow fouling polyacrylamide on gold surfaces via surface-initiated atom transfer radical polymerization.
Q. Liu (2012)
10.1021/bm200368p
Antifouling poly(β-peptoid)s.
S. Lin (2011)
10.1021/bm701208p
Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties.
R. K. Kainthan (2008)
10.1021/JP0473321
Protein adsorption on oligo(ethylene glycol)-terminated alkanethiolate self-assembled monolayers: The molecular basis for nonfouling behavior.
L. Li (2005)
10.1021/JA034820Y
Factors that determine the protein resistance of oligoether self-assembled monolayers --internal hydrophilicity, terminal hydrophilicity, and lateral packing density.
S. Herrwerth (2003)
10.1016/S0006-3495(01)76211-X
The conformation of serum albumin in solution: a combined phosphorescence depolarization-hydrodynamic modeling study.
M. L. Ferrer (2001)
10.1021/la702917z
Poly-2-methyl-2-oxazoline: a peptide-like polymer for protein-repellent surfaces.
Rupert Konradi (2008)
10.1021/LA701910D
Preparation and characterization of structured hydrogel microparticles based on cross-linked hyperbranched polyglycerol.
M. Oudshoorn (2007)
10.1021/bm300345e
Electrospun zwitterionic poly(sulfobetaine methacrylate) for nonadherent, superabsorbent, and antimicrobial wound dressing applications.
Reza Lalani (2012)
10.1016/j.bios.2008.09.035
Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma--material selection and protein immobilization optimization.
Hana Vaisocherová (2009)
10.1021/LA048626G
Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA.
J. Dalsin (2005)
10.1039/B808467J
Polyelectrolyte multilayer coatings that resist protein adsorption at rest and under stretching
Andreas Reisch (2008)
10.1002/BIP.1978.360170711
Ellipsometry as a tool to study the adsorption behavior of synthetic and biopolymers at the air–water interface
J. De Feijter (1978)



This paper is referenced by
Hard and soft nanocomposites enabled by rationally designed nonlinear copolymers derived from high functionality polyols
James Iocozzia (2018)
10.1021/ACSSUSCHEMENG.7B00292
Hyperbranched Polyglycerol Grafting on the Surface of Silica-Coated Nanoparticles for High Colloidal Stability and Low Nonspecific Interaction
Prasanta Panja (2017)
10.1088/1674-1056/25/9/090506
Behavior of lysozyme adsorbed onto biological liquid crystal lipid monolayer at the air/water interface*
Xiaolong Lu (2016)
10.1080/15583724.2020.1720233
Polyglycidol of Linear or Branched Architecture Immobilized on a Solid Support for Biomedical Applications
M. Bochenek (2020)
10.1021/ACS.MACROMOL.7B01074
A Clean and Simple Route to Soft, Biocompatible Nanocapsules via UV-Cross-Linkable Azido-Hyperbranched Polyglycerol
James Iocozzia (2017)
10.1016/J.EURPOLYMJ.2018.03.021
Thermal transitions in hyperbranched polyester-polyol assemblies on carbon
E. Farias (2018)
10.1039/C7TB02515G
Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications.
Srinivas Abbina (2017)
10.1002/marc.201600457
Thioether-Bearing Hyperbranched Polyether Polyols with Methionine-Like Side-Chains: A Versatile Platform for Orthogonal Functionalization.
Jan Seiwert (2017)
10.1039/c9tb02718a
Introduction of an antifouling photoelectrode: an effective strategy for a high-performance photoelectrochemical cytosensor.
Linzheng Ma (2020)
10.1016/j.bios.2018.06.010
The detection of brucellosis antibody in whole serum based on the low-fouling electrochemical immunosensor fabricated with magnetic Fe3O4@Au@PEG@HA nanoparticles.
Shuli Lv (2018)
10.1016/J.COLCOM.2018.02.002
From Homogeneous to Heterogeneous: A Simple Approach to Prepare Polymer Brush Modified Surfaces for Anti-Adhesion of Bacteria
X. Zhang (2018)
10.1016/j.jcis.2016.09.046
Poly-l-lysine/heparin multilayer coatings prevent blood protein adsorption.
A. Barrantes (2017)
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