Online citations, reference lists, and bibliographies.
← Back to Search

Biocompatible Double-Membrane Hydrogels From Cationic Cellulose Nanocrystals And Anionic Alginate As Complexing Drugs Codelivery.

N. Lin, A. Géze, D. Wouessidjewe, J. Huang, A. Dufresne
Published 2016 · Medicine, Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
A biocompatible hydrogel with a double-membrane structure is developed from cationic cellulose nanocrystals (CNC) and anionic alginate. The architecture of the double-membrane hydrogel involves an external membrane composed of neat alginate, and an internal composite hydrogel consolidates by electrostatic interactions between cationic CNC and anionic alginate. The thickness of the outer layer can be regulated by the adsorption duration of neat alginate, and the shape of the inner layer can directly determine the morphology and dimensions of the double-membrane hydrogel (microsphere, capsule, and filmlike shapes). Two drugs are introduced into the different membranes of the hydrogel, which will ensure the complexing drugs codelivery and the varied drugs release behaviors from two membranes (rapid drug release of the outer hydrogel, and prolonged drug release of the inner hydrogel). The double-membrane hydrogel containing the chemically modified cellulose nanocrystals (CCNC) in the inner membrane hydrogel can provide the sustained drug release ascribed to the "nano-obstruction effect" and "nanolocking effect" induced by the presence of CCNC components in the hydrogels. Derived from natural polysaccharides (cellulose and alginate), the novel double-membrane structure hydrogel material developed in this study is biocompatible and can realize the complexing drugs release with the first quick release of one drug and the successively slow release of another drug, which is expected to achieve the synergistic release effects or potentially provide the solution to drug resistance in biomedical application.
This paper references
10.1163/156856207781034160
Controlled release of vascular endothelial growth factor from alginate hydrogels nano-coated with polyelectrolyte multilayer films
M. Matsusaki (2007)
10.1021/nl102184c
Nanotechnology in drug delivery and tissue engineering: from discovery to applications.
J. Shi (2010)
10.1039/c1cs15203c
Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications.
Yulin Li (2012)
Versatile Fabrication
J. Duan (2012)
10.1038/35050141
Controlled growth factor release from synthetic extracellular matrices
K. Lee (2000)
10.1038/nature06619
Multi-membrane hydrogels
S. Ladet (2008)
10.1126/science.1214804
Designing Cell-Compatible Hydrogels for Biomedical Applications
D. Seliktar (2012)
10.1016/J.BIOMATERIALS.2004.06.011
Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs.
Y. Lin (2005)
10.1038/nmat2147
Hydrogels: structure starts to gel.
J. Elisseeff (2008)
10.1039/c3nr06761k
Surface chemistry, morphological analysis and properties of cellulose nanocrystals with gradiented sulfation degrees.
Ning Lin (2014)
10.1016/j.actbio.2010.07.013
In vitro microbial inhibition and cellular response to novel biodegradable composite wound dressings with controlled release of antibiotics.
J. J. Elsner (2011)
10.2174/1389557515666150415150327
A Mini Review on Plant-based Nanocellulose: Production, Sources, Modifications and Its Potential in Drug Delivery Applications.
Lalduh Sanga Pachuau (2015)
10.1016/j.biomaterials.2010.01.014
Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization.
S. Jay (2010)
10.1039/c2nr30260h
Preparation, properties and applications of polysaccharide nanocrystals in advanced functional nanomaterials: a review.
N. Lin (2012)
10.1021/MA4010154
Physical and/or Chemical Compatibilization of Extruded Cellulose Nanocrystal Reinforced Polystyrene Nanocomposites
Ning Lin (2013)
10.1021/BM034519+
Effect of sulfate groups from sulfuric acid hydrolysis on the thermal degradation behavior of bacterial cellulose.
M. Roman (2004)
10.1016/0003-2697(76)90527-3
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
M. M. Bradford (1976)
10.1021/bm501361c
Opportunities for Multicomponent Hybrid Hydrogels in Biomedical Applications
H. K. Lau (2015)
10.1016/j.biomaterials.2010.07.111
Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics.
A. Chan (2010)
10.1016/j.biomaterials.2008.07.028
The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering.
Yu-Shik Hwang (2009)
Nanocomposites of Nanocrystalline
V. Incani
10.1016/j.biomaterials.2011.04.012
Multi-membrane chitosan hydrogels as chondrocytic cell bioreactors.
S. Ladet (2011)
10.1039/C2TB00067A
Versatile fabrication of arbitrarily shaped multi-membrane hydrogels suitable for biomedical applications.
Jiangjiang Duan (2013)
10.1021/am404855q
Fast contact of solid-liquid interface created high strength multi-layered cellulose hydrogels with controllable size.
M. He (2014)
10.1021/ja210638x
Tunable Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
Katarina S. Vulic (2012)
10.1039/C3SM27514K
Electrostatic or steric? – preparations and characterizations of well-dispersed systems containing rod-like nanowhiskers of crystalline polysaccharides
J. Araki (2013)
10.1002/bit.25160
Nanocomposite hydrogels for biomedical applications.
A. Gaharwar (2014)
10.1021/bm301955k
Supramolecular hydrogels from in situ host-guest inclusion between chemically modified cellulose nanocrystals and cyclodextrin.
Ning Lin (2013)
10.1016/J.PROCBIO.2004.06.038
The evaluation of stability of recombinant human epidermal growth factor in burn-injured pigs
C. Yang (2005)
10.1016/J.CARBPOL.2010.10.047
Surface acetylation of cellulose nanocrystal and its reinforcing function in poly(lactic acid)
N. Lin (2011)
10.1021/bm500524s
The potential of cellulose nanocrystals in tissue engineering strategies.
Rui M A Domingues (2014)
10.1007/978-3-319-41418-8
Enzyme Immobilization
Alka Dwevedi (2016)
10.1002/CHIN.200138289
Hydrogels for Tissue Engineering
K. Lee (2001)
10.1016/j.addr.2009.05.006
Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines.
F. Greco (2009)
10.1016/j.colsurfb.2011.02.039
Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres.
N. Lin (2011)
10.1039/B821363A
Multi-membrane hydrogel fabricated by facile dynamic self-assembly
Hongjun Dai (2009)
10.1038/srep07635
Orientation in multi-layer chitosan hydrogel: morphology, mechanism, and design principle
J. Nie (2015)
10.1016/J.EURPOLYMJ.2014.07.025
Nanocellulose in biomedicine: Current status and future prospect
Ning Lin (2014)
10.1002/mabi.201300241
Antitumor efficacy of doxorubicin-loaded laponite/alginate hybrid hydrogels.
M. Gonçalves (2014)
10.1016/J.BIOMATERIALS.2005.12.021
Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery.
D. Kim (2006)
10.1126/SCIENCE.6776628
Microencapsulated islets as bioartificial endocrine pancreas.
F. Lim (1980)
10.1007/s10570-012-9805-2
Nanocomposites of nanocrystalline cellulose for enzyme immobilization
V. Incani (2013)
10.1021/am405544r
Compartmentalized multilayer hydrogel formation using a stimulus-responsive self-assembling polysaccharide.
Yuan Xiong (2014)
10.1039/C1SM06603J
Polysaccharide based covalently linked multi-membrane hydrogels
Anandhan Dhanasingh (2012)
10.1016/J.EURPOLYMJ.2014.11.024
Biomedical applications of hydrogels: A review of patents and commercial products
Enrica Caló (2015)
10.1021/am501755p
Extrusion of polysaccharide nanocrystal reinforced polymer nanocomposites through compatibilization with poly(ethylene oxide).
M. Pereda (2014)
10.1039/B912168D
Multilayer-derived, ultrathin, stimuli-responsive hydrogels
V. Kozlovskaya (2009)
10.2147/IJN.S66526
Biodegradable drug-eluting nanofiber-enveloped implants for sustained release of high bactericidal concentrations of vancomycin and ceftazidime: in vitro and in vivo studies
Yung-Heng Hsu (2014)
10.1002/MABI.200600069
Alginate hydrogels as biomaterials.
Alexander Augst (2006)
10.1039/B806789A
Cationic surface functionalization of cellulose nanocrystals
M. Hasani (2008)
10.1038/185117A0
Hydrophilic Gels for Biological Use
O. Wichterle (1960)



This paper is referenced by
10.1016/j.carbpol.2017.12.014
Cellulose nanocrystals as carriers in medicine and their toxicities: A review.
A. B. Seabra (2018)
10.1016/J.COGSC.2018.04.004
Sustainable self-assembly strategies for emerging nanomaterials
Ana Maria Percebom (2018)
10.1039/C8TB02331J
Multifunctional cellulose-based hydrogels for biomedical applications.
Lian-Hua Fu (2019)
10.1007/s10570-017-1559-4
A green Pickering emulsion stabilized by cellulose nanocrystals via RAFT polymerization
Beifang Liu (2017)
10.1007/978-3-319-76573-0_6-1
Structure-Property Relationships in Cellulose-Based Hydrogels
Diana Elena Ciolacu (2018)
10.1007/978-3-030-12919-4_17
Nanocellulose Composite Biomaterials in Industry and Medicine
O. Shoseyov (2019)
10.1016/j.carbpol.2017.11.079
Rosin modified cellulose nanofiber as a reinforcing and co-antimicrobial agents in polylactic acid /chitosan composite film for food packaging.
Xun Niu (2018)
10.1016/j.carbpol.2019.115740
Novel halochromic cellulose nanowhiskers from rice straw: Visual detection of urea.
Tawfik A Khattab (2020)
10.1016/j.ijbiomac.2018.03.155
A design optimization study on synthesized nanocrystalline cellulose, evaluation and surface modification as a potential biomaterial for prospective biomedical applications.
Fahanwi Asabuwa Ngwabebhoh (2018)
10.1002/9783527803835.CH1
Application of Nanocellulose for Controlled Drug Delivery
L. Pachuau (2017)
10.1016/j.cej.2019.123823
Alginate-based nanomaterials: Fabrication techniques, properties, and applications
I. P. S. Fernando (2020)
10.1016/j.carbpol.2020.116025
Alginate-based composite materials for wound dressing application:A mini review.
K. Varaprasad (2020)
10.1007/s10570-019-02579-7
Injectable all-polysaccharide self-assembling hydrogel: a promising scaffold for localized therapeutic proteins
L. Dai (2019)
10.1002/9781119450467.ch5
Chitosan‐Based Hydrogels
Z. Wang (2019)
10.1016/j.progpolymsci.2020.101221
Development, processing and applications of bio-sourced cellulose nanocrystal composites
C. Calvino (2020)
10.1007/978-3-319-58158-3
Advances in Nanostructured Cellulose-based Biomaterials
Neftali L V Carreño (2017)
10.1002/cmdc.201600570
Preparation of a Salecan/poly(2‐acrylamido‐2‐methylpropanosulfonic acid‐co‐[2‐(methacryloxy)ethyl]trimethylammonium chloride) Semi‐IPN Hydrogel for Drug Delivery
Xiaoliang Qi (2017)
10.1021/acs.biomac.6b00906
Hydrothermal Gelation of Aqueous Cellulose Nanocrystal Suspensions.
Lev Lewis (2016)
10.1016/J.COMPSCITECH.2018.03.038
Self-bonding sandwiched membranes from PDMS and cellulose nanocrystals by engineering strategy of layer-by-layer curing
Tao Xia (2018)
10.1016/j.ijbiomac.2020.02.170
Chitosan-caseinate-dextran ternary complex nanoparticles for potential oral delivery of astaxanthin with significantly improved bioactivity.
Qiaobin Hu (2020)
Estudio del efecto de la adición de nanocelulosa obtenida del desecho del rastrojo de piña en mezclas para materiales de construcción
Esteban Solís Nicolaas (2019)
10.1016/j.carbpol.2017.10.058
Simultaneous enhancement of elasticity and strength of Al2O3-based ceramics body from cellulose nanocrystals via gel-casting process.
Tengfei Deng (2018)
10.1039/C8RA07037G
Bioinspired interconnected hydrogel capsules for enhanced catalysis
Jiayao Chen (2018)
10.3390/FIB6010015
Synthetic Strategies for the Fabrication of Cationic Surface-Modified Cellulose Nanocrystals
Rajesh Sunasee (2018)
10.1016/j.carbpol.2019.01.020
Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications.
Haishun Du (2019)
10.1002/9783527803835
Nanocellulose and Nanohydrogel Matrices: Biotechnological and Biomedical Applications
M. Jawaid (2017)
10.1002/adma.202000717
Recent Progress on Cellulose-Based Ionic Compounds for Biomaterials.
Yang Yang (2020)
10.1007/s10570-017-1228-7
TEMPO-mediated oxidation of microcrystalline cellulose: limiting factors for cellulose nanocrystal yield
Reeta Salminen (2017)
10.1016/j.carbpol.2020.116492
Recent advances on sustainable cellulosic materials for pharmaceutical carrier applications.
Guihua Yan (2020)
10.1021/ACS.CHEMMATER.7B00531
Review of Hydrogels and Aerogels Containing Nanocellulose
T. Hoare (2017)
10.1016/j.actbio.2017.08.048
Synthesis and characterization of arginine-NIPAAm hybrid hydrogel as wound dressing: In vitro and in vivo study.
Dequn Wu (2018)
10.1002/app.48832
Physicochemical and antimicrobial properties of in situ crosslinked alginate/hydroxypropyl methylcellulose/ε‐polylysine films
Tatiana Schafranski Blachechen (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar