Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Surface-Enhanced Raman Scattering Nanoparticles For Multiplexed Imaging Of Bladder Cancer Tissue Permeability And Molecular Phenotype

R. M. Davis, B. Kiss, Dharati Trivedi, Thomas J. Metzner, J. Liao, S. Gambhir
Published 2018 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Bladder cancer has the highest recurrence rate of all cancers due in part to inadequate transurethral resection. Inadequate resection is caused by the inability of cystoscopes to detect invisible lesions during the resection procedure. To improve detection and resection of nonmuscle invasive bladder cancer, we quantified the ability of a surface-enhanced Raman nanoparticle and endoscope system to classify bladder tissue as normal or cancerous. Both antibody-based (active) and tissue permeability-based (passive) targeting mechanisms were evaluated by topically applying nanoparticles to ex vivo human bladder tissue samples. Multiplexed molecular imaging of CD47 and Carbonic Anhydrase 9 tumor proteins gave a receiver operating characteristic area under the curve (ROC AUC of 0.93 (0.75, 1.00). Furthermore, passively targeted nanoparticles enabled tissue classification with an ROC AUC of 0.93 (0.73, 1.00). Passively targeted nanoparticles penetrated 5-fold deeper and bound to tumor tissue at 3.3-fold higher concentrations in cancer compared to normal bladder urothelium, suggesting the existence of an enhanced surface permeability and retention effect in human bladder cancer.
This paper references
A phase III, multicenter comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of superficial papillary lesions in patients with bladder cancer.
H. Grossman (2007)
Rational Design and Synthesis of fe < inf > 2 O < inf > 3@Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics
J. Huang (2015)
Rational Design and Synthesis of Γ fe < inf > 2 < / Inf > O < inf > 3 < / Inf > @ Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics
S. Harmsen (2015)
Rapid ratiometric biomarker detection with topically applied SERS nanoparticles.
Y. Wang (2014)
Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends.
S. Antoni (2017)
In vivo biodistribution and toxicity of intravesical administration of quantum dots for optical molecular imaging of bladder cancer
Y. Pan (2017)
Intravesical drug delivery: Challenges, current status, opportunities and novel strategies.
Shruti Guhasarkar (2010)
Long-term benefit of 5-aminolevulinic acid fluorescence assisted transurethral resection of superficial bladder cancer: 5-year results of a prospective randomized study.
D. Daniltchenko (2005)
Rational Design of a Chalcogenopyrylium-Based Surface-Enhanced Resonance Raman Scattering-Nanoprobe with Attomolar Sensitivity
S. Harmsen (2015)
Carbonic Anhydrase IX in Bladder
T. Klatte
Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy
Y. Wang (2016)
The CD 47-signal regulatory protein alpha ( SIRPa ) interaction is a therapeutic target for human solid tumors
Stephen B. Willinghama (2012)
The value of a second transurethral resection for T1 bladder cancer
H. Schwaibold (2006)
Cystoscopy for the Detection of Superficial Papillary Lesions in Patients With Bladder Cancer
White Light (2007)
Fluorescence and white light cystoscopy for detection of carcinoma in situ of the urinary bladder.
S. Lerner (2012)
A Real-Time Clinical Endoscopic System for Intraluminal, Multiplexed Imaging of Surface-Enhanced Raman Scattering Nanoparticles
E. Garai (2015)
Carbonic Anhydrase IX in Bladder Cancer: A Diagnostic, Prognostic, and Therapeutic Molecular Marker
T Klatte (2009)
236: Carbonic Anhydrase IX (CAIX) in Bladder Cancer: A Diagnostic, Prognostic and Therapeutic Molecular Marker
T. Klatte (2007)
Rational Design and Synthesis of γFe2 O3 @Au Magnetic Gold Nanoflowers for Efficient Cancer Theranostics.
Jie Huang (2015)
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential
J. Liu (2015)
Maximizing Capture Efficiency and Specificity of Magnetic Separation for Mycobacterium avium subsp. paratuberculosis Cells
A. Foddai (2010)
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
M. Babjuk (2013)
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.
N. Shore (2017)
Recent advances in nanotechnology-based detection and separation of circulating tumor cells.
J. H. Myung (2016)
Update on the Management of NonMuscle Invasive Bladder Cancer
S. Aldousari (2010)
Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging
S. Harmsen (2015)
New optical imaging technologies for bladder cancer: considerations and perspectives.
Jen‐Jane Liu (2012)
Multicenter Comparison of Hexaminolevulinate Fluorescence Cystoscopy and White Light Cystoscopy for the Detection of Superficial Papillary Lesions in Patients With Bladder Cancer
H B Grossman (2007)
Endoscopic molecular imaging of human bladder cancer using a CD47 antibody
Y. Pan (2014)
The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice
A. Thakor (2011)
Improved detection of urothelial carcinoma in situ with hexaminolevulinate fluorescence cystoscopy.
J. Schmidbauer (2004)
Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics.
T. Yang (2016)
Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy
C. Zavaleta (2009)
Improved detection and treatment of bladder cancer using hexaminolevulinate imaging: a prospective, phase III multicenter study.
D. Jocham (2005)
In vivo multiplexed molecular imaging of esophageal cancer via spectral endoscopy of topically applied SERS nanoparticles.
Y. Wang (2015)
High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device
E. Garai (2013)
Image-Guided Transurethral Resection of Bladder Tumors – Current Practice and Future Outlooks
Timothy Chang (2017)
Scattering Nanoparticles
X. Robin (2011)
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
S. Willingham (2012)
Update on the management of non-muscle invasive bladder cancer.
S. Aldousari (2010)
A comparison of hexaminolevulinate fluorescence cystoscopy and white light cystoscopy for the detection of carcinoma in situ in patients with bladder cancer: a phase III, multicenter study.
Y. Fradet (2007)
A Raman-based endoscopic strategy for multiplexed molecular imaging
C. Zavaleta (2013)
5‐aminolaevulinic acid‐induced fluorescence cystoscopy during transurethral resection reduces the risk of recurrence in stage Ta/T1 bladder cancer
M. Babjuk (2005)
Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy.
Tao Yang (2017)
Multiplexed Molecular Imaging of Fresh Tissue Surfaces Enabled by Convection-Enhanced Topical Staining with SERS-Coded Nanoparticles.
Y. Wang (2016)
Intravesical Drug Delivery Pharmacokinetic and Clinical Considerations
M. S. Highley (1999)
Quantification of non‐specific binding of magnetic micro‐ and nanoparticles using cell tracking velocimetry: Implication for magnetic cell separation and detection
J. Chalmers (2010)
The role of carbonic anhydrase IX as a molecular marker for transitional cell carcinoma of the bladder
T. Klatte (2008)
pROC: an open-source package for R and S+ to analyze and compare ROC curves
X. Robin (2010)

This paper is referenced by
Continuous-Wave Coherent Raman Spectroscopy via Plasmonic Enhancement
Y. E. Monfared (2019)
A Raman Imaging Approach Using CD47 Antibody-Labeled SERS Nanoparticles for Identifying Breast Cancer and Its Potential to Guide Surgical Resection
R. M. Davis (2018)
Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer
Hui Guo (2020)
Highly Stable and Long-Circulating Metal-Organic Frameworks Nanoprobes for Sensitive Tumor Detection In Vivo.
R. Zhang (2019)
Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications
Mehdi Azizi (2020)
Smart Nanotechnologies to Target Tumor with Deep Penetration Depth for Efficient Cancer Treatment and Imaging
Xue Feng (2019)
Cancer Diagnosis through SERS and Other Related Techniques
M. Blanco-Formoso (2020)
Size dependent SERS activity of Ag triangular nanoplates on different substrates: Glass vs paper
G. Weng (2019)
Versatile metal graphitic nanocapsules for SERS bioanalysis
Shengkai Li (2019)
Multiplex micro-SERS imaging of cancer-related markers in cells and tissues using poly(allylamine)-coated Au@Ag nanoprobes
A. Verdin (2020)
Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer.
Guangzhi Li (2019)
Image-guided tumor surgery: The emerging role of nanotechnology.
Nicholas E Wojtynek (2020)
Surface-Enhanced Raman Spectroscopy in Cancer Diagnosis, Prognosis and Monitoring
L. Guerrini (2019)
Nanoscale systems for local drug delivery.
T. Ji (2019)
Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research
M. Ghita (2019)
Advanced Nanotechnology Leading the Way to Multimodal Imaging-Guided Precision Surgical Therapy.
C. Wang (2019)
From single cells to complex tissues in applications of surface-enhanced Raman scattering.
Gregory Q Wallace (2020)
Semantic Scholar Logo Some data provided by SemanticScholar