← Back to Search
Morphological And Semi-empirical Study Of The Pluronic F68/Imogolite/Sudan III Intersurfaces Composite For The Controlled Temperature Release Of Hydrophobic Drugs
V. D. Samith, S. Navarro, Reza Dabirian
Published 2020 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
Some PluronicF68 (F68) triblock copolymer properties demonstrate surprising applications in selective drug administration, such as the transportation of hydrophobic anti-inflammatories through epithelial barriers. Nuclear magnetic resonance (1H-NMR) spectroscopy was carried out for micelle precursor dispersions and F68 films modified with a synthetic imogolite (IMO) biocompatible hydrogel. Theoretical calculations and morphological assessment for the process of morphogenesis of dendritic crystallization were performed by molecular docking and atomic force microscopy (AFM) of the Sudan III-IMO-F68 composite, which was more hydrophobic than Sudan III-F68 and carried out the prolonged release of the Sudan III “drug” captured by a water–octanol interface determined by standard absorbance. Surface fusions were measured and compared to the unmodified matrix. However, despite the superior properties of the composite, the critical micelle concentration (CMC) was practically unmodified because solitary IMO strands attached to Sudan III formed Sudan III-IMO. These strands unraveled in a stable manner by expanding like a “spiderweb” in hydrophilic interfaces according to NMR analysis of the hydrogen one H1 polarization of Sudan III and F68 methyl, whose correlation relates hydrophobicity of Sudan III-IMO-F68 with dendrite properties from F68 concentrations. CMC and surface fusions equivalent to F68 surface properties, calculated by differential scanning calorimetry and dynamic Raman spectroscopy, were determined by AFM and high-resolution ellipsometry. Our results show highly specialized pharmacological applications since micelle surfaces expand, triggering maximum deliveries of “Drugs” from its interior to the physiological environment. The implanted sensor prototype determined equilibria reached Sudan III according to temperature (32–50 °C) and time it took to cross the membrane model 1-octanol (48 h). The findings suggest that the targested design of a F68-IMO-“Drug” would function as a microdevice for the prolonged release of hydrophobic drugs. In addition, the said microdevice could regenerate the damaged tissue in the central nervous system or other organs of the body. This is due to the fact that it could perform both tasks simultaneously, given the properties and characteristics acquired by the compatible material depending on the temperature of the physiological environment.
This paper references
Engineered polymeric nanoparticles for receptor-targeted blockage of oxidized low density lipoprotein uptake and atherogenesis in macrophages.
E. Chnari (2006)
P-glycoprotein efflux inhibition by amphiphilic diblock copolymers: relationship between copolymer concentration and substrate hydrophobicity.
J. Zastre (2008)
Characterization of the Doxorubicin-Pluronic F68 Conjugate Micelles and Their Effect on Doxorubicin Resistant Human Erythroleukemic Cancer Cells
C. Sun (2011)
Drug delivery in polymeric micelles: from in vitro to in vivo.
N. Rapoport (2003)
A mosaic of nonallophanic Andosols, Umbrisols and Cambisols on rhyodacite in the southern Brazilian highlands
Alexander Dümig (2008)
Pluronic L 121 , BMIM BF 4 and PEG - 400 Comparision to Identify the Best Solvent for CO 2 Sorption
G. Angelini (2018)
Binary Mixtures of Sodium Salt of Ibuprofen and Selected Bile Salts: Interface, Micellar, Thermodynamic, and Spectroscopic Study
M. A. Rub (2017)
Poly(glycidol)-Based Analogues to Pluronic Block Copolymers. Synthesis and Aqueous Solution Properties
Silvia Halacheva (2006)
Glass transition of polystyrene (PS) studied by Raman spectroscopic investigation of its phenyl functional groups
D. B. Menezes (2017)
Preparation of a novel (polymer/inorganic nanofiber) composite through surface modification of natural aluminosilicate nanofiber
K. Yamamoto (2002)
Polyion complex nanomaterials from block polyelectrolyte micelles and linear polyelectrolytes of opposite charge. 2. Dynamic properties.
Pavel S. Chelushkin (2008)
Polymeric Aggregates in Ionic Liquids: The Green Future of the Delivery Systems.
G. Angelini (2015)
Transparent polymer nanohybrid prepared by in situ synthesis of aluminosilicate nanofibers in poly(vinyl alcohol) solution.
K. Yamamoto (2005)
Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(d,l-lactide)
F. Kohori (1999)
Anti-inflammatory Agents: Present and Future
C. Dinarello (2010)
Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats.
D. Curry (2004)
Self-Assembly and Critical Aggregation Concentration Measurements of ABA Triblock Copolymers with Varying B Block Types: Model Development, Prediction, and Validation.
F. Aydin (2016)
Solubility and partitioning VI: octanol solubility and octanol-water partition coefficients.
S. Yalkowsky (1983)
The effect of poloxamer-188 on neuronal cell recovery from mechanical injury.
G. Serbest (2005)
Preparation of hybrid films of aluminosilicate nanofiber and conjugated polymer
Nattha Jiravanichanun (2009)
Optimal Structure Requirements for Pluronic Block Copolymers in Modifying P-glycoprotein Drug Efflux Transporter Activity in Bovine Brain Microvessel Endothelial Cells
E. Batrakova (2003)
Determination of the temperatures of the γ, β and α relaxation processes in nylon 6,6 by Raman spectroscopy
D. B. Menezes (2016)
Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease
A. Sosnik (2016)
Adsorption behaviors of methanol, ethanol, n-butanol, n-hexanol and n-octanol on mica surface studied by atomic force microscopy
L. Wang (2004)
The Use of Some Clay Minerals as Natural Resources for Drug Carrier Applications †
M. Massaro (2018)
Application of ALOGPS to predict 1-octanol/water distribution coefficients, logP, and logD, of AstraZeneca in-house database.
I. Tetko (2004)
Study of glass transition in functionalized poly(itaconate)s by differential scanning calorimetry, Raman spectroscopy and thermogravimetric analysis
V. D. Samith (2015)
BMIM BF4 and PEG-400 Comparision to Identify the Best Solvent for CO2 Sorption
M. Abdul Rub (2018)
Thermo-sensitive and biodegradable hydrogels based on stereocomplexed Pluronic multi-block copolymers for controlled protein delivery.
H. J. Chung (2008)
Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge.
Y. Yamamoto (2001)
Pluronic triblock copolymer systems and their interactions with Ibuprofen.
Beth Foster (2009)
Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer.
Alakhov VYu (1996)
Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury
Yunlong Li (2012)
Microcanonical molecular dynamics simulation of the vitreous phase transition of poly(binaphthylphosphazene)
V. D. Samith (2017)
X-ray specular reflection studies of silicon coated by organic monolayers (alkylsiloxanes).
Temperature dependence of poloxamer insertion into and squeeze-out from lipid monolayers.
S. Frey (2007)
Towards bio-silicon interfaces: formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase.
M. J. Retamal (2014)
Temperature and concentration effects on supramolecular aggregation and phase behavior for poly(propylene oxide)-b-poly(ethylene oxide)- b-poly(propylene oxide) copolymers of different composition in aqueous mixtures, 1.
G. D'Errico (2004)
Comparison of dual solvent-stir bars microextraction and U-shaped hollow fiber-liquid phase microextraction for the analysis of Sudan dyes in food samples by high-performance liquid chromatography-ultraviolet/mass spectrometry.
C. Yu (2008)
Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association
P. Alexandridis (1994)
Effects of poloxamer 188 on phospholipid monolayer morphology: an atomic force microscopy study.
Guohui Wu (2009)
Association behavior of a mixed system of the antidepressant drug imipramine hydrochloride and dioctyl sulfosuccinate sodium salt: Effect of temperature and salt
Dileep Kumar (2018)
Molecular self-assembly across multiple length scales.
V. Palermo (2007)
Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules.
N. Anton (2009)
Crystalline-to-plastic phase transitions in molecularly thin n-dotriacontane films adsorbed on solid surfaces.
E. Cisternas (2009)
Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity.
Y. Zhang (2016)
Adsorption of Amino Acids and Glutamic Acid-Based Surfactants on Imogolite Clays.
Massimo Bonini (2017)
Preparation and Characterization of Complex Gel of Type I Collagen and Aluminosilatae Cointaining Imogolite Nanofibers
A. Nakano (2010)
Temperature-related change in the properties relevant to drug delivery of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles in aqueous milieu.
Y. Yamamoto (2002)
Effects of pluronic F68 micellization on the viability of neuronal cells in culture
V. D. Samith (2013)
Atomic force microscopy of synthetic imogolite
M. Tani (2004)
A prodrug strategy based on chitosan for efficient intracellular anticancer drug delivery.
C. Chen (2014)
Application of photoluminescent CdS/PAMAM nanocomposites in fingerprint detection.
Yujuan Jin (2008)
Green Synthesis , Characterization , Photophysical and Electrochemical Properties of Bis - Chalcones
A. Asiri (2014)
Thermally reversible materials based on thermosetting systems modified with polymer dispersed liquid crystals for optoelectronic application
A. Tercjak (2006)
Effect of Ionic Strength on the Bundling of Metal Oxide Imogolite Nanotubes
E. Paineau (2017)
Fluorescence studies of the conformational changes of poly(methacrylic acid) with pH
A. Olea (1989)
Recent NMR Developments Applied to Organic‐Inorganic Materials
C. Bonhomme (2014)
Nanostructured devices based on block copolymer assemblies for drug delivery: Designing structures for enhanced drug function
N. Nishiyama (2006)
The synthesis and characterization of imogolite
S. M. Barrett (1991)
Synthesis of platinum nanoparticles in aqueous host dispersions of inorganic (imogolite) rods
L. L. Marzán (1994)
Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
E. Batrakova (2008)
Phenomenology of the growth of single-walled aluminosilicate and aluminogermanate nanotubes of precise dimensions
S. Mukherjee (2005)
Sorption of Proteins by Slightly Cross-Linked Polyelectrolyte Hydrogels: Kinetics and Mechanism
V. Kabanov (2004)
Surfactant-induced sealing of electropermeabilized skeletal muscle membranes in vivo.
R. Lee (1992)
Multiple glass-transition temperatures in thin supported films of isotactic PMMA as revealed by enhanced Raman scattering.
G. Vignaud (2005)
Some novel insights into the binding of oseltamivir and zanamivir to H5N1 and N9 influenza virus neuraminidases: a homology modeling and flexible docking study
L. Mihajlovic (2009)
Nanoscale amphiphilic macromolecules as lipoprotein inhibitors: the role of charge and architecture
Jinzhong Wang (2007)
Relationship between pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes
M. Kozlov (2000)
A natural length scale for the glass transition of conjugated polymer film.
H. Liem (2007)
Non-electrostatic components of short and strong hydrogen bonds induced by compression inside fullerenes
G. Mino (2010)
Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions
A. Kabanov (1995)
Rheology of cellulose nanofibrils in the presence of surfactants.
N. Quennouz (2016)
Self-association and micro-environmental properties of sodium salt of ibuprofen with BRIJ-56 under the influence of aqueous/urea solution
Naved Azum (2017)
Structural symmetry breaking of silicon‐containing poly(amide‐imide) oligomers and its relation to electrical conductivity and Raman‐active vibrations
C. M. G. Henríquez (2012)
Assessment of drug-loaded nanoparticles in a 3D in vitro brain tumour model
D. Ivanov (2015)
Modulation of P‐glycoprotein‐mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane
R. Regev (2007)
Preparation and characterization of imogolite/DNA hybrid hydrogels.
Nattha Jiravanichanun (2012)
Validation of ArgusLab Efficiencies for Binding Free Energy Calculations
A. Oda (2009)
Substrate-induced modulation of the Raman scattering signals from self-assembled organic nanometric films.
A. Baptiste (2004)
Direct observation of poloxamer 188 insertion into lipid monolayers.
Stacey A. Maskarinec (2002)