Online citations, reference lists, and bibliographies.
← Back to Search

High-frequency, Magnetic-field-responsive Drug Release From Magnetic Nanoparticle/organic Hybrid Based On Hyperthermic Effect.

K. Hayashi, K. Ono, H. Suzuki, M. Sawada, M. Moriya, W. Sakamoto, T. Yogo
Published 2010 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Magnetic nanoparticles (MNPs) generate heat when a high-frequency magnetic field (HFMF) is applied to them. Induction heat is useful not only for hyperthermia treatment but also as a driving force for drug-release. beta-Cyclodextrin (CD) can act as drug container because of its inclusion properties. Drugs incorporated in the CD can thus be released through the use of induction heating, or hyperthermic effects, by applying a HFMF. In this study, we have synthesized folic acid (FA) and CD-functionalized superparamagnetic iron oxide nanoparticles, FA-CD-SPIONs, by chemically modifying SPIONs derived from iron(III) allylacetylacetonate. FA is well-known as a targeting ligand for breast cancer tumor and endows the SPIONs with cancer-targeting capability. Immobilization of FA and CD on spinel iron oxide nanoparticles was confirmed by Fourier transform IR (FTIR) and X-ray photoelectron spectroscopy (XPS). The FA-CD-SPIONs have a hydrodynamic diameter of 12.4 nm and prolonged stability in water. They are superparamagnetic with a magnetization of 51 emu g(-1) at 16 kOe. They generate heat when an alternating current (AC) magnetic field is applied to them and have a specific absorption rate (SAR) of 132 W g(-1) at 230 kHz and 100 Oe. Induction heating triggers drug release from the CD cavity on the particle - a behavior that is controlled by switching the HFMF on and off. The FA-CD-SPIONs are noncytotoxic for cells. Thus, FA-CD-SPIONs can serve as a novel device for performing drug delivery and hyperthermia simultaneously.

This paper is referenced by
Functional magnetic Prussian blue nanoparticles for enhanced gene transfection and photothermal ablation of tumor cells.
P. Xue (2016)
Strategies for Functionalisation of Magnetic Nanoparticles for Biological Targets
N. T. Thanh (2012)
Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging.
D. Kirui (2013)
Synthesis and characterization of hollow magnetic nanospheres modified with Au nanoparticles for bio-encapsulation
Satoshi Seisno (2017)
A remotely triggered drug release system with dot array-like configuration for controlled release of multiple drugs
Lingmei Guo (2018)
In situ synthesis and photoresponsive rupture of organosilica nanocapsules.
K. Hayashi (2011)
Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability
Weerakanya Maneeprakorn (2017)
Remotely controlled opening of delivery vehicles and release of cargo by external triggers.
Dingcheng Zhu (2019)
Computational modeling of drug diffusion and inductive heating in an implantable biomedical device for localized thermo-chemotherapy of cancer cells/tissue
C. Ani (2018)
Medical Applications of Iron Oxide Nanoparticles
A. Silva (2016)
Developing novel strategies for the functionalization of core–shell magnetic nanoparticles with folic acid derivatives
C. Socaci (2015)
Folate-conjugated β-cyclodextrin from click chemistry strategy and for tumor-targeted drug delivery.
Huaihong Zhang (2012)
Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment.
Şükran Alpdemir (2020)
Nanoparticle-mediated hyperthermia in cancer therapy.
D. Chatterjee (2011)
Surface Functionalized Magnetic Nanoparticles for Cancer Therapy Applications
Robert J. Wydra (2015)
β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications.
A. Z. M. Badruddoza (2013)
Multi-stimuli-responsive magnetic assemblies as tunable releasing carriers.
X. Zhang (2015)
Multifunctional Polymeric Platform of Magnetic Ferrite Colloidal Superparticles for Luminescence, Imaging, and Hyperthermia Applications.
Z. Iatridi (2016)
Facile one-pot synthesis of iron oxide nanoparticles cross-linked magnetic poly(vinyl alcohol) gel beads for drug delivery.
L. Zhou (2012)
Evaluation of atherosclerotic lesions using dextran- and mannan–dextran-coated USPIO: MRI analysis and pathological findings
K. Tsuchiya (2012)
Cyclodextrin/Paclitaxel Complex in Biodegradable Capsules for Breast Cancer Treatment
J. Jing (2013)
pH-Sensitive stimulus-responsive nanocarriers for targeted delivery of therapeutic agents.
Mahdi Karimi (2016)
Enhanced magnetic fluid hyperthermia by micellar magnetic nanoclusters composed of Mn(x)Zn(1-x)Fe(2)O(4) nanoparticles for induced tumor cell apoptosis.
Y. Qu (2014)
Targeted polysaccharide nanoparticle for adamplatin prodrug delivery.
Y. Yang (2013)
Comparison Between Folic Acid and gH625 Peptide-Based Functionalization of Fe3O4 Magnetic Nanoparticles for Enhanced Cell Internalization
C. Tudisco (2018)
Stabilization in Water of Large Hydrophobic Uniform Magnetite Cubes by Silica Coating
G. Marcelo (2011)
Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics
Maheshika Palihawadana-Arachchige (2017)
Magnetic nanoparticles with multifunctional water-soluble polymers for bioapplications
Muhammad Irfan Majeed (2016)
Metal-free thermally-responsive pseudohybrid nanoparticles based on 2-hydroxypropyl-β-cyclodextrin
V. V. Spiridonov (2016)
Parenteral Controlled and Prolonged Drug Delivery Systems: Therapeutic Needs and Formulation Strategies
Imran Vhora (2019)
Synthesis and 3D hierarchical organization of 2D structured iron oxide based on enzymatic structure, activity and thermostability
K. Hayashi (2012)
pH- and thermosensitive thin lipid layer coated mesoporous magnetic nanoassemblies as a dual drug delivery system towards thermochemotherapy of cancer.
L. Pradhan (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar