← Back to Search
Unimolecular Micelles Based On Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies.
R. K. Kainthan, D. E. Brooks
Published 2008 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
We recently reported the synthesis and testing of a new class of unimolecular micelles based on hyperbranched polyglycerols as second generation synthetic plasma expanders and as general drug delivery vehicles. A detailed biodistribution study of two derivatized hyperbranched polyglycerols of different molecular weights derivatized with hydrophobic groups and short poly(ethylene glycol) chains is reported in this article. In mice, these materials are nontoxic with circulation half-lives as high as 31 h, controllable by manipulating the molecular weight and the degree of PEG derivatization. Organ accumulation is low, presumably due to the "pegylation" effect. Thermal degradation and hydrolysis data suggest that these polymers are highly stable with a long shelf life, a major advantage for a pharmaceutical product. Degradation under acidic conditions has been observed for these polymers.
This paper references
Tissue Storage of 14C-Labelled Hydroxyethyl Starch (HES) 130/0.4 and HES 200/0.5 after Repeated Intravenous Administration to Rats
J. Leuschner (2003)
Biocompatibility testing of branched and linear polyglycidol.
R. K. Kainthan (2006)
Alternatives to albumin: Starch replacement for plasma exchange
M. Brecher (1997)
In vivo biological evaluation of high molecular weight hyperbranched polyglycerols.
R. K. Kainthan (2007)
Controlled Synthesis of Hyperbranched Polyglycerols by Ring-Opening Multibranching Polymerization
A. Sunder (1999)
On the transport of compact particles through solutions of chain-polymers
A. Ogston (1973)
Unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols: ligand binding properties.
R. K. Kainthan (2008)
In vitro biological evaluation of high molecular weight hyperbranched polyglycerols.
R. K. Kainthan (2007)
Retention and storage sites of radioactive polyvinylpyrrolidone.
B. Hulme (1968)
Effects of different plasma substitutes on blood coagulation: A comparative review
E. de Jonge (2001)
Prevention of antibody-mediated elimination of ligand-targeted liposomes by using poly(ethylene glycol)-modified lipids.
W. Li (2002)
Microbial degradation of polyethers
F. Kawai (2001)
Self-assembled monolayers of dendritic polyglycerol derivatives on gold that resist the adsorption of proteins.
Conrad Siegers (2004)
Clinical Pharmacokinetic Considerations in the Use of Plasma Expanders
U. Klotz (1987)
Ether-cleaving enzyme and diol dehydratase involved in anaerobic polyethylene glycol degradation by a new Acetobacterium sp.
E. Schramm (2004)
Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.
Tatsuya Okuda (2006)
Sterically stabilized liposomes.
M. Woodle (1992)
Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives.
R. Mehvar (2003)
Hydroxyethyl Starch in Balanced Electrolyte Solution (Hextend®)—Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers
N. Wilkes (2002)
Immune response mediated by liposome-associated protein antigens. III. Immunogenicity of bovine serum albumin covalently coupled to vesicle surface.
P. Shek (1983)
Designing dendrimers for biological applications
C. C. Lee (2005)
Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute.
R. K. Kainthan (2008)
Determination of glomerular size-selectivity in the normal rat with Ficoll.
J. D. Oliver (1992)
Albumin and hypovolaemia: time to move on and generate new evidence
I. Roberts (2002)
An international view of hydroxyethyl starches
J. Treib (1999)
A novel nicotinoprotein aldehyde dehydrogenase involved in polyethylene glycol degradation
T. Ohta (2005)
Chapter 26 – Biophysical Behavior of Red Cells in Suspensions
S. Chien (1975)
Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture.
E. Gillies (2005)
A systematic review of the comparative safety of colloids.
M. Barron (2004)
Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes.
J. A. Harding (1997)
Conjugates of Anticancer Agents and Polymers: Advantages of Macromolecular Therapeutics in vivo
H. Maeda (1993)
This paper is referenced by
Polymers in Drug Delivery—State of the Art and Future Trends
Stefan Grund (2011)
Progesterone-binding modified hyperbranched polyglycerols : synthesis, characterization and biological assessment
Mahsa Alizadeh Noghani (2016)
Mechanical and barrier properties of soy protein isolate films plasticized with a mixture of glycerol and dendritic polyglycerol
M. Božič (2015)
Progesterone binding nano-carriers based on hydrophobically modified hyperbranched polyglycerols.
M. Alizadeh Noghani (2016)
Polyphosphoesters: Controlled Ring-Opening Polymerization and Biological Applications
J. Wang (2012)
Self-assembly of hyperbranched polymers and its biomedical applications.
Y. Zhou (2010)
Evaluation of nanomechanical properties of hyperbranched polyglycerols as prospective cell membrane engineering block.
Haigang Wu (2020)
Comparative study on the supramolecular nanocarriers derived from the assembly of gemini and conventional surfactants onto hyperbranched polyethylenimine
Zhan-Long Yu (2011)
Towards the Fabrication of Polyelectrolyte-Based Nanocapsules for Bio-Medical Applications
L. Pastorino (2016)
Amphiphilic Ionic Perylenediimides: Structures, Self-Assembly Studies and Biomedical Applications
Meizhen Yin (2017)
Hyperbranched polyglycerols as trimodal imaging agents: design, biocompatibility, and tumor uptake.
K. Saatchi (2012)
A bifunctional nanocarrier based on amphiphilic hyperbranched polyglycerol derivatives.
I. Kurniasih (2013)
Self-assemblies of amphiphilic homopolymers: synthesis, morphology studies and biomedical applications.
J. Zhang (2015)
Adsorption of amphiphilic hyperbranched polyglycerol derivatives onto human red blood cells.
Z. Liu (2010)
Amphiphilic multiarm star polylactide with hyperbranched polyethylenimine as core: A systematic reinvestigation
C. Zhang (2012)
Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives.
Katrin Knop (2010)
Co-assembly of two types of complementary dendritic units into amphiphilic supramolecular complexes capable of hosting guest molecules
Y. Liu (2015)
Bioreducible unimolecular micelles based on amphiphilic multiarm hyperbranched copolymers for triggered drug release
Yan Rong Pang (2010)
Tissue uptake of docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols and their effects on the morphology of the bladder urothelium.
C. Mugabe (2012)
In vitro and in vivo evaluation of intravesical docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols in an orthotopic model of bladder cancer.
C. Mugabe (2011)
Synthesis and therapeutic applications of biocompatible or biodegradable hyperbranched polymers
Yu Huang (2015)
Nanomicellar formulations for sustained drug delivery: strategies and underlying principles.
Ruchit Trivedi (2010)
In vitro stability and cytotoxicity analysis of liposomes anchored with octylamine-graft-poly (aspartic)
X. Shen (2016)
Investigation of hydrophobically derivatized hyperbranched polyglycerol with PEGylated shell as a nanocarrier for systemic delivery of chemotherapeutics.
Ripen Misri (2015)
Dendritic core-shell systems as soft drug delivery nanocarriers.
Maike C. Lukowiak (2015)
Development of a nanoparticulate formulation of docetaxel for the treatment of non-muscle-invasive bladder cancer
Rakhi Pandey (2014)
Synthesis of thermoresponsive unimolecular polymeric micelles with a hydrophilic hyperbranched poly(glycidol) core
Shi-zhong Luo (2011)
Pseudo-branched polyester copolymer: an efficient drug delivery system to treat cancer.
Zachary Shaw (2020)
Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen
Katrin Knop (2010)
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery.
J. Suk (2016)
Effect of side-chain length on solute encapsulation by amphiphilic heterografted brush copolymers.
E. A. Garcia (2020)
Hyperbranched double hydrophilic block copolymer micelles of poly(ethylene oxide) and polyglycerol for pH-responsive drug delivery.
S. Lee (2012)See more