Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Amphiphilic Self-assembled "polymeric Drugs": Morphology, Properties, And Biological Behavior Of Nanoparticles.

M. L. López-Donaire, E. M. Sussman, M. Fernández-Gutiérrez, A. Mendezvilas, B. Ratner, B. Vázquez-Lasa, J. San Roman
Published 2012 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
This article reports the fabrication and characterization of NPs based on the self-assembling of polymeric drugs with amphiphilic character synthetized from oleyl 2-acetamido-2-deoxy-α-d-glucopyranoside methacrylate and vinyl pyrrolidone (OAGMA-VP). NPs were spherical, with an apparent hydrodynamic diameter between 91 and 226 nm and with zeta potential values that ensure stability. Atomic concentrations of C, O, and N, determined by X-ray photoelectron spectroscopy (XPS) of NPs, compared well with the corresponding theoretical values. High resolution XPS C1s spectra suggest that the carbons bound to heteroatoms or carbonyl groups are preferentially situated on the surface of the NP samples. ToF-SIMS spectra analyzed by principal component analysis (PCA) indicated that ions coming from acetyl and oleyl groups of OAGMA play important roles in the outer structure of NPs. Water contact angle and surface tension values of NPs were characteristic of hydrophilic surfaces, confirming the location of VP sequences on the surface. Cell culture assays showed that copolymeric NPs did not compromise biocompatibility of human fibroblasts according to ISO standard, but they were cytotoxic on a human glioblastoma cell line (A-172).
This paper references
10.1021/AC00298A004
Analysis of polymer surface structure by low-energy ion scattering spectroscopy
Thomas J. Hook (1986)
10.1016/S0032-3861(02)00768-1
Preparation and structure characterization of hairy nanoparticles consisting of hydrophobic core and thermosensitive hairs
S. Takata (2003)
10.1007/S00396-005-1323-4
Self-assembled nanostructures of a biomimetic glycopolymer–polypeptide triblock copolymer
Chang-Ming Dong (2005)
10.1021/ja1056714
High-Affinity Glycopolymer Binding to Human DC-SIGN and Disruption of DC-SIGN Interactions with HIV Envelope Glycoprotein
C. R. Becer (2010)
10.1016/j.biomaterials.2008.12.006
Polymeric drugs based on bioactive glycosides for the treatment of brain tumours.
M. L. López Donaire (2009)
10.1002/APP.1969.070130815
Estimation of the surface free energy of polymers
D. Owens (1969)
10.1021/LA011454S
Hierarchical Self-Assembly of Hydrophobically Modified Pullulan in Water: Gelation by Networks of Nanoparticles
K. Kuroda (2002)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1002/marc.201100331
Thiol-alkyne chemistry for the preparation of micelles with glycopolymer corona: dendritic surfaces versus linear glycopolymer in their ability to bind to lectins.
Jatin Kumar (2011)
10.1002/POLC.5070510111
Structure and properties of pharmacologically active polymers
H. Ringsdorf (2007)
analysis of some important classes of polymeric biomaterials
A. P. Pijpers (1996)
10.1021/bm200643c
Diblock glycopolymers promote colloidal stability of polyplexes and effective pDNA and siRNA delivery under physiological salt and serum conditions.
A. E. Smith (2011)
10.1016/j.ejpb.2008.02.021
Development of novel polymeric micellar drug conjugates and nano-containers with hydrolyzable core structure for doxorubicin delivery.
A. Mahmud (2008)
10.1016/j.biomaterials.2010.01.009
The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells.
R. Tong (2010)
hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery
E. E. Johnston (2009)
10.1039/C0PY00141D
Synthesis of glycopolymers and their multivalent recognitions with lectins
S. Ting (2010)
10.1002/POLA.23482
Synthesis of dendritic carbohydrate end‐functional polymers via RAFT: Versatile multi‐functional precursors for bioconjugations
Jiangtao Xu (2009)
10.3891/ACTA.CHEM.SCAND.18-1551
Localization of Double Bonds by Mass Spectrometry.
G. Kenner (1964)
10.1021/MA980087X
Multiple Morphologies Formed from an Amphiphilic ABC Triblock Copolymer in Solution
Ga-er Yu (1998)
10.1002/(SICI)1096-9918(200005)29:5<303::AID-SIA868>3.0.CO;2-5
Positive secondary ion mass spectrum of poly(methyl methacrylate): a high mass resolution ToF‐SIMS study
D. Briggs (2000)
10.1016/J.JCONREL.2006.11.028
Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells.
Y. Hu (2007)
10.1021/MA970350E
Tapping-Mode AFM Studies Using Phase Detection for Resolution of Nanophases in Segmented Polyurethanes and Other Block Copolymers
R. S. M. and (1997)
10.1021/LA970091M
Factors Affecting the Height and Phase Images in Tapping Mode Atomic Force Microscopy. Study of Phase-Separated Polymer Blends of Poly(ethene-co-styrene) and Poly(2,6-dimethyl-1,4-phenylene oxide)
G. Bar (1997)
10.1007/s11745-997-0071-7
Nonionic surfactants. Regioselective synthesis of fatty acid esters of α- and β-glucopyranose
D. Luca (1997)
10.1021/bm800684b
From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates.
M. Barz (2008)
biomimetic glycopolymer-polypeptide triblock copolymer
M. Nieto-Sampedro (2005)
10.1016/j.biomaterials.2009.06.047
Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.
Erin M Anderson (2009)
10.1016/S0032-3861(00)00464-X
Imaging of sub-surface nano particles by tapping-mode atomic force microscopy
Jiyun Feng (2001)
10.1016/S0927-7757(01)00865-2
Phase equilibria and physical-chemical properties of sugar-based surfactants in aqueous solutions
L. Coppola (2002)
10.1016/S0142-9612(03)00159-5
Time-of-flight secondary ion mass spectrometry: techniques and applications for the characterization of biomaterial surfaces.
A. Belu (2003)
equilibria and physical-chemical properties of sugar-based surfactants in aqueous solutions
K. Kuroda (2002)
10.1016/J.EURPOLYMJ.2008.07.056
Biodegradable and thermoresponsive micelles of triblock copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and ε-caprolactone for controlled drug delivery
V. Miguel (2008)
10.1021/IE50660A008
ATTRACTIVE FORCES AT INTERFACES
F. Fowkes (1964)
10.1002/MARC.200700663
Acid-Degradable Core-Crosslinked Micelles Prepared from Thermosensitive Glycopolymers Synthesized via RAFT Polymerization
Ling Zhang (2008)
10.1002/(SICI)1097-4636(19990605)45:3<184::AID-JBM4>3.0.CO;2-8
Hydrophilic acrylic biomaterials derived from vitamin E with antioxidant properties.
C. Ortiz (1999)
10.1002/SIA.3189
TOF‐SIMS depth profiling of deuterated polystyrene‐block‐poly(n‐propyl methacrylate) diblock copolymer films
J. Lee (2010)
10.1016/j.biomaterials.2011.10.031
Cationic glycopolymers for the delivery of pDNA to human dermal fibroblasts and rat mesenchymal stem cells.
Karina Kizjakina (2012)
10.1002/HEP.1840100215
Effect of galactose on interaction of N‐(2‐hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: Preliminary application to an anticancer agent, daunomycin
Kathryn B. O'Hare (1989)
10.1016/S0939-6411(02)00119-4
Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by Caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers.
J. Zastre (2002)
10.1126/SCIENCE.3289118
Astrocyte mitogen inhibitor related to epidermal growth factor receptor.
M. Nieto-Sampedro (1988)
10.1039/B717177C
Synthesis of well-defined glycopolymers and some studies of their aqueous solution behaviour.
N. Cameron (2008)
10.1016/0368-2048(95)02528-6
XPS and SIMS surface chemical analysis of some important classes of polymeric biomaterials
L. Sabbatini (1996)
10.1016/j.jconrel.2009.11.002
Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) nanoparticles: preparation and antitumor activity in vivo.
Zhenshu Zhu (2010)
10.1016/J.APSUSC.2004.03.063
ToF-SIMS molecular characterization and nano-SIMS imaging of submicron domain formation at the surface of PS/PMMA blend and copolymer thin films
L. Kailas (2004)
10.1016/j.biomaterials.2008.09.056
Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery.
Y. Patil (2009)
10.1002/POL.1985.170230219
Quantitative determination of the surface composition of acrylate copolymer latex films by XPS (ESCA)
A. P. Pijpers (1985)
10.1038/nrd1088
The dawning era of polymer therapeutics
R. Duncan (2003)
10.1002/1521-3935(20011101)202:17<3273::AID-MACP3273>3.0.CO;2-8
Amphiphilic Block Copolymers with Pendent Sugar as Hydrophilic Segments and Their Surface Properties
Yongming Chen (2001)
10.1007/S00396-009-2022-3
Self-assembling chitosan/poly-γ-glutamic acid nanoparticles for targeted drug delivery
Z. Keresztessy (2009)
10.1021/LA036274S
Plasma deposition and surface characterization of oligoglyme, dioxane, and crown ether nonfouling films.
E. Johnston (2005)
10.1063/1.2961027
X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy.
S. Ptasińska (2008)
10.1016/J.POLYMER.2006.07.068
Initiated chemical vapor deposition of polyvinylpyrrolidone-based thin films
K. Chan (2006)
10.1016/J.APSUSC.2006.02.225
PLA-PMMA blends: A study by XPS and ToF-SIMS
D. Cossement (2006)
10.1007/S10856-007-3317-X
The preparation of high conversion polymeric systems containing eugenol residues and their rheological characterization
L. Rojo (2008)
10.1021/IE50655A007
SURFACE ANALYSIS - "Interdisciplinary Aspects of Surface Phenomena"
L. J. Bonis (1964)
10.1021/AC00054A032
Location of double bonds in unsaturated fatty alcohols by microderivatization and liquid secondary ion tandem mass spectrometry
T. Nakamura (1993)
10.1021/JM0611556
Design and synthesis of glycoside inhibitors of glioma and melanoma growth.
I. García-Álvarez (2007)
10.1016/j.biomaterials.2011.03.082
The effect of polymer architecture, composition, and molecular weight on the properties of glycopolymer-based non-viral gene delivery systems.
M. Ahmed (2011)
10.1021/LA048646I
Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates.
Kyeongsoon Park (2004)
10.1002/SIA.1070
ToF‐SIMS study of the surface morphology of blends of polystyrene and poly(N‐vinyl‐2‐pyrrolidone) compatibilized by poly(styrene‐co‐4‐vinylphenol)
X. Zeng (2001)
10.1016/j.biomaterials.2009.09.061
Surface characterization of extracellular matrix scaffolds.
B. Brown (2010)
10.1002/CHEM.200400318
Machinable long PVP-stabilized silver nanowires.
Pei-hsun Jiang (2004)
10.1021/BM060105F
Biotinylated glycopolymers synthesized by atom transfer radical polymerization.
Vimary Vázquez-Dorbatt (2006)
10.1002/SIA.2008
Degradation of poly(acrylates) under SF5+ primary ion bombardment studied using time‐of‐flight secondary ion mass spectrometry. 3. Poly(hydroxyethyl methacrylate) with chemical derivatization
M. Wagner (2005)
10.1002/SIA.3028
Wetting properties of polystyrene/divinylbenzene crosslinked porous polymers obtained using W/O highly concentrated emulsions as templates
R. Molina (2009)



This paper is referenced by
10.1002/mabi.201300141
Self-assembling gradient copolymers of vinylimidazol and (acrylic)ibuprofen with anti-inflammatory and zinc chelating properties.
P. Suárez (2013)
10.1016/J.EURPOLYMJ.2013.06.025
Recent advances in the preparation of glycopolymer bioconjugates
M. Ahmed (2013)
10.1017/dce.2020.14
Numerical simulation, clustering, and prediction of multicomponent polymer precipitation
Pavan Inguva (2020)
10.1016/J.PROGPOLYMSCI.2015.07.005
Self-assembling polymer systems for advanced treatment of cancer and inflammation
Raquel Palao-Suay (2016)
1 Bioactive and Bioadhesive Catechol Conjugated 2 Polymers for Tissue Regeneration 3
María Puertas-Bartolomé (2018)
10.20944/preprints201806.0130.v1
Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
María Puertas-Bartolomé (2018)
Anticancer drug delivery to the brain : Outwitting the blood-brain barrier
Karlijn Zents (2012)
10.1021/acs.biomac.5b01449
Self-Assembled Cationic Biodegradable Nanoparticles from pH-Responsive Amino-Acid-Based Poly(Ester Urea Urethane)s and Their Application As a Drug Delivery Vehicle.
M. He (2016)
Sself-assembling polymerELF-ASSEMBLING POLYMER SYSTEMS FOR ADVANCED TREATMENT OF CANCER AND INFLAMMATIONR.Palao-Suay systems for advanced treatment of cancer and inflammation
M. Aguilar (2016)
Nanoinformatics approaches for information extraction and text mining in nanomedical research texts
I. Jimenez (2015)
10.3390/POLYM10070768
Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
María Puertas-Bartolomé (2018)
10.1177/0883911514554336
Amphiphilic polysaccharide nanocarriers with antioxidant properties
Ornella Bossio (2014)
10.1002/MACP.201500034
Bioactive Chitosan Nanoparticles Loaded with Retinyl Palmitate: A Simple Route Using Ionotropic Gelation
M. Fernández-Gutiérrez (2015)
10.1016/j.jcis.2013.04.025
Surface grafted glycopolymer brushes to enhance selective adhesion of HepG2 cells.
Sergey Chernyy (2013)
10.1039/C6RA03725A
Soft amphiphilic polyesters obtained from PEGs and silicon fatty compounds: structural characterizations and self-assembly studies
D. Andrade (2016)
Semantic Scholar Logo Some data provided by SemanticScholar