← Back to Search
Adhesion Of Mussel Foot Protein-3 To TiO2 Surfaces: The Effect Of PH.
J. Yu, W. Wei, M. Menyo, A. Masic, J. Waite, J. Israelachvili
Published 2013 · Medicine, Chemistry
Download PDFAnalyze on Scholarcy
The underwater adhesion of marine mussels relies on mussel foot proteins (mfps) rich in the catecholic amino acid 3,4-dihydroxyphenylalanine (Dopa). As a side chain, Dopa is capable of strong bidentate interactions with a variety of surfaces, including many minerals and metal oxides. Titanium is among the most widely used medical implant material and quickly forms a TiO2 passivation layer under physiological conditions. Understanding the binding mechanism of Dopa to TiO2 surfaces is therefore of considerable theoretical and practical interest. Using a surface forces apparatus, we explored the force-distance profiles and adhesion energies of mussel foot protein 3 (mfp-3) to TiO2 surfaces at three different pHs (pH 3, 5.5 and 7.5). At pH 3, mfp-3 showed the strongest adhesion force on TiO2, with an adhesion energy of ∼-7.0 mJ/m(2). Increasing the pH gives rise to two opposing effects: (1) increased oxidation of Dopa, thus, decreasing availability for the Dopa-mediated adhesion, and (2) increased bidentate Dopa-Ti coordination, leading to the further stabilization of the Dopa group and, thus, an increase in adhesion force. Both effects were reflected in the resonance-enhanced Raman spectra obtained at the three deposition pHs. The two competing effects give rise to a higher adhesion force of mfp-3 on the TiO2 surface at pH 7.5 than at pH 5.5. Our results suggest that Dopa-containing proteins and synthetic polymers have great potential as coating materials for medical implant materials, particularly if redox activity can be controlled.
This paper references
Strong reversible Fe3+-mediated bridging between dopa-containing protein films in water
Hongbo Zeng (2010)
TiO2 photocatalysis: Design and applications
K. Nakata (2012)
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
H. Lee (2007)
Effects of interfacial redox in mussel adhesive protein films on mica.
J. Yu (2011)
Variation of oxide films on titanium induced by osteoblast-like cell culture and the influence of an H2O2 pretreatment.
J. Pan (1998)
Self-assembly of focal point oligo-catechol ethylene glycol dendrons on titanium oxide surfaces: adsorption kinetics, surface characterization, and nonfouling properties.
Torben Gillich (2011)
Hydrophobic forces, electrostatic steering, and acid-base bridging between atomically smooth self-assembled monolayers and end-functionalized PEGolated lipid bilayers.
M. Valtiner (2012)
STUDY OF INTERFACIAL CHARGE-TRANSFER COMPLEX ON TIO2 PARTICLES IN AQUEOUS SUSPENSION BY SECOND-HARMONIC GENERATION
Y. Liu (1999)
Mussel-inspired block copolymer lithography for low surface energy materials of teflon, graphene, and gold.
B. H. Kim (2011)
A spectroscopic and electrochemical approach to the study of the interactions and photoinduced electron transfer between catechol and anatase nanoparticles in aqueous solution.
T. Lana-Villarreal (2005)
Ultraviolet Irradiation Suppresses Adhesion on TiO2
R. Jribi (2009)
Raman Scattering and Lattice-Dynamical Calculations of Crystalline KNO 3
D. Liu (1992)
Hydrophobic enhancement of Dopa-mediated adhesion in a mussel foot protein.
W. Wei (2013)
Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3
Q. Lin (2007)
Mussel-Inspired Adhesives and Coatings.
B. P. Lee (2011)
Mussel foot protein-1 (mcfp-1) interaction with titania surfaces().
D. Hwang (2012)
Raman spectroscopy of the acetates of sodium, potassium and magnesium at liquid nitrogen temperature
R. Frost (2000)
Critical survey of formation constants of complexes of histidine, phenylalanine, tyrosine, L-DOPA and tryptophan
L. Pettit (1984)
The Contribution of DOPA to Substrate-Peptide Adhesion and Internal Cohesion of Mussel-Inspired Synthetic Peptide Films.
T. Anderson (2010)
Simplified Polymer Mimics of Cross-Linking Adhesive Proteins
G. Westwood (2007)
The phylogeny and chemical diversity of quinone-tanned glues and varnishes.
J. Waite (1990)
Adsorption of Catechol on TiO2 Rutile (100): A Density Functional Theory Investigation
U. Terranova (2010)
Mussel protein adhesion depends on thiol-mediated redox modulation
J. Yu (2011)
Probing the Adhesive Footprints of Mytilus californianus Byssus*
H. Zhao (2006)
Excited-state dynamics of alizarin-sensitized TiO2 nanoparticles from resonance Raman spectroscopy
Lian C. T. Shoute (2002)
Recent advances in the surface forces apparatus (SFA) technique
J. Israelachvili (2010)
pH-induced metal-ligand cross-links inspired by mussel yield self-healing polymer networks with near-covalent elastic moduli
Niels Holten-Andersen (2011)
Protein- and Metal-dependent Interactions of a Prominent Protein in Mussel Adhesive Plaques*
D. Hwang (2010)
Mussel-inspired load bearing metal-polymer glues.
Alexander Stepuk (2012)
Biomimetic underwater adhesives with environmentally triggered setting mechanisms.
H. Shao (2010)
Single-molecule mechanics of mussel adhesion
H. Lee (2006)
Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces.
J. Dalsin (2003)
Iron-Clad Fibers: A Metal-Based Biological Strategy for Hard Flexible Coatings
Matthew J. Harrington (2010)
Zwitterion formation upon deprotonation in L-3, 4-dihydroxyphenylalanine and other phenolic amines.
Martin Rb (1971)
Bone response to surface modified titanium implants: studies on electropolished implants with different oxide thicknesses and morphology.
C. Larsson (1994)
Protein resistance of titanium oxide surfaces modified by biologically inspired mPEG-DOPA.
J. Dalsin (2005)
Adhesion mechanisms of the contact interface of TiO2 nanoparticles in films and aggregates.
S. Salameh (2012)
This paper is referenced by
An implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release.
Arathyram Ramachandra Kurup Sasikala (2016)
Stimuli-responsive degrafting of polymer brushes via addressable catecholato-metal attachments
Asger Holm Agergaard (2020)
Peptide Length and Dopa Determine Iron-Mediated Cohesion of Mussel Foot Proteins.
S. Das (2015)
Effect of pH on the Rate of Curing and Bioadhesive Properties of Dopamine Functionalized Poly(ethylene glycol) Hydrogels
M. Cencer (2014)
Recombinant Tyrosinase from Verrucomicrobium spinosum: Isolation, Characteristics, and Use for the Production of a Protein with Adhesive Properties
Altynai S Aksambayeva (2019)
Natural and bio-inspired underwater adhesives: Current progress and new perspectives
Mengkui Cui (2017)
Molecular interactions between DOPA and surfaces with different functional groups: a chemical force microscopy study
Wei Zhang (2017)
Mussel-inspired bioadhesives in healthcare: design parameters, current trends, and future perspectives.
Nikhil Pandey (2020)
Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide.
Mohammad Vatankhah-Varnoosfaderani (2015)
One-step dip coating of zwitterionic sulfobetaine polymers on hydrophobic and hydrophilic surfaces.
Harihara S. Sundaram (2014)
ADHESION OF DOPA FUNCTIONALIZED GELS TO SPIN LABELED SURFACES
Ü. H. Yıldız (2017)
Effect of Nitro-Functionalization on the Cross-Linking and Bioadhesion of Biomimetic Adhesive Moiety
M. Cencer (2015)
Fabrication of highly efficient ultraviolet absorbing PVDF membranes via surface polydopamine deposition
Li Dong (2018)
Hypoxia weakens mussel attachment by interrupting DOPA cross-linking during adhesive plaque curing
Matthew N George (2018)
Adsorption mechanism of mussel-derived adhesive proteins onto various self-assembled monolayers
Shizhe Huang (2017)
Studies on Preparation of Poly(3,4-Dihydroxyphenylalanine)-Polylactide Copolymers and the Effect of the Structure of the Copolymers on Their Properties
Dongjian Shi (2016)
Recovery property of double-network hydrogel containing mussel-inspired adhesive moiety and nano-silicate.
Yang Liu (2016)
Self-Assembled Nanofibers for Strong Underwater Adhesion: The Trick of Barnacles.
Chao Liang (2018)
Marine mussel adhesion and bio-inspired wet adhesives
L. Li (2016)
Catechol and HCl Adsorption on TiO2(110) in Vacuum and at the Water-TiO2 Interface.
H. Kristoffersen (2015)
Single-Molecule Force Spectroscopy Reveals Multiple Binding Modes between DOPA and Different Rutile Surfaces.
Yiran Li (2017)
Complex coacervates based on recombinant mussel adhesive proteins: their characterization and applications.
H. Kim (2017)
Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers
Amal Narayanan (2020)
The role of hydrophobic, aromatic and electrostatic interactions between amino acid residues and a titanium dioxide surface.
Avia Leader (2018)
Adaptive hydrophobic and hydrophilic interactions of mussel foot proteins with organic thin films
J. Yu (2013)
Unusual Stability of a Recombinant Verrucomicrobium spinosum Tyrosinase to Denaturing Agents and Its Use for a Production of a Protein with Adhesive Properties
A. S. Axambayeva (2018)
Single molecule evidence for the adaptive binding of DOPA to different wet surfaces.
Yiran Li (2014)
DESIGN OF ROBUST HYDROGEL BASED ON MUSSEL-INSPIRED CHEMISTRY
Yuan Liu (2017)
Perspectives on Mussel-Inspired Wet Adhesion.
B. Ahn (2017)
α,β-Dehydro-Dopa: A Hidden Participant in Mussel Adhesion.
R. Mirshafian (2016)
Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances
K. Xu (2021)
Metal-mediated molecular self-healing in histidine-rich mussel peptides.
S. Schmidt (2014)See more