Online citations, reference lists, and bibliographies.
← Back to Search

Polysaccharide-based Polyelectrolyte Complex Nanoparticles From Chitosan, Heparin, And Hyaluronan.

Soheil Boddohi, N. Moore, Patrick A Johnson, M. Kipper
Published 2009 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
The formation of polyelectrolyte complex nanoparticles (PCN) was investigated at different charge mixing ratios for the chitosan-heparin (chi-hep) and chitosan-hyaluronan (chi-ha) polycation-polyanion pairs. The range of 0.08-19.2 for charge mixing ratio (n(+)/n(-)) was examined. The one-shot addition of polycation and polyanion solutions used for the formation of the PCN permitted formation of both cationic and anionic particles from both polysaccharide pairs. The influence of the charge mixing ratio on the size and zeta potential of the particles was investigated. The morphology and stability of the particles when adsorbed to surfaces was studied by scanning electron microscopy (SEM). For most conditions studied, colloidally stable, nonstoichiometric PCN were formed in solution. However, PCN formation was inhibited by flocculation at charge mixing ratios near 1. When adsorbed to surfaces and dried, some formulations resulted in discrete nanoparticles, while others partially or completely aggregated or coalesced, leading to different surface morphologies.

This paper is referenced by
In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template.
S. Abbah (2012)
Europium(III)-induced water-soluble nano-aggregates of hyaluronic acid and chitosan: structure and fluorescence
J. Guo (2018)
Atomic force microscopy of adsorbed proteoglycan mimetic nanoparticles: Toward new glycocalyx-mimetic model surfaces.
M. Hedayati (2018)
Novel nanoparticle materials for drug/food delivery-polysaccharides
L. Chen (2016)
Élaboration d'assemblages colloïdaux à partir de nanoparticules de poly(acide lactique) et de chitosane
R. Roux (2013)
Micro- and nanofabrication of chitosan structures for regenerative engineering.
T. Jiang (2014)
Investigation of Self-Assembly Processes for Chitosan-Based Coagulant-Flocculant Systems: A Mini-Review
Savi Bhalkaran (2016)
Structure et mécanisme d’élaboration de biomatériaux par complexation contrôlée de polysaccharides
M. Costalat (2014)
Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives
Pasquale Sacco (2018)
General and biomimetic approach to biopolymer-functionalized graphene oxide nanosheet through adhesive dopamine.
Chong Cheng (2012)
Effect of stoichiometry and pH on the structure and properties of Chitosan/Chondroitin sulfate complexes
A. R. Fajardo (2011)
A comprehensive review on green synthesis of nature-inspired metal nanoparticles: Mechanism, application and toxicity
Anu Rana (2020)
Understanding the adsorption of salmon calcitonin, antimicrobial peptide AP114 and polymyxin B onto lipid nanocapsules.
A. Umerska (2016)
Nanocarriers for cytoplasmic delivery: cellular uptake and intracellular fate of chitosan and hyaluronic acid-coated chitosan nanoparticles in a phagocytic cell model.
N. M. Zaki (2011)
Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules.
T. Delair (2011)
Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends.
M. Rahmati (2018)
Manufacture Techniques of Chitosan‐Based Microparticles and Nanoparticles for Biopharmaceuticals
F. Ferrari (2012)
Tailorable Trimethyl chitosans as adjuvant for intranasal immunization
Rolf J. Verheul (2010)
Two-Phase Electrospinning to Incorporate Polyelectrolyte Complexes and Growth Factors into Electrospun Chitosan Nanofibers.
Laura W. Place (2016)
Heparin-Based Nanoparticles: An Overview of Their Applications
M. Rodriguez-Torres (2018)
Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology
P. Dutta (2013)
Biopolymer-based microgels/nanogels for drug delivery applications
J. Oh (2009)
Engineering nanoassemblies of polysaccharides.
Soheil Boddohi (2010)
Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering
Sachiko Nitta (2013)
Encapsulation of rat bone marrow stromal cells using a poly‐ion complex gel of chitosan and succinylated poly(Pro–Hyp–Gly)
Y. Kusumastuti (2017)
Engineering Soft Nanostructures for Guided Cell Response
Matt J Kipper (2010)
Review of polysaccharide particle-based functional drug delivery.
Thomas G Barclay (2019)
In Vitro Efficacy of Polysaccharide-Based Nanoparticles Containing Disease-Modifying Antirheumatic Drugs
N. Zhang (2014)
Facile preparation of cationic P (St-BA-METAC) copolymer nanoparticles and the investigation of their interaction with bovine serum albumin
Penghui Li (2012)
Intermolecular interactions between salmon calcitonin, hyaluronate, and chitosan and their impact on the process of formation and properties of peptide-loaded nanoparticles.
A. Umerska (2014)
Hard tissue regeneration using bone substitutes: an update on innovations in materials
S. Sarkar (2015)
Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques.
S. Beyer (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar