Online citations, reference lists, and bibliographies.
← Back to Search

Polysaccharide-based Polyelectrolyte Complex Nanoparticles From Chitosan, Heparin, And Hyaluronan.

Soheil Boddohi, N. Moore, Patrick A Johnson, M. Kipper
Published 2009 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The formation of polyelectrolyte complex nanoparticles (PCN) was investigated at different charge mixing ratios for the chitosan-heparin (chi-hep) and chitosan-hyaluronan (chi-ha) polycation-polyanion pairs. The range of 0.08-19.2 for charge mixing ratio (n(+)/n(-)) was examined. The one-shot addition of polycation and polyanion solutions used for the formation of the PCN permitted formation of both cationic and anionic particles from both polysaccharide pairs. The influence of the charge mixing ratio on the size and zeta potential of the particles was investigated. The morphology and stability of the particles when adsorbed to surfaces was studied by scanning electron microscopy (SEM). For most conditions studied, colloidally stable, nonstoichiometric PCN were formed in solution. However, PCN formation was inhibited by flocculation at charge mixing ratios near 1. When adsorbed to surfaces and dried, some formulations resulted in discrete nanoparticles, while others partially or completely aggregated or coalesced, leading to different surface morphologies.



This paper is referenced by
10.1016/j.jconrel.2012.07.027
In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template.
S. Abbah (2012)
10.1557/MRC.2018.107
Europium(III)-induced water-soluble nano-aggregates of hyaluronic acid and chitosan: structure and fluorescence
J. Guo (2018)
10.1016/j.carbpol.2018.02.023
Atomic force microscopy of adsorbed proteoglycan mimetic nanoparticles: Toward new glycocalyx-mimetic model surfaces.
M. Hedayati (2018)
10.1515/psr-2016-0053
Novel nanoparticle materials for drug/food delivery-polysaccharides
L. Chen (2016)
Élaboration d'assemblages colloïdaux à partir de nanoparticules de poly(acide lactique) et de chitosane
R. Roux (2013)
10.1016/j.actbio.2013.07.003
Micro- and nanofabrication of chitosan structures for regenerative engineering.
T. Jiang (2014)
10.3390/ijms17101662
Investigation of Self-Assembly Processes for Chitosan-Based Coagulant-Flocculant Systems: A Mini-Review
Savi Bhalkaran (2016)
Structure et mécanisme d’élaboration de biomatériaux par complexation contrôlée de polysaccharides
M. Costalat (2014)
10.3390/gels4030067
Concepts for Developing Physical Gels of Chitosan and of Chitosan Derivatives
Pasquale Sacco (2018)
10.1021/bm3014999
General and biomimetic approach to biopolymer-functionalized graphene oxide nanosheet through adhesive dopamine.
Chong Cheng (2012)
10.1007/S00396-011-2497-6
Effect of stoichiometry and pH on the structure and properties of Chitosan/Chondroitin sulfate complexes
A. R. Fajardo (2011)
10.1016/j.jclepro.2020.122880
A comprehensive review on green synthesis of nature-inspired metal nanoparticles: Mechanism, application and toxicity
Anu Rana (2020)
10.1016/j.ijpharm.2016.04.028
Understanding the adsorption of salmon calcitonin, antimicrobial peptide AP114 and polymyxin B onto lipid nanocapsules.
A. Umerska (2016)
10.1002/mabi.201100156
Nanocarriers for cytoplasmic delivery: cellular uptake and intracellular fate of chitosan and hyaluronic acid-coated chitosan nanoparticles in a phagocytic cell model.
N. M. Zaki (2011)
10.1016/j.ejpb.2010.12.001
Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules.
T. Delair (2011)
10.1007/5584_2018_278
Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends.
M. Rahmati (2018)
10.1002/9781119962977.CH9
Manufacture Techniques of Chitosan‐Based Microparticles and Nanoparticles for Biopharmaceuticals
F. Ferrari (2012)
Tailorable Trimethyl chitosans as adjuvant for intranasal immunization
Rolf J. Verheul (2010)
10.1002/mabi.201500288
Two-Phase Electrospinning to Incorporate Polyelectrolyte Complexes and Growth Factors into Electrospun Chitosan Nanofibers.
Laura W. Place (2016)
10.1155/2018/9780489
Heparin-Based Nanoparticles: An Overview of Their Applications
M. Rodriguez-Torres (2018)
10.1007/978-3-642-40123-7
Multifaceted Development and Application of Biopolymers for Biology, Biomedicine and Nanotechnology
P. Dutta (2013)
10.1016/J.PROGPOLYMSCI.2009.08.001
Biopolymer-based microgels/nanogels for drug delivery applications
J. Oh (2009)
10.1002/adma.200903790
Engineering nanoassemblies of polysaccharides.
Soheil Boddohi (2010)
10.3390/ijms14011629
Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering
Sachiko Nitta (2013)
10.1002/term.1987
Encapsulation of rat bone marrow stromal cells using a poly‐ion complex gel of chitosan and succinylated poly(Pro–Hyp–Gly)
Y. Kusumastuti (2017)
10.1201/B10372-14
Engineering Soft Nanostructures for Guided Cell Response
Matt J Kipper (2010)
10.1016/J.CARBPOL.2019.05.067
Review of polysaccharide particle-based functional drug delivery.
Thomas G Barclay (2019)
10.1007/s11095-014-1329-z
In Vitro Efficacy of Polysaccharide-Based Nanoparticles Containing Disease-Modifying Antirheumatic Drugs
N. Zhang (2014)
10.1002/APP.35676
Facile preparation of cationic P (St-BA-METAC) copolymer nanoparticles and the investigation of their interaction with bovine serum albumin
Penghui Li (2012)
10.1016/j.ijpharm.2014.10.023
Intermolecular interactions between salmon calcitonin, hyaluronate, and chitosan and their impact on the process of formation and properties of peptide-loaded nanoparticles.
A. Umerska (2014)
10.3904/kjim.2015.30.3.279
Hard tissue regeneration using bone substitutes: an update on innovations in materials
S. Sarkar (2015)
10.1016/j.jconrel.2016.06.013
Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques.
S. Beyer (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar