Online citations, reference lists, and bibliographies.
← Back to Search

Role Of Caco‐2 Cell Monolayers In Prediction Of Intestinal Drug Absorption

Pranav J. Shah, Viral V Jogani, T. Bagchi, A. Misra
Published 2006 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The usefulness of Caco‐2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco‐2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.
This paper references
10.1038/sj.bjp.0702703
Active intestinal elimination of ciprofloxacin in rats: modulation by different substrates
S. Dautrey (1999)
10.1002/JPS.10570
Transport of octreotide and evaluation of mechanism of opening the paracellular tight junctions using superporous hydrogel polymers in Caco-2 cell monolayers.
F. Dorkoosh (2004)
10.1002/JPS.10176
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.
Erin D. Hugger (2002)
10.1016/0928-0987(95)00007-Z
Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption
A. Wikman-Larhed (1995)
10.1021/JS980082D
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
V. Wacher (1998)
10.1208/ps050324
High glucose concentration in isotonic media alters Caco-2 cell permeability
V. M. Souza (2008)
10.1002/JPS.2600790604
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells.
P. Artursson (1990)
10.1023/A:1016245711557
Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon
Y. Tanaka (2004)
Intestinal barriers to oral drug absorption: Cytochrome P450 3A and ABC-transport proteins
H. Engman (2003)
10.1016/0016-5085(92)90829-N
Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line.
P. Vachon (1992)
10.1023/A:1016207809199
Effects of Absorption Enhancers on Rat Nasal Epithelium in Vivo: Release of Marker Compounds in the Nasal Cavity
E. Marttin (2004)
Evidence for a polarized efflux system in Caco - 2 cells capable of modulating cyclosporine A
P. F. Augustijns (1993)
10.1093/JN/124.10.1907
Mechanisms and kinetics of uptake and efflux of L-methionine in an intestinal epithelial model (Caco-2).
J. Chen (1994)
10.1124/MOL.51.5.741
Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.
P. Schmiedlin-Ren (1997)
10.1016/j.clpt.2004.09.001
P‐Glycoprotein and Surfactants: Effect on Intestinal Talinolol Absorption
K. Bogman (2005)
10.1023/B:PHAM.0000008043.71001.43
Development of a 7-Day, 96-Well Caco-2 Permeability Assay with High-Throughput Direct UV Compound Analysis
J. Alsenz (2004)
10.1016/0022-1759(83)90303-4
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
T. Mosmann (1983)
10.1016/0005-2736(90)90309-C
Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2.
A. Dantzig (1990)
10.1016/S0378-5173(01)00599-3
Targeted drug delivery systems 6: Intracellular bioreductive activation, uptake and transport of an anticancer drug delivery system across intestinal Caco-2 cell monolayers.
L. Gharat (2001)
10.1016/j.addr.2012.09.005
Caco-2 monolayers in experimental and theoretical predictions of drug transport.
P. Artursson (2001)
10.1016/0378-5173(95)04204-0
Comparison between active and passive drug transport in human intestinal epithelial (Caco-2) cells in vitro and human jejunum in vivo
H. Lennernäs (1996)
10.2174/1568026013395010
Assessing the absorption of new pharmaceuticals.
I. Hidalgo (2001)
10.1021/JS9803205
MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening.
J. D. Irvine (1999)
10.1016/S0169-409X(96)00416-4
The use of the intestinal epithelial cell culture model, Caco-2, in pharmaceutical development
C. Bailey (1996)
10.1016/S0378-5173(98)00330-5
Prediction of dissolution-absorption relationships from a dissolution/Caco-2 system.
M. Ginski (1999)
10.1002/(SICI)1097-0231(20000331)14:6<523::AID-RCM906>3.0.CO;2-T
High-throughput caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry.
H. Bu (2000)
10.1023/A:1015844104539
A Model of Human Small Intestinal Absorptive Cells. 1. Transport Barrier
J. N. Cogburn (2004)
10.1016/S0014-827X(99)00069-5
Use of a Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics.
E. Biganzoli (1999)
10.1021/JS960158A
Strategies for delivery of peptides utilizing absorption-enhancing agents.
J. Fix (1996)
10.1016/J.IJPHARM.2004.07.055
Comparison of different intestinal epithelia as models for absorption enhancement studies.
I. Legen (2005)
10.1007/s00125-001-0751-z
Self-assembled “nanocubicle” as a carrier for peroral insulin delivery
H. Chung (2001)
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
M. Pinto (1983)
10.3109/03639049409038322
USE OF CACO-2 CELLS AS AN IN VITRO INTESTINAL ABSORPTION AND METABOLISM MODEL
Liang Gan (1994)
10.1016/S0378-5173(99)00254-9
Lectin-mediated transport of nanoparticles across Caco-2 and OK cells.
G. J. Russell-Jones (1999)
10.1016/0168-3659(96)86691-0
P 1 Caco-2 cells as an in vitro model for adenoviral gene transfer to the gut epithelium
E. Walter (1996)
10.1016/S1359-6446(04)03354-9
Cell culture-based models for intestinal permeability: a critique.
P. Balimane (2005)
10.1023/A:1020957430400
Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl)Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug
Lian Zhou (2004)
P - glycoprotein ( Pgp ) mediated efflux on Caco - 2 cell monolayers : The influence of culturing conditions and drug exposure on Pgp expression levels
P. Anderle (1998)
10.1016/S1461-5347(00)00302-3
Enhancing paracellular permeability by modulating epithelial tight junctions.
Ward (2000)
10.1023/A:1011919003030
Correlation Between Oral Drug Absorption in Humans, and Apparent Drug Permeability in TC-7 Cells, A Human Epithelial Intestinal Cell Line: Comparison with the Parental Caco-2 Cell Line
Marie-Catherine Grès (2004)
10.1016/J.BCP.2005.02.010
Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells.
C. Koehle (2005)
10.1016/S0939-6411(01)00172-2
Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin.
D. S. Cox (2001)
10.1023/A:1018937416447
Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption
W. Rubas (2004)
10.1023/B:PHAM.0000003379.76417.3e
Uptake of Chitosan and Associated Insulin in Caco-2 Cell Monolayers: A Comparison Between Chitosan Molecules and Chitosan Nanoparticles
Zengshuan Ma (2004)
Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model.
S. P. Ng (2004)
Implementation of the caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In-house evaluation procedures.
F. Ingels (2002)
10.1016/S0928-0987(03)00205-7
In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model.
S. A. Bravo (2004)
10.1023/A:1016212804288
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
G. Amidon (2004)
10.1016/0378-5173(94)00233-U
Drug delivery studies in Caco-2 monolayers. III. Intestinal transport of various vasopressin analogues in the presence of lysophosphatidylcholine
H. Brøndsted (1995)
10.1002/JPS.2600830521
Cytotoxic effects of pamidronate on monolayers of human intestinal epithelial (Caco-2) cells and its epithelial transport.
I. Twiss (1994)
Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.
R. H. Stephens (2001)
10.1016/S0378-5173(03)00300-4
Effects of various absorption enhancers on transport of clodronate through Caco-2 cells.
J. Raiman (2003)
10.1111/j.1476-5381.1993.tb13914.x
Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein
J. Karlsson (1993)
Cell cultures as models for drug absorption across the intestinal mucosa.
P. Artursson (1991)
10.1023/A:1020456632737
Characterization of the Transport of Uracil Across Caco-2 and LLC-PK1 Cell Monolayers
H. Li (2004)
10.1007/BF00756522
The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications
V. Meunier (2004)
10.1146/ANNUREV.BB.07.060178.002251
Interactions of liposomes with mammalian cells.
R. Pagano (1978)
Drug transport across gastrointestinal epithelia
J. JacksonM.
10.1016/S0168-3659(02)00027-5
Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins.
M. Torres-Lugo (2002)
10.1016/J.EJPB.2004.02.014
Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery.
P. Balimane (2004)
10.1023/A:1011929016601
Chitosan and its use as a pharmaceutical excipient.
L. Illum (1998)
10.1016/S0168-3659(02)00419-4
Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers.
L. Bromberg (2003)
10.1016/0168-3659(93)90179-9
Absorption enhancers in nasal drug delivery: efficacy and safety
F. W. H. M. Merkus (1993)
10.1016/J.EJPB.2003.10.016
Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC.
J. Palmgrén (2004)
10.1023/A:1012112820371
Evaluation of Biocoat® Intestinal Epithelium Differentiation Environment (3-Day Cultured Caco-2 Cells) as an Absorption Screening Model with Improved Productivity
S. Chong (2004)
Toxicity and permeability screening of microemulsions using Caco - 2 cells and class II drugs
S. Effer (2002)
Mechanisms and kinetics of uptake and effect of L-Methionine in an intestinal epithelial model
J Chen
10.3109/10611869308996092
Intestinal tissue distribution and epithelial transport of the oral immunogen LTB, the B subunit of E. coli heat-labile enterotoxin.
L. Lazorova (1993)
NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR CANCER CHEMOTHARAPY
K. Y. Win
10.1016/0006-291X(91)91647-U
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells.
P. Artursson (1991)
10.1016/0005-2736(90)90261-L
Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2.
I. Hidalgo (1990)
10.1016/J.IJPHARM.2005.03.008
Validation of the 96 well Caco-2 cell culture model for high throughput permeability assessment of discovery compounds.
A. Marino (2005)
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators.
J. Hunter (1993)
10.1023/A:1012126301290
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
M. P. Desai (2004)
10.1023/A:1018990602102
In Vitro/in Vivo Models for Peptide Oral Absorption: Comparison of Caco-2 Cell Permeability with Rat Intestinal Absorption of Renin Inhibitory Peptides
R. Conradi (2004)
10.1023/A:1011908128045
Recent Advances in Intestinal Macromolecular Drug Delivery via Receptor-Mediated Transport Pathways
P. Swaan (2004)
10.1016/S0168-3659(02)00238-9
Preparation and evaluation of proliposomes containing salmon calcitonin.
Keon-Hyoung Song (2002)
10.1023/A:1012155124489
Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond
P. Artursson (2004)
10.1016/J.JCONREL.2003.12.006
The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability.
A. D’Emanuele (2004)
Tight ( occluding ) junctions in cultured and native epithelial cells
J. L. Madara
Interplay between CYP 3 A - mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco - 2 ( TC 7 ) cell monolayers
S. D. Raeissi (1999)
10.1016/S0168-3659(97)00154-5
Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2).
A. Kotzé (1998)
10.1016/S0378-5173(01)00663-9
Development of a new system for prediction of drug absorption that takes into account drug dissolution and pH change in the gastro-intestinal tract.
M. Kobayashi (2001)
A conditionally immortalized epithelial cell line for studies of intestinal drug transport.
S. Tavelin (1999)
10.1016/S0168-3659(97)00058-8
Comparison of permeability characteristics of the human colonic Caco-2 and rat small intestinal IEC-18 cell lines
E. Duizer (1997)
10.1023/A:1018903931777
Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments
P. Artursson (2004)
10.1016/S0939-6411(00)00113-2
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
P. Saha (2000)
10.1211/0022357044085
Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco‐2 cell lines, and rat jejunum
G. Sandri (2004)
Poly ( ethylene glycol ) - coated liposomes for oral delivery of recombinant human epidermal growth factor
H. Li (2003)
Evaluation of an accelerated Caco - 2 permeability model
E. Liang (2000)
In vitro permeability across Caco - 2 cells ( colonic ) can predict in vivo absorption in man - Fact or myth
S. Yee (1997)
10.1016/S0378-5173(98)00013-1
Drug absorption studies of prodrug esters using the Caco-2 model: evaluation of ester hydrolysis and transepithelial transport
P. Augustijns (1998)
10.1021/JS980111K
Link between drug absorption solubility and permeability measurements in Caco-2 cells.
V. Pade (1998)
10.1023/A:1018838121975
Automated Absorption Assessment Using Caco-2 Cells Cultured on Both Sides of Polycarbonate Membranes
P. Garberg (2004)
10.1007/BF01871231
Common characteristics for Na+-dependent sugar transport in Caco-2 cells and human fetal colon
A. Blais (2005)
10.1023/A:1015937605100
Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa
A. Hilgers (2004)
An automated system for the determination of intestinal permeability ( Caco - 2 cells ) in support of drug discovery
J. Russell (1999)
P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4.
J. Hochman (2001)
10.1023/A:1016204602471
Drug Delivery Studies in Caco-2 Monolayers. Synthesis, Hydrolysis, and Transport of O-Cyclopropane Carboxylic Acid Ester Prodrugs of Various β-Blocking Agents
L. Hovgaard (2004)
10.1124/MOL.59.4.806
P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.
M. T. Huisman (2001)
10.1016/J.LFS.2004.05.027
The effect of various liposome formulations on insulin penetration across Caco-2 cell monolayer.
Z. Değim (2004)
10.1016/J.EJPB.2004.02.008
Investigation of the cytotoxicity and insulin transport of acrylic-based copolymer protein delivery systems in contact with Caco-2 cultures.
Aaron C Foss (2004)
10.1023/A:1012106907708
N-Trimethyl Chitosan Chloride as a Potential Absorption Enhancer Across Mucosal Surfaces: In Vitro Evaluation in Intestinal Epithelial Cells (Caco-2)
Awie R Kotzé (2004)
10.1016/0168-3659(95)00146-8
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
G. Borchard (1996)
The paracellular approach : Drug transport and its enhancement via the paracellular pathway
A . G. de-Boer
Vitamin B 12 - mediated transport of nanoparticles across Caco - 2 cells
G. J. Russell-Jones (1999)
10.1002/JPS.20234
Evaluation of dodecylmaltoside as a permeability enhancer for insulin using human carcinoma cells.
P. P. Tirumalasetty (2005)
10.1016/S0928-0987(02)00055-6
Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
B. Rege (2002)
10.1023/A:1015906409585
Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2)
M. Hu (2004)
10.1021/JS9800735
Enhancement of intestinal model compound transport by DS-1, a modified Quillaja saponin.
A. Chao (1998)
10.1016/S0168-3659(98)00043-1
Lectin-mediated bioadhesion: binding characteristics of plant lectins on the enterocyte-like cell lines Caco-2, HT-29 and HCT-8.
F. Gabor (1998)
10.1016/0378-5173(94)00232-T
Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines
L. Hovgaard (1995)
Thakker , D . CYP 3 A - like cytochrome P 450 - mediated metabolism and polarized efflux of cyclosporin A in Caco - 2 cells
L.-S. Gan (1996)
10.1023/B:PHAM.0000045247.09724.26
Binding and Uptake of Wheat Germ Agglutinin-Grafted PLGA-Nanospheres by Caco-2 Monolayers
A. Weissenboeck (2004)
10.1016/S1382-6689(01)00122-3
Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: comparison of active and passive transport with the human colon carcinoma Caco-2 cell line.
C. H. Versantvoort (2002)
10.1016/S0939-6411(03)00111-5
Solubilization of cyclosporin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles.
M. Francis (2003)
10.1080/10717540490280345
Transepithelial Electrical Resistance is Not a Reliable Measurement of the Caco-2 Monolayer Integrity in Transwell
T. Mukherjee (2004)
10.1023/A:1022211127890
Microfabricated Porous Silicon Particles Enhance Paracellular Delivery of Insulin Across Intestinal Caco-2 Cell Monolayers
Amy B. Foraker (2004)
10.1023/A:1022262818573
N-in-One Permeability Studies of Heterogeneous Sets of Compounds Across Caco-2 Cell Monolayers
L. Laitinen (2004)
10.1016/S0169-409X(96)00427-9
Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium
Liang Gan (1997)
10.1023/A:1016207525186
Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans
B. Stewart (2004)
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.
L. Gan (1996)
10.1152/AJPGI.1982.242.6.G558
Horseradish peroxidase transport across adult rabbit jejunum in vitro.
M. Heyman (1982)
10.1016/S0014-2999(98)00607-4
Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells.
M. Takano (1998)
10.2174/1568026013394886
Strategies for absorption screening in drug discovery and development.
H. Bohets (2001)
In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome.
D. Sun (2004)
10.1038/sj.bjp.0703150
Active transport of the angiotensin‐II antagonist losartan and its main metabolite EXP 3174 across MDCK‐MDR1 and Caco‐2 cell monolayers
A. Soldner (2000)
10.3109/10611869509015920
Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions.
E. Björk (1995)
10.1208/ps010203
Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system
M. Ginski (2008)
10.1016/J.EJPS.2004.05.009
Drug permeation in biomembranes: in vitro and in silico prediction and influence of physicochemical properties.
Annika Mälkiä (2004)
10.1016/0168-3659(96)86694-6
P 2 Characterization of (paracellular-)transport properties of IEC-18 and Caco-2
E. Duizer (1996)
10.1073/PNAS.94.5.2031
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.
A. Sparreboom (1997)
10.1016/0304-4165(90)90179-Z
Transport of bile acids in a human intestinal epithelial cell line, Caco-2.
I. Hidalgo (1990)
10.1016/S0016-5085(89)80072-1
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.
I. Hidalgo (1989)
Applications of the Caco - 2 model in the design and development of orally active drugs : elucidation of 196 Biotechnol
D. R. Thakker (2006)
Interaction of Pristinmaycin I with Pgp in human intestinal epithelial cells
V. Phung-Ba (1995)
10.1016/J.IJPHARM.2004.08.004
Normal flora: living vehicles for non-invasive protein drug delivery.
J. Shao (2004)
10.1016/S0378-5173(98)00331-7
Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures.
C. L. Stevenson (1999)
10.1007/BF01875056
Enhancement of paracellular drug transport across epithelia —in vitro andin vivo studies
A. Noach (2005)
10.1177/1087057104267162
Comparison of in Vitro Models for the Prediction of Compound Absorption across the Human Intestinal Mucosa
S. Miret (2004)
10.1016/J.JCONREL.2003.09.010
Bacterial ghosts as novel advanced drug delivery systems: antiproliferative activity of loaded doxorubicin in human Caco-2 cells.
S. Paukner (2004)
10.1016/0378-5173(95)04259-8
Transfer of metformin across monolayers of human intestinal Caco-2 cells and across rat intestine
P. Nicklin (1996)
10.1016/S0928-0987(00)00076-2
Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells.
S. Yamashita (2000)
10.1023/A:1015807904558
The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport Barrier
Moo J. Cho (2004)
10.1126/SCIENCE.8153632
Association of intestinal peptide transport with a protein related to the cadherin superfamily.
A. Dantzig (1994)
10.1016/0378-5173(93)90363-K
The mucus layer as a barrier to drug absorption in monolayers of human intestinal epithelial HT29-H goblet cells
J. Karlsson (1993)



This paper is referenced by
10.1201/B11401-17
Nanoparticle Processing of Cholesterol-Lowering Drug
T. Fukami (2011)
Fetal and Perinatal Exposure to Drugs and Chemicals : Novel Biomarkers of Risk
Manjeet Deshmukh (2014)
10.1016/j.jddst.2019.101248
A novel microfluidic mucus-chip for studying the permeation of compounds over the mucus barrier
Linda Elberskirch (2019)
10.1016/j.jafr.2020.100031
Perspectives on Important Considerations in Designing Nanoparticles for Oral Delivery Applications in Food
Y. Luo (2020)
10.13016/M27B08
Investigation of intercellular adhesion molecule-1 targeted drug transport across the gastrointestinal epithelium
Rasa Ghaffarian (2015)
Functional genomics for proving the existence of calcium binding proteins in finger millet and their facilitating role in calcium uptake under intestinal mimicking environment
Mamta Metwal (2016)
10.1897/IEAM-2008-088.1
Bioaccumulation Assessment Using Predictive Approaches
J. Nichols (2009)
10.1021/bm200116z
Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers.
I. Lin (2011)
10.1124/dmd.109.030775
Monocarboxylate Transporter-Mediated Transport of γ-Hydroxybutyric Acid in Human Intestinal Caco-2 Cells
W. K. Lam (2010)
10.3109/10408444.2013.768596
Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans
C. Thompson (2013)
10.1089/ten.tec.2008.0410
Cryopreservation of adherent cells: strategies to improve cell viability and function after thawing.
Rita Malpique (2009)
10.2147/DDDT.S109589
Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation
Iúri Frias (2016)
10.1016/j.foodchem.2012.10.137
Transepithelial transport of 6-O-caffeoylsophorose across Caco-2 cell monolayers.
H. Phuong (2013)
Development of curcumin lipid formulations for food applications: transport, permeability and safety evaluation on a mucus-secreting intestinal epithelial cell model
João Paulo Caseiro Baixinho (2018)
10.1016/J.BMCL.2007.11.043
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.
D. Cole (2008)
10.1186/1472-6750-12-90
Chemo-enzymatic synthesis and in vitro cytokine profiling of tailor-made oligofructosides
Arne Homann (2012)
10.1016/j.chroma.2018.07.081
pH-dependent surface electrostatic effects in retention on immobilized artificial membrane chromatography: Determination of the intrinsic phospholipid-water sorption coefficients of diverse analytes.
Yu-Xiu Yang (2018)
10.1016/J.FOODRES.2012.07.063
Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model
Y. Xie (2013)
10.1007/s12272-015-0704-6
Functional and cytometric examination of different human lung epithelial cell types as drug transport barriers
K. A. Min (2016)
10.1007/978-1-4939-8600-2_11
3D Model Replicating the Intestinal Function to Evaluate Drug Permeability.
I. Pereira (2018)
10.1039/c7fo01388d
Production, optimisation and characterisation of angiotensin converting enzyme inhibitory peptides from sea cucumber (Stichopus japonicus) gonad.
Chan Zhong (2018)
10.2174/1389200211309010028
Improving oral absorption via drug-loaded nanocarriers: absorption mechanisms, intestinal models and rational fabrication.
M. Shahbazi (2013)
10.1089/jmf.2016.0024
Assessment of Beneficial and Possible Toxic Effects of Two New Alfalfa-Derived Shelf Products.
M. G. Soto-Zarazúa (2016)
10.21519/0234-2758-2020-36-1-25-29
Transcriptome analysis of signaling pathways involved in the formation of intestinal villi in Caco-2 cells
M. P. Raigorodskaya (2020)
10.1365/S10337-006-0140-3
Prediction of Human Drug Absorption Using Liposome Electrokinetic Chromatography
Y. Wang (2007)
CACO-2 CELLS: AN OVERVIEW
A. L. Rao (2009)
10.3390/nu12030762
A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Maria Maares (2020)
10.1002/9780470929278.CH4
Drug‐Metabolizing Enzymes, Transporters, and Drug–Drug Interactions
S. W. Louie (2011)
10.1080/03639040701655952
In Vitro Assessment of Acyclovir Permeation Across Cell Monolayers in the Presence of Absorption Enhancers
Pranav J. Shah (2008)
10.1016/j.clnu.2008.08.003
Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells.
S. Bahri (2008)
10.1016/j.ejmech.2010.04.040
Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors.
Frédéric De Wael (2010)
10.1039/c9fo01345h
Mulberry leaf polyphenols attenuated postprandial glucose absorption via inhibition of disaccharidases activity and glucose transport in Caco-2 cells.
Q. Li (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar