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Blue Light-mediated Manipulation Of Transcription Factor Activity In Vivo.

S. Masuda, Y. Nakatani, Shukun Ren, Mikiko Tanaka
Published 2013 · Biology, Medicine

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We developed a novel technique for manipulating the activity of transcription factors with blue light (termed "PICCORO") using the bacterial BLUF-type photoreceptor protein PixD. The chimeric dominant-negative T-box transcription factor No Tail formed heterologous complexes with a PixD decamer in a light-dependent manner, and these complexes affected transcription repressor activity. When applied to zebrafish embryos, PICCORO permitted regulation of the activity of the mutant No Tail in response to 472-nm light provided by a light-emitting diode.
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