Exploring Disease Through Metabolomics.
Nawaporn Vinayavekhin, Edwin A. Homan, Alan Saghatelian
Published 2010 · Biology, Medicine
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Metabolomics approaches provide an analysis of changing metabolite levels in biological samples. In the past decade, technical advances have spurred the application of metabolomics in a variety of diverse research areas spanning basic, biomedical, and clinical sciences. In particular, improvements in instrumentation, data analysis software, and the development of metabolite databases have accelerated the measurement and identification of metabolites. Metabolomics approaches have been applied to a number of important problems, which include the discovery of biomarkers as well as mechanistic studies aimed at discovering metabolites or metabolic pathways that regulate cellular and physiological processes. By providing access to a portion of biomolecular space not covered by other profiling approaches (e.g., proteomics and genomics), metabolomics offers unique insights into small molecule regulation and signaling in biology. In the following review, we look at the integration of metabolomics approaches in different areas of basic and biomedical research, and try to point out the areas in which these approaches have enriched our understanding of cellular and physiological biology, especially within the context of pathways linked to disease.
This paper references
The lipid maps initiative in lipidomics.
Kara Schmelzer (2007)
Meta - bolic profiling technologies for biomarker discovery in biomedicine and drug development
G. Schlotterbeck (2006)
Electrostatic axially harmonic orbital trapping: a high-performance technique of mass analysis
Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry.
Xianlin Han (2004)
Direct-coupling of FT-NMR to high performance liquid chromatography.
Noriyuki Watanabe (1978)
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.
Kyle Chiang (2006)
A Contribution to the Study of Alkaptonuria.
Archibald E. Sir Garrod (1899)
Differential metabolic networks unravel the effects of silent plant phenotypes.
Wolfram Weckwerth (2004)
Metabolomics tools for identifying biomarkers for neuropsychiatric diseases
M. Quiñones (2009)
Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism
J. Wang (2009)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um (2004)
LC-NMR coupling technology: recent advancements and applications in natural products analysis.
Vassiliki Exarchou (2005)
On-line coupling of high-performance liquid chromatography and nuclear magnetic resonance
Ernst Bayer (1979)
Mass spectrometry - basedmetabolomics , Mass Spectrom
K. Dettmer (2007)
Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
S. H. Um (2004)
Pharmaco-metabonomic phenotyping and personalized drug treatment
T. Andrew Clayton (2006)
Extending the scope of NMR spectroscopy with microcoil probes.
Frank C. Schroeder (2006)
Mass spectrometry-based metabolomics.
K. Dettmer (2007)
Metabolomics and biochemical profiling in drug discovery and development.
Watkins Sm (2002)
Kinetic flux profiling of nitrogen assimilation in Escherichia coli
J. Yuan (2006)
Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography.
Linus Pauling (1971)
Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling.
Mary A. Rodgers (2009)
Metabolic profiling technologies for biomarker discovery in biomedicine and drug development.
Goetz Schlotterbeck (2006)
High-resolution microcoil H-1-NMR for mass-limited
D. L. Olson (1995)
A comprehensive urinary metabolomic approach for identifying kidney cancerr.
Tobias Kind (2007)
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry.
Sunil U. Bajad (2006)
METLIN: A Metabolite Mass Spectral Database
C. A. Smith (2005)
Alkyl and alk-1-enyl ethers of glycerol in lipids from normal and neoplastic human tissues.
F. S. Snyder (1969)
Global metabolic responses of mice to Trypanosoma brucei brucei infection
Yulan Wang (2008)
Über den Stoff - wechsel der Carcinomzelle TheM 2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
O. Warburg (1924)
High-Resolution Microcoil 1H-NMR for Mass-Limited, Nanoliter-Volume Samples
Dean L. Olson (1995)
Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques.
W. R. Wikoff (2008)
Techniques of orthomolecular diagnosis.
Arthur B. Robinson (1974)
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
Arvind Ramanathan (2005)
Assignment of endogenous substrates to enzymes by global metabolite profiling.
A. Saghatelian (2004)
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
Christopher B. Newgard (2009)
LMSD: LIPID MAPS structure database
M. Sud (2007)
XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
C. A. Smith (2006)
Lipid metabolome-wide effects of the PPARγ agonist rosiglitazones⃞s The online version of this article (available at http://www.jlr.org) contains an additional 4 tables. Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200169-JLR200
Steven M. Watkins (2002)
Metabonomics: a platform for studying drug toxicity and gene function
Jeremy K. Nicholson (2002)
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
Joshua Munger (2008)
Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research.
Simone J Rochfort (2005)
Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library.
Frank C. Schroeder (2007)
Extending the Scope of NMR Spectroscopy with Microcoil Probes
Frank C. Schroeder (2007)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R Christofk (2008)
Use of phenylalanine-to-tyrosine ratio determined by tandem mass spectrometry to improve newborn screening for phenylketonuria of early discharge specimens collected in the first 24 hours.
Donald H. Chace (1998)
High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer.
Howard R. Morris (1996)
ward fingerprinting cellular lipidomes directly from biological samples by two - dimensional electrospray ionization mass spectrome
X. L. Han (2004)
XCMS2: processing tandem mass spectrometry data for metabolite identification and structural characterization.
H. Benton (2008)
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.
Xianlin Han (2005)
Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
T. Andrew Clayton (2009)
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
Oded Shaham (2008)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
L. Dang (2009)
Rapid 'de novo' peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer.
A. Shevchenko (1997)
Metabolomics: a global biochemical approach to drug response and disease.
R. Kaddurah-Daouk (2008)
Analysis of highly polar compounds of plant origin: combination of hydrophilic interaction chromatography and electrospray ion trap mass spectrometry.
Vladimir V. Tolstikov (2002)
A branched-chain amino acidrelated metabolic signature that differentiates obese and lean humans and contributes to insulin
C. B. Newgard (2009)
Metabolomics by numbers: acquiring and understanding global metabolite data.
Royston Goodacre (2004)
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Arun Sreekumar (2009)
This paper is referenced by
Multi-omics of obesity and weight change in the post-genomic era
Simone Wahl (2015)
Traditional Chinese medicine ZHENG and Omics convergence: a systems approach to post-genomics medicine in a global world.
Peng Wang (2013)
Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis
Ryan J Shirey (2018)
Two complementary reversed-phase separations for comprehensive coverage of the semipolar and nonpolar metabolome
Fuad J Naser (2017)
Balancing metabolome coverage and reproducibility for untargeted NMR-based metabolic profiling in tissue samples through mixture design methods
Hong Zheng (2018)
Glycyrrhiza glabra-Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells
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A metabolic biosignature of early response to anti-tuberculosis treatment
Sebabrata Mahapatra (2014)
Informatics-driven Infectious Disease Research
Bruno W. S. Sobral (2011)
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Rita Ostan (2015)
Biotinylation and high affinity avidin capture as a strategy for LC-MS based metabolomics
Sofie Rhönnstad (2010)
Lipidome and proteome map of myelin membranes.
Gopakumar M. Gopalakrishnan (2013)
Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry
Shuxin Liu (2017)
Serial Metabolome Changes in a Prospective Cohort of Subjects with Influenza Viral Infection and Comparison with Dengue Fever.
Liang Cui (2017)
A Metabolomic Study of Rats with Doxorubicin-Induced Cardiomyopathy and Shengmai Injection Treatment
Yu Chen (2015)
Exhaled breath profiling in diagnosing wheezy preschool children
Kim D. G. van de Kant (2013)
Urinary metabolomics in newborns and infants.
Vassilios Fanos (2012)
HPLC-MS-Based Metabonomics Reveals Disordered Lipid Metabolism in Patients with Metabolic Syndrome
Shili Chen (2011)
Studies on Distribution and Persistence of Halquinol and its Metabolites in Various Tissues of Chicken
Indu Thripathi (2013)
Development of nanoflow liquid chromatography-nanoelectrospray ionization mass spectrometry methodology for improved urine metabolomics
Andrew J Chetwynd (2015)
Chiral Metabolomics Using Triazine-Based Chiral Labeling Reagents by UPLC-ESI-MS/MS.
Toshimasa Toyo’oka (2019)
Activity-based protein profiling for biochemical pathway discovery in cancer
Daniel K. Nomura (2010)
Functional Proteomics: Mapping Lipid-Protein Interactomes
Clive S. D’Santos (2012)
Metabolomic investigation of cholestasis in a rat model using ultra-performance liquid chromatography/tandem mass spectrometry.
Masayo Aoki (2011)
Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy
Carmen Galbis-Estrada (2014)
Gas chromatography-mass spectrometry metabolite profiling of worker honey bee (Apis mellifera L.) hemolymph for the study of Nosema ceranae infection.
Konstantinos A. Aliferis (2012)
Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes
Natalia V Voge (2016)
A LC-MS–based workflow for measurement of branched fatty acid esters of hydroxy fatty acids
Tejia Zhang (2016)
The use of EEM fluorescence data and OPLS/UPLS-DA algorithm to discriminate between normal and cancer cell lines: a feasibility study.
Ana Carolina de Oliveira Neves (2014)
Metabolomics analyses to better understand complex phenotypes
Zhonghao Yu (2013)
Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites.
Manuel Föcker (2012)
A comprehensive high-resolution mass spectrometry approach for characterization of metabolites by combination of ambient ionization, chromatography and imaging methods.
A. Berisha (2014)
Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness
Daniel Globisch (2013)See more