Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Dietary Fermented Soybean Suppresses UVB-induced Skin Inflammation In Hairless Mice Via Regulation Of The MAPK Signaling Pathway.
Taek Hwan Lee, Moon ho Do, Y. Oh, D. W. Cho, S. Kim, S. Kim
Published 2014 · Chemistry, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Soybean may be a promising ingredient for regulating UVB-induced inflammatory damage to the skin. We investigated the anti-inflammatory effects of diets supplemented with fermented soybean on UVB-induced skin photodamage and the effectiveness of soybean (S) and fermented soybean (FS) dietary supplementation. To investigate the effects of two major isoflavones-daidzein and genistein-from FS, we used cocultures with keratinocytes and fibroblasts. Genistein treatment strongly inhibited the production of IL-6 and MAPK signaling. Forty hairless male mice divided into four groups were fed with a control diet (group N: normal, group C; +UVB) or diets with 2.5% S+UVB or 2.5% FS+UVB (group S, group FS) for 8 weeks. Macrophage infiltration to the dermis was reduced more in groups S and FS than in group C. The expression levels of iNOS and COX-2 were significantly decreased in group FS (by 7.7% ± 0.4% and 21.2% ± 0.3%, respectively [p < 0.05]).
This paper references
Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli.
Brian D. Lamon (2010)
Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells.
I. Nizamutdinova (2009)
Red-Koji Fermented Red Ginseng Ameliorates High Fat Diet-Induced Metabolic Disorders in Mice
C. M. Kim (2013)
UVB-Induced Skin Inflammation and Cutaneous Tissue Injury Is Dependent on the MHC Class I–Like Protein, CD1d
S. Ryser (2014)
Deficient inflammatory response to UV radiation in neonatal mice
A. Wolnicka-Glubisz (2007)
β-Amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation
M. Koistinaho (2002)
Hexahydro-β-acids potently inhibit 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice.
Chung-Huei Hsu (2013)
Chronic Administration of Daidzein, a Soybean Isoflavone, Improves Endothelial Dysfunction and Attenuates Oxidative Stress in Streptozotocin‐induced Diabetic Rats
M. Roghani (2013)
Supplementation of the fermented soy product ImmuBalance™ effectively reduces itching behavior of atopic NC/Tnd mice.
A. Matsuda (2012)
Nondenatured Soy Extracts Reduce UVB‐induced Skin Damage via Multiple Mechanisms
Nannan Chen (2008)
7,3′,4′-Trihydroxyisoflavone, a Metabolite of the Soy Isoflavone Daidzein, Suppresses Ultraviolet B-induced Skin Cancer by Targeting Cot and MKK4*
D. Lee (2011)
Novel Aspects of Intrinsic and Extrinsic Aging of Human Skin: Beneficial Effects of Soy Extract¶
Kirstin M Südel (2005)
The UVB cutaneous inflammatory pain model: a reproducibility study in healthy volunteers.
C. D. Mørch (2013)
T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of MKP1 Protein Prevents Solar Ultraviolet Light-induced Inflammation through Inhibition of the p38 Protein Signaling Pathway*
S. Li (2011)
Matrix metalloproteinase-9 expression and release from skin fibroblasts interacting with keratinocytes: Upregulation in response to sulphur mustard.
C. Ries (2009)
Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling.
Akira Shibata (2010)
Anti-Photoaging Effects of Soy Isoflavone Extract (Aglycone and Acetylglucoside Form) from Soybean Cake
Chieh-Chen Huang (2010)
Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein.
Y. Wang (1998)
UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo.
U. Wölfle (2011)
Effect of soybean protein on novel cardiovascular disease risk factors: a randomized controlled trial
C. Rebholz (2013)
Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway.
K. Tsoyi (2008)
Bioconversion of isoflavone glycosides to aglycones, mineral bioavailability and vitamin B complex in fermented soymilk by probiotic bacteria and yeast
C. Rekha (2010)
Allergenicity of peanut and soybean extracts altered by chemical or thermal denaturation in patients with atopic dermatitis and positive food challenges.
A. Burks (1992)
Metabolite profiling of enzymatically hydrolyzed and fermented forms of Opuntia ficus-indica and their effect on UVB-induced skin photoaging
D. Cho (2014)
Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages.
R. Au (2007)
Functional melanocortin 1 receptor Mc1r is not necessary for an inflammatory response to UV radiation in adult mouse skin
A. Wolnicka-Glubisz (2013)
Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair
B. Thiers (2007)
A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice.
Yuki Kanamoto (2011)
Isoflavone transformation during soybean koji preparation and subsequent miso fermentation supplemented with ethanol and NaCl.
R. Y. Chiou (2001)
Role of Dietary Soy Protein in Obesity
M. Velásquez (2007)
Soybean isoflavone genistein regulates apoptosis through NF-κB dependent and independent pathways.
Y. Lee (2013)
Anti-inflammatory activity of the ethanol extract of Chungkukjang, Korean fermented bean: 5-lipoxygenase inhibition.
Y. H. Choi (2008)
In vitro and in vivo anti-photoaging effects of an isoflavone extract from soybean cake.
Tsu-Man Chiu (2009)
MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits.
B. Kamińska (2005)
In vitro and in vivo evaluation of topical delivery and potential dermal use of soy isoflavones genistein and daidzein.
Zih-rou Huang (2008)
HIV and skin cancer.
K. Honda (2006)
Targeting inflammation by modulating the Jun/AP-1 pathway
H. B. Schonthaler (2011)
Genistein aglycone, a soy‐derived isoflavone, improves skin changes induced by ovariectomy in rats
F. Polito (2012)
A Comparative Analysis of the Photo-Protective Effects of Soy Isoflavones in Their Aglycone and Glucoside Forms
B. Iovine (2012)
Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin.
E. Yoshida (2006)
Synergic Effect of Genistein and Daidzein on UVB-Induced DNA Damage: An Effective Photoprotective Combination
B. Iovine (2011)
Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice.
Akira Shibata (2010)
p38 MAP kinase plays a functional role in UVB‐Induced mouse skin carcinogenesis
Sally E. Dickinson (2011)
Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice.
A. Kim (2005)
UV, stress and aging
F. Debacq-Chainiaux (2012)
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
M. Koistinaho (2002)
8-Oxo-2'-deoxyguanosine ameliorates UVB-induced skin damage in hairless mice by scavenging reactive oxygen species and inhibiting MMP expression.
Jin-Ku Lee (2013)
Protective Effects of Dietary Soy Isoflavones against UV-Induced Skin-Aging in Hairless Mouse Model
S. Kim (2004)
This paper is referenced by
Dietary supplementation with a fermented barley and soybean mixture attenuates UVB-induced skin aging and dehydration in hairless mouse skin
O. Kwon (2015)
Effect of ethanol extract from Lactobacillus plantarum TWK10-fermented soymilk on wound healing in streptozotocin-induced diabetic rat
Yu-chun Chuang (2019)
Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice
Yuhui Ye (2018)
Modulating effect of cromolyn on Akt, MAPK, ERK and DNMT expression pattern in 7,12-dimethylbenz (a) anthracene induced hamster buccal pouch carcinogenesis
S. Manoharan (2015)
Down-regulation of genes related to photoaging and inflammation in UVBirradiated mice premature skin photoaging by linoleic acid-rich tempeh oil
D. Subali (2019)
The Daidzein Metabolite, 6,7,4'-Trihydroxyisoflavone, Is a Novel Inhibitor of PKCα in Suppressing Solar UV-Induced Matrix Metalloproteinase 1
Tae-Gyu Lim (2014)
Dihydrolipoyl dehydrogenase as a potential UVB target in skin epidermis; using an integrated approach of label-free quantitative proteomics and targeted metabolite analysis.
E. Moon (2015)
Molecular mechanisms of selenium-biofortified soybean protein and polyphenol conjugates in protecting mouse skin damaged by UV-B.
X. Zhang (2020)
Accumulation of Citrus Flavanones in Bovine Milk Following Citrus Pulp Incorporation into the Diet of Dairy Cows
Seungwoo Lee (2017)
Dietary Supplementation with Isoflavones Prevents Muscle Wasting in Tumor-Bearing Mice.
K. Hirasaka (2016)
PEPTIDE EXTRACTS FROM TEMPEH PROTECT AGAINST PHOTOAGING VIA DOWN-REGULATING MATRIX METALLOPROTEINASE-3 GENE EXPRESSION
Steffanus Pranoto Hallis (2019)
Effects of Natural and Chemically Defined Nutrients on Candida albicans Water-soluble Fraction (CAWS) Vasculitis in Mice.
W. Sato (2017)
Antioxidant activity and anti-inflammatory activity of ethanol extract and fractions of Doenjang in LPS-stimulated RAW 264.7 macrophages
C. S. Kwak (2015)
OF PHARMACOLOGICAL EFFECTS
Meng-yao Sun (2016)
DAIDZEIN: A REVIEW OF PHARMACOLOGICAL EFFECTS
M. Sun (2016)
Isotrifoliol inhibits pro‐inflammatory mediators by suppression of TLR/NF‐&kgr;B and TLR/MAPK signaling in LPS‐induced RAW264.7 cells☆
Hua Li (2017)
An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
T. Chu (2020)
Moisturizers: Treatment of Dry Skin Syndrome and Barrier Defects
M. Lodén (2015)
Photoprotective effects of 2S,3R-6-methoxycarbonylgallocatechin isolated from Anhua dark tea on UVB-induced inflammatory responses in human keratinocytes.
Donghwa Kim (2019)
Rapid Screening and Identification of Daidzein Metabolites in Rats Based on UHPLC-LTQ-Orbitrap Mass Spectrometry Coupled with Data-Mining Technologies
W. Zhao (2018)
Fermented barley and soybean (BS) mixture enhances intestinal barrier function in dextran sulfate sodium (DSS)-induced colitis mouse model
J. K. Woo (2016)
A Novel lncRNA Regulates the Toll-Like Receptor Signaling Pathway and Related Immune Function by Stabilizing FOS mRNA as a Competitive Endogenous RNA
H. Fan (2019)
Safflower bud inhibits RANKL-induced osteoclast differentiation and prevents bone loss in ovariectomized mice.
Joo-hee Choi (2017)
Changes in the Anti-Allergic Activities of Sesame by Bioconversion
T. Jung (2018)
Dietary Management of Skin Health: The Role of Genistein
N. Irrera (2017)
The anthocyanin extracts from purple-fleshed sweet potato exhibited anti-photoaging effects on ultraviolent B-irradiated BALB/c-nu mouse skin
Q. Zhi (2020)
Plant extracts and natural compounds used against UVB-induced photoaging
M. Cavinato (2017)
Botanicals and Cosmeceuticals for Sun Protection
W. Tuong (2015)
Defense potential of secondary metabolites in medicinal plants under UV-B stress.
S. Takshak (2019)
Silk peptide production from whole silkworm cocoon using ultrasound and enzymatic treatment and its suppression of solar ultraviolet-induced skin inflammation.
S. J. Eom (2019)