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Room Temperature Aryl Trifluoromethylation Via Copper-mediated Oxidative Cross-coupling.
Todd D. Senecal, A. T. Parsons, S. L. Buchwald
Published 2011 · Chemistry, Medicine
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A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1-4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
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