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Comprehensive Synthesis Of Photoreactive (3-trifluoromethyl)diazirinyl Indole Derivatives From 5- And 6- Trifluoroacetylindoles For Photoaffinity Labeling.

Yuta Murai, K. Masuda, Yasuko Sakihama, Y. Hashidoko, Y. Hatanaka, M. Hashimoto
Published 2012 · Chemistry, Medicine

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5- and 6-trifluoromethyldiazirinyl indoles were synthesized from corresponding bromoindole derivatives for the first time. They acted as mother skeletons for the comprehensive synthesis of various bioactive indole metabolites. These can be used in biological functional analysis as diazirine-based photoaffinity labels.
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