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Total Synthesis Of The Lycopodium Alkaloid Serratezomine A Using Free Radical-mediated Vinyl Amination To Prepare A β-stannyl Enamine Linchpin.

Julie A Pigza, Jeong-seok Han, Aroop Chandra, D. Mutnick, M. Pink, J. Johnston
Published 2013 · Chemistry, Medicine

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Serratezomine A is a member of the structurally diverse class of compounds known as the Lycopodium alkaloids. The key supporting studies and successful total synthesis of serratezomine A are described in this account. Significant features of the synthesis include the first application of free radical mediated vinyl amination and Hwu's oxidative allylation in a total synthesis and an intramolecular lactonization via a transannular S(N)i reaction. Minimal use of protecting groups and the highly diastereoselective formation of a hindered, quaternary stereocenter using an umpolung allylation are also highlights from a strategy perspective. Observation of quaternary carbon epimerization via a retro-Mannich/Mannich sequence highlights the additional challenge presented by the axial alcohol at C8 in serratezomine A.
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