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Asymmetric Total Syntheses Of Cyclic Nitrone-containing Phlegmarine-type Lycopodium Alkaloids, Lycoposerramines-X And -Z.

T. Tanaka, N. Kogure, M. Kitajima, H. Takayama
Published 2009 · Chemistry, Medicine

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The total syntheses of cyclic nitrone-containing phlegmarine-type Lycopodium alkaloids, lycoposerramines-X and -Z, were accomplished starting from (R)-3-methylcyclohexanone via Pd-catalyzed Suzuki-Miyaura coupling, Johnson-Claisen rearrangement, stereoselective hydroboration-oxidation reaction, and Mitsunobu reaction, thereby establishing the structures including the absolute configuration.



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