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Film Thickness Dependence Of Protein Adsorption From Blood Serum And Plasma Onto Poly(sulfobetaine)-grafted Surfaces.

W. Yang, S. Chen, G. Cheng, Hana Vaisocherová, H. Xue, W. Li, J. Zhang, S. Jiang
Published 2008 · Chemistry, Medicine

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In this work, we investigate protein adsorption from single protein solutions and complex media such as 100% blood serum and plasma onto poly(sulfobetaine methacrylate) (polySBMA)-grafted surfaces via atom transfer radical polymerization (ATRP) at varying film thicknesses. It is interesting to observe that protein adsorption exhibits a minimum at a medium film thickness. Results show that the surface with 62 nm polySBMA brushes presents the best nonfouling character in 100% blood serum and plasma although all of these surfaces are highly resistant to nonspecific protein adsorption from single fibrinogen and lysozyme solutions. Surface resistance to 100% blood serum or plasma is necessary for many applications from blood-contacting devices to drug delivery. This work provides a new in vitro evaluation standard for the application of biomaterials in vivo.



This paper is referenced by
10.2478/s11696-012-0147-1
Functional polymer thin films designed for antifouling materials and biosensors
C. Zhao (2012)
10.1021/BK-2012-1120.CH031
Protein-repellent functionalizable surfaces based on covalently bonded phospholipids with phosphorylcholine head
Lynda Ferez (2012)
10.1016/J.REACTFUNCTPOLYM.2010.11.017
Adhesion force of proteins against hydrophilic polymer brush surfaces
Y. Inoue (2011)
10.1201/B12138-7
Dual-Functional Zwitterionic Carboxybetaine for Highly Sensitive and Specific Cancer Biomarker Detection in Complex Media Using SPR Biosensors
Norman D. Brault (2012)
10.1021/bm5004515
Application of isothermal titration calorimetry for characterizing thermodynamic parameters of biomolecular interactions: peptide self-assembly and protein adsorption case studies.
M. Kabiri (2014)
10.1002/anie.201400546
Protein interactions with polymer coatings and biomaterials.
Q. Wei (2014)
10.1021/la402287a
Enhanced stability of low fouling zwitterionic polymer brushes in seawater with diblock architecture.
R. Quintana (2013)
10.1002/jbm.a.35245
Role of molecular properties of ulvans on their ability to elaborate antiadhesive surfaces.
Virginie Gadenne (2015)
10.1016/j.actbio.2010.12.021
Anti-fouling bioactive surfaces.
Q. Yu (2011)
10.1007/978-3-319-57494-3_8
Anti-fouling Medical Coatings
J. Li (2017)
Zwitterionic Poly(carboxybetaine) Materials for Blood-Contacting Medical Devices and Nanoparticles
W. Yang (2014)
10.1038/PJ.2014.46
Hemocompatibility of zwitterionic interfaces and membranes
M. Sin (2014)
10.1021/bm201814p
Ultralow fouling polyacrylamide on gold surfaces via surface-initiated atom transfer radical polymerization.
Q. Liu (2012)
10.1021/acs.biomac.7b01247
Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption.
S. Kobayashi (2017)
10.1163/092050609X12578498982998
Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes
L. Li (2011)
10.1002/mabi.201800137
Multipurpose Antifouling Coating of Solid Surfaces with the Marine-Derived Polymer Fucoidan.
Yeonwoo Jeong (2018)
10.1039/C5RA16414A
Synthesis, characterization and self-assembly behavior of zwitterionic amphiphilic triblock copolymers bearing pendant amino acid residues
Xiaohong Shang (2015)
10.1002/wnan.1278
Recent development of antifouling polymers: structure, evaluation, and biomedical applications in nano/micro-structures.
Lingyun Liu (2014)
10.1080/09205063.2014.948332
Amino acid-based zwitterionic polymers: antifouling properties and low cytotoxicity
W. Li (2014)
10.1021/la2038558
Phase behavior of poly(sulfobetaine methacrylate)-grafted silica nanoparticles and their stability in protein solutions.
Z. Dong (2011)
10.1021/jf204741p
Advances in nonfouling materials: perspectives for the food industry.
Tiphaine Mérian (2012)
10.1021/acs.langmuir.6b01329
Amino Acid-Based Zwitterionic Polymer Surfaces Highly Resist Long-Term Bacterial Adhesion.
Q. Liu (2016)
10.1039/c6cc00109b
A zwitterionic macro-crosslinker for durable non-fouling coatings.
W. Wang (2016)
10.1021/acsami.7b09725
Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry
E. van Andel (2017)
10.1039/C5TB01336D
Improving antifouling ability and hemocompatibility of poly(vinylidene fluoride) membranes by polydopamine-mediated ATRP.
Jinhong Jiang (2015)
10.1016/j.colsurfb.2015.01.011
An intuitive thermal-induced surface zwitterionization for versatile, well-controlled haemocompatible organic and inorganic materials.
M. Sin (2015)
10.1002/9781119455042.CH11
Glycopolymer Brushes Presenting Sugars in Their Natural Form: Synthesis and Applications
K. Yu (2017)
10.1016/j.jcis.2009.10.004
Temperature-responsive polymer-brush constructed on a glass substrate by atom transfer radical polymerization.
H. Kitano (2010)
10.1002/9781119308713.CH2
Antimicrobial Coatings and Other Surface Modifications for Infection Prevention
M. Mittelman (2016)
Interfacial and transport properties of nanoconstrained inorganic and organic materials
Lakshmi S. Kocherlakota (2013)
Electrospinning of sulfobetaine methacrylate nanofibers
Erin Emerick (2011)
10.1016/j.colsurfb.2012.01.004
Nonfouling polyampholyte polymer brushes with protein conjugation capacity.
Tapashree Tah (2012)
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