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Reversible PH Lability Of Cross-linked Vault Nanocapsules.

M. Yu, B. Ng, L. Rome, S. Tolbert, H. Monbouquette
Published 2008 · Chemistry, Medicine

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Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.
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