Online citations, reference lists, and bibliographies.
← Back to Search

Reversible PH Lability Of Cross-linked Vault Nanocapsules.

M. Yu, B. Ng, L. Rome, S. Tolbert, H. Monbouquette
Published 2008 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10,000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.
This paper references



This paper is referenced by
Precisely engineered protein-based PRINT(RTM) particles for delivery of nucleic acids
Jing Xu (2012)
10.1021/ja302363r
Rendering protein-based particles transiently insoluble for therapeutic applications.
Jing Xu (2012)
10.1021/nn901167s
Immobilization of recombinant vault nanoparticles on solid substrates.
Y. Xia (2010)
10.1021/cr300047q
Can controversial nanotechnology promise drug delivery?
Venkat Ratnam Devadasu (2013)
10.1021/nn2014613
Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm.
Muri Han (2011)
10.1021/nn102051r
Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange.
J. Yang (2010)
10.1016/j.copbio.2012.05.004
Vault particles: a new generation of delivery nanodevices.
A. Casañas (2012)
10.1016/j.colsurfb.2009.07.042
Crosslinked polymeric nanocapsules from polymer brushes grafted silica nanoparticles via surface-initiated atom transfer radical polymerization.
B. Mu (2009)
Artificial bioparticle and method for manufacturing same
秀明 田中 (2013)
10.1021/nn3052082
Development of the vault particle as a platform technology.
L. Rome (2013)
10.1021/nn800638x
Targeting vault nanoparticles to specific cell surface receptors.
V. Kickhoefer (2009)
10.1021/nn900555d
Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins.
Lisa E Goldsmith (2009)
10.1007/s11671-008-9238-x
Mono-dispersed Functional Polymeric Nanocapsules with Multi-lacuna via Soapless Microemulsion Polymerization with Spindle-like α-Fe2O3Nanoparticles as Templates
G. Liu (2009)
10.1021/acsnano.6b07440
Vault Nanoparticles: Chemical Modifications for Imaging and Enhanced Delivery.
N. Benner (2017)
Surface modification of poly (L-lactic acid) to improve endothelial cell-material interaction
Y. Xia (2011)
10.1038/srep34143
Decrease in pH destabilizes individual vault nanocages by weakening the inter-protein lateral interaction
A. Llauró (2016)
10.1039/c6nr07315h
Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger.
Mahdi Karimi (2017)
Semantic Scholar Logo Some data provided by SemanticScholar