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Synergistic Effect Of Graphene Oxide/MWCNT Films In Laser Desorption/ionization Mass Spectrometry Of Small Molecules And Tissue Imaging.

Young-Kwan Kim, Hee-Kyung Na, Sul-Jin Kwack, Soo-Ryoon Ryoo, Youngmin Lee, Seunghee Hong, Sungwoo Hong, Y. Jeong, Dal‐Hee Min
Published 2011 · Materials Science, Medicine

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Matrix-assisted laser desorption/ionization mass spectrometry has been considered an important tool for various biochemical analyses and proteomics research. Although addition of conventional matrix efficiently supports laser desorption/ionization of analytes with minimal fragmentation, it often results in high background interference and misinterpretation of the spatial distribution of biomolecules especially in low-mass regions. Here, we show design, systematic characterization, and application of graphene oxide/multiwalled carbon nanotube-based films fabricated on solid substrates as a new matrix-free laser desorption/ionization platform. We demonstrate that the graphene oxide/multiwalled carbon nanotube double layer provides many advantages as a laser desorption/ionization substrate, such as efficient desorption/ionization of analytes with minimum fragmentation, high salt tolerance, no sweet-spots for mass signal, excellent durability against mechanical and photoagitation and prolonged exposure to ambient conditions, and applicability to tissue imaging mass spectrometry. This platform will be widely used as an important tool for mass spectrometry-based biochemical analyses because of its outstanding performance, long-term stability, and cost effectiveness.
This paper references
10.1021/JA01539A017
Preparation of Graphitic Oxide
W. S. Hummers (1958)
10.1002/BIT.260190908
A new approach to preparative enzymatic synthesis
A. Klibanov (1977)
10.1016/0168-1176(87)87041-6
Matrix-assisted ultraviolet laser desorption of non-volatile compounds
M. Karas (1987)
10.1002/RCM.1290020802
Protein and polymer analyses up to m/z 100 000 by laser ionization time-of-flight mass spectrometry
K. Tanaka (1988)
10.1021/AC00171A028
Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.
M. Karas (1988)
10.1002/RCM.1290081105
C60‐assisted laser desorption/ionization mass spectrometry in the analysis of phosphotungstic acid
F. Hopwood (1994)
10.1021/AC00119A021
Graphite surface-assisted laser desorption/ionization time-of-flight mass spectrometry of peptides and proteins from liquid solutions.
J. Sunner (1995)
10.1021/ac960558i
Graphite/Liquid mixed matrices for laser desorption/ionization mass spectrometry.
M. Dale (1996)
10.1038/20400
Desorption–ionization mass spectrometry on porous silicon
Jing Wei (1999)
10.1002/(SICI)1096-9888(200003)35:3<417::AID-JMS952>3.0.CO;2-#
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an inorganic particle matrix for small molecule analysis
Kinumi (2000)
10.1016/S1044-0305(00)00129-X
An activated carbon substrate surface for laser desorption mass spectrometry
Mei Han (2000)
10.1073/pnas.081069298
Desorption/ionization on silicon (DIOS): A diverse mass spectrometry platform for protein characterization
J. J. Thomas (2001)
10.1002/1615-9861(200209)2:9<1277::AID-PROT1277>3.0.CO;2-P
Graphite powder as an alternative or supplement to reversed‐phase material for desalting and concentration of peptide mixtures prior to matrix‐assisted laser desorption/ionization‐mass spectrometry
M. Larsen (2002)
10.1021/AC010979M
A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry.
Z. Guo (2002)
10.1021/AC0345695
Carbon nanotubes as assisted matrix for laser desorption/ionization time-of-flight mass spectrometry.
Songyun Xu (2003)
10.1016/S1387-3806(02)00973-9
Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications
W. G. Lewis (2003)
10.1021/AC020750M
Use of a water-soluble fullerene derivative as precipitating reagent and matrix-assisted laser desorption/ionization matrix to selectively detect charged species in aqueous solutions.
J. Shiea (2003)
10.1016/J.JASMS.2004.01.004
Collisional cooling enhances the ability to observe non-covalent interactions within the inducible nitric oxide synthase oxygenase domain: Dimerization, complexation, and dissociation
J. Smith (2004)
10.1021/AC049192X
MALDI matrices for biomolecular analysis based on functionalized carbon nanomaterials.
M. Ugarov (2004)
10.1002/CHIN.200414280
Chemistry, Biological Activity and Chemotherapeutic Potential of Betulinic Acid for the Prevention and Treatment of Cancer and HIV Infection
R. Cichewicz (2004)
10.1016/J.JASMS.2004.08.001
Carbon nanotubes as affinity probes for peptides and proteins in MALDI MS analysis
W. Chen (2004)
10.1021/JA043907W
Size-selected (2-10 nm) gold nanoparticles for matrix assisted laser desorption ionization of peptides.
J. McLean (2005)
10.1002/RCM.1779
Oxidized carbon nanotubes as matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of biomolecules.
S. Ren (2005)
10.1016/J.JASMS.2004.11.005
Carbon nanotubes as adsorbent of solid-phase extraction and matrix for laser desorption/ionization mass spectrometry
Chensong Pan (2005)
10.1007/S00216-006-0600-5
Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry—applications and perspectives
A. Tholey (2006)
10.1038/nmeth1094
MALDI imaging mass spectrometry: molecular snapshots of biochemical systems
D. Cornett (2007)
10.1021/AC0706170
Colloidal graphite-assisted laser desorption/ionization MS and MS(n) of small molecules. 2. Direct profiling and MS imaging of small metabolites from fruits.
Hui Zhang (2007)
10.1021/AC062251H
Colloidal graphite-assisted laser desorption/ionization mass spectrometry and MSn of small molecules. 1. Imaging of cerebrosides directly from rat brain tissue.
Sangwon Cha (2007)
Colloidal Graphite-Assisted Laser Desorption/Ionization MS and MSn of Small Molecules
H. Zhang (2007)
Colloidal GraphiteAssisted Laser Desorption / Ionization Mass Spectrometry and MSn of Small Molecules . 1 . Imaging of Cerebrosides Directly from Rat Brain Tissue
S. Cha (2007)
10.1021/ac801662n
Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix.
E. Astigarraga (2008)
10.1038/nrm2330
Membrane lipids: where they are and how they behave
G. Meer (2008)
10.1021/ac800789t
Layer-by-layer self-assembled mutilayer films of gold nanoparticles for surface-assisted laser desorption/ionization mass spectrometry.
H. Kawasaki (2008)
10.1021/ac802576q
Nanostructure initiator mass spectrometry: tissue imaging and direct biofluid analysis.
Ó. Yanes (2009)
10.1021/ac8026367
Ion desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: desorption mechanism(s) and the design of SALDI substrates.
Ho-Wai Tang (2009)
10.1016/j.jasms.2008.09.008
Improved MALDI-TOF imaging yields increased protein signals at high molecular mass
Barbara D Leinweber (2009)
10.1021/la9029744
Durable large-area thin films of graphene/carbon nanotube double layers as a transparent electrode.
Y. Kim (2009)
10.1038/nrc2917
Molecular imaging by mass spectrometry — looking beyond classical histology
K. Schwamborn (2010)
10.1021/ac101022m
Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS.
Xiaoli Dong (2010)
10.1002/adma.200901942
Microstructuring of graphene oxide nanosheets using direct laser writing.
Y. Zhou (2010)
10.1038/ja.2010.2
Anti-leishmanial activity of betulin derivatives
S. Alakurtti (2010)
10.1021/ja104017y
Graphene-based SELDI probe with ultrahigh extraction and sensitivity for DNA oligomer.
L. Tang (2010)
10.1021/ja106276j
Laser desorption/ionization mass spectrometric assay for phospholipase activity based on graphene oxide/carbon nanotube double-layer films.
J. Lee (2010)
10.1039/c0cc01681k
Reduced graphene oxide films used as matrix of MALDI-TOF-MS for detection of octachlorodibenzo-p-dioxin.
Xiaozhu Zhou (2010)



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10.1007/s00216-020-03083-9
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Ari Chae (2021)
10.3390/nano11020288
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Seung-Woo Kim (2021)
10.1007/s00604-020-4142-x
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Xueyun Wang (2020)
10.1002/adfm.202002791
Vanadium Core–Shell Nanorods Inspect Metabolic Changes of Diabetic Retinopathy
Vadanasundari Vedarethinam (2020)
10.1002/smll.202003902
Zirconia Hybrid Nanoshells for Nutrient and Toxin Detection.
M. Rana (2020)
10.1016/j.talanta.2019.120531
Exfoliated MXene as a mediator for efficient laser desorption/ionization mass spectrometry analysis of various analytes.
Ari Chae (2020)
10.1016/J.CCLET.2020.09.026
Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds
Shumu Li (2020)
10.1002/mas.21670
Surface-assisted laser desorption/ionization mass spectrometry imaging: A review.
Wendy H Müller (2020)
10.1080/05704928.2019.1570519
Desorption and ionization mechanisms and signal enhancement in surface assisted laser desorption ionization mass spectrometry (SALDI-MS)
K. Song (2020)
10.1002/adma.202000906
Metabolic Fingerprinting on Synthetic Alloys for Medulloblastoma Diagnosis and Radiotherapy Evaluation.
Jing Cao (2020)
10.1007/s00604-020-04544-9
Bi, Fe, and Ti ternary co-doped ZrO2 nanocomposites as a mass spectrometry matrix for the determination of bisphenol A and tetrabromobisphenol A in tea
Deshuai Zhen (2020)
10.5483/BMBRep.2020.53.7.078
Organic matrix-free imaging mass spectrometry
Eunjin Kim (2020)
10.1016/j.foodchem.2020.127165
Colorimetric sensor and LDI-MS detection of biogenic amines in food spoilage based on porous PLA and graphene oxide.
Tatiya Siripongpreda (2020)
10.1016/J.IJMS.2019.05.004
Synthesis and application of nitrogen-doped carbon dots as a matrix in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
S. Maleki (2019)
10.1039/c9an01738k
3D paper-based microfluidic device: a novel dual-detection platform of bisphenol A.
Jutiporn Yukird (2019)
10.1016/J.TRAC.2018.10.033
Recent advances in metal-organic frameworks for separation and enrichment in proteomics analysis
Qianjing Liu (2019)
10.1007/s00604-019-3770-5
Nanoparticle-based surface assisted laser desorption ionization mass spectrometry: a review
Hani Nasser Abdelhamid (2019)
10.3390/C5030040
Atmospheric Pressure Plasma-Treated Carbon Nanowalls’ Surface-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (CNW-SALDI-MS)
Takayuki Ohta (2019)
10.1016/J.CARBON.2019.01.107
Protein WW domain denaturation on defective graphene reveals the significance of nanomaterial defects in nanotoxicity
Baoyu Li (2019)
10.1016/j.matt.2019.08.014
A Multifunctional Platinum Nanoreactor for Point-of-Care Metabolic Analysis
Lin Huang (2019)
10.1002/jms.4488
Immersion by Rotation-Based Application of the Matrix for Fast and Reproducible Sample Preparations and Robust Results in Mass Spectrometry Imaging.
Johanna Schäfermann (2019)
10.3390/ijms20122975
Graphene- and Graphene Oxide-Based Nanocomposite Platforms for Electrochemical Biosensing Applications
Madasamy Thangamuthu (2019)
10.1007/s00216-019-01610-x
Metal–organic framework-based affinity materials in proteomics
A. Saeed (2019)
10.1039/c8sc03692f
Hybrid CuCoO–GO enables ultrasensitive detection of antibiotics with enhanced laser desorption/ionization at nano-interfaces† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03692f
Enhui Wu (2019)
Non-Isothermal Crystallization Kinetics of Graphene Oxide-Carbon Nanotubes Hybrids / Polyamide 6 Composites
Z. Wang (2019)
10.1016/J.TALANTA.2019.03.078
Tailoring the surface chemistry of SiO2-based monoliths to enhance the selectivity of SALDI-MS analysis of small molecules.
M. O. Amin (2019)
10.1016/j.jhazmat.2019.121817
Fe3O4-assisted laser desorption ionization mass spectrometry for typical metabolite analysis and localization: Influencing factors, mechanisms, and environmental applications.
Wen-Wen Wei (2019)
10.1007/s00604-019-3816-8
Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels
Deshuai Zhen (2019)
10.1021/acsami.9b02620
Graphene-Coated Glass Substrate for Continuous Wave Laser Desorption and Atmospheric Pressure Mass Spectrometric Imaging of Live Hippocampal Tissue.
J. Kim (2019)
10.1007/978-3-319-69378-1_9
CNT Applications in Sensors and Actuators
P. Chandrasekhar (2018)
10.1007/978-3-319-69378-1_32
Structural Aspects and Morphology of CPs
P. Chandrasekhar (2018)
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